Risk for low pathogenicity avian influenza virus on poultry farms, The Netherlands, 2007–2013

Using annual serologic surveillance data from all poultry farms in the Netherlands during 2007–2013, we quantified the risk for the introduction of low pathogenicity avian influenza virus (LPAIV) in different types of poultry production farms and putative spatial-environmental risk factors: distance from poultry farms to clay soil, waterways, and wild waterfowl areas. Outdoor-layer, turkey (meat and breeder), and duck (meat and breeder) farms had a significantly higher risk for LPAIV introduction than did indoor-layer farms. Except for outdoor-layer, all poultry types (i.e., broilers, chicken breeders, ducks, and turkeys) are kept indoors. For all production types, LPAIV risk decreased significantly with increasing distance to medium-sized waterways and with increasing distance to areas with defined wild waterfowl, but only for outdoor-layer and turkey farms. Future research should focus not only on production types but also on distance to waterways and wild bird areas. In addition, settlement of new poultry farms in high-risk areas should be discouraged

Progress in Alternative Strategies to Combat Antimicrobial Resistance: Focus on Antibiotics

Antibiotic resistance, and, in a broader perspective, antimicrobial resistance (AMR), continues to evolve and spread beyond all boundaries. As a result, infectious diseases have become more challenging or even impossible to treat, leading to an increase in morbidity and mortality. Despite the failure of conventional, traditional antimicrobial therapy, in the past two decades, no novel class of antibiotics has been introduced. Consequently, several novel alternative strategies to combat these (multi-) drug-resistant infectious microorganisms have been identified. The purpose of this review is to gather and consider the strategies that are being applied or proposed as potential alternatives to traditional antibiotics. These strategies include combination therapy, techniques that target the enzymes or proteins responsible for antimicrobial resistance, resistant bacteria, drug delivery systems, physicochemical methods, and unconventional techniques, including the CRISPR-Cas system. These alternative strategies may have the potential to change the treatment of multi-drug-resistant pathogens in human clinical settings

The tension between sociocultural patterns and individual models in the shaping of the logical sequences that define the professionalisation of sport trainers

Le statut et la fonction de l'entraîneur sportif se sont progressivement développés avec la naissance du sport moderne, à partir de la fin du XVIIIe siècle. Du début du XXe siècle à aujourd'hui, le modèle le plus prégnant est celui du technicien de « terrain » dont les méthodes se construisent avant tout sous l'influence socioculturelle dans laquelle il est « baigné ». À partir des années 1980, le processus de professionnalisation qui s'est développé a eu comme conséquence une subdivision des modèles stabilisés en nombreux profils individuels, qui vont bien au-delà du simple triptyque technicien-meneur d'hommes-stratège, mis en avant dans les différentes représentations de sens commun. L'analyse des discours de vingt entraîneurs sportifs, choisis pour représenter au mieux l'ensemble de cette population, nous permet de confirmer les modèles socioculturels connus, et de faire apparaître des profils individuels variés. Elle permet surtout de mettre en évidence l'ensemble des logiques de professionnalisation de cette population. Qu'elles soient communicationnelles, techniques, organisationnelles ou de formation, ces logiques ont comme intérêt scientifique de montrer comment les entraîneurs sportifs se construisent professionnellement aujourd'hui.The status and function of the sport coach have steadily developed since the birth of modern-era sport, in the late 18th century. From the early 20th c. to the present day, the most significant model is that of the field technician whose methods have been built under the influence of his or her social and cultural background. The 1980s saw the emergence of a professionalisation process which subdivided the existing patterns into a variety of individual models, going further beyond the mere three-dimensional combination of the technician-leader-strategist that seems to be the most received representation. Material collected from twenty interviews with sport trainers who were chosen as the best possible sample of the population has been analyzed. This analysis both confirms the received social and cultural patterns and highlights various individual models. In particular, it traces all the logical sequences that define the professionalisation of the population.Be they related to communication, techniques, organisation or training, these sequences find their scientific value in the demonstration they make of how sport coaching takes shape nowadays

Dengue viruses cluster antigenically but not as discrete serotypes

The four genetically divergent dengue virus (DENV) types are traditionally classified as serotypes. Antigenic and genetic differences among the DENV types influence disease outcome, vaccine-induced protection, epidemic magnitude, and viral evolution.We scharacterized antigenic diversity in the DENV types by antigenic maps constructed from neutralizing antibody titers obtained from African green monkeys and after human vaccination and natural infections. Genetically, geographically, and temporally, diverse DENV isolates clustered loosely by type, but we found that many are as similar antigenically to a virus of a different type as to some viruses of the same type. Primary infection antisera did not neutralize all viruses of the same DENV type any better than other types did up to 2 years after infection and did not show improved neutralization to homologous type isolates. That the canonical DENV types are not antigenically homogeneous has implications for vaccination and research on the dynamics of immunity, disease, and the evolution of DENV