5,473 research outputs found
A Biogeographic Perspective on the Evolution of Fire Syndromes in Pine Trees (Pinus: Pinaceae)
Our goals were to explore the relationship between biogeography and the evolution of fire-adaptive syndromes in the genus Pinus. We used a previously published time-calibrated phylogeny and conducted ancestral trait reconstruction to estimate the likely timing of diversification in Pinus, and to determine when fire-adaptive syndromes evolved in the lineage. To explore trait conservation among fire syndromes and to investigate historical biogeography, we constructed ancestral state reconstructions using the program RASP and estimated the degree of conservatism for fire-adapted traits in the program BaTS. Our reconstructions suggest that the Bering land bridge, which connected North America and Asia, probably played a major role in early pine evolution. Our estimates indicated that fire-adaptive syndromes seem to have evolved more frequently in New World taxa and probably are related to the uplift of major North American mountain ranges. Our data suggest that certain geographically widespread adaptations to fire evolved repeatedly, possibly due to localized changes in climate and environment, rather than resulting from large dispersal events of pre-adapted individuals
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Renin-Angiotensin-Aldosterone System, Glucose Metabolism and Incident Type 2 Diabetes Mellitus: MESA.
Background Mechanistic studies suggest that aldosterone impairs glucose metabolism. We investigated the cross-sectional associations of aldosterone and plasma renin activity with fasting plasma glucose, insulin resistance ( IR ), β-cell function, and longitudinal association with incident diabetes mellitus among adults in MESA (the multiethnic study of atherosclerosis) prospective cohort study. Methods and Results Homeostatic model assessment of IR ( HOMA 2- IR ) and HOMA 2-β were used to estimate IR and β-cell function, respectively. Incident diabetes mellitus was defined as fasting plasma glucose ≥126 mg/dL or anti-diabetic medication use at follow-up. Linear regression was used to examine cross-sectional associations of aldosterone with fasting plasma glucose, HOMA 2- IR and HOMA 2-β; Cox regression was used to estimate hazard ratios ( HR ) for incident diabetes mellitus with multivariable adjustment. There were 116 cases of incident diabetes mellitus over 10.5 years among 1570 adults (44% non-Hispanic white, 13% Chinese American, 19% Black, 24% Hispanic American, mean age 64±10 years, 51% female). A 100% increase in log-aldosterone was associated with a 2.6 mg/dL higher fasting plasma glucose, 15% higher HOMA 2- IR and 6% higher HOMA 2-β ( P<0.01). A 1- SD increase in log-aldosterone was associated with a 44% higher risk of incident diabetes mellitus ( P<0.01) with the greatest increase of 142% ( P<0.01) observed in Chinese Americans ( P for interaction=0.09 versus other ethnicities). Similar cross-sectional findings for log-plasma renin activity existed, but log-plasma renin activity was not associated with incident diabetes mellitus after full adjustment. Conclusions Aldosterone is associated with glucose homeostasis and diabetes mellitus risk with graded associations among Chinese Americans and blacks, suggesting that pleiotropic effects of aldosterone may represent a modifiable mechanism in diabetes mellitus pathogenesis with potential racial/ethnic variation
Fundamental properties of the mammalian innate immune system revealed by multispecies comparison of type I interferon responses
The host innate immune response mediated by type I interferon (IFN) and the resulting up-regulation of hundreds of interferon-stimulated genes (ISGs) provide an immediate barrier to virus infection. Studies of the type I ‘interferome’ have mainly been carried out at a single species level, often lacking the power necessary to understand key evolutionary features of this pathway. Here, using a single experimental platform, we determined the properties of the interferomes of multiple vertebrate species and developed a webserver to mine the dataset. This approach revealed a conserved ‘core’ of 62 ISGs, including genes not previously associated with IFN, underscoring the ancestral functions associated with this antiviral host response. We show that gene expansion contributes to the evolution of the IFN system and that interferomes are shaped by lineage-specific pressures. Consequently, each mammal possesses a unique repertoire of ISGs, including genes common to all mammals and others unique to their specific species or phylogenetic lineages. An analysis of genes commonly down-regulated by IFN suggests that epigenetic regulation of transcription is a fundamental aspect of the IFN response. Our study provides a resource for the scientific community highlighting key paradigms of the type I IFN response
Giant aortic root aneurysm in a patient with D-transposition of the great arteries and Marfan syndrome
Creating a Field-Wide Forage Canopy Model Using UAVs and Photogrammetry Processing
Alfalfa canopy structure reveals useful information for managing this forage crop, but manual measurements are impractical at field-scale. Photogrammetry processing with images from Unmanned Aerial Vehicles (UAVs) can create a field-wide three-dimensional model of the crop canopy. The goal of this study was to determine the appropriate flight parameters for the UAV that would enable reliable generation of canopy models at all stages of alfalfa growth. Flights were conducted over two separate fields on four different dates using three different flight parameters. This provided a total of 24 flights. The flight parameters considered were the following: 30 m altitude with 90° camera gimbal angle, 50 m altitude with 90° camera gimbal angle, and 50 m altitude with 75° camera gimbal angle. A total of 32 three-dimensional canopy models were created using photogrammetry. Images from each of the 24 flights were used to create 24 separate models and images from multiple flights were combined to create an additional eight models. The models were analyzed based on Model Ground Sampling Distance (GSD), Model Root Mean Square Error (RMSE), and camera calibration difference. Of the 32 attempted models, 30 or 94% were judged acceptable. The models were then used to estimate alfalfa yield and the best yield estimates occurred with flights at a 50 m altitude with a 75° camera gimbal angle; therefore, these flight parameters are suggested for the most consistent results
Raman Quantum Memory with Built-In Suppression of Four-wave Mixing Noise
Quantum memories are essential for large-scale quantum information networks.
Along with high efficiency, storage lifetime and optical bandwidth, it is
critical that the memory add negligible noise to the recalled signal. A common
source of noise in optical quantum memories is spontaneous four-wave mixing. We
develop and implement a technically simple scheme to suppress this noise
mechanism by means of quantum interference. Using this scheme with a Raman
memory in warm atomic vapour we demonstrate over an order of magnitude
improvement in noise performance. Furthermore we demonstrate a method to
quantify the remaining noise contributions and present a route to enable
further noise suppression. Our scheme opens the way to quantum demonstrations
using a broadband memory, significantly advancing the search for scalable
quantum photonic networks.Comment: 6 pages, 5 figures plus Supplementary Materia
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