Los acuerdos reparatorios en materia de tránsito cuando existe la agravante de la embriaguez

La presente investigación sobre el proyecto de tesis, tiene como finalidad, proponer un proyecto de reforma a la Ley Orgánica de Transporte Terrestre, Tránsito y Seguridad Vial (LOTTSV), para que se establezca una sanción, en cuanto al ámbito de aplicación de los acuerdos reparatorios que se encuentra establecido en el Art. 171 de la Ley, pero resulta que al emitirse una sentencia aceptando el acuerdo reparatorio que han llegado voluntariamente las partes el señor Juez emite una resolución ratificando el estado de inocencia y declara extinguida la acción penal, sin que se determine, ni se considere el agravante en que se produjo el accidente de tránsito cuando uno de los participantes del mismo estaba con ingesta alcohólica o aliento a licor, ya que en virtud del acuerdo se da por terminado el proceso penal de tránsito, y por ello no se está garantizado la seguridad a la población ni la lucha contra la impunidad y no se está protegiendo los derechos de los ciudadanos, que observan que la ley no castiga esta clase de conducta.The current thesis project research is intended to propose a reformatory law the Organic Law for Land Transportation, Traffic and Road Security (LOTTSV), so that a sanction is imposed in the application of reparatory agreements provided in the Art. 171, of the Law. When a judgment is pronounced accepting a reparatory agreement, voluntarily agreed by the parties, the Judge in view of such agreement issues a resolution to confirm the innocence status and extinguish the traffic penal action, without determining or considering aggravating circumstances of the traffic accident, such as, one of the parties had drunk alcohol or a an alcohol breath was detected in him, in such case, population security of citizens rights are not being protected; there is no fight against impunity, because the law has not punished behavior

Elastin-like recombinamers: Deconstructing and recapitulating the functionality of extracellular matrix proteins using recombinant protein polymers

Producción CientíficaIn the development of tissue engineering strategies to replace, remodel, regenerate, or support damaged tissue, the development of bioinspired biomaterials that recapitulate the physicochemical characteristics of the extracellular matrix has received increased attention. Given the compositional heterogeneity and tissue-to-tissue variation of the extracellular matrix, the design, choice of polymer, crosslinking, and nature of the resulting biomaterials are normally depended on intended application. Generally, these biomaterials are usually made of degradable or nondegradable biomaterials that can be used as cell or drug carriers. In recent years, efforts to endow reciprocal biomaterial–cell interaction properties in scaffolds have inspired controlled synthesis, derivatization, and functionalization of the polymers used. In this regard, elastin-like recombinant proteins have generated interest and continue to be developed further owing to their modular design at a molecular level. In this review, the authors provide a summary of key extracellular matrix features relevant to biomaterials design and discuss current approaches in the development of extracellular matrix-inspired elastin-like recombinant protein based biomaterials.Comisión Europea (grants MSCA-ITN-2014-ETN-642687 and NMP-2014-646075)Gobierno de España (grants MAT2016-78903-R, MAT2015-68901-R, and RTI2018-096320-B-C22)Junta de Castilla y León (project VA317P18)"Interreg V A España Portugal" Programa operativo de cooperación transfronteriza España Portugal (POCTEP) (grant 0624_2IQBIONEURO_6_E

Recombinant AMP/Polypeptide Self-Assembled Monolayers with Synergistic Antimicrobial Properties for Bacterial Strains of Medical Relevance

Producción CientíficaNosocomial infections are one of the most frequent causes of indwelling biomedical device failure. In this regard, the use of antibiofilm nanocoatings based on antimicrobial peptides (AMPs) is a promising alternative to prevent multiresistant biofilm infections. However, the limitations of chemical production impede the large-scale development of advanced antimicrobial materials that improve the properties of AMPs. Herein, we present a multifunctional modular design for the recombinant coproduction of self-assembled monolayers (SAMs) based on AMPs and elastin-like recombinamers (ELRs), which combine the antimicrobial properties of a designer AMP, GL13K, and low-fouling activity of an ELR in a synergistic manner. The inclusion of a grafting domain intended for oriented tethering onto surfaces allowed the recombinant polymers to be covalently immobilized onto model gold surfaces. The antibiofilm properties against two of the bacterial strains most frequently responsible for indwelling medical device-associated infections, namely Staphylococcus epidermidis and Staphylococcus aureus, were then evaluated. GL13K peptide was found to provide antibiofilm properties to the surface, with these being synergistically enhanced by the antifouling effect of the ELR. This new design offers a promising tool for the development of advanced AMP-based nanocoatings for medical devices with powerful and enhanced features.Comisión Europea (project NMP-2014-646075)Ministerio de Economía, Industria y Competitividad (project PCIN-2015-010 / MAT2015-68901-R / MAT2016-78903-R)Junta de Castilla y León (project VA317P18

Single and joint effects of cadmium and selenium on bioaccumulation, oxidative stress and metabolomic responses in the clam Scrobicularia plana

Selenium (Se) is a vital trace element for many living organisms inclusive of aquatic species. Although the antagonistic action of this element against other pollutants has been previously described for mammals and birds, limited information on the join effects in bivalves is available. To this end, bivalves of the species Scrobicularia plana were exposed to Se and Cd individually and jointly. Digestive glands were analysed to determine dose-dependent effects, the potential influence of Se on Cd bioaccumulationas well as the possible recover of the oxidative stress and metabolic alterations induced by Cd. Selenium co-exposure decreased the accumulation of Cd at low concentrations. Cd exposure significantly altered the metabolome of clams such as aminoacyltRNA biosynthesis, glycerophospholipid and amino acid metabolism, while Se co-exposure ameliorated several altered metabolites such asLysoPC (14:0), LysoPE (20:4), LysoPE (22:6), PE (14:0/18:0), PE (20:3/18:4) andpropionyl-Lcarnitine. Additionally, Se seems to be able to regulate the redox status of the digestive gland of clams preventing the induction of oxidativedamage in this organ. This study shows the potential Se antagonism against Cd toxicity in S. plana and the importance to study join effects of pollutants to understand the mechanism underlined the effects.This study has been carried out within the research projects (CTM2012-38720-C03-03 and CTM2016-75908-R) founded by the Spanish Ministry of Economy and Competitiveness, who also provided a pre-doc grant for Chiara Trombini (BES-2013-063426), and the project PGC-2018- 096608-B-C21 from the Spanish Ministry of Science and innovation (MCIN). (Generaci´on del Conocimiento. MCIN/AEI/ 10.13039/501100011033/FEDER “Una manera de hacer Europa”). Authors are grateful to FEDER (European Community) for financial support, Grant UNHU13-1E-1611. Rodríguez-Moro, G. thanks to Plan Andaluz de Investigaci´on, Desarrollo e Innovaci´on (PAIDI 2020) and European Union for a post-doctoral grant (DOC_01115). Funding for open access charge: Universidad de Huelva / CBUA

An inventory model for multiple items assuming time-varying demands and limited storage

Producción CientíficaA model for inventory systems with multiple products is studied. Demands of items are time-dependent and follow power patterns. Shortages are allowed and fully back logged. For this inventory system, our findings provide the efficient inventory policy that helps decision-makers to obtain the initial inventory levels and the reorder points that maximize the profit per unit time. Moreover, when it is assumed that the warehouse used for the storage of products has a limited capacity, the optimal inventory policy is also developed. The model presented here extends some inventory systems studied by other authors. Numerical examples are introduced to illustrate the applicability of the theoretical results presented.Ministerio de Ciencia, Innovación y Universidades cofinanciado por la Comunidad Europea (FEDER) (project MTM2017-84150-P)Publicación en abierto financiada por el Consorcio de Bibliotecas Universitarias de Castilla y León (BUCLE), con cargo al Programa Operativo 2014ES16RFOP009 FEDER 2014-2020 DE CASTILLA Y LEÓN, Actuación:20007-CL - Apoyo Consorcio BUCL

Optimal price and lot size for an EOQ model with full backordering under power price and time dependent demand

Producción CientíficaIn this paper, we address an inventory system where the demand rate multiplicatively combines the effects of time and selling price. It is assumed that the demand rate is the product of two power functions, one depending on the selling price and the other on the time elapsed since the last inventory replenishment. Shortages are allowed and fully backlogged. The aim is to obtain the lot sizing, the inventory cycle and the unit selling price that maximize the profit per unit time. To achieve this, two efficient algorithms are proposed to obtain the optimal solution to the inventory problem for all possible parameter values of the system. We solve several numerical examples to illustrate the theoretical results and the solution methodology. We also develop a numerical sensitivity analysis of the optimal inventory policy and the maximum profit with respect to the parameters of the demand function.Ministerio de Ciencia, Innovación y Universidades y Fondo Europeo de Desarrollo Regional (FEDER) - (Project MTM2017-84150-P

Metabolic impairments caused by a “chemical cocktail” of DDE and selenium in mice using direct infusion triple quadrupole time of flight and gas chromatography mass spectrometry

Among organic contaminants, pesticides are one of the most important groups of chemicals due to their persistent character and toxicity. However, the biological systems are exposed to a complex environment in which the contaminants can interact in a synergistic/antagonistic fashion, and for this reason, the study of “chemical cocktails” is of great interest to fully understand the final biological effect. In this way, selenium is known for its antagonistic action against several toxicants. In this paper, metabolic impairments caused by the joint exposure of p,p′-dichloro diphenyl trichloroethane (DDE) and selenium (Se) have been issued for the first time. A metabolomic workflow was applied to mice fed DDE and DDE with Se diet, on the basis of the complementary use of two organic mass spectrometric techniques, combining direct infusion mass spectrometry (DI-ESI-QqQ-TOF MS) and gas chromatography–mass spectrometry (GC–MS). The results show a good classification between the studied groups caused by about 70 altered metabolites in the liver, kidney, or brain, including the pathways of energy metabolism, degradation of phospholipidic membrane, β-oxidation, and oxidative stress, which confirm the potential of combined metabolomic platforms in environmental studies.This work has been supported by projects CTM2015-67902-C2-1-P and PG2018-096608 B-C21 from the Spanish Ministry of Economy and Competitiveness and P12-FQM-0442 and B10-1657 from the Regional Ministry of Economy, Innovation, Science and Employment (Andalusian Government, Spain). G.R.-M. thanks the Spanish Ministry of Economy and Competitiveness for a PhD scholarship (BES-2013-064501). S.R.-A. thanks the Spanish Ministry of Economy and Competitiveness for a PhD scholarship (BES-2016-076364). Finally, the authors are grateful to FEDER (European Community) for financial support, Grant Nos. UNHU13-1E-1611 and UNHU15-CE-3140

Understanding 6He induced reactions at energies around the Coulomb barrier

Recent developments aimed to understand the observed features arising in the scattering of the Borromean nucleus 6He on heavy targets are discussed and compared with recent data for 6He+208Pb measured at the RIB facility at Louvain-la-Neuve at energies around the Coulomb barrier. The analysis of the elastic scattering data in terms of the optical model, reveals the presence of a long range absorption mechanism, that manifests in the form of a large value of the imaginary diffuseness parameter. The elastic data have been also compared with three–body CDCC calculations, based on a di-neutron model of 6He, and four–body CDCC calculations, based on a more realistic three-body model of this nucleus. Finally, the angular and energy distribution of a particles emitted at backward angles are discussed and compared with different theoretical approaches.We find that these a particles are produced mainly by a two-neutron transfer mechanism to very excited states in the residual nucleus

Enantiopure Double ortho-Oligophenylethynylene-Based Helical Structures with Circularly Polarized Luminescence Activity

We thank the Ministerio de Economia y Competitividad (CTQ2017-85454-C2-1-P and CTQ2017-85454-C2-2-P), Ministerio de Ciencia e Innovacion (PID2020-113059GB-C21 and PID2020-113059GB-C22) and Junta de Andalucia (P20.00162) (Spain) for funding and P.R. and A. O. G. also for FPU contracts. Funding for open access charge is acknowledged to Universidad de Granada / CBUA.We also thank Big&Open Data Innovation Laboratory (BODaI-Lab), University of Brescia, granted by Fondazione Cariplo and Regione Lombardia, for access to resources of Computing Center CINECA (Bologna), Italy. Support from the Italian MIUR (Grant No. 2017A4XRCA) is also acknowledged.In this paper, we describe the optical and chiroptical properties of an enantiopure multipodal ortho-oligophenylethynylene (S,S,S,S)-1 presenting four chiral sulfoxide groups at the extremes. The presence of these groups together with alkynes allows the coordination with carbophilic Ag(I), and/or oxophilic Zn(II) cations, yielding double helical structures in an enantiopure way. In this sense, different behaviors in absorption, fluorescence, ECD and CPL spectra have been found depending on the stoichiometry and nature of the metal. We have observed that Zn(II) coordination favors an intensity increase of the electronic circular dichroism (ECD) spectra of compound (S,S,S,S)-1 yielding an M-helicity in the ortho-oligophenylene ethynylene (o-OPE) backbone. On the other hand, ECD spectra of final Ag(I) complex shows two different bands with an opposite sign to the free ligand, thus giving the P-helical isomer. In addition, circularly polarized luminescence (CPL) exhibit an enhanced intensity and negative sign in both complexes. Computational studies were also carried out, supporting the experimental results.Spanish Government CTQ2017-85454-C2-1-P CTQ2017-85454-C2-2-PInstituto de Salud Carlos III Spanish Government European Commission PID2020-113059GB-C21 PID2020-113059GB-C22Junta de Andalucia European Commission P20.00162University of Brescia / CBUAFondazione CariploMinistry of Education, Universities and Research (MIUR) 2017A4XRCARegione Lombardi