Interprofessional Simulation in Accredited Paramedic Programs

Introduction: Healthcare leaders advocate for interprofessional education as a means to promote collaborative practice, enhance interdisciplinary communication, and improve patient safety in the health professions. There is little evidence specific to interprofessional simulation in paramedic education. Methods: The National Association of EMS Educators (NAEMSE) surveyed paramedic programs that were accredited or in the process of becoming accredited. Program respondents were asked to characterize their resources and their use of those resources, and then were asked about their perceptions pertaining to simulation in their program. Chi-square analysis was used to compare characteristics of programs that participated in interdisciplinary simulation with those that did not. Results: Of the 389 of 638 (61%) paramedic program survey respondents, 44% (159 of 362) report interprofessional simulation. They perceived they used the right amount of simulation more frequently than other paramedic programs X2 (1, N=362) = 8.425, p X2 (1, N=362) = 11.751, pX2 (1, N=356) = 8.838, pX2 (1, N=362) = 4.704, pX2 (1, N=362) = 11.508 pX2 (1, N=362) = 5.495, pX2 (1, N=359) = 12.595, p\u3c0.01.Conclusion: This research suggests that paramedic programs conducting interdisciplinary simulation indicated they have greater access to resources and faculty training to support simulation

\u3cb\u3eP\u3c/b\u3e-Wave Nucleon-Pion Scattering Amplitude in the \u3cb\u3eΔ(1232)\u3c/b\u3e Channel from Lattice QCD

We determine the Δ(1232) resonance parameters using lattice QCD and the Lüscher method. The resonance occurs in elastic pion-nucleon scattering with JP = 3/2+ in the isospin I=3/2, P-wave channel. Our calculation is performed with Nf = 2+1 flavors of clover fermions on a lattice with L ≈ 2.8 fm. The pion and nucleon masses are mπ = 255.4 (1.6) MeV and mN = 1073(5) MeV, respectively, and the strong decay channel Δ → πN is found to be above the threshold. To thoroughly map out the energy dependence of the nucleon-pion scattering amplitude, we compute the spectra in all relevant irreducible representations of the lattice symmetry groups for total momenta up to →P = 2πL(1,1,1), including irreps that mix S and P waves. We perform global fits of the amplitude parameters to up to 21 energy levels, using a Breit-Wigner model for the P-wave phase shift and the effective-range expansion for the S-wave phase shift. From the location of the pole in the P-wave scattering amplitude, we obtain the resonance mass mΔ = 1378(7)(9) MeV and the coupling gΔ-πN = 23.8(2.7)(0.9)

Mycobacteria activate γδ T-cell anti-tumour responses via cytokines from type 1 myeloid dendritic cells: a mechanism of action for cancer immunotherapy

Attenuated and heat-killed mycobacteria display demonstrable activity against cancer in the clinic; however, the induced immune response is poorly characterised and potential biomarkers of response ill-defined. We investigated whether three mycobacterial preparations currently used in the clinic (BCG and heat-killed Mycobacterium vaccae and Mycobacterium obuense) can stimulate anti-tumour effector responses in human γδ T-cells. γδ T-cell responses were characterised by measuring cytokine production, expression of granzyme B and cytotoxicity against tumour target cells. Results show that γδ T-cells are activated by these mycobacterial preparations, as indicated by upregulation of activation marker expression and proliferation. Activated γδ T-cells display enhanced effector responses, as shown by upregulated granzyme B expression, production of the TH1 cytokines IFN-γ and TNF-α, and enhanced degranulation in response to susceptible and zoledronic acid-treated resistant tumour cells. Moreover, γδ T-cell activation is induced by IL-12, IL-1β and TNF-α from circulating type 1 myeloid dendritic cells (DCs), but not from type 2 myeloid DCs or plasmacytoid DCs. Taken together, we show that BCG, M. vaccae and M. obuense induce γδ T-cell anti-tumour effector responses indirectly via a specific subset of circulating DCs and suggest a mechanism for the potential immunotherapeutic effects of BCG, M. vaccae and M. obuense in cancer