Investigation of plasticity-induced fatigue crack closure

Plasticity induced crack closure and constraint effects due to finite plate thickness are both fundamental aspects in the mechanics of fatigue cracks. Moreover, plasticity induced crack closure provides an effective first-order correction to the crack driving force, as used in the correlation and prediction of fatigue crack growth. The approach developed in this study utilises the distributed dislocation technique to model fatigue cracks growing under constant amplitude loading in finite thickness plates. Numerical results are obtained through the application of Gauss-Chebyshev quadrature and are presented for the crack opening stress ratio. An excellent agreement is observed with previous three-dimensional finite element studies

Geotechnical considerations for onshore wind turbines : adapting knowledge and experience for founding on South African pedocretes

Wind energy has been placed at the centre of the South African Government's Renewable Energy Independent Producer Programme (REIPPP) with the purpose of addressing electricity capacity deficits and poor service delivery. In doing so, substantial wind farm development has been proposed for the Western, Eastern and Northern Cape of South Africa, with several projects already underway. Wind energy, from a technological standpoint, is regarded as a mature form of renewable energy. However, much of the wind turbine geotechnical experience was gained in the temperate climate of the Northern Hemisphere, where soil conditions differ significantly from those of South Africa. Simultaneously, although mature, wind energy is a novel field in South Africa. Therefore, this study sought the need bridge the gap between local South African soil conditions and international wind energy experience. It was against this backdrop that the following study was initiated, which aimed to provide insight into the site-specific geotechnical design of foundations for wind turbine structures. In doing so, this major objective was divided into four minor objectives, each contributing a major theme to the study, the key points of which are summarised below. It should be noted that the following study was limited to three-blade wind turbines mounted on conical tubular steel towers with shallow foundations

Youth ministry at the margins and/or centre as space of the other: Reflections on the resolutions of the Anglican dioceses in the Western Cape 2017

Youth within the context of faith-based organisations carry with them certain power relations and misconstrued connotations. These power relations and connotations can contribute to alienation and marginalisation. The resolutions taken at the recent synods of the three dioceses within the Western Cape reflect and identify the areas - both liturgical and governance - of marginalisation of youth within the Anglican Church in southern Africa. The resolutions also call on the church governing bodies and the leaders to create safe spaces for the youth to be a central part of the mission of the church. Areas such as liturgy, training and formation, contemporary worship and nurturing relationships are identified within the resolutions. Theological notions of personhood within the Anglican tradition are to be investigated as possible motivations for more acceptable power relations of the youth and leaders and governance structures. What implications do such theological formulations have for the space that the youth occupy within the margins of the church? A critical reflection of the synod resolutions answers such questions and points to some contours for sense making of the youth within the margins of the church from a faith-based organisational perspective

Severity of acute Zika virus infection:A prospective emergency room surveillance study during the 2015-2016 outbreak in Suriname

Acute Zika virus (ZIKV) infection is usually mild and self-limiting. Earlier, we reported three cases of fatal acute ZIKV infection in patients without typical signs of ZIKV, but rather with criteria of systemic inflammation response syndrome (SIRS). To follow up these observations, we prospectively included patients at the emergency room with temperature instability and suspected to have acute ZIKV infection, SIRS, or both. A total of 102 patients were included of whom N = 21 (21%) were suspected of acute ZIKV infection, N = 56 (55%) of acute ZIKV infection with SIRS criteria, and N = 25 (24%) of SIRS alone. ZIKV-PCR was positive in N = 21 (20%) patients. Eight (38%) ZIKV-positive patients needed admission to the hospital of whom four (50%) presented with SIRS alone. One ZIKV-positive patient had vascular co-morbidity and died following shock and severe coagulopathy. We confirm the hypothesis that acute ZIKV infection can present atypical and severely with systemic inflammation and have lethal course particularly amongst patients with significant prior disease

Zika virus infection and Guillain-Barré syndrome in three patients from Suriname

We present three patients from Suriname who were diagnosed with Guillain-Barré syndrome (GBS) during the Zika virus (ZIKV) outbreak in this country. One patient had a positive ZIKV urine real-time RT-PCR (qRT-PCR) result. The other two patients had a negative ZIKV urine qRT-PCR but a positive virus neutralization test and presence of IgG antibodies against ZIKV in the serum. Considering the evidence of a past ZIKV infection and absence of evidence for recent infections with the most common preceding infections of GBS, it is very likely that these GBS cases were triggered by ZIKV

Subregional DXA-derived vertebral bone mineral measures are stronger predictors of failure load in specimens with lower areal bone mineral density, compared to those with higher areal bone mineral density

Measurement of areal bone mineral density (aBMD) in intravertebral subregions may increase the diagnostic sensitivity of dual-energy X-ray absorptiometry (DXA)-derived parameters for vertebral fragility. This study investigated whether DXA-derived bone parameters in vertebral subregions were better predictors of vertebral bone strength in specimens with low aBMD, compared to those with higher aBMD. Twenty-five lumbar vertebrae (15 embalmed and 10 fresh-frozen) were scanned with posteroanterior- (PA) and lateral-projection DXA, and then mechanically tested in compression to ultimate failure. Whole-vertebral aBMD and bone mineral content (BMC) were measured from the PA- and lateral-projection scans and within 6 intravertebral subregions. Multivariate regression was used to predict ultimate failure load by BMC, adjusted for vertebral size and specimen fixation status across the whole specimen set, and when subgrouped into specimens with low aBMD and high aBMD. Adjusted BMC explained a substantial proportion of variance in ultimate vertebral load, when measured over the whole vertebral area in lateral projection (adjusted R2 0.84) and across the six subregions (ROIs 2–7) (adjusted R2 range 0.58–0.78). The association between adjusted BMC, either measured subregionally or across the whole vertebral area, and vertebral failure load, was increased for the subgroup of specimens with identified ‘low aBMD’, compared to those with ‘high aBMD’, particularly in the anterior subregion where the adjusted R2 differed by 0.44. The relative contribution of BMC measured in vertebral subregions to ultimate failure load is greater among specimens with lower aBMD, compared to those with higher aBMD, particularly in the anterior subregion of the vertebral body

Relative adrenal insufficiency in mice deficient in 5α-reductase 1

Patients with critical illness or hepatic failure exhibit impaired cortisol responses to ACTH, a phenomenon known as ‘relative adrenal insufficiency’. A putative mechanism is that elevated bile acids inhibit inactivation of cortisol in liver by 5α-reductases type 1 and type 2 and 5β-reductase, resulting in compensatory downregulation of the hypothalamic–pituitary–adrenal axis and adrenocortical atrophy. To test the hypothesis that impaired glucocorticoid clearance can cause relative adrenal insufficiency, we investigated the consequences of 5α-reductase type 1 deficiency in mice. In adrenalectomised male mice with targeted disruption of 5α-reductase type 1, clearance of corticosterone was lower after acute or chronic (eightfold, P<0.05) administration, compared with WT control mice. In intact 5α-reductase-deficient male mice, although resting plasma corticosterone levels were maintained, corticosterone responses were impaired after ACTH administration (26% lower, P<0.05), handling stress (2.5-fold lower, P<0.05) and restraint stress (43% lower, P<0.05) compared with WT mice. mRNA levels of Nr3c1 (glucocorticoid receptor), Crh and Avp in pituitary or hypothalamus were altered, consistent with enhanced negative feedback. These findings confirm that impaired peripheral clearance of glucocorticoids can cause ‘relative adrenal insufficiency’ in mice, an observation with important implications for patients with critical illness or hepatic failure, and for patients receiving 5α-reductase inhibitors for prostatic disease

Non-linear individual and interaction phenomena associated with fatigue crack growth.

The fatigue of materials and structures is a subject that has been under investigation for almost 160 years; yet reliable fatigue life predictions are still more of an empirical art than a science. The traditional safe-life approach to fatigue design is based upon the total time to failure of a virtually defect free component. This approach is heavily reliant on the use of safety factors and empirical equations, and therefore much scatter in the fatigue life predictions is normally observed. Furthermore, the safe-life approach is unsuitable for many important applications such as aircraft, pressure vessels, welded structures, and microelectronic devices. In these applications the existence of initial defects is practically unavoidable and the time of propagation from an initial defect to final failure is comparable with the total life of the component. In the early 1970’s, the aircraft industry pioneered a new approach for the analysis of fatigue crack growth, known as damage tolerant design. This approach utilises fracture mechanics principles to consider the propagation of fatigue cracks from an initial crack length until final fracture, or a critical crack length, is reached. Since the first implementation of damage tolerant design, much research and development has been undertaken. In particular, theoretical and experimental fracture mechanics techniques have been utilised for the investigation of a wide variety of fatigue crack growth phenomena. One such example is the retardation and acceleration in crack growth rate caused by spike overloads or underloads. It is generally accepted, however, that the current level of understanding of fatigue crack growth phenomena and the adequacy of fatigue life prediction techniques are still far from satisfactory. This thesis theoretically investigates various non-linear individual and interaction phenomena associated with fatigue crack growth. Specifically, the effect of plate thickness on crack growth under constant amplitude loading, crack growth retardation due to an overload cycle, and small crack growth from sharp notches are considered. A new semianalytical method is developed for the investigations, which utilises the distributed dislocation technique and the well-known concept of plasticity-induced crack closure. The effects of plate thickness are included through the use of first-order plate theory and a fundamental solution for an edge dislocation in plate of arbitrary thickness. Numerical results are obtained via the application of Gauss-Chebyshev quadrature and an iterative procedure. The developed methods are verified against previously published theoretical and experimental data. The elastic out-of-plane stress and displacement fields are first investigated using the developed method and are found to be in very good agreement with past experimental results and finite element simulations. Crack tip plasticity is then introduced by way of a strip-yield model. The effects of thickness on the crack tip plasticity zone and plasticity-induced crack closure are studied for both small and large-scale yielding conditions. It is shown that, in general, an increase in plate thickness will lead to a reduction in the extent of the plasticity and associated crack closure, and therefore an increase in the crack growth rates. This observation is in agreement with many findings of past experimental and theoretical studies. An incremental crack growth scheme is implemented into the developed method to allow for the investigation of variable amplitude loading and small fatigue crack growth. The case of a single tensile overload is first investigated for a range of overload ratios and plate thicknesses. This situation is of practical importance as an overload cycle can significantly increase the service life of a cracked component by temporarily retarding the crack growth. Next to be studied is growth of physically small cracks from sharp notches. Fatigue cracks typically initiate from stress concentrations, such as notches, and can grow at rates higher than as predicted for a long established crack. This can lead to non-conservative estimates for the total fatigue life of a structural component. For both the overload and small crack cases, the present theoretical predictions correlate well with past experimental results for a range of materials. Furthermore, trends observed in the experiments match those of the predictions and can be readily explained through use of crack closure arguments. This thesis is presented in the form of a collection of published or submitted journal articles that are the result of research by the author. These nine articles have been chosen to best demonstrate the development and application of the new theoretical techniques. Additional background information and an introduction into the chosen field of research are provided in order to establish the context and significance of this work.Thesis (Ph.D.) - University of Adelaide, School of Mechanical Engineering, 200

Long-Range Pseudorapidity Correlations at High pT in sqrt(S_NN) = 200 GeV Au+Au Collisions with STAR

The Quark Gluon Plasma (QGP) is a form of matter in which quarks and gluons are deconfined, and was suggested to be formed in high-energy heavy-ion collisions. Since the discovery of high-pT hadron suppression in central Au+Au collisions at the Relativistic Heavy Ion Collider (RHIC), and the related discovery of the quenching of the away-side jet in these collisions, the role of jets as key probes of the QGP was re-affirmed. The Solenoidal Tracker At RHIC (STAR) detector system, which is suited for jet studies because of its large solid-angle coverage, has produced a number of interesting jet measurements in recent years, including gamma-jet measurements, attempts at full heavy-ion jet reconstruction, and two-dimensional correlations. A long-range correlation in pseudorapidity (the ?Ridge?) was studied (with statistical significance) out to pT^trig. <? 7 GeV /c and was assumed to have an integrated yield independent of pT^trig. Further studies out to higher pT were limited by the minimum biased statistics taken in Run 4 (2004) with STAR. This work presents results of a ridge analysis with (non-reconstructed) pi0s and direct-gamma-rich triggers out to ?13.5 GeV /c in pT^trig. Using triggered data from Run 7 (2007) and Run 10 (2010) Au+Au collisions detected with STAR. Preliminary results seem to indicate that the ridge yield decreases with pT^trig., and that the ridge yield for direct-?-rich triggers is consistent with zero

New passive defect detection technique

Crows Nest, N.S.W