Behind at the Starting Line: Poverty Among Hispanic Infants

In this brief, authors Daniel Lichter, Scott Sanders, and Kenneth Johnson examine the economic circumstances of Hispanic infants using the Census Bureau’s American Community Survey annual microdata files from 2006 through 2010. They report that a disproportionate share of Hispanic infants start life’s race behind the starting line, poor and disadvantaged—an important finding because the proportion of all U.S. births that are Hispanic is growing rapidly. The poverty risk is especially high among rural Hispanic infants and those in new destinations. Despite higher poverty risks, Hispanic infants receive less governmental assistance. High Hispanic infant poverty has immediate and long-term consequences for infants and the nation. Failing to invest in families and children now has long-term consequences because early childhood poverty tends to set into motion a series of lifecycle disadvantages (such as insufficient parenting, bad neighborhoods, underfunded schools, and poor health care) that greatly increases the likelihood of poverty in adulthood. The authors conclude that whether today’s Hispanic children will assimilate into America’s economic mainstream is an open question, but the Hispanic infants who will help reshape America’s future require public policy attention now

The Judge’s Hold: A Struggle for Voice in Cormac McCarthy’s Blood Meridian

Cormac McCarthy\u27s Blood Meridian is a novel that provides a clear critique on the ways in which the American west was acquired. The text is awash with gratuitous violence, symbolism and storytelling, together creating a piece that offers a modern interpretation of American identity. This analysis will approach the novel by examining a struggle for voice between the two main characters Judge Holden and The Kid in the narration. In doing so, it will be shown that Blood Meridian uses Holden\u27s voice to suppress all other worldviews within the text in order to show the invulnerability of the political rhetoric employed in the nineteenth century

High turnover in electro-oxidation of alcohols and ethers with a glassy carbon-supported phenanthroimidazole mediator.

Glassy carbon electrodes covalently modified with a phenanthroimidazole mediator promote electrochemical alcohol and ether oxidation: three orders of magnitude increase in TON, to ∼15 000 in each case, was observed compared with homogeneous mediated reactions. We propose the deactivation pathways in homogeneous solution are prevented by the immobilization: modified electrode reversibility is increased for a one-electron oxidation reaction. The modified electrodes were used to catalytically oxidize p-anisyl alcohol and 1-((benzyloxy)methyl)-4-methoxybenzene, selectively, to the corresponding benzaldehyde and benzyl ester, respectively

Rural Land-Use Trends in the Conterminous United States, 1950-2000.

In order to understand the magnitude, direction, and geographic distribution of land-use changes, we evaluated land-use trends in U.S. counties during the latter half of the 20th century. Our paper synthesizes the dominant spatial and temporal trends in population, agriculture, and urbanized land uses, using a variety of data sources and an ecoregion classification as a frame of reference. A combination of increasing attractiveness of nonmetropolitan areas in the period 1970–2000, decreasing household size, and decreasing density of settlement has resulted in important trends in the patterns of developed land. By 2000, the area of low-density, exurban development beyond the urban fringe occupied nearly 15 times the area of higher density urbanized development. Efficiency gains, mechanization, and agglomeration of agricultural concerns has resulted in data that show cropland area to be stable throughout the Corn Belt and parts of the West between 1950 and 2000, but decreasing by about 22% east of the Mississippi River. We use a regional case study of the Mid-Atlantic and Southeastern regions to focus in more detail on the land-cover changes resulting from these dynamics. Dominating were land-cover changes associated with the timber practices in the forested plains ecoregions and urbanization in the piedmont ecoregions. Appalachian ecoregions show the slowest rates of landcover change. The dominant trends of tremendous exurban growth, throughout the United States, and conversion and abandonment of agricultural lands, especially in the eastern United States, have important implications because they affect large areas of the country, the functioning of ecological systems, and the potential for restoratio

Targeting STAT3 in Cancer with Nucleotide Therapeutics.

Signal transducer and activator of transcription 3 (STAT3) plays a critical role in promoting the proliferation and survival of tumor cells. As a ubiquitously-expressed transcription factor, STAT3 has commonly been considered an "undruggable" target for therapy; thus, much research has focused on targeting upstream pathways to reduce the expression or phosphorylation/activation of STAT3 in tumor cells. Recently, however, novel approaches have been developed to directly inhibit STAT3 in human cancers, in the hope of reducing the survival and proliferation of tumor cells. Several of these agents are nucleic acid-based, including the antisense molecule AZD9150, CpG-coupled STAT3 siRNA, G-quartet oligodeoxynucleotides (GQ-ODNs), and STAT3 decoys. While the AZD9150 and CpG-STAT3 siRNA interfere with STAT3 expression, STAT3 decoys and GQ-ODNs target constitutively activated STAT3 and modulate its ability to bind to target genes. Both STAT3 decoy and AZD9150 have advanced to clinical testing in humans. Here we will review the current understanding of the structures, mechanisms, and potential clinical utilities of the nucleic acid-based STAT3 inhibitors

amei: An R Package for the Adaptive Management of Epidemiological Interventions

The amei package for R is a tool that provides a flexible statistical framework for generating optimal epidemiological interventions that are designed to minimize the total expected cost of an emerging epidemic. Uncertainty regarding the underlying disease parameters is propagated through to the decision process via Bayesian posterior inference. The strategies produced through this framework are adaptive: vaccination schedules are iteratively adjusted to reflect the anticipated trajectory of the epidemic given the current population state and updated parameter estimates. This document briefly covers the background and methodology underpinning the implementation provided by the package and contains extensive examples showing the functions and methods in action.

LGBTQ Students

As with any sub-population of college stu­dents, there is a great deal of variance among individual LGBTQ students in terms of their ex­pectations and desires when it comes to choos­ing or persisting at a particular college. Perhaps the one unifying objective among members of this group is a goal common to almost every student at every level of study: to find an edu­cational environment in which the student will feel valued and supported while pursuing his or her educational goals. To this end, LGBTQ stu­dents have unique needs that historically have gone unaddressed