GraFIX: a semiautomatic approach for parsing low- and high-quality eye-tracking data

Fixation durations (FD) have been used widely as a measurement of information processing and attention. However, issues like data quality can seriously influence the accuracy of the fixation detection methods and, thus, affect the validity of our results (Holmqvist, Nyström, & Mulvey, 2012). This is crucial when studying special populations such as infants, where common issues with testing (e.g., high degree of movement, unreliable eye detection, low spatial precision) result in highly variable data quality and render existing FD detection approaches highly time consuming (hand-coding) or imprecise (automatic detection). To address this problem, we present GraFIX, a novel semiautomatic method consisting of a two-step process in which eye-tracking data is initially parsed by using velocity-based algorithms whose input parameters are adapted by the user and then manipulated using the graphical interface, allowing accurate and rapid adjustments of the algorithms’ outcome. The present algorithms (1) smooth the raw data, (2) interpolate missing data points, and (3) apply a number of criteria to automatically evaluate and remove artifactual fixations. The input parameters (e.g., velocity threshold, interpolation latency) can be easily manually adapted to fit each participant. Furthermore, the present application includes visualization tools that facilitate the manual coding of fixations. We assessed this method by performing an intercoder reliability analysis in two groups of infants presenting low- and high-quality data and compared it with previous methods. Results revealed that our two-step approach with adaptable FD detection criteria gives rise to more reliable and stable measures in low- and high-quality data

Non-Perturbative String Equations for Type 0A

Well-defined non-perturbative formulations of the physics of string theories, sometimes with D-branes present, were identified over a decade ago, from a careful study of double scaled matrix models. Following recent work which recasts some of those old results in the context of type 0 string theory, a study is made of a much larger family of models, which are proposed as type 0A models of the entire superconformal minimal series coupled to gravity. This gives many further examples of important physical phenomena, including non-perturbative descriptions of transitions between D-branes and fluxes, tachyon condensation, and holography. In particular, features of a large family of non-perturbatively stable string equations are studied, and results are extracted which pertain to type 0A string theory, with D-branes and fluxes, in this large class of backgrounds. For the entire construction to work, large parts of the spectrum of the supergravitationally dressed superconformal minimal models and that of the gravitationally dressed bosonic conformal minimal models must coincide, and it is shown how this happens. The example of the super-dressed tricritical Ising model is studied in some detail.Comment: 29 pages LaTe

Antithrombotic therapy in palliative care

Management of venous thromboembolism (VTE) in patients in advanced cancer can be difficult due to the increased risk of recurrent and extending VTE despite therapeutic anticoagulation, and of bleeding due to or exacerbated by anticoagulation. Currently, best practice is long term administration of low molecular weight heparin (LMWH), but a recurrent VTE and bleeding rate remains, and some patients have contra-indications to anticoagulation. Newer anticoagulants such as oral anti-thrombin agents and biotinylated idrapurinux may have a role in the future.Management of venous thromboembolism (VTE) in patients in advanced cancer can be difficult due to the increased risk of recurrent and extending VTE despite therapeutic anticoagulation, and of bleeding due to or exacerbated by anticoagulation. Currently, best practice is long term administration of low molecular weight heparin (LMWH), but a recurrent VTE and bleeding rate remains, and some patients have contra-indications to anticoagulation. Newer anticoagulants such as oral anti-thrombin agents and biotinylated idrapurinux may have a role in the future

Electronic, magnetic properties and correlation effects in the layered quaternary iron oxyselenide Na2Fe2Se2O from first principles

By means of the first-principle calculations, we have investigated electronic, magnetic properties and correlation effects for the newly discovered layered oxyselenide Na2Fe2Se2O. Our results reveal that the electron correlations in the Fe 3d bands promote a transition of Na2Fe2Se2O from magnetic metallic or half-metallic states to the antiferromagnetic Mott-insulating state. In addition, the bonding picture in Na2Fe2Se2O is described as an anisotropic mixture of ionic and covalent contributions.Comment: 12 pages, 3 figure

Annulus Amplitudes in the Minimal Superstring

We study the annulus amplitudes in the (2,4) minimal superstring theory using the continuum worldsheet approach. Our results reproduce the semiclassical behavior of the wavefunctions of FZZT-branes recently studied in hep-th/0412315 using the dual matrix model. We also study the multi-point functions of neutral FZZT-branes and find the agreement between their semiclassical limit and the worldsheet annulus calculation.Comment: 15 pages, lanlma

Canine mesenchymal stem cells are neurotrophic and angiogenic:an in vitro assessment of their paracrine activity

Mesenchymal stem cells (MSCs) have been used in cell replacement therapies for connective tissue damage, but also can stimulate wound healing through paracrine activity. In order to further understand the potential use of MSCs to treat dogs with neurological disorders, this study examined the paracrine action of adipose-derived canine MSCs on neuronal and endothelial cell models. The culture-expanded MSCs exhibited a MSC phenotype according to plastic adherence, cell morphology, CD profiling and differentiation potential along mesenchymal lineages. Treating the SH-SY5Y neuronal cell line with serum-free MSC culture-conditioned medium (MSC CM) significantly increased SH-SY5Y cell proliferation (P < 0.01), neurite outgrowth (P = 0.0055) and immunopositivity for the neuronal marker βIII-tubulin (P = 0.0002). Treatment of the EA.hy926 endothelial cell line with MSC CM significantly increased the rate of wound closure in endothelial cell scratch wound assays (P = 0.0409), which was associated with significantly increased endothelial cell proliferation (P < 0.05) and migration (P = 0.0001). Furthermore, canine MSC CM induced endothelial tubule formation in EA.hy926 cells in a soluble basement membrane matrix. Hence, this study has demonstrated that adipose-derived canine MSC CM stimulated neuronal and endothelial cells probably through the paracrine activity of MSC-secreted factors. This supports the use of canine MSC transplants or their secreted products in the clinical treatment of dogs with neurological disorders and provides some insight into possible mechanisms of action

Open/closed duality for FZZT branes in c=1

We describe how the matrix integral of Imbimbo and Mukhi arises from a limit of the FZZT partition function in the double-scaled c=1 matrix model. We show a similar result for 0A and comment on subtleties in 0B.Comment: 26 pages, 2 figure

Tachyon Condensation, Open-Closed Duality, Resolvents, and Minimal Bosonic and Type 0 Strings

Type 0A string theory in the (2,4k) superconformal minimal model backgrounds and the bosonic string in the (2,2k-1) conformal minimal models, while perturbatively identical in some regimes, may be distinguished non-perturbatively using double scaled matrix models. The resolvent of an associated Schrodinger operator plays three very important interconnected roles, which we explore perturbatively and non-perturbatively. On one hand, it acts as a source for placing D-branes and fluxes into the background, while on the other, it acts as a probe of the background, its first integral yielding the effective force on a scaled eigenvalue. We study this probe at disc, torus and annulus order in perturbation theory, in order to characterize the effects of D-branes and fluxes on the matrix eigenvalues. On a third hand, the integrated resolvent forms a representation of a twisted boson in an associated conformal field theory. The entire content of the closed string theory can be expressed in terms of Virasoro constraints on the partition function, which is realized as wavefunction in a coherent state of the boson. Remarkably, the D-brane or flux background is simply prepared by acting with a vertex operator of the twisted boson. This generates a number of sharp examples of open-closed duality, both old and new. We discuss whether the twisted boson conformal field theory can usefully be thought of as another holographic dual of the non-critical string theory.Comment: 37 pages, some figures, LaTe