4,105 research outputs found
Decision Making in Drug Development via Confidence Distributions
In clinical drug development a typical phase three power calculation for a
Go/No-Go decision is performed by replacing unknown population-level quantities
in the power function with what is observed from a literature review or what is
observed in phase two. Many authors and practitioners view this as an assumed
value of power and offer the Bayesian quantity probability of success or
assurance as an alternative. The claim is by averaging over a prior or
posterior distribution, probability of success transcends power by capturing
the uncertainty around the unknown true treatment effect and any other
population-level parameters. We use confidence distributions to frame both the
probability of success calculation and the typical power calculation as merely
producing two different point estimates of power. We demonstrate that Go/No-Go
decisions based on either point estimate of power do not adequately quantify
and control the risk involved, and instead we argue for Go/No-Go decisions that
utilize inference on power for better risk management and decision making. This
inference on power can be derived and displayed using confidence distributions
A Cereal Chemist's Quick Guide to Genetics, Plant Breeding and BioIT
This book is intended as a guide for cereal chemists in quality testing laboratories and grain product development companies, to help them in their understanding of fundamental genetics, functional genomics and other concepts of relevance during their interactions with crop breeding programs. Consequently the emphasis is on quick definitions of terms and concepts, assuming that the expertise of the reader is predominantly in another field.Established and supported under the Australian Government’s Cooperative Research Centre Progra
The Identification of Extreme Asymptotic Giant Branch Stars and Red Supergiants in M33 by 24 {\mu}m Variability
We present the first detection of 24 {\mu}m variability in 24 sources in the
Local Group galaxy M33. These results are based on 4 epochs of MIPS
observations, which are irregularly spaced over ~750 days. We find that these
sources are constrained exclusively to the Holmberg radius of the galaxy, which
increases their chances of being members of M33. We have constructed spectral
energy distributions (SEDs) ranging from the optical to the sub-mm to
investigate the nature of these objects. We find that 23 of our objects are
most likely heavily self-obscured, evolved stars; while the remaining source is
the Giant HII region, NGC 604. We believe that the observed variability is the
intrinsic variability of the central star reprocessed through their
circumstellar dust shells. Radiative transfer modeling was carried out to
determine their likely chemical composition, luminosity, and dust production
rate (DPR). As a sample, our modeling has determined an average luminosity of
(3.8 0.9) x 10 L and a total DPR of (2.3 0.1) x
10 M yr. Most of the sources, given the high DPRs and
short wavelength obscuration, are likely "extreme" AGB (XAGB) stars. Five of
the sources are found to have luminosities above the classical AGB limit
(M 54,000 L), which classifies them as probably
red supergiants (RSGs). Almost all of the sources are classified as oxygen
rich. As also seen in the LMC, a significant fraction of the dust in M33 is
produced by a handful of XAGB and RSG stars.Comment: 36 pages, 14 figures, 4 tables, Accepted for publication in A
Psychotherapy and Counseling with Minorities: A Cognitive Approach to Individual and Cultural Differences, by Manuel Ramirez III
La presente investigación tiene el propósito de demostrar cómo a través de una red social conocida como Facebook, mediante su plataforma de fanpage, puede servir como herramienta táctica de convocatoria para que los movimientos sociales generen grandes marchas multitudinarias en la ciudad de Lima durante el año 2017. Siendo un estudio no experimental con diseño transeccional. La población y muestra está formada por los participantes de la red social Facebook dentro de los fanpage. La técnica fue la observación y la entrevista y como instrumentos la ficha de observación y la guÃa de entrevista. Los resultados indican que Se hallaron 349 funciones del lenguaje en todos los estados de los fanpages. Siendo la función apelativa y referencial las más utilizadas por estos movimientos en un 87,11 %; mientras que la metalingüÃstica y la fática no se emplearon en ningún momento. Asimismo, y en menor cantidad se usaron la función expresiva y la función poética teniendo un 11.17 % y 1.72 % respectivamente. Cabe resaltar, que en reiteradas ocasiones los estados de los fanpages contenÃan más de una función del lenguaje, llegando a tener hasta las 4 funciones combinadas en un solo estado. Se concluye que las fanpage son utilizadas como herramienta de convocatoria de movimientos sociales mediante mensajes a través de sus estados, imágenes y videos
Psychotherapy and Counseling with Minorities: A Cognitive Approach to Individual and Cultural Differences, by Manuel Ramirez III
A Third Exoplanetary System with Misaligned Orbital and Stellar Spin Axes
We present evidence that the WASP-14 exoplanetary system has misaligned
orbital and stellar-rotational axes, with an angle lambda = 33.1 +/- 7.4 deg
between their sky projections. The evidence is based on spectroscopic
observations of the Rossiter-McLaughlin effect as well as new photometric
observations. WASP-14 is now the third system known to have a significant
spin-orbit misalignment, and all three systems have "super-Jupiter" planets
(M_P > 3 Mjup) and eccentric orbits. This finding suggests that the migration
and subsequent orbital evolution of massive, eccentric exoplanets is somehow
different from that of less massive close-in Jupiters, the majority of which
have well-aligned orbits.Comment: 8 pages, 5 figures, 3 tables, PASP accepte
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