Late multimodal fusion for image and audio music transcription

Music transcription, which deals with the conversion of music sources into a structured digital format, is a key problem for Music Information Retrieval (MIR). When addressing this challenge in computational terms, the MIR community follows two lines of research: music documents, which is the case of Optical Music Recognition (OMR), or audio recordings, which is the case of Automatic Music Transcription (AMT). The different nature of the aforementioned input data has conditioned these fields to develop modality-specific frameworks. However, their recent definition in terms of sequence labeling tasks leads to a common output representation, which enables research on a combined paradigm. In this respect, multimodal image and audio music transcription comprises the challenge of effectively combining the information conveyed by image and audio modalities. In this work, we explore this question at a late-fusion level: we study four combination approaches in order to merge, for the first time, the hypotheses regarding end-to-end OMR and AMT systems in a lattice-based search space. The results obtained for a series of performance scenarios–in which the corresponding single-modality models yield different error rates–showed interesting benefits of these approaches. In addition, two of the four strategies considered significantly improve the corresponding unimodal standard recognition frameworks.This paper is part of the I+D+i PID2020-118447RA-I00 (MultiScore) project, funded by MCIN/AEI/10.13039/501100011033. Some of the computing resources were provided by the Generalitat Valenciana and the European Union through the FEDER funding programme (IDIFEDER/2020/003). The first and second authors are respectively supported by grants FPU19/04957 from the Spanish Ministerio de Universidades and APOSTD/2020/256 from Generalitat Valenciana

BIM and 3D impression

This research is the result of work carried out by the PIE-DIBARQ Group of Educational Innovation ETSEM-UPM during the 2016-2017 courses in its effort to implement a methodology adapted to the new requirements of European Convergence in Higher Education through the use of new technologies and the introduction to them for the students. Nowadays we are not only teaching conventional techniques, but they´re trying, at least experimentally, to show each student more innovative ways in Architectural Representation. This is the case of the use of computers, and the new language BIM. We are not only referring to the computer-assisted instruction, where the teacher is developing several experimental units as fixing the theoretical concepts taught, but also to the use and knowledge of the computer as an element used by the professional as a graphic expression of their ideas, or studies. Although the concept of 3D printer has its origin in the 80’s it is now taking more and more strength, and it is already starting to be used in many industries. The future of 3D printers is promising and from 2014 we begun to be more familiar with them and for sure we will get better printer with a lower prices. The 3D printer is considered by the European Space Agency (ESA) as a pioneering invention of the Third Industrial Revolution, as the steam engine and the internal combustion engine were once. The ability to print anything we have in our computer modelling before is a real change in our conception of production, being classified by experts as disruptive technology more powerful than the Internet itself. If it was possible to print parts for spaceships, food and even human organs, the range of possibilities expands the conception of a giant 3D printer in 24 hours can build a house of more than 200 square meters. Although this is the future of printing the truth it is that when one starts to learn seriously about a 3D printer, discovers with some frustration that the information accessible is rather fanciful. Much is written about the potential of these machines, and we found images of beautiful sculptures of impossible shapes, jewellery or accessories that seem to be taken from a workshop of professional jewellery. In this paper we will see the problems and resolution of the 3D printing in Architecture

A nanometre-scale resolution interference-based probe of interfacial phenomena between microscopic objects and surfaces

Interferometric techniques have proven useful to infer proximity and local surface profiles of microscopic objects near surfaces. But a critical trade-off emerges between accuracy and mathematical complexity when these methods are applied outside the vicinity of closest approach. Here we introduce a significant advancement that enables reflection interference contrast microscopy to provide nearly instantaneous reconstruction of an arbitrary convex object’s contour next to a bounding surface with nanometre resolution, making it possible to interrogate microparticle/surface interaction phenomena at radii of curvature 1,000 times smaller than those accessible by the conventional surface force apparatus. The unique view-from-below perspective of reflection interference contrast microscopy also reveals previously unseen deformations and allows the first direct observation of femtolitre-scale capillary condensation dynamics underneath micron-sized particles. Our implementation of reflection interference contrast microscopy provides a generally applicable nanometre-scale resolution tool that can be potentially exploited to dynamically probe ensembles of objects near surfaces so that statistical/probabilistic behaviour can be realistically captured

Decoupling music notation to improve end-to-end Optical Music Recognition

Inspired by the Text Recognition field, end-to-end schemes based on Convolutional Recurrent Neural Networks (CRNN) trained with the Connectionist Temporal Classification (CTC) loss function are considered one of the current state-of-the-art techniques for staff-level Optical Music Recognition (OMR). Unlike text symbols, music-notation elements may be defined as a combination of (i) a shape primitive located in (ii) a certain position in a staff. However, this double nature is generally neglected in the learning process, as each combination is treated as a single token. In this work, we study whether exploiting such particularity of music notation actually benefits the recognition performance and, if so, which approach is the most appropriate. For that, we thoroughly review existing specific approaches that explore this premise and propose different combinations of them. Furthermore, considering the limitations observed in such approaches, a novel decoding strategy specifically designed for OMR is proposed. The results obtained with four different corpora of historical manuscripts show the relevance of leveraging this double nature of music notation since it outperforms the standard approaches where it is ignored. In addition, the proposed decoding leads to significant reductions in the error rates with respect to the other cases.This paper is part of the project I+D+i PID2020-118447RA-I00 (MultiScore), funded by MCIN/AEI/10.13039/501100011033. The first author is supported by grant FPU19/04957 from the Spanish Ministerio de Universidades. The second author is supported by grant ACIF/2021/356 from “Programa I+D+i de la Generalitat Valenciana“. The third author is supported by grant APOSTD/2020/256 from “Programa I+D+i de la Generalitat Valenciana”

A Comparative Study of Age-Related Hearing Loss in Wild Type and Insulin-Like Growth Factor I Deficient Mice

Insulin-like growth factor-I (IGF-I) belongs to the family of insulin-related peptides that fulfils a key role during the late development of the nervous system. Human IGF1 mutations cause profound deafness, poor growth and mental retardation. Accordingly, Igf1−/− null mice are dwarfs that have low survival rates, cochlear alterations and severe sensorineural deafness. Presbycusis (age-related hearing loss) is a common disorder associated with aging that causes social and cognitive problems. Aging is also associated with a decrease in circulating IGF-I levels and this reduction has been related to cognitive and brain alterations, although there is no information as yet regarding the relationship between presbycusis and IGF-I biodisponibility. Here we present a longitudinal study of wild type Igf1+/+ and null Igf1−/− mice from 2 to 12 months of age comparing the temporal progression of several parameters: hearing, brain morphology, cochlear cytoarchitecture, insulin-related factors and IGF gene expression and IGF-I serum levels. Complementary invasive and non-invasive techniques were used, including auditory brainstem-evoked response (ABR) recordings and in vivo MRI brain imaging. Igf1−/− null mice presented profound deafness at all the ages studied, without any obvious worsening of hearing parameters with aging. Igf1+/+ wild type mice suffered significant age-related hearing loss, their auditory thresholds and peak I latencies augmenting as they aged, in parallel with a decrease in the circulating levels of IGF-I. Accordingly, there was an age-related spiral ganglion degeneration in wild type mice that was not evident in the Igf1 null mice. However, the Igf1−/− null mice in turn developed a prematurely aged stria vascularis reminiscent of the diabetic strial phenotype. Our data indicate that IGF-I is required for the correct development and maintenance of hearing, supporting the idea that IGF-I-based therapies could contribute to prevent or ameliorate age-related hearing loss

Bases genéticas, moleculares y bioquímicas del envejecimiento auditivo ¿Qué nos enseñan los modelos experimentales

Age-related hearing loss (ARHL) affects one in three people older than 65 years and is the most prevalent sensorineural deficit. This type of hearing loss precedes and accelerates the onset of cognitive impairment and is associated with an increased risk for neurodegenerative diseases such as dementia and Alzheimer disease. The onset and progression of ARHL is influenced by genetic factors, which are still poorly understood, and environmental factors, which in particular include exposure to excessive noise and ototoxic substances. At present, no effective drug treatments are available for ARHL prevention or treatment, and therefore research in this field is a priority. In the research field, animal models offer a crucial tool for i) identifying new genes associated with ARHL, ii) understanding the cellular and molecular basis of auditory ageing and iii) defining new therapeutic targets and evaluating candidate treatments.La presbiacusia afecta a una de cada tres personas mayores de 65 años y constituye el déficit neurosensorial más prevalente. Antecede a la aparición de la fragilidad cognitiva, la acelera y se asocia con un mayor riesgo de padecer enfermedades neurodegenerativas como la demencia o el Alzheimer. La aparición y evolución de la presbiacusia están influidas por factores genéticos, todavía poco conocidos, y ambientales, entre los que destacan la exposición a ruido excesivo o a sustancias ototóxicas. En la actualidad no disponemos de tratamientos farmacológicos eficaces para prevenir o tratar la presbiacusia, por lo que la investigación en este campo es prioritaria. En este contexto, los modelos animales son una herramienta esencial para: a) identificar nuevos genes de presbiacusia, b) comprender las bases celulares y moleculares del envejecimiento auditivo, y c) definir nuevas dianas terapéuticas y evaluar posibles tratamientos

Enzymatic, immunological and phylogenetic characterization of Brucella suis urease

<p>Abstract</p> <p>Background</p> <p>The sequenced genomes of the <it>Brucella </it>spp. have two urease operons, <it>ure</it>-1 and <it>ure</it>-2, but there is evidence that only one is responsible for encoding an active urease. The present work describes the purification and the enzymatic and phylogenomic characterization of urease from <it>Brucella suis </it>strain 1330. Additionally, the urease reactivity of sera from patients diagnosed with brucellosis was examined.</p> <p>Results</p> <p>Urease encoded by the <it>ure</it>-1 operon of <it>Brucella suis </it>strain 1330 was purified to homogeneity using ion exchange and hydrophobic interaction chromatographies. The urease was purified 51-fold with a recovery of 12% of the enzyme activity and 0.24% of the total protein. The enzyme had an isoelectric point of 5, and showed optimal activity at pH 7.0 and 28–35°C. The purified enzyme exhibited a Michaelis-Menten saturation kinetics with a <it>K</it>_{<it>m </it>}of 5.60 ± 0.69 mM. Hydroxyurea and thiourea are competitive inhibitors of the enzyme with K_iof 1.04 ± 0.31 mM and 26.12 ± 2.30 mM, respectively. Acetohydroxamic acid also inhibits the enzyme in a competitive way. The molecular weight estimated for the native enzyme was between 130–135 kDa by gel filtration chromatography and 157 ± 7 kDa using 5–10% polyacrylamide gradient non-denaturing gel. Only three subunits in SDS-PAGE were identified: two small subunits of 14,000 Da and 15,500 Da, and a major subunit of 66,000 Da. The amino terminal sequence of the purified large subunit corresponded to the predicted amino acid sequence encoded by <it>ureC1</it>. The UreC1 subunit was recognized by sera from patients with acute and chronic brucellosis. By phylogenetic and cluster structure analyses, <it>ureC1 </it>was related to the <it>ureC </it>typically present in the <it>Rhizobiales</it>; in contrast, the <it>ureC2 </it>encoded in the <it>ure</it>-2 operon is more related to distant species.</p> <p>Conclusion</p> <p>We have for the first time purified and characterized an active urease from <it>B. suis</it>. The enzyme was characterized at the kinetic, immunological and phylogenetic levels. Our results confirm that the active urease of <it>B. suis </it>is a product of <it>ure</it>-1 operon.</p

New Eruptive YSOs from SPICY and WISE

© Published under Creative Commons license CC BY-SA 4.0.This work presents four high-amplitude variable YSOs (≃3 mag at near-or mid-IR wavelengths) arising from the SPICY catalog. Three outbursts show a duration that is longer than 1 year, and are still ongoing. And additional YSO brightened over the last two epochs of NEOWISE observations and the duration of the outburst is thus unclear. Analysis of the spectra of the four sources confirms them as new members of the eruptive variable class. We find two YSOs that can be firmly classified as bona fide FUors and one object that falls in the V1647 Ori-like class. Given the uncertainty in the duration of its outburst, an additional YSO can only be classified as a candidate FUor. Continued monitoring and follow-up of these particular sources is important to better understand the accretion process of YSOs.Peer reviewe

New Eruptive YSOs from SPICY and WISE

This work presents four high-amplitude variable YSOs ($\simeq$ 3 mag at near- or mid-IR wavelengths) arising from the SPICY catalog. Three outbursts show a duration that is longer than 1 year, and are still ongoing. And additional YSO brightened over the last two epochs of NEOWISE observations and the duration of the outburst is thus unclear. Analysis of the spectra of the four sources confirms them as new members of the eruptive variable class. We find two YSOs that can be firmly classified as bona fide FUors and one object that falls in the V1647 Ori-like class. Given the uncertainty in the duration of its outburst, an additional YSO can only be classified as a candidate FUor. Continued monitoring and follow-up of these particular sources is important to better understand the accretion process of YSOs.Comment: 10 pages, 10 figures, Accepted for publication at the Journal of the Korean Astronomical Societ