Bimekizumab efficacy and safety through two years in patients with moderate psoriasis: Analysis of pooled data from five phase 3/3b clinical trials

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Living Well with Diabetes: a randomized controlled trial of a telephone-delivered intervention for maintenance of weight loss, physical activity and glycaemic control in adults with type 2 diabetes

Background By 2025, it is estimated that approximately 1.8 million Australian adults (approximately 8.4% of the adult population) will have diabetes, with the majority having type 2 diabetes. Weight management via improved physical activity and diet is the cornerstone of type 2 diabetes management. However, the majority of weight loss trials in diabetes have evaluated short-term, intensive clinic-based interventions that, while producing short-term outcomes, have failed to address issues of maintenance and broad population reach. Telephone-delivered interventions have the potential to address these gaps. Methods/Design Using a two-arm randomised controlled design, this study will evaluate an 18-month, telephone-delivered, behavioural weight loss intervention focussing on physical activity, diet and behavioural therapy, versus usual care, with follow-up at 24 months. Three-hundred adult participants, aged 20-75 years, with type 2 diabetes, will be recruited from 10 general practices via electronic medical records search. The Social-Cognitive Theory driven intervention involves a six-month intensive phase (4 weekly calls and 11 fortnightly calls) and a 12-month maintenance phase (one call per month). Primary outcomes, assessed at 6, 18 and 24 months, are: weight loss, physical activity, and glycaemic control (HbA1c), with weight loss and physical activity also measured at 12 months. Incremental cost-effectiveness will also be examined. Study recruitment began in February 2009, with final data collection expected by February 2013. Discussion This is the first study to evaluate the telephone as the primary method of delivering a behavioural weight loss intervention in type 2 diabetes. The evaluation of maintenance outcomes (6 months following the end of intervention), the use of accelerometers to objectively measure physical activity, and the inclusion of a cost-effectiveness analysis will advance the science of broad reach approaches to weight control and health behaviour change, and will build the evidence base needed to advocate for the translation of this work into population health practice

Traumatic events, other operational stressors and physical and mental health reported by Australian Defence Force personnel following peacekeeping and war-like deployments

Background: The association between stressful events on warlike deployments and subsequent mental health problems has been established. Less is known about the effects of stressful events on peacekeeping deployments. Methods: Two cross sectional studies of the Australian Defence Force were used to contrast the prevalence of exposures reported by a group deployed on a peacekeeping operation (Bougainville, n=1704) and those reported by a group deployed on operations which included warlike and non-warlike exposures (East Timor, n=1333). A principal components analysis was used to identify groupings of non-traumatic exposures on deployment. Multiple regression models were used to assess the association between self-reported objective and subjective exposures, stressors on deployment and subsequent physical and mental health outcomes. Results: The principal components analysis produced four groups of non-traumatic stressors which were consistent between the peacekeeping and more warlike deployments. These were labelled ‘separation’, ‘different culture’, ‘other people’ and ‘work frustration’. Higher levels of traumatic and non-traumatic exposures were reported by veterans of East Timor compared to Bougainville. Higher levels of subjective traumatic exposures were associated with increased rates of PTSD in East Timor veterans and more physical and psychological health symptoms in both deployed groups. In Bougainville and East Timor veterans some non-traumatic deployment stressors were also associated with worse health outcomes. Conclusion: Strategies to best prepare, identify and treat those exposed to traumatic events and other stressors on deployment should be considered for Defence personnel deployed on both warlike and peacekeeping operations.Michael Waller, Susan A Treloar, Malcolm R Sim, Alexander C McFarlane, Annabel C L McGuire, Jonathan Bleier and Annette J Dobso

Decoy Cropping Methods for Luring Blackbirds Away From Commercial Sunflower: USDA Wildlife Conservation Sunflower Plots

In an effort to reduce blackbird damage to commercial sunflower, which can range from $4-11 million annually in North Dakota and South Dakota, we evaluated Wildlife Conservation Sunflower Plots (WCSP) for efficacy and wildlife benefits. Blackbird depredation has caused some producers to reduce sunflower acreages and seek alternative crops in this optimal sunflower growing region. USDA’s Wildlife Services funded 8-ha units of oil sunflower (WCSP) to lure migrating blackbirds away from commercial sunflower fields. Vegetative data, habitat variables, GIS-analyzed land-use data, weekly blackbird surveys, sunflower damage surveys, and avian point counts will be used to evaluate the effectiveness of the WCSP. Preliminary analysis of the 2004 field data showed that blackbird and non-blackbird density is significantly greater in WCSP than in commercial sunflower. Habitat variables and spatial landscape features are currently being reviewed in order to account for the difference. Under some conditions, trees and wetlands are significantly correlated with blackbird damage and abundance in sunflower. We further hypothesize that proximity to shelter belts, wetlands, cattail stands, other grain crops, and/or large commercial sunflower acreages influences avian use of WCSP

Blackbird Use and Damage of Wildlife Conservation Sunflower Plots

Annual blackbird damage to sunflower is valued at $5 to$10 million. Perhaps more importantly, the National Sunflower Association has identified blackbirds as the key reason for growers to abandon sunflower in areas of prime production. North Dakota and South Dakota together produce approximately 70% of sunflower grown in the United States. This crop adds $906 million to the regional economy. To date, cost effective and environmentally safe methods to reduce bird damage to sunflower remain elusive. In the 1980’s, scientists from the National Wildlife Research Center (NWRC) showed that “decoy” sunflower plots can greatly reduce bird damage to local commercial sunflower fields. At the time, this idea was abandoned due to lack of grower support. Support has increased, however, over the past 10 years due to conservation interests and new federal farm programs. In 2004, Wildlife Services (WS) along with North Dakota State University (NDSU) started the “Wildlife Conservation Sunflower Plot” (WCSP) study

Blackbird Use and Damage of Wildlife Conservation Sunflower Plots: The Second Year

Annual blackbird damage to sunflower is valued at $5 to$10 million. Perhaps more importantly, the National Sunflower Association has identified blackbirds as the key reason for growers to abandon sunflower in areas of prime production. North Dakota and South Dakota together produce approximately 70% of sunflower grown in the United States. This crop adds $906 million to the regional economy. To date, cost effective and environmentally safe methods to reduce bird damage to sunflower remain elusive. In the 1980’s, scientists from the National Wildlife Research Center (NWRC) showed that “decoy” sunflower plots can greatly reduce bird damage to local commercial sunflower fields. At the time, this idea was abandoned due to lack of grower support. Support has increased, however, over the past 10 years due to conservation interests and new federal farm programs. In 2004, Wildlife Services (WS) along with North Dakota State University (NDSU) started the “Wildlife Conservation Sunflower Plots” (WCSP) study

BLACKBIRD USE OF WILDLIFE CONSERVATION SUNFLOWER PLOTS

In North Dakota, annual blackbird damage to sunflower ranges from $5-10 million. Blackbird damage to ripening sunflower has forced some growers to plant alternative crops. From 2004 to 2006, USDA-Wildlife Services cost-shared Wildlife Conservation Sunflower Plots (WCSP) with sunflower growers. The objective of the WCSP was to provide blackbirds an attractive nearby alternative food source to reduce damage to commercial fields. A secondary benefit of WCSP was to provide a safe-haven for other wildlife that frequently use shelterbelts and wetlands along the edges of sunflower fields. In 2004 (n=13), 2005 (n=21), and 2006 (n=25), sunflower damage in the WCSP’s was 39%, 32%, and 60%, respectively. Damage in nearby commercial fields was 5% in 2004, 4% in 2005, and 18% in 2006. In 2006, dry conditions may have concentrated blackbirds into bigger roosts in the larger and deeper wetlands, contributing to higher levels of sunflower damage compared to 2004 and 2005. Lower levels of damage in 2004 and 2005 may have been caused by the greater availability of wetlands, which dispersed the flocks. We believe that avian use of WCSP was influenced by the nearness of shelterbelts, cattail-dominated wetlands, and contiguous blocks of commercial sunflower. We speculate that WCSP can reduce bird damage in nearby commercial fields. Based on these data, additional large-scale field tests appear to be warranted

Folate Levels in Patients Hospitalized with Coronavirus Disease 2019

We aimed to investigate the prevalence of decreased folate levels in patients hospitalized with Coronavirus Disease 2019 (COVID-19) and evaluate their outcome and the prognostic signifi-cance associated with its different levels. In this retrospective cohort study, data were obtained from the electronic medical records at the Sheba Medical Center. Folic acid levels were available in 333 out of 1020 consecutive patients diagnosed with COVID-19 infection hospitalized from January 2020 to November 2020. Thirty-eight (11.4%) of the 333 patients comprising the present study population had low folate levels. No significant difference was found in the incidence of acute kidney injury, hypoxemia, invasive ventilation, length of hospital stay, and mortality be-tween patients with decreased and normal-range folate levels. When sub-dividing the study population according to quartiles of folate levels, similar findings were observed. In conclusion, decreased serum folate levels are common among hospitalized patients with COVID-19, but there was no association between serum folate levels and clinical outcomes. Due to the important role of folate in cell metabolism and the potential pathologic impact when deficient, a follow-up of folate levels or possible supplementation should be encouraged in hospitalized COVID-19 patients. Fur-ther studies are required to assess the prevalence and consequences of folate deficiency in COVID-19 patients