Junkets and Clarissimus: The Clare - Keats Dialogue

Although Clare and Keats never met or directly corresponded, they were close contemporaries with much in common, including a publisher and overlapping literary circles and interests. Moreover, they passed messages to each other via their publisher John Taylor, and the evidence suggests a significant level of literary and personal engagement between them. In particular, Clare took a keen interest in Keats's poetry and person in the last year of the latter's life, responding richly and enthusiastically to the 1820 volume, and following Keats's failing health and final journey to Rome with increasing concern and sadness. All this is documented in the correspondence between Clare and Taylor, much of it unpublished, including three hitherto unrecorded letters from Clare to Taylor. This essay, drawing on transcripts of these unpublished materials by Bob Heyes and Emma Trehane, offers a detailed, chronological study of this under-examined but invaluable correspondence between two key Romantic poets

The Politics of Feeling: Reading Emotion in Philip K. Dick

This essay argues that Dick is as much a chronicler of human feelings as he is a prophet of futuristic strangeness. Dick writes in an emotionally heightened way, explores the nature of human feeling, and uses the portrayal of feeling as a way of engaging with his readers, setting out a philosophical and moral agenda in a singularly intense and driven way. Focusing closely on four scenes from three novels, the essay shows how Dick’s interest in emotion and emotional response offers a powerful social and political critique of his society and its persistent tendency to foster human alienation. The essay offers a broadly humanistic reading, shaped in the agendas set by Dick’s biographers, and inflected by cultural materialist and feminist thinking. It is designed to be useful to the general as well as the scholarly reader

A survey of practices, procedures, and time allotments devoted to the National Lunch Program by the principals, teachers, and lunchroom workers of the elementary public schools of Essex County

Thesis (Ed.M.)--Boston Universit

‘O Bristol, be worthy of your worthiest sons’: John Gregory, St Mary Redcliffe and the Memorialisation of Thomas Chatterton

This essay examines the poetry of John Gregory (1831-1922) focusing on his four ‘Sonnets on Chatterton's Church, Bristol' (1877) and verses ‘Concerning Chatterton' (1908). In the long history of tributary poems to the Redcliffe poet Thomas Chatterton (1752-70), Gregory's are distinctive. The sonnet sequence celebrates the church that had inspired Chatterton's mock-medieval ‘Rowley' poems, before demanding that its doors be thrown open to re-admit the spirit of the poet, whose statue then stood on unconsecrated ground, reflecting ambivalent local feeling about this perceived ‘forger' and ‘suicide' (an ambivalence that continues). The later poem forms a sequel to the sonnets, bringing the Chatterton statue imaginatively to life so that the earlier poet can make his own posthumous ‘wail' for fairer treatment from his erstwhile community. Predominant in these poems is the desire to re-localise and re-socialise Chatterton's spirit and art. As a radical socialist and a Christian Gregory saw the church, with its fine ring of twelve bells and beautiful medieval craftsmanship, as a place that could inspire those in humble life like Chatterton and himself to ‘look up' and aspire to more, and could reinstate Chatterton's lonely art into the joyfully socialised world of Gregory's political and social milieu. As well as a poet, a shoemaker and a singer-musician, Gregory was a pioneering figure in the development of an independent working-class movement in Bristol, a passionate speaker against capital punishment and war. His call for Chatterton's readmission into Bristol culture is fired with his campaigning instincts and remains relevant

Rowley’s Ghost: A Checklist of Creative Works Inspired by Thomas Chatterton’s Life and Writings, 1770-2020

This is a discursive checklist of poems, novels, plays, paintings, musical and other creative works inspired by the life and works of the poet Thomas Chatterton (1752-1770), Wordsworth's 'Marvellous Boy'. It is a much-expanded and revised second edition, posted to commemorate the 250th anniversary in 2020 of Chatterton's early death in 1770. It has been further revised in 2023 and will continue to be developed and improved

Water quality effects of intermittent water supply in Arraiján, Panama

Intermittent drinking water supply is common in low- and middle-income countries throughout the world and can cause waterquality to degrade in the distribution system.In this study,we characterized waterquality in one study zone with continuous supply and three zoneswith intermittentsupply in the drinking waterdistribution network in Arraija!n,Panama.Low orzero pressuresoccurred in allzones,and negative pressuresoccurred in the continuouszone and two ofthe intermittentzones.Despite hydraulic conditions that created risks for backflow and contaminant intrusion, only four of 423 (0.9%) grab samplescollected atrandom timeswere positive fortotalcoliform bacteria and only one waspositive for E.coli.Only nine of 496 (1.8%) samples had turbidity >1.0 NTU and all samples had !0.2 mg/L free chlorine residual.In contrast,water quality was often degraded during the first-flush period (when supply first returned after an outage).Still, routine and first-flush water quality under intermittent supply was much better in Arraija!n than that reported in a previous study conducted in India.Better waterquality in Arraija!n could be due to betterwaterquality leaving the treatmentplant,shortersupply outages,highersupply pressures,a more consistentand higherchlorine residual,and fewercontaminant sourcesnearpipes.The resultsillustrate thatintermittentsupply and itseffectson waterquality can vary greatly between and within distribution networks.The study also demonstrated thatmonitoring techniques designed specifically for intermittentsupply,such as continuous pressure monitoring and sampling the firstflush,can detectwaterquality threats and degradation thatwould notlikely be detected with conventionalmonitoring.Intermittent drinking water supply is common in low- and middle-income countries throughout the world and can cause waterquality to degrade in the distribution system.In this study,we characterized waterquality in one study zone with continuous supply and three zoneswith intermittentsupply in the drinking waterdistribution network in Arraija!n,Panama.Low orzero pressuresoccurred in allzones,and negative pressuresoccurred in the continuouszone and two ofthe intermittentzones.Despite hydraulic conditions that created risks for backflow and contaminant intrusion, only four of 423 (0.9%) grab samplescollected atrandom timeswere positive fortotalcoliform bacteria and only one waspositive for E.coli.Only nine of 496 (1.8%) samples had turbidity >1.0 NTU and all samples had !0.2 mg/L free chlorine residual.In contrast,water quality was often degraded during the first-flush period (when supply first returned after an outage).Still, routine and first-flush water quality under intermittent supply was much better in Arraija!n than that reported in a previous study conducted in India.Better waterquality in Arraija!n could be due to betterwaterquality leaving the treatmentplant,shortersupply outages,highersupply pressures,a more consistentand higherchlorine residual,and fewercontaminant sourcesnearpipes.The resultsillustrate thatintermittentsupply and itseffectson waterquality can vary greatly between and within distribution networks.The study also demonstrated thatmonitoring techniques designed specifically for intermittentsupply,such as continuous pressure monitoring and sampling the firstflush,can detectwaterquality threats and degradation thatwould notlikely be detected with conventionalmonitoring

Activation of the innate immune receptor Dectin-1 upon formation of a 'phagocytic synapse'.

Innate immune cells must be able to distinguish between direct binding to microbes and detection of components shed from the surface of microbes located at a distance. Dectin-1 (also known as CLEC7A) is a pattern-recognition receptor expressed by myeloid phagocytes (macrophages, dendritic cells and neutrophils) that detects β-glucans in fungal cell walls and triggers direct cellular antimicrobial activity, including phagocytosis and production of reactive oxygen species (ROS). In contrast to inflammatory responses stimulated upon detection of soluble ligands by other pattern-recognition receptors, such as Toll-like receptors (TLRs), these responses are only useful when a cell comes into direct contact with a microbe and must not be spuriously activated by soluble stimuli. In this study we show that, despite its ability to bind both soluble and particulate β-glucan polymers, Dectin-1 signalling is only activated by particulate β-glucans, which cluster the receptor in synapse-like structures from which regulatory tyrosine phosphatases CD45 and CD148 (also known as PTPRC and PTPRJ, respectively) are excluded (Supplementary Fig. 1). The 'phagocytic synapse' now provides a model mechanism by which innate immune receptors can distinguish direct microbial contact from detection of microbes at a distance, thereby initiating direct cellular antimicrobial responses only when they are required

Household stored water quality in an intermittent water supply network in Panama

Safe water storage is critical to preserve water quality, especially when intermittent piped drinking water supply creates a need for household storage. This study characterized household storage practices and stored water quality in 94 households (N = 94) among four peri-urban neighborhoods in Arraiján, Panama with varying degrees of supply intermittency. We found that 18 (19.1%) households stored drinking water in unsafe containers. Forty-four (47%) samples of household stored drinking water had residual chlorine levels 10 most probable number (MPN)/100 mL total coliform bacteria. Eight (44%) samples were positive for Escherichia coli, whereas only one (1.3%) sample from the safe containers was positive. Twenty-nine (30.9%) samples had >500 MPN/mL heterotrophic plate count bacteria. These findings suggest that longer supply interruptions were associated with longer storage times and lower chlorine residual, which were associated with higher concentrations of indicator bacteria. This is one of the first studies in the Central-American region to show an association between the lack of turnover (replacement with fresh water) and greater contamination during household water storage. Thus, when drinking water supply is not completely continuous and household storage is required, decreasing the time between supply periods can facilitate safer water storage. Public awareness and education are also recommended to increase hygiene practices during water collection and storage.Safe water storage is critical to preserve water quality, especially when intermittent piped drinking water supply creates a need for household storage. This study characterized household storage practices and stored water quality in 94 households (N = 94) among four peri-urban neighborhoods in Arraiján, Panama with varying degrees of supply intermittency. We found that 18 (19.1%) households stored drinking water in unsafe containers. Forty-four (47%) samples of household stored drinking water had residual chlorine levels 10 most probable number (MPN)/100 mL total coliform bacteria. Eight (44%) samples were positive for Escherichia coli, whereas only one (1.3%) sample from the safe containers was positive. Twenty-nine (30.9%) samples had >500 MPN/mL heterotrophic plate count bacteria. These findings suggest that longer supply interruptions were associated with longer storage times and lower chlorine residual, which were associated with higher concentrations of indicator bacteria. This is one of the first studies in the Central-American region to show an association between the lack of turnover (replacement with fresh water) and greater contamination during household water storage. Thus, when drinking water supply is not completely continuous and household storage is required, decreasing the time between supply periods can facilitate safer water storage. Public awareness and education are also recommended to increase hygiene practices during water collection and storage

Hopping between distant basins

We present and numerically analyse the Basin Hopping with Skipping (BH-S) algorithm for stochastic optimisation. This algorithm replaces the perturbation step of basin hopping (BH) with a so-called skipping mechanism from rare-event sampling. Empirical results on benchmark optimisation surfaces demonstrate that BH-S can improve performance relative to BH by encouraging non-local exploration, that is, by hopping between distant basins

Potential Quality Indicators for Seriously Ill Home Care Clients: A Cross-Sectional Analysis Using Resident Assessment Instrument for Home Care (RAI-HC) Data for Ontario

Background Currently, there are no formalized measures for the quality of home based palliative care in Ontario. This study developed a set of potential quality indicators for seriously ill home care clients using a standardized assessment. Methods Secondary analysis of Resident Assessment Instrument for Home Care data for Ontario completed between 2006 and 2013 was used to develop quality indicators (QIs) thought to be relevant to the needs of older (65+) seriously ill clients. QIs were developed through a review of the literature and consultation with subject matter experts in palliative care. Serious illness was defined as a prognosis of less than 6 months to live or the presence of severe health instability. The rates of the QIs were stratified across Ontario’s geographic regions, and across four common life-limiting illnesses to observe variation. Results Within the sample, 14,312 clients were considered to be seriously ill and were more likely to experience negative health outcomes such as cognitive performance (OR = 2.77; 95% CI: 2.66–2.89) and pain (OR = 1.59; 95% CI: 1.53–1.64). Twenty subject matter experts were consulted and a list of seven QIs was developed. Indicators with the highest overall rates were prevalence of falls (50%) prevalence of daily pain (47%), and prevalence of caregiver distress (42%). The range in QI rates was largest across regions for prevalence of caregiver distress (21.5%), the prevalence of falls (16.6%), and the prevalence of social isolation (13.7%). Those with some form of dementia were most likely to have a caregiver that was distressed (52.6%) or to experience a fall (53.3%). Conclusion Home care clients in Ontario who are seriously ill are experiencing high rates of negative health outcomes, many of which are amenable to change. The RAI-HC can be a useful tool in identifying these clients in order to better understand their needs and abilities. These results contribute significantly to the process of creating and validating a standardized set of QIs that can be generated by organizations using the RAI-HC as part of normal clinical practice