Protecting Internet Users with Epilepsy or Chronic Migraine from Graphic-Based Attacks

Flagging graphics interchangeable formats (GIFs) on personal devices are essential to protect users with epilepsy or chronic migraine. The research broke GIFs into frames and compared consecutive frames in pairs with three conditions: the ratio of average intensity, percentage of dangerous pixels, and hertz value. First, the average intensity of each frame is calculated using the formula: 0.299 * red + 0.587 * green + 0.114 * blue (Sedgewick & Wayne, 2017), for each pixel in the frame. Next, to obtain the percentage of dangerous pixels, each pixel of the same location from the two frames is compared. The absolute value of the difference between intensities of the pixels is found. A value less than 128.0 (Sedgewick & Wayne, 2017) is incompatible. Then, the ratio of incompatible and different pixels is obtained, which is multiplied by the ratio of different and total pixels. Finally, if the hertz value, inverse of the duration of each frame divided by 1000, falls within 3 to 30 (Wirrell & Hernandez), the GIF can be potentially dangerous. Thus, three threat levels, risky, dangerous, and extreme, have been established if one, two, or three conditions are met, respectively. After taking these results, viewers can be notified so that they can be protected from potential graphic-based attacks. Keywords: epilepsy; chronic migraine; graphics interchangeable format; Sedgewick, R., & Wayne, K. (2017). Object-Oriented Programming. Computer science an interdisciplinary approach. Addison-Wesley Professional. (pp. 330-381). Boston: Addision-Wesley. Wirrell, E., & Hernandez, A. (Eds.). (2019). Photosensitivity and Seizures. Epilepsy. https://www.epilepsy.com/learn/triggers-seizures/photosensitivity-and-seizur

Exploring the Relationship between Organizational Culture and Information Security Culture

Managing Information Security is becoming more challenging in today’s business because people are both a cause of information security incidents as well as a key part of the protection from them. As the impact of organizational culture (OC) on employees is significant, many researchers have called for the creation of information security culture (ISC) in organizations to influence the actions and behaviour of employees towards better organizational information security. Although researchers have called for the creation of ISC to be embedded in organizations, nonetheless, literature suggests that little past research examining the relationship between the nature of OC and ISC. This paper seeks to explore the relationship between the nature of OC and ISC and argues that organizations that have a medium to high security risk profile need to embed the ISC to influence employee actions and behaviours in relation to information security practices. In addition, this paper also introduces a framework to assist organizations in determining the extent to which the desired ISC is embedded into OC

Crosstalk between Nuclear Factor I-C and Transforming Growth Factor-β1 Signaling Regulates Odontoblast Differentiation and Homeostasis

Transforming growth factor-β1 (TGF-β1) signaling plays a key role in vertebrate development, homeostasis, and disease. Nuclear factor I-C (NFI-C) has been implicated in TGF-β1 signaling, extracellular matrix gene transcription, and tooth root development. However, the functional relationship between NFI-C and TGF-β1 signaling remains uncharacterized. The purpose of this study was to identify the molecular interactions between NFI-C and TGF-β1 signaling in mouse odontoblasts. Real-time polymerase chain reaction and western analysis demonstrated that NFI-C expression levels were inversely proportional to levels of TGF-β1 signaling molecules during in vitro odontoblast differentiation. Western blot and immunofluorescence results showed that NFI-C was significantly degraded after TGF-β1 addition in odontoblasts, and the formation of the Smad3 complex was essential for NFI-C degradation. Additionally, ubiquitination assay results showed that Smurf1 and Smurf2 induced NFI-C degradation and polyubiquitination in a TGF-β1-dependent manner. Both kinase and in vitro binding assays revealed that the interaction between NFI-C and Smurf1/Smurf2 requires the activation of the mitogen-activated protein kinase pathway by TGF-β1. Moreover, degradation of NFI-C induced by TGF-β1 occurred generally in cell types other than odontoblasts in normal human breast epithelial cells. In contrast, NFI-C induced dephosphorylation of p-Smad2/3. These results show that crosstalk between NFI-C and TGF-β1 signaling regulates cell differentiation and homeostatic processes in odontoblasts, which might constitute a common cellular mechanism

Measurement of the cosmic ray spectrum above 4×10184{\times}10^{18} eV using inclined events detected with the Pierre Auger Observatory

A measurement of the cosmic-ray spectrum for energies exceeding $4{\times}10^{18}$ eV is presented, which is based on the analysis of showers with zenith angles greater than $60^{\circ}$ detected with the Pierre Auger Observatory between 1 January 2004 and 31 December 2013. The measured spectrum confirms a flux suppression at the highest energies. Above $5.3{\times}10^{18}$ eV, the "ankle", the flux can be described by a power law $E^{-\gamma}$ with index $\gamma=2.70 \pm 0.02 \,\text{(stat)} \pm 0.1\,\text{(sys)}$ followed by a smooth suppression region. For the energy ($E_\text{s}$) at which the spectral flux has fallen to one-half of its extrapolated value in the absence of suppression, we find $E_\text{s}=(5.12\pm0.25\,\text{(stat)}^{+1.0}_{-1.2}\,\text{(sys)}){\times}10^{19}$ eV.Comment: Replaced with published version. Added journal reference and DO

Energy Estimation of Cosmic Rays with the Engineering Radio Array of the Pierre Auger Observatory

The Auger Engineering Radio Array (AERA) is part of the Pierre Auger Observatory and is used to detect the radio emission of cosmic-ray air showers. These observations are compared to the data of the surface detector stations of the Observatory, which provide well-calibrated information on the cosmic-ray energies and arrival directions. The response of the radio stations in the 30 to 80 MHz regime has been thoroughly calibrated to enable the reconstruction of the incoming electric field. For the latter, the energy deposit per area is determined from the radio pulses at each observer position and is interpolated using a two-dimensional function that takes into account signal asymmetries due to interference between the geomagnetic and charge-excess emission components. The spatial integral over the signal distribution gives a direct measurement of the energy transferred from the primary cosmic ray into radio emission in the AERA frequency range. We measure 15.8 MeV of radiation energy for a 1 EeV air shower arriving perpendicularly to the geomagnetic field. This radiation energy -- corrected for geometrical effects -- is used as a cosmic-ray energy estimator. Performing an absolute energy calibration against the surface-detector information, we observe that this radio-energy estimator scales quadratically with the cosmic-ray energy as expected for coherent emission. We find an energy resolution of the radio reconstruction of 22% for the data set and 17% for a high-quality subset containing only events with at least five radio stations with signal.Comment: Replaced with published version. Added journal reference and DO

Measurement of the Radiation Energy in the Radio Signal of Extensive Air Showers as a Universal Estimator of Cosmic-Ray Energy

We measure the energy emitted by extensive air showers in the form of radio emission in the frequency range from 30 to 80 MHz. Exploiting the accurate energy scale of the Pierre Auger Observatory, we obtain a radiation energy of 15.8 \pm 0.7 (stat) \pm 6.7 (sys) MeV for cosmic rays with an energy of 1 EeV arriving perpendicularly to a geomagnetic field of 0.24 G, scaling quadratically with the cosmic-ray energy. A comparison with predictions from state-of-the-art first-principle calculations shows agreement with our measurement. The radiation energy provides direct access to the calorimetric energy in the electromagnetic cascade of extensive air showers. Comparison with our result thus allows the direct calibration of any cosmic-ray radio detector against the well-established energy scale of the Pierre Auger Observatory.Comment: Replaced with published version. Added journal reference and DOI. Supplemental material in the ancillary file

OGLE-2018-BLG-0799Lb: a Sub-Saturn-Mass Planet Orbiting a Very Low Mass Dwarf

We report the discovery and analysis of a sub-Saturn-mass planet in the microlensing event OGLE-2018-BLG-0799. The planetary signal was observed by several ground-based telescopes, and the planet-host mass ratio is q = (2.65±0.16)×10⁻³. The ground-based observations yield a constraint on the angular Einstein radius θ_E, and the microlens parallax π_E is measured from the joint analysis of the Spitzer and ground-based observations, which suggests that the host star is most likely to be a very low-mass dwarf. A full Bayesian analysis using a Galactic model indicates that the planetary system is composed of an M_(planet) = 0.22^(+0.19)_(−0.06) M_J planet orbiting an M_(host) = 0.080^(+0.080)_(−0.020) M⊙, at a distance of D_L = 4.42^(+1.73)_(−1.23) kpc. The projected planet-host separation is r⊥ = 1.27^(+0.45)_(−0.29) AU, implying that the planet is located beyond the snowline of the host star. However, because of systematics in the Spitzer photometry, there is ambiguity in the parallax measurement, so the system could be more massive and farther away

Genetic diversity fuels gene discovery for tobacco and alcohol use

Tobacco and alcohol use are heritable behaviours associated with 15% and 5.3% of worldwide deaths, respectively, due largely to broad increased risk for disease and injury(1-4). These substances are used across the globe, yet genome-wide association studies have focused largely on individuals of European ancestries(5). Here we leveraged global genetic diversity across 3.4 million individuals from four major clines of global ancestry (approximately 21% non-European) to power the discovery and fine-mapping of genomic loci associated with tobacco and alcohol use, to inform function of these loci via ancestry-aware transcriptome-wide association studies, and to evaluate the genetic architecture and predictive power of polygenic risk within and across populations. We found that increases in sample size and genetic diversity improved locus identification and fine-mapping resolution, and that a large majority of the 3,823 associated variants (from 2,143 loci) showed consistent effect sizes across ancestry dimensions. However, polygenic risk scores developed in one ancestry performed poorly in others, highlighting the continued need to increase sample sizes of diverse ancestries to realize any potential benefit of polygenic prediction.Peer reviewe