203 research outputs found
Characteristics Relating to Adherence and Persistence to Basal Insulin Regimens Among Elderly Insulin-Naïve Patients with Type 2 Diabetes: Pre-Filled Pens versus Vials/Syringes
Quality of penicillin allergy management in the intensive care unit and internal medicine ward
F-theory and Neutrinos: Kaluza-Klein Dilution of Flavor Hierarchy
We study minimal implementations of Majorana and Dirac neutrino scenarios in
F-theory GUT models. In both cases the mass scale of the neutrinos m_nu ~
(M_weak)^2/M_UV arises from integrating out Kaluza-Klein modes, where M_UV is
close to the GUT scale. The participation of non-holomorphic Kaluza-Klein mode
wave functions dilutes the mass hierarchy in comparison to the quark and
charged lepton sectors, in agreement with experimentally measured mass
splittings. The neutrinos are predicted to exhibit a "normal" mass hierarchy,
with masses m_3,m_2,m_1 ~ .05*(1,(alpha_GUT)^(1/2),alpha_GUT) eV. When the
interactions of the neutrino and charged lepton sectors geometrically unify,
the neutrino mixing matrix exhibits a mild hierarchical structure such that the
mixing angles theta_23 and theta_12 are large and comparable, while theta_13 is
expected to be smaller and close to the Cabibbo angle: theta_13 ~ theta_C ~
(alpha_GUT)^(1/2) ~ 0.2. This suggests that theta_13 should be near the current
experimental upper bound.Comment: v2: 83 pages, 10 figures, references adde
Long-term evolution of the coupled boundary layers (STRATUS) mooring recovery and deployment cruise report NOAA Research Vessel R H Brown • cruise RB-01-08 9 October - 25 October 2001
This report documents the work done on cruise RB-01-08 of the NOAA R/V Ron Brown. This was Leg 2 of R/V Ron Brown’s
participation in Eastern Pacific Investigation of Climate (EPIC) 2001, a study of air-sea interaction, the atmosphere, and the upper
ocean in the eastern tropical Pacific. The science party included groups from the Woods Hole Oceanographic Institution (WHOI),
NOAA Environmental Technology Laboratory (ETL), the University of Washington (UW), the University of California, Santa
Barbara (UCSB), and the University Nacional Autonoma de Mexico (UNAM). The work done by these groups is summarized in this
report. In addition, the routine underway data collected while aboard R/V Ron Brown is also summarized here.Funding was provided by the National Oceanic and Atmospheric Administration under
Grant Numbers NA96GPO429 and NA17RJ1223
The Conformal Sector of F-theory GUTs
D3-brane probes of exceptional Yukawa points in F-theory GUTs are natural
hidden sectors for particle phenomenology. We find that coupling the probe to
the MSSM yields a new class of N = 1 conformal fixed points with computable
infrared R-charges. Quite surprisingly, we find that the MSSM only weakly mixes
with the strongly coupled sector in the sense that the MSSM fields pick up
small exactly computable anomalous dimensions. Additionally, we find that
although the states of the probe sector transform as complete GUT multiplets,
their coupling to Standard Model fields leads to a calculable threshold
correction to the running of the visible sector gauge couplings which improves
precision unification. We also briefly consider scenarios in which SUSY is
broken in the hidden sector. This leads to a gauge mediated spectrum for the
gauginos and first two superpartner generations, with additional contributions
to the third generation superpartners and Higgs sector.Comment: v2: 51 pages, 2 figures, remark added, typos correcte
Evidence for F(uzz) Theory
We show that in the decoupling limit of an F-theory compactification, the
internal directions of the seven-branes must wrap a non-commutative four-cycle
S. We introduce a general method for obtaining fuzzy geometric spaces via toric
geometry, and develop tools for engineering four-dimensional GUT models from
this non-commutative setup. We obtain the chiral matter content and Yukawa
couplings, and show that the theory has a finite Kaluza-Klein spectrum. The
value of 1/alpha_(GUT) is predicted to be equal to the number of fuzzy points
on the internal four-cycle S. This relation puts a non-trivial restriction on
the space of gauge theories that can arise as a limit of F-theory. By viewing
the seven-brane as tiled by D3-branes sitting at the N fuzzy points of the
geometry, we argue that this theory admits a holographic dual description in
the large N limit. We also entertain the possibility of constructing string
models with large fuzzy extra dimensions, but with a high scale for quantum
gravity.Comment: v2: 66 pages, 3 figures, references and clarifications adde
Mineralization of Acephate, a Recalcitrant Organophosphate Insecticide Is Initiated by a Pseudomonad in Environmental Samples
An aerobic bacterium capable of breaking down the pesticide acephate (O,S-dimethyl acetyl phosphoramidothioic acid) was isolated from activated sludge collected from a pesticide manufacturing facility. A phylogenetic tree based on the 16 S rRNA gene sequence determined that the isolate lies within the Pseudomonads. The isolate was able to grow in the presence of acephate at concentrations up to 80 mM, with maximum growth at 40 mM. HPLC and LC-MS/MS analysis of spent medium from growth experiments and a resting cell assay detected the accumulation of methamidophos and acetate, suggesting initial hydrolysis of the amide linkage found between these two moieties. As expected, the rapid decline in acephate was coincident with the accumulation of methamidophos. Methamidophos concentrations were maintained over a period of days, without evidence of further metabolism or cell growth by the cultures. Considering this limitation, strains such as described in this work can promote the first step of acephate mineralization in soil microbial communities
On the sources of the height–intelligence correlation: New insights from a bivariate ACE model with assortative mating
A robust positive correlation between height and intelligence, as measured by IQ tests, has been established in the literature. This paper makes several contributions toward establishing the causes of this association. First, we extend the standard bivariate ACE model to account for assortative mating. The more general theoretical framework provides several key insights, including formulas to decompose a cross-trait genetic correlation into components attributable to assortative mating and pleiotropy and to decompose a cross-trait within-family correlation. Second, we use a large dataset of male twins drawn from Swedish conscription records and examine how well genetic and environmental factors explain the association between (i) height and intelligence and (ii) height and military aptitude, a professional psychogologist’s assessment of a conscript’s ability to deal with wartime stress. For both traits, we find suggestive evidence of a shared genetic architecture with height, but we demonstrate that point estimates are very sensitive to assumed degrees of assortative mating. Third, we report a significant within-family correlation between height and intelligence \documentclass[12pt]{minimal}
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A trematode parasite derived growth factor binds and exerts influences on host immune functions via host cytokine receptor complexes
The trematode Fasciola hepatica is responsible for chronic zoonotic infection globally. Despite causing a potent T-helper 2 response, it is believed that potent immunomodulation is responsible for rendering this host reactive non-protective host response thereby allow- ing the parasite to remain long-lived. We have previously identified a growth factor, FhTLM, belonging to the TGF superfamily can have developmental effects on the parasite. Herein we demonstrate that FhTLM can exert influence over host immune functions in a host receptor specific fashion. FhTLM can bind to receptor members of the Transforming Growth Factor (TGF) superfamily, with a greater affinity for TGF-β RII. Upon ligation FhTLM initiates the Smad2/3 pathway resulting in phenotypic changes in both fibroblasts and macrophages. The formation of fibroblast CFUs is reduced when cells are cultured with FhTLM, as a result of TGF-β RI kinase activity. In parallel the wound closure response of fibroblasts is also delayed in the presence of FhTLM. When stimulated with FhTLM blood monocyte derived macrophages adopt an alternative or regulatory phenotype. They express high levels interleukin (IL)-10 and arginase-1 while displaying low levels of IL-12 and nitric oxide. Moreover they also undergo significant upregulation of the inhibitory recep- tor PD-L1 and the mannose receptor. Use of RNAi demonstrates that this effect is depen- dent on TGF-β RII and mRNA knock-down leads to a loss of IL-10 and PD-L1. Finally, we demonstrate that FhTLM aids newly excysted juveniles (NEJs) in their evasion of antibody- dependent cell cytotoxicity (ADCC) by reducing the NO response of macrophages—again dependent on TGF-β RI kinase. FhTLM displays restricted expression to the F. hepatica gut resident NEJ stages. The altered fibroblast responses would suggest a role for damp- ened tissue repair responses in facilitating parasite migration. Furthermore, the adoption of a regulatory macrophage phenotype would allow for a reduced effector response targetingjuvenile parasites which we demonstrate extends to an abrogation of the ADCC response. Thus suggesting that FhTLM is a stage specific evasion molecule that utilises host cytokine receptors. These findings are the first to clearly demonstrate the interaction of a helminth cytokine with a host receptor complex resulting in immune modifications that facilitate the non-protective chronic immune response which is characteristic of F. hepatica infection
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