1,663 research outputs found
Correction: Statin Use and Cognitive Function:Population-Based Observational Study with Long-Term Follow-Up (vol 9, e115755, 2014)
Towards net zero CO2 in 2050: an emission reduction pathway for organic soils in Germany
The Paris Agreement reflects the global endeavour to limit the increase of global average temperature to 2 °C, better 1.5 °C above pre-industrial levels to prevent dangerous climate change. This requires that global anthropogenic net carbon dioxide (CO2) emissions are reduced to zero around 2050. The German Climate Protection Plan substantiates this goal and explicitly mentions peatlands, which make up 5 % of the total area under land use and emit 5.7 % of total annual greenhouse gas emissions in Germany. Based on inventory reporting and assumptions of land use change probability, we have developed emission reduction pathways for organic soils in Germany that on a national level comply with the IPCC 1.5 °C pathways. The more gradual pathway 1 requires the following interim (2030, 2040) and ultimate (2050) milestones: Cropland use stopped and all Cropland converted to Grassland by 2030; Water tables raised to the soil surface on 15 % / 60 % / 100 % of all Grassland, on 50 % / 75 % / 100 % of all Forest land, and ultimately on 2/3 of all Settlements and on 100 % of all Wetlands. Also a more direct pathway 2 without interim ‘moist’ water tables and the climate effect (radiative forcing) of different scenarios is presente
Study of the and reactions close to threshold
Two--kaon production in proton--deuteron collisions has been studied at three
energies close to threshold using a calibrated magnetic spectrograph to measure
the final He and a vertex detector to measure the pair.
Differential and total cross sections are presented for the production of
--mesons, decaying through , as well as for prompt
production. The prompt production seems to follow phase space in both
its differential distributions and in its energy dependence. The amplitude for
the {He} reaction varies little for excess energies below 22
MeV and the value is consistent with that obtained from a threshold
measurement. The angular distribution of the decay pair shows that
near threshold the --mesons are dominantly produced with polarization
along the initial proton direction. No conclusive evidence for
production is found in the data.Comment: 13 figure
Upper limits for a narrow resonance in the reaction p + p -> K^+ + (Lambda p)
The reaction pp -> K^+ + (Lambda p) has been measured at T_p = 1.953 GeV and
\Theta = 0 deg with a high missing mass resolution in order to study the Lambda
p final state interaction. Narrow S = -1 resonances predicted by bag model
calculations are not visible in the missing mass spectrum. Small structures
observed in a previous experiment are not confirmed. Upper limits for the
production cross section of a narrow resonance are deduced for missing masses
between 2058 and 2105 MeV/c^2.Comment: 8 pages, 5 figure
Adding time to the conservation toolkit: palaeoecology and long term wetland function dynamics
Diffusing-wave spectroscopy of nonergodic media
We introduce an elegant method which allows the application of diffusing-wave
spectroscopy (DWS) to nonergodic, solid-like samples. The method is based on
the idea that light transmitted through a sandwich of two turbid cells can be
considered ergodic even though only the second cell is ergodic. If absorption
and/or leakage of light take place at the interface between the cells, we
establish a so-called "multiplication rule", which relates the intensity
autocorrelation function of light transmitted through the double-cell sandwich
to the autocorrelation functions of individual cells by a simple
multiplication. To test the proposed method, we perform a series of DWS
experiments using colloidal gels as model nonergodic media. Our experimental
data are consistent with the theoretical predictions, allowing quantitative
characterization of nonergodic media and demonstrating the validity of the
proposed technique.Comment: RevTeX, 12 pages, 6 figures. Accepted for publication in Phys. Rev.
Engineering Thermostability in Artificial Metalloenzymes to Increase Catalytic Activity
Protein engineering has shown widespread use in improving the industrial application of enzymes and broadening the conditions they are able to operate under by increasing their thermostability and solvent tolerance. Here, we show that protein engineering can be used to increase the thermostability of an artificial metalloenzyme. Thermostable variants of the human steroid carrier protein 2L, modified to bind a metal catalyst, were created by rational design using structural data and a 3DM database. These variants were tested to identify mutations that enhanced the stability of the protein scaffold, and a significant increase in melting temperature was observed with a number of modified metalloenzymes. The ability to withstand higher reaction temperatures resulted in an increased activity in the hydroformylation of 1-octene, with more than fivefold improvement in turnover number, whereas the selectivity for linear aldehyde remained high up to 80%
Treatable Vascular Risk and Cognitive Performance in Persons Aged 35 Years or Older:Longitudinal Study of Six Years
BACKGROUND: Poor cognitive performance is associated with high vascular risk. However, this association is only investigated in elderly. As neuropathological changes precede clinical symptoms of cognitive impairment by several decades, it is likely that cognitive performance is already associated with vascular risk at middle-age. OBJECTIVES: To investigate the association of cognitive performance with treatable vascular risk in middle-aged and old persons. DESIGN: Longitudinal study with three measurements during follow-up period of 5.5 years. SETTING: City of Groningen, the Netherlands. PARTICIPANTS: Cohort of 3,572 participants (age range, 35-82 years; mean age, 54 years; men, 52%). EXPOSURE: Treatable vascular risk as defined by treatable components of the Framingham Risk Score for Cardiovascular Disease at the first measurement (diabetes mellitus, smoking, hypercholesterolemia and hypertension). MEASUREMENTS: Change in cognitive performance during follow-up. Cognitive performance was measured with Ruff Figural Fluency Test (RFFT) and Visual Association Test (VAT), and calculated as the average of the standardized RFFT and VAT score per participant. RESULTS: The mean (SD) cognitive performance changed from 0.00 (0.79) at the first measurement to 0.15 (0.83) at second measurement and to 0.39 (0.82) at the third measurement (Ptrend CONCLUSIONS: Change in cognitive performance was associated with treatable vascular risk in persons aged 35 years or older
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