The conceptual roles of negative and positive affectivity in the stressor-strain relationship

The purpose of this study was to compare the data/model fit for two competing theories of the conceptual roles that Negative Affectivity (NA) and Positive Affectivity (PA) play in the stressor-strain relationship. In the 'trait model', NA is understood to be a confounder that inflates the perceived work-related stressor-outcome relationship, while PA is unrelated to either stressors or strain. Alternatively, the 'situational model' assumes that NA and PA are directly affected by stressors and are thought to mediate the stressor-relationship. The sample consisted of 731 Swedish engine room officers. Role stress was used as a stressor indicator, perceived stress was the outcome measure, and the PANAS was used to assess levels of affectivity. The path analysis gave strong support for the work situational model (RMSEA = 0.034) while no support was found for the trait model. No moderating effects from affectivity were found

The conceptual roles of negative and positive affectivity in the stressor-strain relationship

The purpose of this study was to compare the data/model fit for two competing theories of the conceptual roles that Negative Affectivity (NA) and Positive Affectivity (PA) play in the stressor-strain relationship. In the \u27trait model\u27, NA is understood to be a confounder that inflates the perceived work-related stressor-outcome relationship, while PA is unrelated to either stressors or strain. Alternatively, the \u27situational model\u27 assumes that NA and PA are directly affected by stressors and are thought to mediate the stressor-relationship. The sample consisted of 731 Swedish engine room officers. Role stress was used as a stressor indicator, perceived stress was the outcome measure, and the PANAS was used to assess levels of affectivity. The path analysis gave strong support for the work situational model (RMSEA = 0.034) while no support was found for the trait model. No moderating effects from affectivity were found

Author Correction: Rare SLC13A1 variants associate with intervertebral disc disorder highlighting role of sulfate in disc pathology (Nature Communications, (2022), 13, 1, (634), 10.1038/s41467-022-28167-1)

The original version of this Article contained an error in Fig. 3, in which the blue and red trend lines on the left plot were incorrect. In addition, the text “Dorsalgia variants” in the table should have been italicized and underlined. The correct version of Fig. 3 is: (Figure presented.) which replaces the previous incorrect version: (Figure presented.). This has been corrected in both the PDF and HTML versions of the Article. © The Author(s) 2022

Rare SLC13A1 variants associate with intervertebral disc disorder highlighting role of sulfate in disc pathology

Back pain is a common and debilitating disorder with largely unknown underlying biology. Here we report a genome-wide association study of back pain using diagnoses assigned in clinical practice; dorsalgia (119,100 cases, 909,847 controls) and intervertebral disc disorder (IDD) (58,854 cases, 922,958 controls). We identify 41 variants at 33 loci. The most significant association (ORIDD = 0.92, P = 1.6 × 10−39; ORdorsalgia = 0.92, P = 7.2 × 10−15) is with a 3’UTR variant (rs1871452-T) in CHST3, encoding a sulfotransferase enzyme expressed in intervertebral discs. The largest effects on IDD are conferred by rare (MAF = 0.07 − 0.32%) loss-of-function (LoF) variants in SLC13A1, encoding a sodium-sulfate co-transporter (LoF burden OR = 1.44, P = 3.1 × 10−11); variants that also associate with reduced serum sulfate. Genes implicated by this study are involved in cartilage and bone biology, as well as neurological and inflammatory processes. © 2022, The Author(s)

Rare SLC13A1 variants associate with intervertebral disc disorder highlighting role of sulfate in disc pathology

Back pain is a common and debilitating disorder with largely unknown underlying biology. Here we report a genome-wide association study of back pain using diagnoses assigned in clinical practice; dorsalgia (119,100 cases, 909,847 controls) and intervertebral disc disorder (IDD) (58,854 cases, 922,958 controls). We identify 41 variants at 33 loci. The most significant association (ORIDD = 0.92, P = 1.6 × 10−39; ORdorsalgia = 0.92, P = 7.2 × 10−15) is with a 3’UTR variant (rs1871452-T) in CHST3, encoding a sulfotransferase enzyme expressed in intervertebral discs. The largest effects on IDD are conferred by rare (MAF = 0.07 − 0.32%) loss-of-function (LoF) variants in SLC13A1, encoding a sodium-sulfate co-transporter (LoF burden OR = 1.44, P = 3.1 × 10−11); variants that also associate with reduced serum sulfate. Genes implicated by this study are involved in cartilage and bone biology, as well as neurological and inflammatory processes. © 2022, The Author(s)