Letter from John P. Johnston to James B. Finley

Former work hand, John Johnston, finds himself in the midst of a bad spell of sickness. He is very anxious to settle an account with Finley which was not taken care of because he left rather suddenly. It was always his intention to return to the mission to fulfill his contract, but it has not been possible for him to do so. Abstract Number - 28https://digitalcommons.owu.edu/finley-letters/1027/thumbnail.jp

Letter from John P. Johnston to James B. Finley

John P. Johnston (former work hand at the mission) sends a complete statement of his account as near as he can remember it. He requests that his belongings (books, etc.) be kept for him and that his certificate and a note for his land be sent to him through John Johnston (Indian agent). Abstract Number - 29https://digitalcommons.owu.edu/finley-letters/1028/thumbnail.jp

Letter from John P. Johnston to James B. Finley

John P. Johnston (former work hand at the mission) writes to let Finley know that he has been very ill. He has heard rumors that Finley was responsible for the removal of sub-agent John Shaw, but he knows that this cannot be true. He expresses a desire to obtain employment on the reservation, possibly at the mission store. He has taken to including the initial P as his middle name in order to distinguish himself from Indian agent John Johnston. Abstract Number - 717https://digitalcommons.owu.edu/finley-letters/2228/thumbnail.jp

Aspirin inhibits the acute venodilator response to furosemide in patients with chronic heart failure

OBJECTIVES: We sought to determine the effect of aspirin on the venodilator effect of furosemide in patients with chronic heart failure (CHF) BACKGROUND: Furosemide has an acute venodilator effect preceding its diuretic action, which is blocked by nonsteroidal anti-inflammatory drugs. The ability of therapeutic doses of aspirin to block this effect of furosemide in patients with CHF has not been studied. For comparison, the venodilator response to nitroglycerin (NTG) was also studied. METHODS: Eleven patients with CHF were randomized to receive placebo, aspirin at 75 mg/day or aspirin at 300 mg/day for 14 days in a double-blind, crossover study. The effect of these pretreatments on the change in forearm venous capacitance (FVC) after 20 mg of intravenous furosemide was measured over 20 min by using venous occlusion plethysmography. In a second study, the effect of 400 μg of sublingual NTG on FVC was documented in 11 similar patients (nine participated in the first study). RESULTS: Mean arterial pressure, heart rate and forearm blood flow did not change in response to furosemide. After placebo pretreatment, furosemide caused an increase in FVC of 2.2% (95% confidence interval [CI] −0.9% to 5.2%; mean response over 20 min). By comparison, FVC fell by −1.1% (95% CI −4.2% to 1.9%) after pretreatment with aspirin at 75 mg/day, and by −3.7% (95% CI −6.8% to −0.7%) after aspirin at 300 mg/day (p = 0.020). In the second study, NTG increased FVC by 2.1% (95% CI −1.6% to 5.8%) (p = 0.95 vs. furosemide). CONCLUSIONS: In patients with CHF, venodilation occurs within minutes of the administration of intravenous dose of furosemide. Our observation that aspirin inhibits this effect further questions the use of aspirin in patients with CHF

Physical Properties of Four SZE-Selected Galaxy Clusters in the Southern Cosmology Survey

We present the optical and X-ray properties of four clusters recently discovered by the South Pole Telescope (SPT) using the Sunyaev-Zel'dovich effect (SZE). The four clusters are located in one of the common survey areas of the southern sky that is also being targeted by the Atacama Cosmology Telescope (ACT) and imaged by the CTIO Blanco 4-m telescope. Based on publicly available griz optical images and XMM-Newton and ROSAT X-ray observations we analyse the physical properties of these clusters and obtain photometric redshifts, luminosities, richness and mass estimates. Each cluster contains a central elliptical whose luminosity is consistent with SDSS cluster studies. Our mass estimates are well above the nominal detection limit of SPT and ACT; the new SZE clusters are very likely massive systems with M>~5x10^14 M_sun.Comment: 5 pages, 2 figures. ApJL accepte

Transmission, reflection and localization in a random medium with absorption or gain

We study reflection and transmission of waves in a random tight-binding system with absorption or gain for weak disorder, using a scattering matrix formalism. Our aim is to discuss analytically the effects of absorption or gain on the statistics of wave transport. Treating the effects of absorption or gain exactly in the limit of no disorder, allows us to identify short- and long lengths regimes relative to absorption- or gain lengths, where the effects of absorption/gain on statistical properties are essentially different. In the long-lengths regime we find that a weak absorption or a weak gain induce identical statistical corrections in the inverse localization length, but lead to different corrections in the mean reflection coefficient. In contrast, a strong absorption or a strong gain strongly suppress the effect of disorder in identical ways (to leading order), both in the localization length and in the mean reflection coefficient.Comment: Important revisions and expansion caused by a crucial property of $\hat Q

A Cryogenic Fluid System Simulation in Support of Integrated Systems Health Management

Simulations serve as important tools throughout the design and operation of engineering systems. In the context of sys-tems health management, simulations serve many uses. For one, the underlying physical models can be used by model-based health management tools to develop diagnostic and prognostic models. These simulations should incorporate both nominal and faulty behavior with the ability to inject various faults into the system. Such simulations can there-fore be used for operator training, for both nominal and faulty situations, as well as for developing and prototyping health management algorithms. In this paper, we describe a methodology for building such simulations. We discuss the design decisions and tools used to build a simulation of a cryogenic fluid test bed, and how it serves as a core technology for systems health management development and maturation

Fatigue Crack Closure Analysis Using Digital Image Correlation

Fatigue crack closure during crack growth testing is analyzed in order to evaluate the critieria of ASTM Standard E647 for measurement of fatigue crack growth rates. Of specific concern is remote closure, which occurs away from the crack tip and is a product of the load history during crack-driving-force-reduction fatigue crack growth testing. Crack closure behavior is characterized using relative displacements determined from a series of high-magnification digital images acquired as the crack is loaded. Changes in the relative displacements of features on opposite sides of the crack are used to generate crack closure data as a function of crack wake position. For the results presented in this paper, remote closure did not affect fatigue crack growth rate measurements when ASTM Standard E647 was strictly followed and only became a problem when testing parameters (e.g., load shed rate, initial crack driving force, etc.) greatly exceeded the guidelines of the accepted standard

Optically Stimulated Luminescence Dating of Late Holocene Raised Strandplain Sequences Adjacent to Lakes Michigan and Superior, Upper Peninsula, Michigan, USA

This study evaluates the accuracy of optically stimulated luminescence to date well-preserved strandline sequences at Manistique/ Thompson bay (Lake Michigan), and Tahquamenon and Grand Traverse Bays (Lake Superior) that span the past ~4500 yr. The single aliquot regeneration (SAR) method is applied to produce absolute ages for littoral and eolian sediments. SAR ages are compared against AMS and conventional 14C ages on swale organics. Modern littoral and eolian sediments yield SAR ages b100 yr indicating near, if not complete, solar resetting of luminescence prior to deposition. Beach ridges that yield SAR ages b2000 yr show general agreement with corresponding 14C ages on swale organics. Significant variability in 14C ages N2000 cal yr B.P. complicates comparison to SAR ages at all sites. However, a SAR age of 4280 F 390 yr (UIC913) on ridge77 at Tahquamenon Bay is consistent with regional regression from the high lake level of the Nipissing II phase ca. 4500 cal yr B.P. SAR ages indicate a decrease in ridge formation rate after ~1500 yr ago, likely reflecting separation of Lake Superior from lakes Huron and Michigan. This study shows that SAR is a credible alternative to 14C methods for dating littoral and eolian landforms in Great Lakes and other coastal strandplains where 14C methods prove problematic. D 2004 University of Washington. All rights reserved

No impact of CMV or EBV seropositivity on the frequency of highly differentiated T-cells in Mexican-American adolescents

Recurring activations of the prevalent latent herpes viruses Cytomegalovirus (CMV) and Epstein-Barr virus (EBV) induces immune cell division leading to the premature terminal differentiation of T-cells. Terminally differentiated T-cells are known to accumulate with age causing a reduction in the naïve T-cell repertoire, which compromises the ability of the adaptive immune system to respond to novel pathogens. Although CMV and EBV seropositivity are hallmarks of the “immune risk profile” and are known to influence the frequency of terminally differentiated T-cells and increase infection risk in adults, it is not known if CMV or EBV impacts on the frequency of these cells in a young subject cohort. PURPOSE: To examine the impact of CMV and EBV seropositivity on the frequency of highly differentiated blood T-cells in Mexican-American adolescents. METHODS: Fasted resting blood samples were obtained from 77 adolescents consisting of both males and females. The presence of antibodies against CMV and EBV was determined in serum by ELISA. Lymphocytes isolated from peripheral blood were assessed for a combination of cell surface markers to determine their stage of differentiation. Monoclonal antibodies and four-color flow cytometry were used to identify senescent (CD27-, CD28-, CD57+), naïve (CCR7+, CD45RA+), memory (CCR7-, CD45RA-) and effector memory (CCD7-, CD45RA+) T-cell markers on pan CD3+ T-cells, CD4+ T-cells and CD8+ T-cells. Differences in T-cell phenotype between the CMV/EBV seropositive and seronegative participants were compared using independent Student t-tests. RESULTS: The prevalence of latent CMV and EBV infection among the subject cohort was 16% and 44% respectively, while 7% of all participants were carrying a latent infection for both. No differences in senescent and memory phenotypes were found between the CMV or EBV seropositive and seronegative groups. CONCLUSION: Despite the known influence of latent CMV and EBV infection on the frequency of senescent T-cells in adults, these preliminary data indicate that CMV and EBV seropositivity has no impact on the frequency of senescent T-cells in adolescents. These data suggest that the increased frequency of terminally differentiated T-cells that are associated with CMV and EBV seropositivity in adults is probably due to long-term infections. Future studies will assess the impact of CMV and EBV seropositivity on immunosenescence in association with other factors known to have an effect on T-cells differentiation, such as BMI and physical activity status