The Entrepreneurial State Goes to Europe

This article investigates state-level export programs in response to the emerging new economic and political regime of Europe 1992. Little related export promotion activity is found, even in states reputed to have the most active entrepreneurial policies. The authors conclude that states have few resources to invest in export promotion and are inappropriate jurisdictions around which to organize such policy, despite the much touted entrepreneurial state

The Inclusive-Exclusive Connection and the Neutron Negative Central Charge Density

We find an interpretation of the recent finding that the central charge density of the neutron is negative by using models of generalized parton distributions at zero skewness to relate the behavior of deep inelastic scattering quark distributions, evaluated at large values of Bjorken x, to the transverse charge density evaluated at small distances. The key physical input of these models is the Drell-Yan-West relation We find that the d quarks dominate the neutron structure function for large values of Bjorken x, where the large longitudinal momentum of the struck quark has a significant impact on determining the center-of-momentum of the system, and thus the "center" of the nucleon in the transverse position plane.Comment: 17 pages, 8 figures. Text of an invited talk presented by G. A. Miller at the 2008 Division of Nuclear Physics Meeting in Oakland. Prepared for Int. Journ. Mod. Phys.

The Entrepreneurial State Goes to Europe: State Economic Policies and Europe 1992

This article investigates state-level export programs in response to the emerging new economic and political regime of Europe 1992. Little related export promotion activity is found, even in states reputed to have the most active entrepreneurial policies. The authors conclude that states have few resources to invest in export promotion and are inappropriate jurisdictions around which to organize such policy, despite the much touted entrepreneurial state

A mass spectrometric strategy for absolute quantification of Plasmodium falciparum proteins of low abundance

Selected reaction monitoring mass spectrometry has been combined with the use of an isotopically labelled synthetic protein, made up of proteotypic tryptic peptides selected from parasite proteins of interest. This allows, for the first time, absolute quantification of proteins from Plasmodium falciparum. This methodology is demonstrated to be of sufficient sensitivity to quantify, even within whole cell extracts, proteins of low abundance from the folate pathway as well as more abundant "housekeeping" proteins

The gradual corporatization of the English NHS has created conditions which have precipitated an increasingly commercialized and entrepreneurial healthcare system

Recent healthcare reforms in England, combined with financial austerity, have accelerated both the corporatization and commercialization of the NHS. This combination has encouraged greater public sector entrepreneurialism, argue Damian E. Hodgson, Simon Bailey, Mark Exworthy, Mike Bresnen, John Hassard, and Paula Hyde. They examine the meaning and experience of corporatization in the sector, illustrating their argument with qualitative data from a specialist hospital

Dynamic subcellular localization of isoforms of the folate pathway enzyme serine hydroxymethyltransferase (SHMT) through the erythrocytic cycle of Plasmodium falciparum

<p>Abstract</p> <p>Background</p> <p>The folate pathway enzyme serine hydroxymethyltransferase (SHMT) converts serine to glycine and 5,10-methylenetetrahydrofolate and is essential for the acquisition of one-carbon units for subsequent transfer reactions. 5,10-methylenetetrahydrofolate is used by thymidylate synthase to convert dUMP to dTMP for DNA synthesis. In <it>Plasmodium falciparum </it>an enzymatically functional SHMT (PfSHMTc) and a related, apparently inactive isoform (PfSHMTm) are found, encoded by different genes. Here, patterns of localization of the two isoforms during the parasite erythrocytic cycle are investigated.</p> <p>Methods</p> <p>Polyclonal antibodies were raised to PfSHMTc and PfSHMTm, and, together with specific markers for the mitochondrion and apicoplast, were employed in quantitative confocal fluorescence microscopy of blood-stage parasites.</p> <p>Results</p> <p>As well as the expected cytoplasmic occupancy of PfSHMTc during all stages, localization into the mitochondrion and apicoplast occurred in a stage-specific manner. Although early trophozoites lacked visible organellar PfSHMTc, a significant percentage of parasites showed such fluorescence during the mid-to-late trophozoite and schizont stages. In the case of the mitochondrion, the majority of parasites in these stages at any given time showed no marked PfSHMTc fluorescence, suggesting that its occupancy of this organelle is of limited duration. PfSHMTm showed a distinctly more pronounced mitochondrial location through most of the erythrocytic cycle and GFP-tagging of its N-terminal region confirmed the predicted presence of a mitochondrial signal sequence. Within the apicoplast, a majority of mitotic schizonts showed a marked concentration of PfSHMTc, whose localization in this organelle was less restricted than for the mitochondrion and persisted from the late trophozoite to the post-mitotic stages. PfSHMTm showed a broadly similar distribution across the cycle, but with a distinctive punctate accumulation towards the ends of elongating apicoplasts. In very late post-mitotic schizonts, both PfSHMTc and PfSHMTm were concentrated in the central region of the parasite that becomes the residual body on erythrocyte lysis and merozoite release.</p> <p>Conclusions</p> <p>Both PfSHMTc and PfSHMTm show dynamic, stage-dependent localization among the different compartments of the parasite and sequence analysis suggests they may also reversibly associate with each other, a factor that may be critical to folate cofactor function, given the apparent lack of enzymic activity of PfSHMTm.</p

Management Knowledge and Learning in the UK Healthcare Context: Change and Continuity

Major recent changes witnessed within UK healthcare have had dramatic consequences for management, while the increased expectation that healthcare managers demonstrate leadership has put the spotlight firmly on their managerial knowledge. As yet, however, we know comparatively little about how healthcare managers acquire and apply management knowledge, and how this is influenced by their professional development. Drawing upon situated learning theory and Blackler’s framework of knowledge types, we examine managers’ orientations to knowledge in the context of recent policy changes. Recognizing that healthcare management is complex, comparative case study evidence is presented from three types of hospital trust (acute, care and specialist) and across three generic managerial groups (clinical, general and functional). Our research highlights the obstacles faced by managers in developing their knowledge and learning, and how contemporary changes are reinforcing long-established preferences for embodied (‘tried and tested’) knowledge as well as locally encultured (‘home-grown’) management solutions

Pennsylvania Folklife Vol. 22, Folk Festival Supplement

• Sounds of the Folk Festival: A Visitor\u27s Walking Tour • Herbs at Kutztown • Amish Weddings • Food Varieties at the Festival • Festival Highlights • Folk Festival Program • Taverns and Tavern Lore of Dutchland • The Lure of Tinsmithing • Folk Whittling in Pennsylvania • The Dance in Pennsylvania - Current Status: Folk-Cultural Questionnaire No. 30https://digitalcommons.ursinus.edu/pafolklifemag/1054/thumbnail.jp

Automating the packing heuristic design process with genetic programming

The literature shows that one-, two-, and three-dimensional bin packing and knapsack packing are difficult problems in operational research. Many techniques, including exact, heuristic, and metaheuristic approaches, have been investigated to solve these problems and it is often not clear which method to use when presented with a new instance. This paper presents an approach which is motivated by the goal of building computer systems which can design heuristic methods. The overall aim is to explore the possibilities for automating the heuristic design process. We present a genetic programming system to automatically generate a good quality heuristic for each instance. It is not necessary to change the methodology depending on the problem type (one-, two-, or three-dimensional knapsack and bin packing problems), and it therefore has a level of generality unmatched by other systems in the literature. We carry out an extensive suite of experiments and compare with the best human designed heuristics in the literature. Note that our heuristic design methodology uses the same parameters for all the experiments. The contribution of this paper is to present a more general packing methodology than those currently available, and to show that, by using this methodology, it is possible for a computer system to design heuristics which are competitive with the human designed heuristics from the literature. This represents the first packing algorithm in the literature able to claim human competitive results in such a wide variety of packing domains