3 research outputs found
COBRAPed cohort: Do sensitization patterns differentiate children with severe asthma from those with a milder disease?
International audienceAbstract Background It is unclear whether sensitization patterns differentiate children with severe recurrent wheeze (SRW)/severe asthma (SA) from those with nonâsevere recurrent wheeze (NSRW)/nonâsevere asthma (NSA). Our objective was to determine whether sensitization patterns can discriminate between children from the French COBRAPed cohort with NSRW/NSA and those with SRW/SA. Methods IgE to 112 components (câsIgE) (ImmunoCAPÂź ISAC) were analyzed in 125 preschools (3â6âyears) and 170 schoolâage children (7â12âyears). Supervised analyses and clustering methods were applied to identify patterns of sensitization among children with positive câsIgE. Results We observed câsIgE sensitization in 51% of preschool and 75% of schoolâage children. Sensitization to house dust mite (HDM) components was more frequent among NSRW than SRW (53% vs. 24%, p <â.01). Sensitization to nonâspecific lipid transfer protein (nsLTP) components was more frequent among SA than NSA (16% vs. 4%, p <â.01) and associated with an FEV1/FVCâ<ââ1.64 z âscore. Among sensitized children, seven clusters with varying patterns were identified. The two broader clusters identified in each age group were characterized by âfew sensitizations, mainly to HDM.â One cluster ( n =â4) with âmultiple sensitizations, mainly to grass pollen, HDM, PRâ10, and nsLTPâ was associated with SA in schoolâage children. Conclusions Although children with wheeze/asthma display frequent occurrences and high levels of sensitization, sensitization patterns did not provide strong signals to discriminate children with severe disease from those with milder disease. These results suggest that the severity of wheeze/asthma may depend on both IgEâ and nonâIgEâmediated mechanisms
Pediatric Tumors and Developmental Anomalies: A French Nationwide Cohort Study
International audienceObjective: To assess the associations between congenital abnormalities and pediatric malignancies and evaluate the potential underlying molecular basis by collecting information on pediatric patients with cancer and congenital abnormalities. Study design: Tumeur Et DĂ©veloppement is a national, prospective, and retrospective multicenter study recording data of children with cancer and congenital abnormalities. When feasible, blood and tumoral samples are collected for virtual biobanking. Results: From June 2013 to December 2019, 679 associations between pediatric cancers and congenital abnormalities were recorded. The most represented cancers were central nervous system tumors (n = 139; 20%), leukemia and myelodysplastic syndromes (n = 123; 18.1%), and renal tumors (n = 101; 15%). Congenital abnormalities were not related to any known genetic disorder in 66.5% of cases. In this group, the most common anomaly was intellectual disability (22.3%), followed by musculoskeletal (14.2%) and genitourinary anomalies (12.4%). Intellectual disability was mostly associated with hematologic malignancies. Embryonic tumors (neuroblastoma, Wilms tumor, and rhabdomyosarcoma) were associated with consistent abnormalities, sometimes with a close anatomical neighborhood between the abnormality and the neoplasm. Conclusions: In the first Tumeur Et DĂ©veloppement analysis, 3 major themes have been identified: (1) germline mutations with or without known cancer predisposition, (2) postzygotic events responsible for genomic mosaicism, (3) coincidental associations. New pathways involved in cancer development need to be investigated to improve our understanding of childhood cancers