7,636 research outputs found
Mashing up Visual Languages and Web Mash-ups
Research on web mashups and visual languages
share an interest in human-centered computing. Both
research communities are concerned with supporting
programming by everyday, technically inexpert users.
Visual programming environments have been a focus for
both communities, and we believe that there is much to
be gained by further discussion between these research
communities. In this paper we explore some connections
between web mashups and visual languages, and try to
identify what each might be able to learn from the other.
Our goal is to establish a framework for a dialog
between the communities, and to promote the exchange
of ideas and our respective understandings of humancentered
computing.published or submitted for publicationis peer reviewe
Recall of lost-to-follow-up pre-antiretroviral therapy patients in the Eastern Cape: Effect of mentoring on patient care
Background. In 2011 an experienced HIV nurse from the UK was deployed for 3 months to act as a mentor to nurses learning to initiate antiretroviral therapy (ART) in primary care clinics in a small town in the Eastern Cape, South Africa.Methods. A review of existing pre-ART patient files (N=286) was carried out and lost-to-follow-up (LTFU) HIV patients were recalled.Results. Only 24% of patients had attended the clinics within the preceding 6 months and 20% had not attended for longer than 2 years. Two lay counsellors visited 222 patients to encourage them to return to care; 65/286 (23%) were untraceable, 11/286 (4%) had relocated, 30/286 (10%) declined, and 8/286 (3%) had died. In the 6 weeks following recall, 51/286 patients (18%) returned to the clinics. CD4 count testing was repeated and screening for tuberculosis (TB) and other opportunistic infections was performed for all patients; ART was initiated in 13/51 (25%), 1 patient tested positive for TB, and isionazid (INH) prophylaxis was initiated in 23/51 (45%). The cost of recall was R130/patient. Within 6 months, all clinics began providing full ART services, 17 professional nurses were mentored and they initiated ART in 55 patients.Conclusions. Mentoring plays an important role in professional nurse training and support. Recall of LTFU patients is feasible and effective in improving ART services in rural settings
Toxicity of cancer therapy: what the cardiologist needs to know about angiogenesis inhibitors
Clinical outcomes for patients with a wide range of malignancies have improved substantially over the last two decades. Tyrosine kinase inhibitors (TKIs) are potent signalling cascade inhibitors and have been responsible for significant advances in cancer therapy. By inhibiting vascular endothelial growth factor receptor (VEGFR)-mediated tumour blood vessel growth, VEGFR-TKIs have become a mainstay of treatment for a number of solid malignancies. However, the incidence of VEGFR-TKI-associated cardiovascular toxicity is substantial and previously under-recognised. Almost all patients have an acute rise in blood pressure, and the majority develop hypertension. They are associated with the development of left ventricular systolic dysfunction (LVSD), heart failure and myocardial ischaemia and can have effects on myocardial repolarisation. Attention should be given to rigorous baseline assessment of patients prior to commencing VEGFR-TKIs, with careful consideration of baseline cardiovascular risk factors. Baseline blood pressure measurement, ECG and cardiac imaging should be performed routinely. Hypertension management currently follows national guidelines, but there may be a future role forendothelin-1 antagonism in the prevention or treatment of VEGFR-TKI-associated hypertension. VEGFR-TKI-associated LVSD appears to be independent of dose and is reversible. Patients who develop LVSD and heart failure should be managed with conventional heart failure therapies, but the role of prophylactic therapy is yet to be defined. Serial monitoring of left ventricular function and QT interval require better standardisation and coordinated care. Management of these complex patients requires collaborative, cardio-oncology care to allow the true therapeutic potential from cancer treatment while minimising competing cardiovascular effects
Evaluating 5 years’ NIMART mentoring in South Africa’s HIV treatment programme: Successes, challenges and future needs
Evaluating 5 years’ NIMART mentoring in South Africa’s HIV treatment programme: Successes, challenges and future need
Strings from Feynman Graph counting : without large N
A well-known connection between n strings winding around a circle and
permutations of n objects plays a fundamental role in the string theory of
large N two dimensional Yang Mills theory and elsewhere in topological and
physical string theories. Basic questions in the enumeration of Feynman graphs
can be expressed elegantly in terms of permutation groups. We show that these
permutation techniques for Feynman graph enumeration, along with the Burnside
counting lemma, lead to equalities between counting problems of Feynman graphs
in scalar field theories and Quantum Electrodynamics with the counting of
amplitudes in a string theory with torus or cylinder target space. This string
theory arises in the large N expansion of two dimensional Yang Mills and is
closely related to lattice gauge theory with S_n gauge group. We collect and
extend results on generating functions for Feynman graph counting, which
connect directly with the string picture. We propose that the connection
between string combinatorics and permutations has implications for QFT-string
dualities, beyond the framework of large N gauge theory.Comment: 55 pages + 10 pages Appendices, 23 figures ; version 2 - typos
correcte
Rotational velocities of low-mass stars in the Pleiades and Hyades
We have obtained high-resolution spectra of 89 M dwarf members of the
Pleiades and Hyades and have derived radial velocities, H-alpha equivalent
widths, and spectroscopic rotational velocities for these stars. Typical masses
of the newly-observed Pleiades and Hyades stars are ~ 0.4 M_{\sun} and ~ 0.2
M_{\sun}, respectively. We combine our new observations with previously
published data to explore the rotational evolution of young stars with M < 0.4
M_\sun. The average rotation rate in the Hyades (age 600 Myr) is about 0.4 that
of the Pleiades (110 Myr), and the mean equivalent widths of H-alpha are also
lower. As found in previous studies, the correlation between rotation and
chromospheric activity is identical in both clusters, implying that the lower
activity in the Hyades is a result of the lower rotation rates. We show that a
simple scaling of the Pleiades rotational distribution for M \leq 0.4 M_{\sun},
corrected for the effects of structural evolution, matches that of the Hyades
if the average angular momentum loss from the Pleiades to the Hyades age is
factor of \approx 6. This suggests that the distribution of initial angular
momenta and disk-locking lifetimes for the lowest mass stars was similar in
both clusters. We argue that this result provides further evidence for a
saturation of the angular momentum loss rate at high rotational velocities.Comment: 22 pages, 11 figures, accepted for publication in The Astronomical
Journal, tentatively scheduled for March 200
Access to and experience of later abortion: accounts from women in Scotland
Context:
Except in the presence of significant medical indications, the legal limit for abortion in Great Britain is 24 weeks’ gestation. Nevertheless, abortion for nonmedical reasons is not usually provided in Scotland after 18–20 weeks, meaning women have to travel to England for the procedure.
Methods:
In-depth interviews were conducted with 23 women presenting for "later" abortions (i.e., at 16 or more weeks’ gestation) in Scotland. Participants were women who sought an abortion at a participating National Health Service clinic between January and July 2013. Interviews addressed reasons for and consequences of later presentation, as well as women's experiences of abortion. Thematic analysis attended to emerging issues and employed the conceptual tool of candidacy.
Results:
Delayed recognition of pregnancy, changed life circumstances and conflicting candidacies for motherhood and having an abortion were common reasons for women's presentation for later abortion. Women perceived that the resources required to travel to England for a later abortion were potential barriers to access, and felt that such travel was distressing and stigmatizing. Participants who continued their pregnancy did so after learning they were at a later gestational age than expected or after receiving assurances of support from partners, friends or family.
Conclusions:
Reasons for seeking later abortion are complex and varied among women in Scotland, and suggest that reducing barriers to access and improving local provision of such abortions are a necessity. The candidacy framework allows for a fuller understanding of the difficulties involved in obtaining abortions
- …