Schrodinger formalism, black hole horizons and singularity behavior

The Gauss-Codazzi method is used to discuss the gravitational collapse of a charged Reisner-Nordstr\"om domain wall. We solve the classical equations of motion of a thin charged shell moving under the influence of its own gravitational field and show that a form of cosmic censorship applies. If the charge of the collapsing shell is greater than its mass, then the collapse does not form a black hole. Instead, after reaching some minimal radius, the shell bounces back. The Schrodinger canonical formalism is used to quantize the motion of the charged shell. The limits near the horizon and near the singularity are explored. Near the horizon, the Schrodinger equation describing evolution of the collapsing shell takes the form of the massive wave equation with a position dependent mass. The outgoing and incoming modes of the solution are related by the Bogolubov transformation which precisely gives the Hawking temperature. Near the classical singularity, the Schrodinger equation becomes non-local, but the wave function describing the system is non-singular. This indicates that while quantum effects may be able to remove the classical singularity, it may also introduce some new effects.Comment: 10 pages; v2 added references and further comment on singularity behavior, version to appear in PR

Payload deployment method and system

A method and apparatus for deploying the payload of space shuttle or the like is described. It is referred to as the Stabilized Payload Deployment System (SPDS). The payload is rotated about an axis outside of the payload but approximately longitudinally with the cargo bay of the shuttle craft. The payload may thus be rotated through ninety degrees. In this case, that is, in its rotated position, the payload may or may not have a small portion located within the cargo bay. Alternatively, the payload may be located completely outside of the bay. According to the apparatus two separable hinge-like devices connect at one longitudinal side or edge of the payload to respective ones of the payload trunnions at different longitudinally spaced locations along the length of the payload. Separation of the payload from the cargo bay is made by unlatching a latch and by the use of a repulsion spring at the position of each hinge-like device. Two four-link mechanisms allow movement between payload and bay. Such accommodative movement is required especially during launch when considerable vibration is encountered

Using Biobrane: Techniques to Make Life Easier

Aims: To facilitate the use of Biobrane for those burn care practitioners not familiar with this material. Methods: Two techniques have been developed through extensive use of Biobrane over many years, in both sheet and glove form. These techniques have been described and illustrated with photographs. Results: The use of these techniques has allowed the corresponding author to markedly reduce operating time and to easily apply the material single-handedly. Conclusion: Biobrane is a biosynthetic skin substitute primarily designed for the definitive treatment of superficial partial-thickness to mid-dermal burn injury. Once experienced with its use, the material is quite ubiquitous. The described techniques will facilitate the use of Biobrane for those not familiar with it

Site investigation for the effects of vegetation on ground stability

The procedure for geotechnical site investigation is well established but little attention is currently given to investigating the potential of vegetation to assist with ground stability. This paper describes how routine investigation procedures may be adapted to consider the effects of the vegetation. It is recommended that the major part of the vegetation investigation is carried out, at relatively low cost, during the preliminary (desk) study phase of the investigation when there is maximum flexibility to take account of findings in the proposed design and construction. The techniques available for investigation of the effects of vegetation are reviewed and references provided for further consideration. As for general geotechnical investigation work, it is important that a balance of effort is maintained in the vegetation investigation between (a) site characterisation (defining and identifying the existing and proposed vegetation to suit the site and ground conditions), (b) testing (in-situ and laboratory testing of the vegetation and root systems to provide design parameters) and (c) modelling (to analyse the vegetation effects)

LRG1: an emerging player in disease pathogenesis

The secreted glycoprotein leucine-rich α-2 glycoprotein 1 (LRG1) was first described as a key player in pathogenic ocular neovascularization almost a decade ago. Since then, an increasing number of publications have reported the involvement of LRG1 in multiple human conditions including cancer, diabetes, cardiovascular disease, neurological disease, and inflammatory disorders. The purpose of this review is to provide, for the first time, a comprehensive overview of the LRG1 literature considering its role in health and disease. Although LRG1 is constitutively expressed by hepatocytes and neutrophils, Lrg1-/- mice show no overt phenotypic abnormality suggesting that LRG1 is essentially redundant in development and homeostasis. However, emerging data are challenging this view by suggesting a novel role for LRG1 in innate immunity and preservation of tissue integrity. While our understanding of beneficial LRG1 functions in physiology remains limited, a consistent body of evidence shows that, in response to various inflammatory stimuli, LRG1 expression is induced and directly contributes to disease pathogenesis. Its potential role as a biomarker for the diagnosis, prognosis and monitoring of multiple conditions is widely discussed while dissecting the mechanisms underlying LRG1 pathogenic functions. Emphasis is given to the role that LRG1 plays as a vasculopathic factor where it disrupts the cellular interactions normally required for the formation and maintenance of mature vessels, thereby indirectly contributing to the establishment of a highly hypoxic and immunosuppressive microenvironment. In addition, LRG1 has also been reported to affect other cell types (including epithelial, immune, mesenchymal and cancer cells) mostly by modulating the TGFβ signalling pathway in a context-dependent manner. Crucially, animal studies have shown that LRG1 inhibition, through gene deletion or a function-blocking antibody, is sufficient to attenuate disease progression. In view of this, and taking into consideration its role as an upstream modifier of TGFβ signalling, LRG1 is suggested as a potentially important therapeutic target. While further investigations are needed to fill gaps in our current understanding of LRG1 function, the studies reviewed here confirm LRG1 as a pleiotropic and pathogenic signalling molecule providing a strong rationale for its use in the clinic as a biomarker and therapeutic target

LRG1 as a novel therapeutic target in eye disease (vol 36, pg 328, 2022)

In the first published version of this article, the corresponding author was listed incorrectly. The corresponding author is only Giulia De Rossi, e-mail: [email protected] The original article has been corrected