Effect of phosphorus level and phytase inclusion on the performance, bone mineral concentration, apparent nutrient digestibility, and on mineral and nitrogen utilisation in finisher pigs.

peer-reviewedFunding for this research was provided under the National Development Plan, through the Research Stimulus Fund, administered by the Irish Department of Agriculture, Fisheries and Food.Two experiments were conducted to investigate the interaction between dietary P concentration and phytase (PHY) inclusion in the diet of finisher pigs. In Experiment 1, the growth performance and bone analysis experiment, pigs (6 replicate groups of 14 pigs each per treatment; initial body weight (BW) = 45.2 kg) were allocated to one of six dietary treatments (for 74 days) in a 3 × 2 factorial arrangement: T1 – available P in the diet = 1.5 g/kg; T2 = T1 with 500 units of phytase (FTU)/kg; T3 – available P = 2.0 g/kg; T4 = T3 with 500 FTU/kg; T5 – available P = 2.5 g/kg; T6 = T5 with 500 FTU/kg. Experiment 2 consisted of a digestibility and a P, Ca and N balance study, and pigs (6 per treatment; initial BW = 67.3 kg) were offered identical diets to those offered in Experiment 1. There was an interaction between dietary P level and PHY inclusion for average daily gain (ADG) and carcass weight (CW; P < 0.05) in Experiment 1. Pigs offered the low P diet supplemented with PHY had a higher ADG and CW than pigs offered the non-PHY, low P diet. However, there was no effect (P > 0.05) of PHY inclusion on ADG or CW with the medium or high P diets. Higher concentrations of ash, P and Ca in bone were noted in pigs offered the medium and high P diets (P < 0.001) and PHY (P < 0.01) diets when compared to pigs offered the low P without PHY. Pigs offered diets supplemented with PHY had lower faecal P output (P < 0.01) and a higher P digestibility (P < 0.001) and P retention (P < 0.05) than pigs offered diets without added PHY. In conclusion, supplementation of a low-P finisher diet with PHY resulted in pigs that had a similar carcass weight, but weaker bones than pigs offered a medium or high P diet.Department of Agriculture, Food and the Marin

On the physical interaction between ocean waves and coastal cliffs

Wave impacts have long been posited as the primary forcing mechanism of coastal cliff recession. Recent developments in the study of hydrodynamics at coastal structures such as seawalls and breakwaters have shown that wave pressures are stochastic in nature and have a broad range of first- and second-order controls. This understanding has yet to be translated to coastal cliffs, where it is still largely assumed that wave impact characteristics can be predicted by simple deterministic formulae. Hydraulic components in coastal models are limited by the lack of in-situ measurements of waves at the cliff toe due to the difficulties in deploying instrumentation in such energetic and inaccessible environments. To address this, I have approached the problem threefold. Monthly high-resolution terrestrial laser scanning (TLS) was undertaken over a year at multiple sites at Staithes, North Yorkshire, to evaluate the recession rate and detachment characteristics of the lower cliff section. Concurrently, wave gauges were deployed at the cliff toe of each site to monitor wave conditions. A novel method of measuring wave impacts was undertaken at one of the sites for nine low-to-low tidal cycles. New and established methods for processing this data were used. Analysis of the erosion dataset revealed distinct temporal patterns of erosion, with accelerated erosion rates during winter. Vertical variations in detachment volumes below 0.1 m3 related to the tidal elevation were also observed, suggesting a key marine influence. Detachment frequency and volume were found to be influenced by lithology type and joint density. Wave conditions over the study period were found to be depth-limited, yet some waves at the toe were found to be larger than those offshore due to shoaling. Wave breaking conditions were strongly influenced by platform morphology and tidal stage. Up to 9% of all waves were breaking on impact. Measurements of wave impacts revealed approximately 14% of wave exhibited high-magnitude impulsive pressures generated by breaking and broken waves. These were analysed probabilistically and found to be controlled primarily by the ratio between wave height and water depth. These data were used to develop a conceptual model of forcing at the cliff toe, including an evaluation of the ability of waves to remove material via enhanced pressure inside discontinuities and fragmentation of weathered material. These results have broad implications concerning the process geomorphology of rock coasts and the evaluation of wave forcing in coastal models

I\u27m Thinking of the Past

[Verse 1]You ask of what I\u27m thinking,You mark my brow o\u27er cast,You long to learn the secret;I\u27m thinking of the past.Bright hours of pure enjoyment,I trusted would remain;Alas! they all are vanish\u27d,No more to come again [Verse 2]You ask of what I\u27m thinking,You mark my brow o\u27ercast,You long to learn the secret;I\u27m thinking of the past.And where is she who met me,and listen\u27d to my song,And hoped for years to cheer me life\u27s rugged path along?Bright hours of pure enjoyment.I trusted, would remain,I trusted would remain.You ask of what I\u27m thinking; I\u27m thinking of the past

Next-to-Minimal Supersymmetric Model Higgs Scenarios for Partially Universal GUT Scale Boundary Conditions

We examine the extent to which it is possible to realize the NMSSM "ideal Higgs" models espoused in several papers by Gunion et al in the context of partially universal GUT scale boundary conditions. To this end we use the powerful methodology of nested sampling. We pay particular attention to whether ideal-Higgs-like points not only pass LEP constraints but are also acceptable in terms of the numerous constraints now available, including those from the Tevatron and $B$-factory data, $(g-2)_\mu$ and the relic density $\Omega h^2$. In general for this particular methodology and range of parameters chosen, very few points corresponding to said previous studies were found, and those that were found were at best $2\sigma$ away from the preferred relic density value. Instead, there exist a class of points, which combine a mostly singlet-like Higgs with a mostly singlino-like neutralino coannihilating with the lightest stau, that are able to effectively pass all implemented constraints in the region $80<m_h<100$. It seems that the spin-independent direct detection cross section acts as a key discriminator between ideal Higgs points and the hard to detect singlino-like points.Comment: 22 pages, 15 figure

Evolving the service model for child and adolescent mental health services

A new model for a community mental health service for children and young people aged 0-18 years is described. This has been formulated after multi-level consultation including extensive user/carer involvement. The proposed model is multidisciplinary and integrated with multiagency provision, with smooth access onto and through care pathways. This model brings voluntary and statutory agencies into an integrated collaboration. It reinforces that social and emotional development and psychological functioning is everybody’s business and creates conditions where a child’s needs can be addressed on a day-to-day basis rather than through a “clinic-based model”.</jats:p

UNION (Reino Unido). Inglaterra. Canal. Canales. 1792?. 1:64400

Comprende parte de los condados ingleses de Leicestershire y NorthamptonshireEscalas gráficas de 9 millas y 72 estadios [= 22,5 cm]Orografía a trazosTabla de signos convencionales para indicar el trazado del canal proyectado, distintos tipos de caminos y molinos de aguaConsta una tabla con datos referentes a las dimensiones y capacidad de los tramos de la obra proyectadaForma parte de la Colección Mendoz

DERBYSHIRE (Reino Unido) (Inglaterra). Canales (1770). 1:66500

Escala gráfica de 5 millas [= 12,1 cm]Orografía de perfilConsta una tabla con datos referentes a las dimensiones y capacidad de los tramos en que se divide el canalForma parte de la Colección Mendoz

The serotonergic psychedelic N,N-dipropyltryptamine alters information-processing dynamics in cortical neural circuits

Most of the recent work in psychedelic neuroscience has been done using non-invasive neuroimaging, with data recorded from the brains of adult volunteers under the influence of a variety of drugs. While this data provides holistic insights into the effects of psychedelics on whole-brain dynamics, the effects of psychedelics on the meso-scale dynamics of cortical circuits remains much less explored. Here, we report the effects of the serotonergic psychedelic N,N-diproptyltryptamine (DPT) on information-processing dynamics in a sample of in vitro organotypic cultures made from rat cortical tissue. Three hours of spontaneous activity were recorded: an hour of pre-drug control, and hour of exposure to 10$\mu$M DPT solution, and a final hour of washout, once again under control conditions. We found that DPT reversibly alters information dynamics in multiple ways: first, the DPT condition was associated with higher entropy of spontaneous firing activity and reduced the amount of time information was stored in individual neurons. Second, DPT also reduced the reversibility of neural activity, increasing the entropy produced and suggesting a drive away from equilibrium. Third, DPT altered the structure of neuronal circuits, decreasing the overall information flow coming into each neuron, but increasing the number of weak connections, creating a dynamic that combines elements of integration and disintegration. Finally, DPT decreased the higher-order statistical synergy present in sets of three neurons. Collectively, these results paint a complex picture of how psychedelics regulate information processing in meso-scale cortical tissue. Implications for existing hypotheses of psychedelic action, such as the Entropic Brain Hypothesis, are discussed.Comment: 19 pages, 2 figure

Fractal dimension of cortical functional connectivity networks & severity of disorders of consciousness.

Recent evidence suggests that the quantity and quality of conscious experience may be a function of the complexity of activity in the brain and that consciousness emerges in a critical zone between low and high-entropy states. We propose fractal shapes as a measure of proximity to this critical point, as fractal dimension encodes information about complexity beyond simple entropy or randomness, and fractal structures are known to emerge in systems nearing a critical point. To validate this, we tested several measures of fractal dimension on the brain activity from healthy volunteers and patients with disorders of consciousness of varying severity. We used a Compact Box Burning algorithm to compute the fractal dimension of cortical functional connectivity networks as well as computing the fractal dimension of the associated adjacency matrices using a 2D box-counting algorithm. To test whether brain activity is fractal in time as well as space, we used the Higuchi temporal fractal dimension on BOLD time-series. We found significant decreases in the fractal dimension between healthy volunteers (n = 15), patients in a minimally conscious state (n = 10), and patients in a vegetative state (n = 8), regardless of the mechanism of injury. We also found significant decreases in adjacency matrix fractal dimension and Higuchi temporal fractal dimension, which correlated with decreasing level of consciousness. These results suggest that cortical functional connectivity networks display fractal character and that this is associated with level of consciousness in a clinically relevant population, with higher fractal dimensions (i.e. more complex) networks being associated with higher levels of consciousness. This supports the hypothesis that level of consciousness and system complexity are positively associated, and is consistent with previous EEG, MEG, and fMRI studies