73 research outputs found
An Analysis of Early Software Reliability Improvement Techniques
This research explores early life cycle software reliability prediction models or techniques to predict the reliability of software prior to writing code, and a method for increasing or improving the reliability of software products early in the development life cycle. Five prediction models and two development techniques are examined. Each model is statically analyzed in terms of availability of data early in the life cycle, ease of data collection, and whether data is currently collected. One model and the two techniques satisfied those requirements and are further analyzed for their ability to predict or improve software reliability. While the researchers offer no significant statistical results of the model\u27s ability to predict software reliability, important conclusions are drawn about the cost and time savings of using inspections as a means of improving software reliability. The results indicate that the current software development paradigm needs to be changed to use the Cleanroom Software Development Process for fixture software development. This proactive approach to developing reliable software saves development and testing costs. One obvious benefit of this research is that cost savings realized earlier in the software development cycle have a dramatic effect on making software development practices better and more efficient
Theoretical Limb Darkening for Classical Cepheids: II. Corrections for the Geometric Baade-Wesselink Method
The geometric Baade-Wesselink method is one of the most promising techniques
for obtaining a better calibration of the Cepheid period-luminosity relation by
means of interferometric measurements of accurate diameters. In this paper we
present new wavelength- and phase-dependent limb darkening corrections based on
our time-dependent hydrodynamic models of the classical Cepheid zeta Gem. We
show that a model simulation of a Cepheid atmosphere, taking into account the
hydrodynamic effects associated with the pulsation, shows strong departures
from the limb darkening otherwise predicted by a static model. For most of its
pulsational cycle the hydrodynamic model predicts a larger limb darkening then
the equivalent static model. The hydrodynamics affects the limb darkening
mainly at UV and optical wavelengths. Most of these effects evolve slowly as
the star pulsates, but there are phases, associated with shocks propagating
into the photosphere, in which significant changes in the limb darkening take
place on time-scales of the order of less than a day. We assess the implication
of our model LD corrections fitting the geometric Baade-Wesselink distance of
zeta Gem for the available near-IR PTI data. We discuss the effects of our
model limb darkening on the best fit result, and analyze the requirements
needed to test the time-dependence of the limb darkening with future
interferometric measurements.Comment: 22 pages, 5 figures, to be published on the Astrophysical Journal,
June 1 2003 issu
The Importance of Maine for Ecoregional Conservation Planning
Ecoregional conservation planning aims at protecting biodiversity within a realistic social and economic framework. The authors of this article suggest that Maine’s forests are the ecological core of the entire Northern Appalachian/Acadian ecoregion, which spans four states and five Canadian provinces. Using mapping and mathematical models of the “human footprint,” they note that Maine has a large, contiguous, undeveloped and unfragmented forest compared with neighboring states and provinces. However, compared with its neighbors Maine also has the largest proportion of unprotected forest. The authors conclude with the hope that land use policy and planning can be better informed through the active integration of recent ecoregional conservation mapping model
Retired A Stars and Their Companions. III. Comparing the Mass-Period Distributions of Planets Around A-Type Stars and Sun-Like Stars
We present an analysis of ~5 years of Lick Observatory radial velocity
measurements targeting a uniform sample of 31 intermediate-mass subgiants (1.5
< M*/Msun < 2.0) with the goal of measuring the occurrence rate of Jovian
planets around (evolved) A-type stars and comparing the distributions of their
orbital and physical characteristics to those of planets around Sun-like stars.
We provide updated orbital solutions incorporating new radial velocity
measurements for five known planet-hosting stars in our sample; uncertainties
in the fitted parameters are assessed using a Markov Chain Monte Carlo method.
The frequency of Jovian planets interior to 3 AU is 26 (+9,-8)%, which is
significantly higher than the ~5-10% frequency observed around solar-mass
stars. The median detection threshold for our sample includes minimum masses
down to {0.2, 0.3, 0.5, 0.6, 1.3} MJup within {0.1, 0.3, 0.6, 1.0, 3.0} AU. To
compare the properties of planets around intermediate-mass stars to those
around solar-mass stars we synthesize a population of planets based on the
parametric relationship dN ~ M^{alpha}P^{beta} dlnM dlnP, the observed planet
frequency, and the detection limits we derived. We find that the values of
alpha and beta for planets around solar-type stars from Cumming et al. fail to
reproduce the observed properties of planets in our sample at the 4 sigma
level, even when accounting for the different planet occurrence rates. Thus,
the properties of planets around A stars are markedly different than those
around Sun-like stars, suggesting that only a small (~ 50%) increase in stellar
mass has a large influence on the formation and orbital evolution of planets.Comment: Accepted by the Astrophysical Journal; 15 pages, 15 figure
Hormone-replacement therapy influences gene expression profiles and is associated with breast-cancer prognosis: a cohort study
BACKGROUND: Postmenopausal hormone-replacement therapy (HRT) increases breast-cancer risk. The influence of HRT on the biology of the primary tumor, however, is not well understood. METHODS: We obtained breast-cancer gene expression profiles using Affymetrix human genome U133A arrays. We examined the relationship between HRT-regulated gene profiles, tumor characteristics, and recurrence-free survival in 72 postmenopausal women. RESULTS: HRT use in patients with estrogen receptor (ER) protein positive tumors (n = 72) was associated with an altered regulation of 276 genes. Expression profiles based on these genes clustered ER-positive tumors into two molecular subclasses, one of which was associated with HRT use and had significantly better recurrence free survival despite lower ER levels. A comparison with external data suggested that gene regulation in tumors associated with HRT was negatively correlated with gene regulation induced by short-term estrogen exposure, but positively correlated with the effect of tamoxifen. CONCLUSION: Our findings suggest that post-menopausal HRT use is associated with a distinct gene expression profile related to better recurrence-free survival and lower ER protein levels. Tentatively, HRT-associated gene expression in tumors resembles the effect of tamoxifen exposure on MCF-7 cells
Factors associated with disease evolution in Greek patients with inflammatory bowel disease
BACKGROUND: The majority of Crohn's disease patients with B1 phenotype at diagnosis (i.e. non-stricturing non-penetrating disease) will develop over time a stricturing or a penetrating pattern. Conflicting data exist on the rate of proximal disease extension in ulcerative colitis patients with proctitis or left-sided colitis at diagnosis. We aimed to study disease evolution in Crohn's disease B1 patients and ulcerative colitis patients with proctitis and left-sided colitis at diagnosis. METHODS: 116 Crohn's disease and 256 ulcerative colitis patients were followed-up for at least 5 years after diagnosis. Crohn's disease patients were classified according to the Vienna criteria. Data were analysed actuarially. RESULTS: B1 phenotype accounted for 68.9% of Crohn's disease patients at diagnosis. The cumulative probability of change in disease behaviour in B1 patients was 43.6% at 10 years after diagnosis. Active smoking (Hazard Ratio: 3.01) and non-colonic disease (non-L2) (Hazard Ratio: 3.01) were associated with behavioural change in B1 patients. Proctitis and left-sided colitis accounted for 24.2%, and 48.4% of ulcerative colitis patients at diagnosis. The 10 year cumulative probability of proximal disease extension in patients with proctitis and left-sided colitis was 36.8%, and 17.1%, respectively (p: 0.003). Among proctitis patients, proximal extension was more common in non-smokers (Hazard Ratio: 4.39). CONCLUSION: Classification of Crohn's disease patients in B1 phenotype should be considered as temporary. Smoking and non-colonic disease are risk factors for behavioural change in B1 Crohn's disease patients. Proximal extension is more common in ulcerative colitis patients with proctitis than in those with left-sided colitis. Among proctitis patients, proximal extension is more common in non-smokers
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Top 40 Priorities for Science to Inform US Conservation and Management Policy
To maximize the utility of research to decisionmaking, especially given limited financial resources, scientists must set priorities for their efforts.
We present a list of the top 40 high-priority, multidisciplinary research questions directed toward informing some of the most important current
and future decisions about management of species, communities, and ecological processes in the United States. The questions were generated
by an open, inclusive process that included personal interviews with decisionmakers, broad solicitation of research needs from scientists and
policymakers, and an intensive workshop that included scientifically oriented individuals responsible for managing and developing policy related
to natural resources. The process differed from previous efforts to set priorities for conservation research in its focus on the engagement of decisionmakers
in addition to researchers. The research priorities emphasized the importance of addressing societal context and exploration of trade-offs
among alternative policies and actions, as well as more traditional questions related to ecological processes and functions.Keywords: Priority setting, Natural resource management, Ecosystems, Conservation, Decisionmaker
Fiscal Illusion and Fiscal Obfuscation: An Empirical Study of Tax Perception in Sweden
The Adaptation for Conservation Targets (ACT) Framework: A Tool for Incorporating Climate Change into Natural Resource Management
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