4,445 research outputs found
Recasting Economics as if the Climate and Global Ecology Really Mattered
Peer reviewedPublisher PD
The Maiden of Orleans
First published as an American contribution to the 1959 bicentennial celebration of Friedrich Schiller's birth, Krumpelmann's translation of the poet's Joan of Arc drama retains the iambic pentameter of the original. This revised second edition, published in 1962 following critical acclaim, corrects typographical errors and includes some changes to the text
Effect of Optical Coating and Surface Treatments on Mechanical Loss in Fused Silica
We report on the mechanical loss in fused silica samples with various surface
treatments and compare them with samples having an optical coating. Mild
surface treatments such as washing in detergent or acetone were not found to
affect the mechanical loss of flame-drawn fused silica fibers stored in air.
However, mechanical contact (with steel calipers) significantly increased the
loss. The application of a high-reflective optical coating of the type used for
the LIGO test masses was found to greatly increase the mechanical loss of
commercially polished fused silica microscope slides. We discuss the
implications for the noise budget of interferometers.Comment: 7 pages, 2 figures. Accepted for publication in the Proceedings of
the Third Eduardo Amaldi Conference on Gravitational Waves, July 12-16, 1999.
Updated version contains a correction of Eq. 3 and an estimate for the loss
angle of a LIGO coating. (Neither of these revisions are included in the
version published in the conference proceedings.
Australian co-operation with the national agricultural research project - Project Completion Report 1990
This Project Completion Report (PCR) has been written to meet the project monitoring requirements of AIDAB.
Because the ACNARP Project was part of a larger joint WB/IFAD project known as the National Agricultural Research Project (NARP), a summary of ACNARP and its progress and achievements, cannot be divorced from NARP. The report should therefore be read within the context that ACNARP alone has not been responsible for all the developments and achievements listed. Achievements in relation to some of the project objectives have been the result of Thai inputs, often with advice from ACNARP, rather than being able to be attributed solely to ACNARP. There were also some objectives and components of the larger WB/IFAD NARP Project, for which there were no corresponding specific ACNARP inputs
Studentsā educational experiences and interaction with residents on night shifts
Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/137686/1/tct12561.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/137686/2/tct12561_am.pd
Effect of Preexisting Neutralizing Antibodies on the Anti-tumor Immune Response Induced by Chimeric Human Papillomavirus Virus-like Particle Vaccines
AbstractChimeric human papillomavirus virus-like particles (HPV cVLPs) carrying HPV16 E7 protein are potent vaccines for inducing cell-mediated immunity (CMI) against HPV-induced tumors in animal models. We tested the hypothesis that virion-neutralizing antibodies generated during an initial vaccination might prevent effective boosting of CMI to the cVLPs. Mice with circulating HPV16-neutralizing antibodies, generated by direct immunization with wild-type VLPs or by passive transfer of hyperimmune anti-HPV16 VLP mouse sera, were subsequently vaccinated with HPV16 E7-containing cVLPs. Mice with preexisting neutralizing antibodies were not protected from HPV16 E7-positive TC-1 tumor challenge, compared to the protection seen in mice lacking these antibodies. Antibody-coated VLPs bound very inefficiently to receptor-positive cell lines, suggesting that one of the mechanisms of antibody interference is blocking of VLP binding to its receptor and thereby uptake of VLPs by antigen-presenting cells. Our results suggest that repetitive vaccination with a cVLP for induction of cellular immune responses to an incorporated antigen may be of limited effectiveness due to the presence of neutralizing antibodies against the capsid proteins induced after the first application. This limitation could potentially be overcome by boosting with cVLPs containing the same target antigen incorporated into other papillomavirus-type VLPs
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