A description of an automated database comparison program

An interactive FORTRAN computer comparison program designed to automatically locate regions of incongruity between two databases is described. The software, guided by user input parameters, incrementally compares the databases and generates plots of these regions in the databases which do not compare within a specified tolerance. Additionally, tools are provided within the software which enable the user to statistically reduce the number of data points in the databases compared. To facilitate the description of these tools, the procedures used to compare two aerodynamic databases for an F-18A fighter aircraft are detailed

Using Genomics to Identify High-Risk Myeloma after Autologous Stem Cell Transplantation

AbstractMultiple myeloma is a malignancy of antibody-secreting plasma cells that expand in the bone marrow. Although high-dose therapy/autologous stem cell transplantation has become the standard of care for patients with multiple myeloma, survival is highly variable and can range from a few years to >10 years after diagnosis. Application of high-throughput genomics on a large uniformly untreated cohort of patients has revealed that activation of 1 of the 3 cyclin D genes is a universal initiating event in this disease and that acquisition of abnormalities of chromosome 1 leads to activation of CKS1B, a regulator of p27Kip1 degradation. Synergy between cyclin D2 and CKS1B, but not cyclin D1 and CKS1B, may lead to early treatment failure

Hypersonic vehicle simulation model: Winged-cone configuration

Aerodynamic, propulsion, and mass models for a generic, horizontal-takeoff, single-stage-to-orbit (SSTO) configuration are presented which are suitable for use in point mass as well as batch and real-time six degree-of-freedom simulations. The simulations can be used to investigate ascent performance issues and to allow research, refinement, and evaluation of integrated guidance/flight/propulsion/thermal control systems, design concepts, and methodologies for SSTO missions. Aerodynamic force and moment coefficients are given as functions of angle of attack, Mach number, and control surface deflections. The model data were estimated by using a subsonic/supersonic panel code and a hypersonic local surface inclination code. Thrust coefficient and engine specific impulse were estimated using a two-dimensional forebody, inlet, nozzle code and a one-dimensional combustor code and are given as functions of Mach number, dynamic pressure, and fuel equivalence ratio. Rigid-body mass moments of inertia and center of gravity location are functions of vehicle weight which is in turn a function of fuel flow

Hypersonic vehicle control law development using H(infinity) and micron-synthesis

Hypersonic vehicle control law development using H(infinity) and mu-synthesis is discussed. Airbreathing SSTO vehicles has a mutli-faceted mission that includes orbital operations, as well as re-entry and descent culminating in horizontal landing. However, the most challenging part of the operations is the ascent to orbit. The airbreathing propulsion requires lengthy atmospheric flight that may last as long as 30 minutes and take the vehicle half way around the globe. The vehicles's ascent is characterized by tight payload to orbit margins which translate into minimum fuel orbit as the performance criteria. Issues discussed include: SSTO airbreathing vehicle issues; control system performance requirements; robust control law framework; H(infinity) controller frequency analysis; and mu controller frequency analysis

Hypersonic vehicle model and control law development using H(infinity) and micron synthesis

The control system design for a Single Stage To Orbit (SSTO) air breathing vehicle will be central to a successful mission because a precise ascent trajectory will preserve narrow payload margins. The air breathing propulsion system requires the vehicle to fly roughly halfway around the Earth through atmospheric turbulence. The turbulence, the high sensitivity of the propulsion system to inlet flow conditions, the relatively large uncertainty of the parameters characterizing the vehicle, and continuous acceleration make the problem especially challenging. Adequate stability margins must be provided without sacrificing payload mass since payload margins are critical. Therefore, a multivariable control theory capable of explicitly including both uncertainty and performance is needed. The H(infinity) controller in general provides good robustness but can result in conservative solutions for practical problems involving structured uncertainty. Structured singular value mu framework for analysis and synthesis is potentially much less conservative and hence more appropriate for problems with tight margins. An SSTO control system requires: highly accurate tracking of velocity and altitude commands while limiting angle-of-attack oscillations, minimized control power usage, and a stabilized vehicle when atmospheric turbulence and system uncertainty are present. The controller designs using H(infinity) and mu-synthesis procedures were compared. An integrated flight/propulsion dynamic mathematical model of a conical accelerator vehicle was linearized as the vehicle accelerated through Mach 8. Vehicle acceleration through the selected flight condition gives rise to parametric variation that was modeled as a structured uncertainty. The mu-analysis approach was used in the frequency domain to conduct controller analysis and was confirmed by time history plots. Results demonstrate the inherent advantages of the mu framework for this class of problems

The Maine Annex, vol. 1, no. 3

The Maine Annex, published by the students of the University of Maine at the Brunswick Campus, was launched January 10, 1947. Editors introduced the publication as the product of a group of progressive students attending the Brunswick Campus. The goal of the publication, according to editors, was to tell the story of our life on this campus. The four-page, tabloid-sized paper included display advertising from area businesses. Among front page headlines is: Pres. Hauck Addresses Maine Annex Students. President Hauck States That Education Is Now Recognized As One Of The Prime Factors In Building World Peace

The Maine Annex, vol. 1, no. 2

The Maine Annex, published by the students of the University of Maine at the Brunswick Campus, was launched January 10, 1947. Editors introduced the publication as the product of a group of progressive students attending the Brunswick Campus. The goal of the publication, according to editors, was to tell the story of our life on this campus. The four-page, tabloid-sized paper included display advertising from area businesses. Stories in this issue of The Maine Annex are news items of interest to World War II Veterans, including international news from Europe and tips regarding the filing of federal paperwork to secure veterans benefits

Maximum predictive power of the microarray-based models for clinical outcomes is limited by correlation between endpoint and gene expression profile

<p>Abstract</p> <p>Background</p> <p>Microarray data have been used for gene signature selection to predict clinical outcomes. Many studies have attempted to identify factors that affect models' performance with only little success. Fine-tuning of model parameters and optimizing each step of the modeling process often results in over-fitting problems without improving performance.</p> <p>Results</p> <p>We propose a quantitative measurement, termed consistency degree, to detect the correlation between disease endpoint and gene expression profile. Different endpoints were shown to have different consistency degrees to gene expression profiles. The validity of this measurement to estimate the consistency was tested with significance at a p-value less than 2.2e-16 for all of the studied endpoints. According to the consistency degree score, overall survival milestone outcome of multiple myeloma was proposed to extend from 730 days to 1561 days, which is more consistent with gene expression profile.</p> <p>Conclusion</p> <p>For various clinical endpoints, the maximum predictive powers of different microarray-based models are limited by the correlation between endpoint and gene expression profile of disease samples as indicated by the consistency degree score. In addition, previous defined clinical outcomes can also be reassessed and refined more coherent according to related disease gene expression profile. Our findings point to an entirely new direction for assessing the microarray-based predictive models and provide important information to gene signature based clinical applications.</p

The Maine Annex, vol. 1, no. 6

The Maine Annex, published by the students of the University of Maine at the Brunswick Campus, was launched January 10, 1947. Editors introduced the publication as the product of a group of progressive students attending the Brunswick Campus. The goal of the publication, according to editors, was to tell the story of our life on this campus. The four-page, tabloid-sized paper included display advertising from area businesses. Among front-page news are the results of the election of Class Officers and planning for a student Minstrel Show and dance to include black-face performances by University of Maine, Brunswick campus students

The Maine Annex, vol. 1, no. 5

The Maine Annex, published by the students of the University of Maine at the Brunswick Campus, was launched January 10, 1947. Editors introduced the publication as the product of a group of progressive students attending the Brunswick Campus. The goal of the publication, according to editors, was to tell the story of our life on this campus. The four-page, tabloid-sized paper included display advertising from area businesses. Among front-page news is coverage of the pending election of class officers