7 research outputs found
Dementia With Lewy Bodies A Clinicopathologic Series of False-positive Cases
Diagnosing dementia with Lewy bodies (DLB) is challenging as symptoms are heterogenous and not specific to the disease.
Here we present a clinicopathologic series of false-positive DLB
cases. Patients were enrolled retrospectively from the Netherlands
Brain Bank when they met the clinical criteria of probable DLB, but
with a pathologic diagnosis other than DLB or Parkinson’s disease
dementia. Twenty-two false-positive cases were selected. Alzheimer
disease with or without copathology was the most common (64%)
pathologic diagnosis. Other pathologic diagnoses, such as frontotemporal dementia, multiple-system atrophy, Creutzfeldt-Jakob disease, and autoimmune encephalitis, were also encountered. Atypical
clinical signs for DLB were present in almost half of the cases and
could be a trigger to consider other diagnoses than DLB. Additional
diagnostic examinations, feedback of pathologic diagnosis, and the
creation of a set of clinical features that are indicative of other conditions, could reduce the amount of false-positive DLB cases
Differential insular cortex sub-regional atrophy in neurodegenerative diseases: a systematic review and meta-analysis
The insular cortex is proposed to function as a central brain hub characterized by wide-spread connections and diverse functional
roles. As a result, its centrality in the brain confers high metabolic demands predisposing it to dysfunction in disease. However,
the functional profile and vulnerability to degeneration varies across the insular sub-regions. The aim of this systematic review
and meta-analysis is to summarize and quantitatively analyze the relationship between insular cortex sub-regional atrophy,
studied by voxel based morphometry, with cognitive and neuropsychiatric deficits in frontotemporal dementia (FTD),
Alzheimer’s disease (AD), Parkinson’s disease (PD), and dementia with Lewy bodies (DLB). We systematically searched
through Pubmed and Embase and identified 519 studies that fit our criteria. A total of 41 studies (n = 2261 subjects) fulfilled
the inclusion criteria for the meta-analysis. The peak insular coordinates were pooled and analyzed using Anatomic Likelihood
Estimation. Our results showed greater left anterior insular cortex atrophy in FTD whereas the right anterior dorsal insular cortex
showed larger clusters of atrophy in AD and PD/DLB. Yet contrast analyses did not reveal significant differences between disease
groups. Functional analysis showed t
Trajectories and Determinants of Quality of Life in Dementia with Lewy Bodies and Alzheimer's Disease
Background: Quality of Life (QoL) is an important outcome measure in dementia, particularly in the context of interventions.
Research investigating longitudinal QoL in dementia with Lewy bodies (DLB) is currently lacking.
Objective: To investigate determinants and trajectories of QoL in DLB compared to Alzheimer’s disease (AD) and controls.
Methods: QoL was assessed annually in 138 individuals, using the EQ5D-utility-score (0–100) and the health-related Visual
Analogue Scale (VAS, 0–100). Twenty-nine DLB patients (age 69 ± 6), 68 AD patients (age 70 ± 6), and 41 controls (age
70 ± 5) were selected from the Dutch Parelsnoer Institute-Neurodegenerative diseases and Amsterdam Dementia Cohort. We
examined clinical work-up over time as determinants of QoL, including cognitive tests, neuropsychiatric inventory, Geriatric
Depression Scale (GDS), and disability assessment of dementia (DAD).
Results: Mixed models showed lower baseline VAS-scores in DLB compared to AD and controls (AD: ±SE = -7.6 ± 2.8,
controls: ±SE = -7.9 ± 3.0, p < 0.05). An interaction between diagnosis and time since diagnosis indicated steeper decline
on VAS-scores for AD patients compared to DLB patients (±SE = 2.9 ± 1.5, p < 0.1). EQ5D-utility-scores over time did not
differ between groups. Higher GDS and lower DAD-scores were independently associated with lower QoL in dementia patients
(GDS: VAS ±SE = -1.8 ± 0.3, EQ5D-utility ±SE = -3.7 ± 0.4; DAD: VAS = 0.1 ± 0.0, EQ5D-utility ±SE = 0.1 ± 0.1,
p < 0.05). No associations between cognitive tests and QoL remained in the multivariate model.
Conclusion: QoL is lower in DLB, while in AD QoL shows steepe
Early-stage differentiation between presenile Alzheimer’s disease and frontotemporal dementia using arterial spin labeling MRI
Objective: To investigate arterial spin labeling (ASL)-MRI for the early diagnosis of and differentiation between the two most common types of presenile dementia: Alzheimer’s disease (AD) and frontotemporal dementia (FTD), and for distinguishing age-related from pathological perfusion changes. Methods: Thirteen AD and 19 FTD patients, and 25 age-matched older and 22 younger controls underwent 3D pseudo-continuous ASL-MRI at 3 T. Gray matter (GM) volume and cerebral blood flow (CBF), corrected for partial volume effects, were quantified in the entire supratentorial cortex and in 10 GM regions. Sensitivity, specificity and diagnostic performance were evaluated in regions showing significant CBF differences between patient groups or between patients and older controls. Results: AD compared with FTD patients had hypoperfusion in the posterior cingulate cortex,
Clinical and Pathological Phenotypes of LRP10 Variant Carriers with Dementia
BACKGROUND: Rare variants in the low-density lipoprotein receptor related protein 10 gene (LRP10) have recently been implicated in the etiology of Parkinson's disease (PD) and dementia with Lewy bodies (DLB). OBJECTIVE: We searched for LRP10 variants in a new series of brain donors with dementia and Lewy pathology (LP) at autopsy, or dementia and parkinsonism without LP but with various other neurodegenerative pathologies. METHODS: Sanger sequencing of LRP10 was performed in 233 donors collected by the Netherlands Brain Bank. RESULTS: Rare, possibly pathogenic heterozygous LRP10 variants were present in three patients: p.Gly453Ser in a patient with mixed Alzheimer's disease (AD)/Lewy body disease (LBD), p.Arg151Cys in a DLB patient, and p.Gly326Asp in an AD patient without LP. All three patients had a positive family history for dementia or PD. CONCLUSION: Rare LRP10 variants are present in some patients with dementia and different brain pathologies including DLB, mixed AD/LBD, and AD. These findings suggest a role for LRP10 across a broad neurodegenerative spectrum
Coma in thrombotic thrombocytopenic purpura
Thrombotic thrombocy topenic purpura (TTP) is characterised by a thrombotic, haemolytic microangiopathy leading to microvascular occlusion, haemolysis and ischaemic dysfunction of various organs including the brain. TTP may present with a variety of neurological symptoms, including headache, focal deficits, seizures and coma. The authors describe a 55-year-old man presenting with abdominal pain and rapidly progressive deterioration into coma without focal neurological deficits or seizures. A concomitant, transient, rapid increase in blood pressure raised the suspicion of a hypertensive crisis. Yet, our patient did not improve after vigorous treatment with antihy pertensives. Brain imaging excluded a hypertensive leucoencephalopathy . Despite the absence of a disintegrin and metalloproteinase with a thrombospondin type 1 motif member 13 (ADAMTS13) deficiency, the diagnosis idiopathic TTP was made after excluding secondary causes of TTP. Upon treatment with plasma exchange, corticosteroids and vincristin our patient gradually improved. On discharge to a rehabilitation centre he was awake and alert, had minor cognitive deficits and a mild proximal tetraparesis consistent with a critical illness poly (neuro)myopathy
Thyroid hormones, dementia, and atrophy of the medial temporal lobe
Context: Thyroid function has been related to Alzheimer disease (AD), but it remains unclear whether thyroid dysfunction results from or contributes to developing AD. Objective: The objective of the study was to determine the association between thyroid function and both medial temporal lobe atrophy on brain magnetic resonance imaging (MRI) as putative early sign of AD and risk of dementia. Design and Participants: This was a population-based cohort study among 1077 elderly subjects aged 60-90 yr and dementia free at baseline (1995-1996). Main Outcome Measures: Nonfasting serum levels of TSH, free T 4 (fT4), T3, and rT3 were available in 1025 subjects followed up for incident dementia until 2005. In a subset of 489 nondemented elderly, we assessed volumes of the hippocampus and amygdala on brain MRI. Subjects using thyroid medication were excluded. Results: During 5657 person-years of follow-up (mean 5.5 yr), 63 subjects were diagnosed with dementia (46 with AD). TSH and thyroid hormones were not associated with risk of dementia or AD. TSH and T3 were also not related to brain atrophy, whereas nondemented subjects with higher fT4 levels had more hippocampal and amygdalar atrophy on MRI. Similar associations were found for rT3. Excluding subjects with thyroid disorders or incipient AD did not change the results. Conclusion: In our study, TSH was related neither to risk of AD nor with early MRI markers thereof, arguing against an important role of thyroid function in the development of AD. Whether the association of higher fT4 and rT3 levels with brain atrophy on MRI has functional significance remains to be elucidated. Copyrigh