Chapter 9 Gene Drive Strategies for Population Replacement

Gene drive systems are selfish genetic elements capable of spreading into a population despite a fitness cost. A variety of these systems have been proposed for spreading disease-refractory genes into mosquito populations, thus reducing their ability to transmit diseases such as malaria and dengue fever to humans. Some have also been proposed for suppressing mosquito populations. We assess the alignment of these systems with design criteria for their safety and efficacy. Systems such as homing endonuclease genes, which manipulate inheritance through DNA cleavage and repair, are highly invasive and well-suited to population suppression efforts. Systems such as Medea, which use combinations of toxins and antidotes to favor their own inheritance, are highly stable and suitable for replacing mosquito populations with disease-refractory varieties. These systems offer much promise for future vector-borne disease control

Bus Transit Operational Efficiency Resulting from Passenger Boardings at Park-and-Ride Facilities

In order to save time and money by not driving to an ultimate destination, some urban commuters drive themselves a few miles to specially designated parking lots built for transit customers and located where trains or buses stop. The focus of this paper is the effect Park-and-Ride (P&R) lots have on the efficiency of bus transit as measured in five bus transit systems in the western U.S. This study describes a series of probes with models and data to find objective P&R influence measures that, when combined with other readily-available data, permit a quantitative assessment of the significance of P&R on transit efficiency. The authors developed and describe techniques that examine P&R as an influence on transit boardings at bus stops and on bus boardings along an entire route. The regression results reported are based on the two in-depth case studies for which sufficient data were obtained to examine (using econometric techniques) the effects of park-and-ride availability on bus transit productivity. Both Ordinary Least Square (OLS) regression and Poisson regression are employed. The results from the case studies suggest that availability of parking near bus stops is a stronger influence on transit ridership than residential housing near bus stops. Results also suggest that expanding parking facilities near suburban park-and-ride lots increases the productivity of bus operations as measured by ridership per service hour. The authors also illustrate that reasonable daily parking charges (compared to the cost of driving to much more expensive parking downtown) would provide sufficient capital to build and operate new P&R capacity without subsidy from other revenue sources

Spitzer spectroscopy of circumstellar disks in the 5 Myr old upper Scorpius OB association

We present mid-infrared spectra between 5.2 and 38 μm for 26 disk-bearing members of the ~5 Myr old Upper Scorpius OB association obtained with the Infrared Spectrograph (IRS) onboard the Spitzer Space Telescope. We find clear evidence for changes in the spectral characteristics of dust emission between the early-type (B+A) and late-type (K+M) infrared excess stars. The early-type members exhibit featureless continuum excesses that become apparent redward of ~8 μm. In contrast, 10 and 20 μm silicate features or polycyclic aromatic hydrocarbon emission are present in all but one of the late-type excess members of Upper Scorpius. The strength of silicate emission among late-type Upper Scorpius members is spectral-type dependent, with the most prominent features being associated with K5-M2-type stars. By fitting the spectral energy distributions (SED) of a representative sample of low-mass stars with accretion disk models, we find that the SEDs are consistent with models having inner disk radii ranging from ~0.2 to 1.2 AU. Complementary high-resolution (R ~ 33,000) optical (λλ4800-9200) spectra for the Upper Scorpius excess stars were examined for signatures of gaseous accretion. Of the 35 infrared excess stars identified in Upper Scorpius, only seven (all late-type) exhibit definitive signatures of accretion. Mass-accretion rates (M) for these stars were estimated to range from 10^–11 to 10^–8.9 M⊙ yr^–1. Compared to Class II sources in Taurus-Auriga, the disk population in Upper Scorpius exhibits reduced levels of near- and mid-infrared excess emission and an order of magnitude lower mass-accretion rates. These results suggest that the disk structure has changed significantly over the 2-4 Myr in age separating these two stellar populations. The ubiquity of depleted inner disks in the Upper Scorpius excess sample implies that such disks are a common evolutionary pathway that persists for some time

The Terwilliger algebra of an almost-bipartite P- and Q-polynomial association scheme

Let $Y$ denote a $D$-class symmetric association scheme with $D \geq 3$, and suppose $Y$ is almost-bipartite P- and Q-polynomial. Let $x$ denote a vertex of $Y$ and let $T=T(x)$ denote the corresponding Terwilliger algebra. We prove that any irreducible $T$-module $W$ is both thin and dual thin in the sense of Terwilliger. We produce two bases for $W$ and describe the action of $T$ on these bases. We prove that the isomorphism class of $W$ as a $T$-module is determined by two parameters, the dual endpoint and diameter of $W$. We find a recurrence which gives the multiplicities with which the irreducible $T$-modules occur in the standard module. We compute this multiplicity for those irreducible $T$-modules which have diameter at least $D-3$.Comment: 22 page

Summary of Workshop to Review an OMB Report on Regulatory Risk Assessment and Management

Summary of the results of an invitational workshop conducted to peer review the 1990 OMB report, CURRENT REGULATORY ISSUES IN Risk ASSESSMENT AND Risk MANAGENMENTIN REGULATORY PROGRAM OF THE UNITED STATES GOVERNMENT, APRIL 1, 1990 - MARCH 31, 1991