Friends of Henderson Library Newsletter

In This Issue: The Budget Crisis and Henderson Library , Collection Spotlight: Oral History Collection , Statesboro Magazine Enhanced by Index , Henderson Heroes: Spotlight on Employees , Limited Edition Frank Fortune Print , national Library Week Events , FOHL Advisory Board , Georgia Literary Festival in Statesboro: October 22-23, 2010 , New Benefits for Friends of Henderson Library Member

Friends of Henderson Library Newsletter

In This Issue: University & Library Strategic Planning , Improving Access to Henderson Library\u27s Collections-In Person & Online , Henderson Heroes: Spotlight on Employees , Recent Friends Events , Georgia Southern Student\u27s Work Featured as part of 15th Anniversary GALILEO Celebration , Georgia Southern Student Artist Collaborates with Friends , Honoring Henderson Library Retiree

Examination of the Role of Religious and Psychosocial Factors in HIV Medication Adherence Rates

Optimal adherence to antiretroviral therapy (ART) is associated with favorable HIV outcomes, including higher CD4 cell counts, HIV virus suppression and a lower risk of HIV transmission. However, only 25% of people living with HIV/AIDS (PLWH) in the USA are virally suppressed. Sub-optimal adherence (p\u3c 0.05). Social support satisfaction was also significantly associated with ART adherence (OR = 1.52, 95% CI [1.11–2.08], p \u3c 0.05) and energy/fatigue/vitality (OR = 1.03, 95% CI [1.00–1.05], p \u3c 0.05)

Do NGOs Deliver? The Role of NGOs in Responding to the Syrian Refugee Crisis in Jordan

Eleven million Syrians have fled their homes or have been killed as a result of the Syrian Civil War that began in 2011 (Mercy Corps, 2016). The violence, destruction of homes, human rights violations, and lack of access to basic necessities such as food and medication are the motivations for many Syrians to leave their homes and seek refuge in both neighboring countries and Europe. Each year has seen an exponential increase in the number of Syrian refugees; in 2012 there were 100,000 refugees and today there are 4.3 million refugees. This large increase each year contributes to the already significant workload for NGOs responding to the crisis

Association of lower extremity performance with cardiovascular and all-cause mortality in patients with peripheral artery disease: A systematic review and meta-analysis

Background: Peripheral artery disease (PAD) is associated with impaired mobility and a high rate of mortality. The aim of this systematic review was to investigate whether reduced lower extremity performance was associated with an increased incidence of cardiovascular and all‐cause mortality in people with PAD. Methods and Results: A systematic search of the MEDLINE, EMBASE, SCOPUS, Web of Science, and Cochrane Library databases was conducted. Studies assessing the association between measures of lower extremity performance and cardiovascular or all‐cause mortality in PAD patients were included. A meta‐analysis was conducted combining data from commonly assessed performance tests. The 10 identified studies assessed lower extremity performance by strength tests, treadmill walking performance, 6‐minute walk, walking velocity, and walking impairment questionnaire (WIQ). A meta‐analysis revealed that shorter maximum walking distance was associated with increased 5‐year cardiovascular (unadjusted RR=2.54, 95% CI 1.86 to 3.47, P<10−5, n=1577, fixed effects) and all‐cause mortality (unadjusted RR=2.23 95% CI 1.85 to 2.69, P<10−5, n=1710, fixed effects). Slower 4‐metre walking velocity, a lower WIQ stair‐climbing score, and poor hip extension, knee flexion, and plantar flexion strength were also associated with increased mortality. No significant associations were found for hip flexion strength, WIQ distance score, or WIQ speed score with mortality. Conclusions: A number of lower extremity performance measures are prognostic markers for mortality in PAD and may be useful clinical tools for identifying patients at higher risk of death. Further studies are needed to determine whether interventions that improve measures of lower extremity performance reduce mortality

Friends of Henderson Library Newsletter

In This Issue: Volunteer Opportunities , Art and the Henderson Library , Henderson Library\u27s Automated Retrieval Collection (ARC) , Farm to Table , Recent Friends Events , A Fine Romance , $aving the Green , James Dunwoody Bulloch & Modern US Naval Strategy , \u27Throw My Troubles Out the Door:\u27Bob Dylan & the Southern Musical Landscape , Memorial Books in Henderson Library , Henderson Heroes: Spotlight on Employees , Save the Dat

Protease-activated receptor 4 variant p.Tyr157Cys reduces platelet functional responses and alters receptor trafficking

OBJECTIVE—: Protease-activated receptor 4 (PAR4) is a key regulator of platelet reactivity and is encoded by F2RL3, which has abundant rare missense variants. We aimed to provide proof of principle that rare F2LR3 variants potentially affect on platelet reactivity and responsiveness to PAR1 antagonist drugs and to explore underlying molecular mechanisms. APPROACH AND RESULTS—: We identified 6 rare F2RL3 missense variants in 236 cardiac patients, of which the variant causing a tyrosine 157 to cysteine substitution (Y157C) was predicted computationally to affect most on PAR4 structure. Y157C platelets from 3 cases showed reduced responses to PAR4-activating peptide and to α-thrombin compared with controls, but no reduction in responses to PAR1-activating peptide. Pretreatment with the PAR1 antagonist vorapaxar caused lower residual α-thrombin responses in Y157C platelets than in controls, indicating greater platelet inhibition. HEK293 cells transfected with a PAR4 Y157C expression construct had reduced PAR4 functional responses, unchanged total PAR4 expression but reduced surface expression. PAR4 Y157C was partially retained in the endoplasmic reticulum and displayed an expression pattern consistent with defective N-glycosylation. Mutagenesis of Y322, which is the putative hydrogen bond partner of Y157, also reduced PAR4 surface expression in HEK293 cells. CONCLUSIONS—: Reduced PAR4 responses associated with Y157C result from aberrant anterograde surface receptor trafficking, in part, because of disrupted intramolecular hydrogen bonding. Characterization of PAR4 Y157C establishes that rare F2RL3 variants have the potential to markedly alter platelet PAR4 reactivity particularly after exposure to therapeutic PAR1 antagonists

Caregiver Use of the Core Components of Technology-Enhanced Helping the Noncompliant Child: A Case Series Analysis of Low-Income Families

Children from low-income families are more likely to develop early-onset disruptive behavior disorders (DBDs) compared to their higher income counterparts. Low-income families of children with early-onset DBDs, however, are less likely to engage in the standard-of-care treatment, behavioral parent training (BPT), than families from other sociodemographic groups. Preliminary between-group findings suggested technology-enhanced BPT was associated with increased engagement and boosted treatment outcomes for low-income families relative to standard BPT. The current study used a case series design to take this research a step further by examining whether there was variability in use of, and reactions to, the smartphone enhancements within technology-enhanced BPT and the extent to which this variability paralleled treatment outcome. Findings provide a window into the uptake and use of technology-enhanced service delivery methods among low-income families, with implications for the broader field of children’s mental health

The Ursinus Weekly, November 13, 1975

Volleyball team is Division A champ • Myrin hrs. changed? • Pre-legal Soc. is revived • SFARC update • U.S.A. as seen by Kahata • Temple University lists Irish Studies • Pollution expert talks • Editorial: Pride and perseverance • Editor\u27s comment: My reply to your opinions • Saturday Lunch • Forum review: Ambassador discusses U.N. • Bearpit opens • A new light on Lantern • Newmans organize • A conversation in the board room • Devils demonize Bears! • Diving into action • Intramurals • Mr. Karas • NBA West • A season of kickshttps://digitalcommons.ursinus.edu/weekly/1046/thumbnail.jp