678 research outputs found

    Casino Drink Policies: Limiting Third-Party Liability

    Get PDF
    In their efforts to provide an atmosphere or hospitality to their casino customers, many operators will provide complimentary alcoholic beverage service. This practice is fraught with liability, particularly in venues outside of Nevada. Conscientious operators must take every precaution to mitigate the possibility of lawsuit

    The Structural Basis for Phospholamban Inhibition of the Calcium Pump in Sarcoplasmic Reticulum

    Get PDF
    P-type ATPases are a large family of enzymes that actively transport ions across biological membranes by interconverting between high (E1) and low (E2) ion-affinity states; these transmembrane transporters carry out critical processes in nearly all forms of life. In striated muscle, the archetype P-type ATPase, SERCA (sarco(endo)plasmic reticulum Ca2+-ATPase), pumps contractile-dependent Ca2+ ions into the lumen of sarcoplasmic reticulum, which initiates myocyte relaxation and refills the sarcoplasmic reticulum in preparation for the next contraction. In cardiac muscle, SERCA is regulated by phospholamban (PLB), a small inhibitory phosphoprotein that decreases the Ca2+ affinity of SERCA and attenuates contractile strength. cAMP-dependent phosphorylation of PLB reverses Ca2+-ATPase inhibition with powerful contractile effects. Here we present the long sought crystal structure of the PLB-SERCA complex at 2.8-Å resolution. The structure was solved in the absence of Ca2+ in a novel detergent system employing alkyl mannosides. The structure shows PLB bound to a previously undescribed conformation of SERCA in which the Ca2+ binding sites are collapsed and devoid of divalent cations (E2-PLB). This new structure represents one of the key unsolved conformational states of SERCA and provides a structural explanation for how dephosphorylated PLB decreases Ca2+ affinity and depresses cardiac contractility

    Reduced Scepter Rates for Broadleaf Weed Control in Soybean

    Get PDF
    Public agencies are placing greater scrutiny on herbicide applications by farmers. For example, the corn herbicide atrazine is now classified as a restricted use pesticide, with limits placed on allowable rates. While soybean growers may share some of this concern for the environment, rate reduction is more likely to be attractive for economic reasons. Some growers are already cutting back on herbicide rates. For example, Missouri data shows that the average application rates for soybean herbicides were only 75% of the labelled rate. While reduced rates might save growers money, and may be kinder to the environment, there is a concern that poorer weed control could show up under unfavorable conditions

    Using local knowledge, hydrologic, and climate data to develop a driftwood harvest model in interior Alaska

    Get PDF
    Rural Alaskan residents are concerned that the character of the summer discharge in the Yukon River is changing, which is affecting their ability to harvest driftwood. The Yukon River flows northwesterly through British Columbia and the Yukon Territory before flowing southwest through Alaska. In most summers, residents of Tanana, Alaska harvest driftwood from the Yukon River during two different periods. Typically, driftwood accompanies high flows on the Yukon River associated with spring break‐up. A few weeks later, a second series of driftwood appears, associated with the “2nd rise,” which is reported to occur during early June. This study examines the nature of the differential timing of high flow events in the Yukon River. Many communities in interior Alaska have grown to rely upon driftwood as an important source of wood, which is used in construction, carving, and as a fuel source. Increasingly, villages in rural Alaska are trying to lessen their dependence upon expensive fossil fuels. To achieve this goal, a number of Alaskan villages have recently installed wood chip‐fired boilers to generate heat and/or electricity and additional boilers are slated to be installed in rural Alaska in the near future. These boilers are largely fed by driftwood, a cheap and easily processed wood source. Some Tanana residents have expressed concern that in recent years, driftwood was not readily available because the “2nd rise” flood event was absent. This is disconcerting for rural Alaskans that are becoming increasingly reliant upon the driftwood flows. Our goal is to determine if the perceived changes in driftwood availability are related to changes in river hydrology and if predicted changes in hydrology may affect driftwood flows and the livelihoods of rural Alaskans.NSF, Resilience and Adaptation Program, Water and Environmental Research Center, Alaska EPSCoR

    Using Local Knowledge, Hydrologic, and Climate Data to Develop a Driftwood Harvest Model in Interior Alaska

    Get PDF
    Many rural Alaska residents rely on harvested driftwood from the Yukon River for fuel and construction materials, however they have stated that the character of the summer discharge in the Yukon River is changing and affecting their ability to harvest this resource. We examined whether the perceived changes in driftwood availability are related to changes in river hydrology and how changes in hydrology may affect future driftwood flows and the livelihoods of rural Alaskans.IAB, NSF, RAP, WERC, Alaska APSCo

    Enabling quantitative data analysis through e-infrastructures

    Get PDF
    This paper discusses how quantitative data analysis in the social sciences can engage with and exploit an e-Infrastructure. We highlight how a number of activities which are central to quantitative data analysis, referred to as ‘data management’, can benefit from e-infrastructure support. We conclude by discussing how these issues are relevant to the DAMES (Data Management through e-Social Science) research Node, an ongoing project that aims to develop e-Infrastructural resources for quantitative data analysis in the social sciences

    RELICS: Strong Lens Models for Five Galaxy Clusters From the Reionization Lensing Cluster Survey

    Get PDF
    Strong gravitational lensing by galaxy clusters magnifies background galaxies, enhancing our ability to discover statistically significant samples of galaxies at z>6, in order to constrain the high-redshift galaxy luminosity functions. Here, we present the first five lens models out of the Reionization Lensing Cluster Survey (RELICS) Hubble Treasury Program, based on new HST WFC3/IR and ACS imaging of the clusters RXC J0142.9+4438, Abell 2537, Abell 2163, RXC J2211.7-0349, and ACT-CLJ0102-49151. The derived lensing magnification is essential for estimating the intrinsic properties of high-redshift galaxy candidates, and properly accounting for the survey volume. We report on new spectroscopic redshifts of multiply imaged lensed galaxies behind these clusters, which are used as constraints, and detail our strategy to reduce systematic uncertainties due to lack of spectroscopic information. In addition, we quantify the uncertainty on the lensing magnification due to statistical and systematic errors related to the lens modeling process, and find that in all but one cluster, the magnification is constrained to better than 20% in at least 80% of the field of view, including statistical and systematic uncertainties. The five clusters presented in this paper span the range of masses and redshifts of the clusters in the RELICS program. We find that they exhibit similar strong lensing efficiencies to the clusters targeted by the Hubble Frontier Fields within the WFC3/IR field of view. Outputs of the lens models are made available to the community through the Mikulski Archive for Space TelescopesComment: Accepted to Ap
    corecore