El reto del envejecimiento y la complejidad farmacoterapéutica en el paciente VIH+

Objective: To describe the current knowledge and management of aging and pharmacotherapeutic complexity in HIV + patients. Method: A review of literature was carried out, including articles, originals or reviews, published in English or Spanish, from 2007 to 2017, which analysed the aging and pharmacotherapeutic complexity in HIV + patients. The terms «Polypharmacy»/«Polifarmacia», «Aging»/«Envejecimiento», «Frailty»/«Fragilidad», «Complejidad Farmacotera péutica»/«Medication Regimen Complexity» and «HIV»/«VIH» were combined. The review was carried out independently by two authors. The degree of agreement, according to the Kappa index, was analysed. Results: A total of 208 references were analysed, including, finally, only 68. An aging of the population and an increase in associated comorbidities have been identified, especially over 50 years-old. Immunological changes similar to those that are generated in a non-infected elderly population have been described. These conditions influencing the prescription of antiretroviral treatment, according to studies identified. In parallel, polypharmacy is increasingly present, being defined exclusively by the concomitant use of five drugs. Pharmacotherapeutic complexity, through the Medication Regimen Complexity Index, has begun to analyse and relate to health outcomes. There has been a need to know and apply concepts already known in non-HIV-aged population, such as deprescription, potentially inappropriate medication, cholinergic risk, although few results are available. Conclusions: There is a growing interest to know about the relationship between HIV and aging. Pharmacotherapeutic complexity is beginning to be used as a pharmacotherapeutic follow-up criterion due to its influence on health outcomes. It is necessary to manage and incorporate new concepts that help pharmacotherapeutic optimization in this population

Body composition in breast cancer survivors in Sonorenses women

INTRODUCTION: Breast cancer is the most common type of cancer in the worldwide. In the same sense, this disease is one of the most common cancers affecting Mexican women. In the year 2014 in México, there were 11,372 new cases of breast cancer with an incidence rate of 22.56 per 100,000 in habitants older than 10 years. Women with breast cancer are often subjected to an operation due to this affectation which decreases its functionality and body composition. PURPOSE: To examine the body composition in breast cancer survivors in a sample of women from Hermosillo, Sonora, México. METHODS: This study was a cross-sectional descriptive study design. 21 women with breast cancer who had been operated on left arm and had been recruited at one university-based exercise program for breast cancer survivors in Hermosillo, Sonora, México. Body composition (BC) was measured. The right arm non-operated was considered as control. Statistical difference between the operated versus non-operated arm were determined with t-student test for independent samples. RESULTS: In the present study, body fat (1719.1 ± 456.7 vs. 1819.8 ± 467.9 grams, p ≤ 0.05), lean mass (1960.2 ± 308.7 vs. 2151.5 ± 313.5 grams, p ≤ 0.05) and total body mass (3679.3 ± 643.3 vs. 3971.1 ± 675.9 grams, p ≤ 0.05) of the left operated arm of women who breast cancer survivors were significantly lower than the mean of the right non-operated arm. CONCLUSION: Breast cancer survivors’ women who have underwent an operation on their left arm sowed a lower percentage of fat, fat mass and total mass compared to their non-operate arm. The present study underline the importance to apply rehabilitation or exercise program focused to reduce the changes in the body composition

Glycine methyl ester hydro­chloride

The title compound [systematic name: (methoxy­carbonyl­meth­yl)ammonium chloride], crystallizes as a salt, C3H8NO2 +·Cl−, with the charged species inter­acting mutually via strong and highly directional N+—H⋯Cl− hydrogen bonds which lead to the formation of a supra­molecular tape running parallel to the c axis. Tapes close pack in the solid state mediated by multipoint recognition synthons based on weak C—H⋯O inter­actions and van der Waals contacts between adjacent methyl groups

VO2peak and Watt exercise testing: arm crank vs cycle ergometry

INTRODUCTION: Multiple sclerosis is a disease of the central nervous system that primarily affects the strength and functional capacity of the lower extremities. PURPOSE: The objectives of the present study were evaluate VO2peak and the power output (W) during a leg and an arm test performance in relapsing-remitting multiple sclerosis (MS) versus healthy people (HP). METHODS: Twelve women (age 45.8 ± 11.8 yr) with MS (EDSS 3.3 ± 1.8) and twelve women (age 45.6 ± 10.7 yr) HP were included in this study. They underwent two incremental exercise tests on an electromechanical braked arm crank ergometer and on an electromagnetic braked leg cycling ergometer separately. A computerized gas analysis system collected and analyzed gas exchange during the two kinds of testing. The statistical analysis was determined with the Wilcoxon test. RESULTS: First, VO2peak (21.5 ± 5.9 vs. 30.5 ± 4.8 ml·kg·min-1, p = 0.001) y W (84.5 ± 30.1 vs. 141.0 ± 13.7, Watt, p =0.0001) during cycle ergometer test were significantly lower in MS compared with HP. Similarly, the VO2peak in MS during arm crank was significantly lower (16.7 ± 5.4 vs. 23.4 ± 5.1 ml·kg·min-1, p = 0.023) compared with HP. However, the power generated by the arm was not different between the groups. CONCLUSION: The patients with MS during leg ergometer test showed a lower VO2peak. In the same sense, the patients with MS showed lower VO2peak in the test performed with the arms. Interestingly, the power generated with arms was similar in the two groups. These results indicate, that the patients with MS reflect a greater affectation to produce high loads of physical work with legs but not with arms. Further research is suggested where both the lower and upper extremities are involved to improve the processes of rehabilitation in MS

Pseudotumor de pisiforme: a propósito de 1 caso

Se presenta 1 caso de pseudotumor del pisiforme con dolor crónico en eminencia hipotenar y compresión del nervio cubital en un varón de 33 años. El diagnóstico histológico definitivo fue de callo hipertrófico con degeneración cartilaginosa focal del hueso pisiforme. Se presupone el origen laboral de la lesión, secundaria a microtraumatismos repetidos por martillo neumático. Se practicó exéresis simple del hueso, con un resultado excelente a los 6 meses. Los autores piensan que el tratamiento de elección hubiera sido la inmovilización precoz al comienzo de la sintomatología.A case of pseudotumor of the pisiform vvith cronic pain in the hipothenar eminence and compression neuropathy of the ulnar nerve in Guyon's canal in a 33 year old man is reported. Pathologic diagnosis was consistent vvith hypertrophic fracture callus and focal degenerative changes in the articular surface of the pisiform. Repetitive minor trauma in his job as a miner, while using pneumatic hammer is presumed to be the main etiologic factor. Simple excision of the pisiform was performed vvith excelent functional result at 6 months. The authors believe that early inmobilization when the symptoms started, vvould have been the ideal treatmen

Test-retest and minimal detectable change in the assessment of muscle strength and muscle power in upper and lower extremity exercises in 9- to 14-year-old children

The prescription of maximal dynamic strength training in both adults and children is based on the evaluation of maximum strength, usually by one-repetition maximum tests (1RM). This study examined the test-retest reliability and the minimal detectable change (MDC) of the maximal force test and muscle power test. Forty-eight children (9–14 years old) completed two test–retest sessions that involved a one-repetition maximum (1RM) test and a muscle power test for leg extension (LE) and seated bench press (SBP). The MDC values of the 1RM test in the LE and SBP tests ranged from 7.35 to 11.34 kg and 6.84 to 7.92 kg, respectively. The MDC values of the muscle power test in the LE and SBP ranged from 30.32 to 63.20 Watt and 22.65 to 29.53 Watt, respectively. In children 9 to 14 years old, the increase of maximum strength along the growth curve was different in each muscle group studied. The repeatability of the 1RM test of the SBP was excellent (ICC 0.974) and was better than that of the LE (ICC, 0.954). The MDC of the 1RM test evaluation was 19.56% in the LE and 12.93% in the SBP.info:eu-repo/semantics/publishedVersio

Methyl 2-(4,6-dichloro-1,3,5-triazin-2-yl­amino)acetate

The title compound, C6H6Cl2N4O2, was prepared by the nucleophilic substitution of 2,4,6-trichloro-1,3,5-triazine by glycine methyl ester hydro­chloride, and was isolated from the reaction by using flash chromatography. The crystal structure at 150 K reveals the presence two crystallographically independent mol­ecules in the asymmetric unit which differ in the orientation of the pendant methoxy­carbonyl group. Each mol­ecular unit is engaged in strong and highly directional N—H⋯N hydrogen-bonding inter­actions with a symmetry-related mol­ecule, forming supra­molecular dimers which act as the synthons in the crystal packing

Effect of molecular weight reduction by gamma irradiation on the antioxidant capacity of chitosan from lobster shells

AbstractThis study assessed the effect of molecular weight (MW) reduction by gamma irradiation on the antioxidant capacity of chitosan with potential application in the preservation of foodstuffs. Two batches of chitosan were obtained by heterogeneous chemical N-deacetylation of chitin from common lobster (Panulirus argus). Irradiation of chitosan was performed using a 60Co source and applying doses of 5, 10, 20 and 50 kGy with a dose rate of 10 kGy/h. Attenuated Total Reflection Fourier Transform Infrared Spectroscopy was used to identify main chemical features of chitosan. The average viscosimetric MW was determined by the viscosimetric method while the deacetylation degree by a potentiometric method. Thermogravimetric analysis and differential scanning calorimetry were conducted to evaluate the thermal degradation behavior of the chitosan samples, both under nitrogen flow. The antioxidant activity of chitosan solutions at 1% (w/v) in lactic acid at 1% (v/v) and Tween 80 at 0.1% (v/v) was evaluated through the ABTS assay and scavenging of DPPH radical by chitosan. The increase of irradiation dose with 60Co until 50 kGy decreased significantly the MW of chitosan through the scission of glycosidic bonds without affecting its functional groups, while the DD (72–75 %) did not vary (p > 0.05). The AC of the chitosan solutions increased with the reduction of MW of chitosan by gamma irradiation