Academic Medicine Responds to the Opioid Crisis

Opioid dependence has devastated communities across the nation particularly in rural states and academic medicine has responded in a variety of ways. Through its tripartite mission of education, research, and clinical care, creative solutions are being implanted. Medical schools and teaching hospitals are partnering with public health and law enforcement agencies, as well as local healthcare providers to address the clinical, social, and rehabilitative challenges. Academic medicine continues to adapt to the needs of the nation and teach, train, and prepare the next generation of physicians to be at their best when things are at their worst

Exploring the Cognitive Nature of Boards of Directors and Its Implication for Board Effectiveness

In this paper we propose a theoretical framework that emphasizes the development of a shared mental model (SMM) of a board of directors and its impact on board effectiveness and suggest that the accuracy and scope of the SMM in a board will moderate the relationship between a board’s SMM and board effectiveness. Also, we examine the impact of task and relationship conflict on the development of a SMM. Finally, we examine three board attributes (board size, CEO duality, and the proportion of outside directors on a board) as antecedents to the development of conflict among board members.Boards of directors, corporate governance, shared mental models

The pragmatic concept of truth

The pragmatic concept of truth is both a reaction from and an attack against the older epistemology of the absolutists. Since Plato\u27s time truth had been defined in terms of the idea\u27s copying a transcendental reality. When the pragmatists arrived they felt that this immediate correspondence of the idea was insufficient to establish the content and proof of the truth of the idea

Social learning in mixed-species troops of Saguinus fuscicollis and Saguinus labiatus: tests of foraging benefit hypotheses in captivity

The selective costs and benefits affecting the evolution of group living have long interested behavioural ecologists because knowledge of these selective forces can enhance our understanding not only of why organisms live in groups, but also why species exhibit particular patterns of social organisation. Tamarins form stable and permanent mixed-species troops providing an excellent model for examining the costs and benefits hypothesised for group living. However, testing hypotheses in the wild is difficult, not least because participating species are rarely found out of association. In contrast, in captivity it is possible to compare matched single- and mixed-species troops and also to study the same individuals in single and mixed-species troops to see what effect the presence of a congener has on behaviour. In this way, captive work can help us confirm, reject, or refine the hypotheses, and aids in the generation of new ones, for relating back to the wild. The utility of this approach is demonstrated in this thesis which explored some of the foraging benefit hypotheses and, in particular, the underlying notion that individuals in tamarind mixed-species troops can increase their foraging efficiency through social earning. Single and mixed-species troops of Saguinus fuscicollis and S. labiatus were studied at Belfast Zoological Gardens. It was found that social interaction with conspecifics and congeners facilitated learning by individuals of various types of food-related information (food palatability, location, and method of access). However, although social learning operated in mixed-species troops, it did so under the shadow of inter-specific dominance. The results were used, in conjunction with field observations in Bolivia, to make inferences about the adaptive function of social learning in the wild. These findings strengthen the hypotheses which suggest that increased opportunity for social learning, through an increase in troop size and as a result of species divergence in behaviour, is an adaptive advantage of mixed-species troop formation in tamarins

The adenomatous polyposis coli protein unambiguously localizes to microtubule plus ends and is involved in establishing parallel arrays of microtubule bundles in highly polarized epithelial cells

Loss of full-length adenomatous polyposis coli (APC) protein correlates with the development of colon cancers in familial and sporadic cases. In addition to its role in regulating β-catenin levels in the Wnt signaling pathway, the APC protein is implicated in regulating cytoskeletal organization. APC stabilizes microtubules in vivo and in vitro, and this may play a role in cell migration (Näthke, I.S., C.L. Adams, P. Polakis, J.H. Sellin, and W.J. Nelson. 1996. J. Cell Biol. 134:165–179; Mimori-Kiyosue, Y., N. Shiina, and S. Tsukita. 2000. J. Cell Biol. 148:505–517; Zumbrunn, J., K. Inoshita, A.A. Hyman, and I.S. Näthke. 2001. Curr. Biol. 11:44–49) and in the attachment of microtubules to kinetochores during mitosis (Fodde, R., J. Kuipers, C. Rosenberg, R. Smits, M. Kielman, C. Gaspar, J.H. van Es, C. Breukel, J. Wiegant, R.H. Giles, and H. Clevers. 2001. Nat. Cell Biol. 3:433–438; Kaplan, K.B., A. Burds, J.R. Swedlow, S.S. Bekir, P.K. Sorger, and I.S. Näthke. 2001. Nat. Cell Biol. 3:429–432). The localization of endogenous APC protein is complex: actin- and microtubule-dependent pools of APC have been identified in cultured cells (Näthke et al., 1996; Mimori-Kiyosue et al., 2000; Reinacher-Schick, A., and B.M. Gumbiner. 2001. J. Cell Biol. 152:491–502; Rosin-Arbesfeld, R., G. Ihrke, and M. Bienz. 2001. EMBO J. 20:5929–5939). However, the localization of APC in tissues has not been identified at high resolution. Here, we show that in fully polarized epithelial cells from the inner ear, endogenous APC protein associates with the plus ends of microtubules located at the basal plasma membrane. Consistent with a role for APC in supporting the cytoskeletal organization of epithelial cells in vivo, the number of microtubules is significantly reduced in apico-basal arrays of microtubule bundles isolated from mice heterozygous for APC

Qualitative analysis of complex modularized fault trees using binary decision diagrams

Fault tree analysis is commonly used in the reliability assessment of industrial systems. When complex systems are studied conventional methods can become computationally intensive and require the use of approximations. This leads to inaccuracies in evaluating system reliability. To overcome such disadvantages, the binary decision diagram (BDD) method has been developed. This method improves accuracy and efficiency, because the exact solutions can be calculated without the requirement to calculate minimal cut sets as an intermediate phase. Minimal cut sets can be obtained if needed. BDDs are already proving to be of considerable use in system reliability analysis. However, the difficulty is with the conversion process of the fault tree to the BDD. The ordering of the basic events can have a crucial effect on the size of the final BDD, and previous research has failed to identify an optimum scheme for producing BDDs for all fault trees. This paper presents an extended strategy for the analysis of complex fault trees. The method utilizes simplification rules that are applied to the fault tree to reduce it to a series of smaller subtrees whose solution is equivalent to the original fault tree. The smaller subtree units are less sensitive to the basic event ordering during BDD conversion. BDDs are constructed for every subtree. Qualitative analysis is performed on the set of BDDs to obtain the minimal cut sets for the original top event. It is shown how to extract the minimal cut sets from complex and modular events in order to obtain the minimal cut sets of the original fault tree in terms of basic events

Prime implicants for modularised non-coherent fault trees using binary decision diagrams

This paper presents an extended strategy for the analysis of complex fault trees. The method utilises simplification rules, which are applied to the fault tree to reduce it to a series of smaller subtrees, whose solution is equivalent to the original fault tree. The smaller subtree units are less sensitive to the basic event ordering during BDD conversion. BDDs are constructed for every subtree. Qualitative analysis is performed on the set of BDDs to obtain the prime implicant sets for the original top event. It is shown how to extract the prime implicant sets from complex and modular events in order to obtain the prime implicant sets of the original fault tree in terms of basic events

Smelling the goodness: sniffing as a behavioral measure of learned odor hedonics

Pairing an odor and taste can change ratings of the odor’s perceptual and hedonic characteristics. Behavioral indices of such changes are lacking and here we measured sniffing to assess learned changes in odor liking due to pairing with sweet and bitter tastes. Participants were divided on their liking for sweetness, as well as dietary disinhibition (TFEQ-D scale), both of which influence hedonic odor-taste learning. In sweet likers, both sniff duration and peak amplitude increased for the sweet-paired odor. Sniff magnitude decreased for sweet- and quinine-paired odors in sweet-dislikers, and sweet likers smelling the quinine-paired odor. In sweet-likers, liking for the sweet-paired odor increased with both TFEQ-D score and hunger, and sniff magnitude with TFEQ-D only. There were no predictors of changes in response to the quinine-paired odor. Brief co-experience of odors with sweet tastes can lead therefore to measurable changes in sniffing, providing a novel behavioral index of odor liking

Analysis of non-coherent fault trees using ternary decision diagrams

Risk and safety assessments performed on potentially hazardous industrial systems commonly utilise Fault Tree Analysis (FTA) to forecast the probability of system failure. The type of logic for the top event is usually limited to AND and OR gates which leads to a coherent fault tree structure. In non-coherent fault trees components’ working states as well as components’ failures contribute to the failure of the system. The qualitative and quantitative analyses of non-coherent fault trees can introduce further difficulties over and above those seen in the coherent case. It is shown that the Binary Decision Diagram (BDD) method can be used for this type of assessment. The BDD approach can improve the accuracy and efficiency of the quantitative analysis of non-coherent fault trees. This article demonstrates the value of the Ternary Decision Diagram method (TDD) for the qualitative analysis of non-coherent fault trees. Such analysis can be used to provide information to a decision making process for future actions of an autonomous system and therefore it must be performed in real time. In these circumstances fast processing and small storage requirements are very important. The TDD method provides a fast processing capability and small storage is achieved when a single structure is used for both qualitative and quantitative analyses. The efficiency of the TDD method is discussed and compared to the performance of the established methods for analysis of non-coherent fault trees