A mapping exercise using automated techniques to develop a search strategy to identify systematic review tools

The Systematic Review Toolbox aims provide a web-based catalogue of tools that support various tasks within the systematic review and wider evidence synthesis process. Identifying publications surrounding specific systematic review tools is currently challenging, leading to a high screening burden for few eligible records. We aimed to develop a search strategy that could be regularly and automatically run to identify eligible records for the SR Toolbox, thus reducing time on task and burden for those involved. We undertook a mapping exercise to identify the PubMed IDs of papers indexed within the SR Toolbox. We then used the Yale MeSH Analyser and Visualisation of Similarities (VOS) Viewer text-mining software to identify the most commonly used MeSH terms and text words within the eligible records. These MeSH terms and text words were combined using Boolean Operators into a search strategy for Ovid MEDLINE. Prior to the mapping exercise and search strategy development, 81 software tools and 55 ‘Other’ tools were included within the SR Toolbox. Since implementation of the search strategy, 146 tools have been added. There has been an increase in tools added to the toolbox since the search was developed and its corresponding auto-alert in MEDLINE was originally set up. Developing a search strategy based on a mapping exercise is an effective way of identifying new tools to support the systematic review process. Further research could be conducted to help prioritise records for screening to reduce reviewer burden further and to adapt the strategy for disciplines beyond healthcare

The Systematic Review Toolbox: keeping up to date with tools to support evidence synthesis

Background The Systematic Review (SR) Toolbox was developed in 2014 to collate tools that can be used to support the systematic review process. Since its inception, the breadth of evidence synthesis methodologies has expanded greatly. This work describes the process of updating the SR Toolbox in 2022 to reflect these changes in evidence synthesis methodology. We also briefly analysed included tools and guidance to identify any potential gaps in what is currently available to researchers. Methods We manually extracted all guidance and software tools contained within the SR Toolbox in February 2022. A single reviewer, with a second checking a proportion, extracted and analysed information from records contained within the SR Toolbox using Microsoft Excel. Using this spreadsheet and Microsoft Access, the SR Toolbox was updated to reflect expansion of evidence synthesis methodologies and brief analysis conducted. Results The updated version of the SR Toolbox was launched on 13 May 2022, with 235 software tools and 112 guidance documents included. Regarding review families, most software tools (N = 223) and guidance documents (N = 78) were applicable to systematic reviews. However, there were fewer tools and guidance documents applicable to reviews of reviews (N = 66 and N = 22, respectively), while qualitative reviews were less served by guidance documents (N = 19). In terms of review production stages, most guidance documents surrounded quality assessment (N = 70), while software tools related to searching and synthesis (N = 84 and N = 82, respectively). There appears to be a paucity of tools and guidance relating to stakeholder engagement (N = 2 and N = 3, respectively). Conclusions The SR Toolbox provides a platform for those undertaking evidence syntheses to locate guidance and software tools to support different aspects of the review process across multiple review types. However, this work has also identified potential gaps in guidance and software that could inform future research

The Panchromatic Hubble Andromeda Treasury: Triangulum Extended Region (PHATTER). III. The Mass Function of Young Star Clusters in M33

We measure the star cluster mass function for the Local Group galaxy M33. We use the catalog of stellar clusters selected from the Panchromatic Hubble Andromeda Treasury: Triangulum Extended Region (PHATTER) survey. We analyze 711 clusters in M33 with $\rm 7.0$ 3.0 as determined from color-magnitude diagram fits to individual stars. The M33 cluster mass function is best described by a Schechter function with power law slope $\alpha = -2.06^{+0.14}_{-0.13}$, and truncation mass log($M_c/M_{\odot}$) $= 4.24^{+0.16}_{-0.13}$. The data show strong evidence for a high-mass truncation, thus strongly favoring a Schechter function fit over a pure power law. M33's truncation mass is consistent with the previously identified linear trend between $M_c$, and star formation rate surface density, \SigSFR. We also explore the effect that individual cluster mass uncertainties have on derived mass function parameters, and find evidence to suggest that large cluster mass uncertainties have the potential to bias the truncation mass of fitted mass functions on the one sigma level.Comment: 18 pages, 15 figures, 1 table, Accepted to ApJ (February 2, 2022

Recoil correction to the ground state energy of hydrogenlike atoms

The recoil correction to the ground state energy of hydrogenlike atoms is calculated to all orders in \alpha Z in the range Z = 1-110. The nuclear size corrections to the recoil effect are partially taken into account. In the case of hydrogen, the relativistic recoil correction beyond the Salpeter contribution and the nonrelativistic nuclear size correction to the recoil effect, amounts to -7.2(2) kHz. The total recoil correction to the ground state energy in hydrogenlike uranium (^{238}U^{91+}) constitutes 0.46 eV.Comment: 16 pages, 1 figure (eps), Latex, submitted to Phys.Rev.

Relativistic nuclear recoil corrections to the energy levels of hydrogen-like and high ZZ lithium like atoms in all orders in αZ\alpha Z

The relativistic nuclear recoil corrections to the energy levels of low-laying states of hydrogen-like and high $Z$ lithium-like atoms in all orders in $\alpha Z$ are calculated. The calculations are carried out using the B-spline method for the Dirac equation. For low $Z$ the results of the calculation are in good agreement with the $\alpha Z$ -expansion results. It is found that the nuclear recoil contribution, additional to the Salpeter's one, to the Lamb shift ($n=2$) of hydrogen is $-1.32(6)\,kHz$. The total nuclear recoil correction to the energy of the $(1s)^{2}2p_{\frac{1}{2}}-(1s)^{2}2s$ transition in lithium-like uranium constitutes $-0.07\,eV$ and is largely made up of QED contributions.Comment: 19 pages, latex, accepted for publication in Phys. Rev.

Hydrophilic aldehyde-functional polymer brushes: synthesis, characterization, and potential bioapplications

Surface-initiated activators regenerated by electron transfer atom transfer radical polymerization (ARGET ATRP) is used to polymerize a cis-diol-functional methacrylic monomer (herein denoted GEO5MA) from planar silicon wafers. Ellipsometry studies indicated dry brush thicknesses ranging from 40 to 120 nm. The hydrophilic PGEO5MA brush is then selectively oxidized using sodium periodate to produce an aldehyde-functional hydrophilic PAGEO5MA brush. This post-polymerization modification strategy provides access to significantly thicker brushes compared to those obtained by surface-initiated ARGET ATRP of the corresponding aldehyde-functional methacrylic monomer (AGEO5MA). The much slower brush growth achieved in the latter case is attributed to the relatively low aqueous solubility of the AGEO5MA monomer. X-ray photoelectron spectroscopy (XPS) analysis confirmed that precursor PGEO5MA brushes were essentially fully oxidized to the corresponding PAGEO5MA brushes within 30 min of exposure to a dilute aqueous solution of sodium periodate at 22 °C. PAGEO5MA brushes were then functionalized via Schiff base chemistry using an amino acid (histidine), followed by reductive amination with sodium cyanoborohydride. Subsequent XPS analysis indicated that the mean degree of histidine functionalization achieved under optimized conditions was approximately 81%. Moreover, an XPS depth profiling experiment confirmed that the histidine groups were uniformly distributed throughout the brush layer. Surface ζ potential measurements indicated a significant change in the electrophoretic behavior of the zwitterionic histidine-functionalized brush relative to that of the non-ionic PGEO5MA precursor brush. The former brush exhibited cationic character at low pH and anionic character at high pH, with an isoelectric point being observed at around pH 7. Finally, quartz crystal microbalance studies indicated minimal adsorption of a model globular protein (BSA) on a PGEO5MA brush-coated substrate, whereas strong protein adsorption via Schiff base chemistry occurred on a PAGEO5MA brush-coated substrate

Negative Kaons in Dense Baryonic Matter

Kaon polarization operator in dense baryonic matter of arbitrary isotopic composition is calculated including s- and p-wave kaon-baryon interactions. The regular part of the polarization operator is extracted from the realistic kaon-nucleon interaction based on the chiral and 1/N_c expansion. Contributions of the Lambda(1116), Sigma(1195), Sigma*(1385) resonances are taken explicitly into account in the pole and regular terms with inclusion of mean-field potentials. The baryon-baryon correlations are incorporated and fluctuation contributions are estimated. Results are applied for K- in neutron star matter. Within our model a second-order phase transition to the s-wave K- condensate state occurs at rho_c \gsim 4 \rho_0 once the baryon-baryon correlations are included. We show that the second-order phase transition to the p-wave $K^-$ condensate state may occur at densities $\rho_c \sim 3\div 5 \rho_0$ in dependence on the parameter choice. We demonstrate that a first-order phase transition to a proton-enriched (approximately isospin-symmetric) nucleon matter with a p-wave K- condensate can occur at smaller densities, \rho\lsim 2 \rho_0. The transition is accompanied by the suppression of hyperon concentrations.Comment: 41 pages, 24 figures, revtex4 styl

Histidine‐functionalized diblock copolymer nanoparticles exhibit enhanced adsorption onto planar stainless steel

RAFT aqueous emulsion polymerization of isopropylideneglycerol monomethacrylate (IPGMA) is used to prepare a series of PGEO5MA46-PIPGMAy nanoparticles, where PGEO5MA is a hydrophilic methacrylic steric stabilizer block bearing pendent cis-diol groups. TEM studies confirm a spherical morphology while dynamic light scattering (DLS) analysis indicated that the z-average particle diameter can be adjusted by varying the target degree of polymerization for the core-forming PIPGMA block. Periodate oxidation is used to convert the cis-diol groups on PGEO5MA46-PIPGMA500 and PGEO5MA46-PIPGMA1000 nanoparticles into the analogous aldehyde-functionalized nanoparticles, which are then reacted with histidine via reductive amination. In each case, the extent of functionalization is more than 99% as determined by 1H NMR spectroscopy. Aqueous electrophoresis studies indicate that such derivatization converts initially neutral nanoparticles into zwitterionic nanoparticles with an isoelectric point at pH 7. DLS studies confirmed that such histidine-derivatized nanoparticles remain colloidally stable over a wide pH range. A quartz crystal microbalance is employed at 25°C to assess the adsorption of both the cis-diol- and histidine-functionalized nanoparticles onto planar stainless steel at pH 6. The histidine-bearing nanoparticles adsorb much more strongly than their cis-diol counterparts. For the highest adsorbed amount of 70.5 mg m–2, SEM indicates a fractional surface coverage of 0.23 for the adsorbed nanoparticles

Adsorption of aldehyde-functional diblock copolymer spheres onto surface-grafted polymer brushes via dynamic covalent chemistry enables friction modification

Dynamic covalent chemistry has been exploited to prepare numerous examples of adaptable polymeric materials that exhibit unique properties. Herein, the chemical adsorption of aldehyde-functional diblock copolymer spherical nanoparticles onto amine-functionalized surface-grafted polymer brushes via dynamic Schiff base chemistry is demonstrated. Initially, a series of cis-diol-functional sterically-stabilized spheres of 30–250 nm diameter were prepared via reversible addition–fragmentation chain transfer (RAFT) aqueous dispersion polymerization. The pendent cis-diol groups within the steric stabilizer chains of these precursor nanoparticles were then oxidized using sodium periodate to produce the corresponding aldehyde-functional spheres. Similarly, hydrophilic cis-diol-functionalized methacrylic brushes grafted from a planar silicon surface using activators regenerated by electron transfer atom transfer radical polymerization (ARGET ATRP) were selectively oxidized to generate the corresponding aldehyde-functional brushes. Ellipsometry and X-ray photoelectron spectroscopy were used to confirm brush oxidation, while scanning electron microscopy studies demonstrated that the nanoparticles did not adsorb onto a cis-diol-functional precursor brush. Subsequently, the aldehyde-functional brushes were treated with excess small-molecule diamine, and the resulting imine linkages were converted into secondary amine bonds via reductive amination. The resulting primary amine-functionalized brushes formed multiple dynamic imine bonds with the aldehyde-functional diblock copolymer spheres, leading to a mean surface coverage of approximately 0.33 on the upper brush layer surface, regardless of the nanoparticle size. Friction force microscopy studies of the resulting nanoparticle-decorated brushes enabled calculation of friction coefficients, which were compared to that measured for the bare aldehyde-functional brush. Friction coefficients were reasonably consistent across all surfaces except when particle size was comparable to the size of the probe tip. In this case, differences were ascribed to an increase in contact area between the tip and the brush-nanoparticle layer. This new model system enhances our understanding of nanoparticle adsorption onto hydrophilic brush layers