14,821 research outputs found
Direct evidence for the interaction of the mechanisms of thermally initiated and atom transfer radical polymerization
Surface code implementation of block code state distillation
State distillation is the process of taking a number of imperfect copies of a
particular quantum state and producing fewer better copies. Until recently, the
lowest overhead method of distilling states |A>=(|0>+e^{i\pi/4}|1>)/\sqrt{2}
produced a single improved |A> state given 15 input copies. New block code
state distillation methods can produce k improved |A> states given 3k+8 input
copies, potentially significantly reducing the overhead associated with state
distillation. We construct an explicit surface code implementation of block
code state distillation and quantitatively compare the overhead of this
approach to the old. We find that, using the best available techniques, for
parameters of practical interest, block code state distillation does not always
lead to lower overhead, and, when it does, the overhead reduction is typically
less than a factor of three.Comment: 26 pages, 28 figure
The use of Multiple Displacement Amplified DNA as a control for Methylation Specific PCR, Pyrosequencing, Bisulfite Sequencing and Methylation-Sensitive Restriction Enzyme PCR
<p>Abstract</p> <p>Background</p> <p>Genomic DNA methylation affects approximately 1% of DNA bases in humans, with the most common event being the addition of a methyl group to the cytosine residue present in the CpG (cytosine-guanine) dinucleotide. Methylation is of particular interest because of its role in gene silencing in many pathological conditions. CpG methylation can be measured using a wide range of techniques, including methylation-specific (MS) PCR, pyrosequencing (PSQ), bisulfite sequencing (BS) and methylation-sensitive restriction enzyme (MSRE) PCR. However, although it is possible to utilise these methods to measure CpG methylation, optimisation of the assays can be complicated due to the absence of suitable control DNA samples.</p> <p>Results</p> <p>To address this problem, we have developed an approach that employs multiple displacement based whole genome amplification (WGA) with or without <it>SssI</it>-methylase treatment to generate CpG methylated and CpG unmethylated DNA, respectively, that come from the same source DNA.</p> <p>Conclusion</p> <p>Using these alternately methylated DNA samples, we have been able to develop and optimise reliable MS-PCR, PSQ, BS and MRSE-PCR assays for CpG methylation detection, which would otherwise not have been possible, or at least have been significantly more difficult.</p
Identification of single-site gold catalysis in acetylene hydrochlorination
There remains considerable debate over the active form of gold under operating conditions of a recently validated gold catalyst for acetylene hydrochlorination. We have performed an in situ x-ray absorption fine structure study of gold/carbon (Au/C) catalysts under acetylene hydrochlorination reaction conditions and show that highly active catalysts comprise single-site cationic Au entities whose activity correlates with the ratio of Au(I):Au(III) present. We demonstrate that these Au/C catalysts are supported analogs of single-site homogeneous Au catalysts and propose a mechanism, supported by computational modeling, based on a redox couple of Au(I)-Au(III) species.
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Shergottite Lead Isotope Signature in Chassigny and the Nakhlites
The nakhlites/chassignites and the shergottites represent two differing suites of basaltic martian meteorites. The shergottites have ages less than or equal to 0.6 Ga and a large range of initial Sr-/Sr-86 and epsilon (Nd-143) ratios. Conversely, the nakhlites and chassignites cluster at 1.3-1.4 Ga and have a limited range of initial Sr-87/Sr-86 and epsilon (Nd-143). More importantly, the shergottites have epsilon (W-182) less than 1, whereas the nakhlites and chassignites have epsilon (W-182) approximately 3. This latter observation precludes the extraction of both meteorite groups from a single source region. However, recent Pb isotopic analyses indicate that there may have been interaction between shergottite and nakhlite/chassignite Pb reservoirs.Pb Analyses of Chassigny: Two different studies haveinvestigated 207Pb/204Pb vs. 206Pb/204Pb in Chassigny: (i)TIMS bulk-rock analyses of successive leaches and theirresidue [3]; and (ii) SIMS analysis of individual minerals[4]. The bulk-rock analyses fall along a regression of SIMSplagioclase analyses that define an errorchron that is olderthan the Solar System (4.610.1 Ga); i.e., these define amixing line between Chassignys principal Pb isotopic components(Fig. 1). Augites and olivines in Chassingy (notshown) also fall along or near the plagioclase regression [4].This agreement indicates that the whole-rock leachateslikely measure indigenous, martian Pb, not terrestrial contamination[5]. SIMS analyses of K-spars and sulfides definea separate, sub-parallel trend having higher 207Pb/206Pbvalues ([4]; Fig. 1). The good agreement between the bulkrockanalyses and the SIMS analyses of plagioclases alsoindicates that the Pb in the K-spars and sulfides cannot be amajor component of Chassigny.The depleted reservoir sampled by Chassigny plagioclaseis not the same as the solar system initial (PAT) andrequires a multi-stage origin. Here we show a two-stagemodel (Fig. 1) with a 238U/204Pb () of 0.5 for 4.5-2.4 Gaand a of 7 for 2.4-1.4 Ga. This is not a unique model butdoes produce a Pb composition that falls on the plagioclaseregression at 1.4 Ga, the approximate igneous age of Chassigny [1]. It should be noted that low- single-stage modelsare not capable of producing sufficiently radiogenic 206Pb/204Pb at 1.4 Ga.Relation to Shergottites: The Chassigny K-spars and sulfides fall along a second mixing line defined by leachesand residues of depleted and intermediate shergottites [6]. This mixing line falls above the plagioclase regression.Therefore, we also interpret the radiogenic component of this mixing line to represent indigenous martian Pb. It ispossible that the depleted and intermediate shergottites and the Chassigny plagioclases sample radiogenic Pb from thethe same source, i.e., the mixing lines may intersect at high 206Pb/204Pb.Both K-spar and sulfide are late-stage phases. At the time of their crystallization, the Chassigny system appearsto have remained open to a depleted shergottite Pb reservoir. The depleted component of the shergottite mixing linecan be generated by a single-stage evolution from PAT (4.5 to 1.4 Ga) in a reservoir having a ~2. A similar modelfor the most depleted shergottites is also possible: = 1.5 for 4.5 to 0.3 Ga.Nakhlites: Nakhlite analyses plot between the shergottite and Chassigny plagioclase regressions [3]. So again,members of the nakhlite/chassignite suite show affinities to shergottite Pb
An Integrated Tracker for STAR
The STAR experiment at the Relativistic Heavy Ion Collider RHIC studies the
new state of matter produced in relativistic heavy ion collisions and the spin
structure of the nucleon in collisions of polarized protons. In order to
improve the capabilities for heavy flavor measurements and the reconstruction
of charged vector bosons an upgrade of the tracking system both in the central
and the forward region is pursued. The integrated system providing high
resolution tracking and secondary vertex reconstruction capabilities will use
silicon pixel, strip and GEM technology.Comment: 4 pages, 2 figures, to be published in the Proceedings of the 9th
Conference on the Intersections of Particle and Nuclear Physics (CIPANP
2006), Rio Grande, Puerto Rico, May 30 - June 3, 200
Inclusive Hadron Production in p+p Collisions at STAR
The STAR experiment at RHIC has measured a variety of inclusive hadron cross
sections in collisions at Sqrt(s) = 200 GeV. Measurements of the
differential cross section for inclusive charged pion production at mid
rapidity and for inclusive neutral pion production at forward rapidity (3.0 <
eta < 4.2) as well as the first preliminary result from STAR for the
differential cross section for inclusive neutral pion production near mid
rapidity are presented. These cross sections are compared to next-to-leading
order perturbative QCD calculations and can provide constraints on the pion
fragmentation functions. Good agreement between data and pQCD has been found
for all three cross sections.Comment: 4 pages, 1 figure, to be published in the Proceedings of the 9th
Conference on the Intersections of Particle and Nuclear Physics (CIPANP
2006), Rio Grande, Puerto Rico, May 30 - June 3, 2006, v2 with updated
reference
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