In sickness and in health: a cross-sectional analysis of concordance for musculoskeletal consultations in 13,507 couples

BackgroundMusculoskeletal pain conditions are common and create substantial burden for the individual and society. While research has shown concordance between couples for risk of some diseases, e.g. heart disease or diabetes, little information is available on such effects for musculoskeletal pain conditions. Our aims were to investigate the presence of concordance between couples for consultations about pain, and to examine theoretical influences on such concordance.MethodsThis was a 1-year cross-sectional study of musculoskeletal pain consultations in a UK primary care database. In total 27,014 patients (13,507 couples) aged between 30 and 74 years were included. The main outcome measure was the presence of a musculoskeletal morbidity read code indicating a consultation for musculoskeletal conditions (any, back, neck, knee, shoulder, foot, osteoarthritis). Logistic regression was used to test associations with odds ratios (OR) and 95% confidence intervals (95% CI).ResultsPatients whose partner had a musculoskeletal pain consultation were also more likely to consult for a musculoskeletal condition (OR 1.22, 95% CI 1.12–1.32). This association was found to be strongest for shoulder disorders (OR 1.91, 95% CI 1.06–3.47). No significant associations were found for other pain conditions.ConclusionResults show that partner concordance is present for consultations for some musculoskeletal conditions but not others. Possible explanations for concordance include the shared health behaviours between couples leading to potential heightened awareness of symptoms. Given the high prevalence of musculoskeletal pain within populations, it may be worth considering further the mechanisms that explain partner concordance

Fine-structure constant variability, equivalence principle and cosmology

It has been widely believed that variability of the fine-structure constant alpha would imply detectable violations of the weak equivalence principle. This belief is not justified in general. It is put to rest here in the context of the general framework for alpha variability [J. D. Bekenstein, Phys. Rev. D 25, 1527 (1982)] in which the exponent of a scalar field plays the role of the permittivity and inverse permeability of the vacuum. The coupling of particles to the scalar field is necessarily such that the anomalous force acting on a charged particle by virtue of its mass's dependence on the scalar field is cancelled by terms modifying the usual Coulomb force. As a consequence a particle's acceleration in external fields depends only on its charge to mass ratio, in accordance with the principle. And the center of mass acceleration of a composite object can be proved to be independent of the object's internal constitution, as the weak equivalence principle requires. Likewise the widely employed assumption that the Coulomb energy of matter is the principal source of the scalar field proves wrong; Coulomb energy effectively cancels out in the continuum description of the scalar field's dynamics. This cancellation resolves a cosmological conundrum: with Coulomb energy as source of the scalar field, the framework would predict a decrease of alpha with cosmological expansion, whereas an increase is claimed to be observed. Because of the said cancellation, magnetic energy of cosmological baryonic matter is the main source of the scalar field. Consequently the expansion is accompanied by an increase in alpha; for reasonable values of the framework's sole parameter, this occurs at a rate consistent with the observers' claims.Comment: RevTeX-4, 22 pages, no figures, added a section on caveats as well as several new references with discussion of them in body. To appear in Phys. Rev.

Coronal Diagnostics from Narrowband Images around 30.4 nm

Images taken in the band centered at 30.4 nm are routinely used to map the radiance of the He II Ly alpha line on the solar disk. That line is one of the strongest, if not the strongest, line in the EUV observed in the solar spectrum, and one of the few lines in that wavelength range providing information on the upper chromosphere or lower transition region. However, when observing the off-limb corona the contribution from the nearby Si XI 30.3 nm line can become significant. In this work we aim at estimating the relative contribution of those two lines in the solar corona around the minimum of solar activity. We combine measurements from CDS taken in August 2008 with temperature and density profiles from semiempirical models of the corona to compute the radiances of the two lines, and of other representative coronal lines (e.g., Mg X 62.5 nm, Si XII 52.1 nm). Considering both diagnosed quantities from line ratios (temperatures and densities) and line radiances in absolute units, we obtain a good overall match between observations and models. We find that the Si XI line dominates the He II line from just above the limb up to ~2 R_Sun in streamers, while its contribution to narrowband imaging in the 30.4 nm band is expected to become smaller, even negligible in the corona beyond ~2 - 3 R_Sun, the precise value being strongly dependent on the coronal temperature profile.Comment: 26 pages, 11 figures; to be published in: Solar Physic

Jordan-Wigner approach to dynamic correlations in spin-ladders

We present a method for studying the excitations of low-dimensional quantum spin systems based on the Jordan-Wigner transformation. Using an extended RPA-scheme we calculate the correlation function of neighboring spin flips which well approximates the optical conductivity of ${\rm Sr_2CuO_3}$. We extend this approach to the two-leg $S=1/2$--ladder by numbering the spin operators in a meander-like sequence. We obtain good agreement with the optical conductivity of the spin ladder compound (La,Ca)$_{14}$Cu$_{24}$O$_{41}$ for polarization along the rungs. For polarization along the legs higher order correlations are important to explain the weight of high-energy continuum excitations and we estimate the contribution of 4-- and 6--fermion processes.Comment: 15 pages, 16 figure

Markers of dementia-related health in primary care electronic health records

Objectives: Identifying routinely recorded markers of poor health in patients with dementia may help treatment decisions and evaluation of earlier outcomes in research. Our objective was to determine whether a set of credible markers of dementia-related health could be identified from primary care electronic health records (EHR). Methods: The study consisted of (i) rapid review of potential measures of dementia-related health used in EHR studies; (ii) consensus exercise to assess feasibility of identifying these markers in UK primary care EHR; (iii) development of UK EHR code lists for markers; (iv) analysis of a regional primary care EHR database to determine further potential markers; (v) consensus exercise to finalise markers and pool into higher domains; (vi) determination of 12-month prevalence of domains in EHR of 2328 patients with dementia compared to matched patients without dementia. Results: Sixty-three markers were identified and mapped to 13 domains: Care; Home Pressures; Severe Neuropsychiatric; Neuropsychiatric; Cognitive Function; Daily Functioning; Safety; Comorbidity; Symptoms; Diet/Nutrition; Imaging; Increased Multimorbidity; Change in Dementia Drug. Comorbidity was the most prevalent recorded domain in dementia (69%). Home Pressures were the least prevalent domain (1%). Ten domains had a statistically significant higher prevalence in dementia patients, one (Comorbidity) was higher in non-dementia patients, and two (Home Pressures, Diet/Nutrition) showed no association with dementia. Conclusions: EHR captures important markers of dementia-related health. Further research should assess if they indicate dementia progression. These markers could provide the basis for identifying individuals at risk of faster progression and outcome measures for use in research

The Drosophila melanogaster Genetic Reference Panel

A major challenge of biology is understanding the relationship between molecular genetic variation and variation in quantitative traits, including fitness. This relationship determines our ability to predict phenotypes from genotypes and to understand how evolutionary forces shape variation within and between species. Previous efforts to dissect the genotype-phenotype map were based on incomplete genotypic information. Here, we describe the Drosophila melanogaster Genetic Reference Panel (DGRP), a community resource for analysis of population genomics and quantitative traits. The DGRP consists of fully sequenced inbred lines derived from a natural population. Population genomic analyses reveal reduced polymorphism in centromeric autosomal regions and the X chromosome, evidence for positive and negative selection, and rapid evolution of the X chromosome. Many variants in novel genes, most at low frequency, are associated with quantitative traits and explain a large fraction of the phenotypic variance. The DGRP facilitates genotype-phenotype mapping using the power of Drosophila genetics