Best practices to maximize the use and reuse of quantitative and systems pharmacology models: recommendations from the United Kingdom quantitative and systems pharmacology network

The lack of standardization in the way that quantitative and systems pharmacology (QSP) models are developed, tested, and documented hinders their reproducibility, reusability, and expansion or reduction to alternative contexts. This in turn undermines the potential impact of QSP in academic, industrial, and regulatory frameworks. This article presents a minimum set of recommendations from the UK Quantitative and Systems Pharmacology Network (UK QSP Network) to guide QSP practitioners seeking to maximize their impact, and stakeholders considering the use of QSP models in their environment

Planet Netsweeper

This report describes our investigation into the global proliferation of Internet filtering systems manufactured by the Canadian company, Netsweeper Inc. We outline in detail the methods that we adopted to identify Netsweeper installations worldwide, and those that we employed to reduce the findings to countries of interest. We also present high-level technical findings and observations. Through case studies, we spotlight several countries where we have evidence of public ISPs blocking websites using Netsweeper’s products. Each country has significant human rights, public policy, insecurity, or corruption challenges, and/or a history of using Internet censorship to prevent access to content that is protected under international human rights frameworks. Finally, the Discussion & Conclusions section examines the legal, regulatory, corporate social responsibility, and other public policy issues raised by our report’s findings. We focus on the responsibilities of Netsweeper, Inc. and the obligations of the Canadian government under international human rights law.Financial support for Citizen Lab’s research on information controls is provided by the John D. and Catherine T. MacArthur Foundation, the Ford Foundation, Open Society Foundations, Oak Foundation, and the Sigrid Rausing Trust