Exclusion, Employment and Opportunity

The relationships between employment, education, opportunity, social exclusion and poverty are central to current policy debates. Atkinson argues that the concepts of poverty, unemployment and social exclusion are closely related, but are not the same. People may be poor without being socially excluded, and vice versa. Unemployment may cause poverty, but this can be prevented. Equally, marginal jobs do not ensure social inclusion. Britton argues that convential economic analysis misses a key part of the problem of unemployment: the role of work in providing self-esteem and non-material parts of human well-being. Hills examines whether new evidence on income mobility implies less worry about inequality and relative poverty. Some low income is transitory, but the 'poverty problem' discounting this remains 80-90 per cent of that shown by cross-section surveys. Machin finds that intergenerational mobility is limited in terms of earnings and education, and that childhood disadvantage has effects long into adult life and is an important factor in maintaining immobility of economic status across generations. Arulampalam and Booth suggest that there is a trade-off between expanding more marginal forms of employment and expanding the proportion of the workforce getting work-related training. Workers in temporary or short-term contracts, part-time, and non-unionised employment are less likely to receive work-related training. Green and colleagues compare 1986 and 1997 surveys to show that skill levels for British workers have been rising, not just in the qualifications needed to get jobs, but also in the skills actually used in them. There is no evidence of 'credentialism'.social exclusion, income mobility, employment, skills

Discrete Holomorphicity at Two-Dimensional Critical Points

After a brief review of the historical role of analyticity in the study of critical phenomena, an account is given of recent discoveries of discretely holomorphic observables in critical two-dimensional lattice models. These are objects whose correlation functions satisfy a discrete version of the Cauchy-Riemann relations. Their existence appears to have a deep relation with the integrability of the model, and they are presumably the lattice versions of the truly holomorphic observables appearing in the conformal field theory (CFT) describing the continuum limit. This hypothesis sheds light on the connection between CFT and integrability, and, if verified, can also be used to prove that the scaling limit of certain discrete curves in these models is described by Schramm-Loewner evolution (SLE).Comment: Invited talk at the 100th Statistical Mechanics Meeting, Rutgers, December 200

Plate-like subsidence of the East Pacific Rise - South Pacific Superswell system

In previous studies the removal of small-scale features such as seamounts and oceanic islands from bathymetry has revealed a large and unusually shallow region in the South Pacific Ocean, which, at 3000 km wide and up to 1 km high, has been dubbed a “superswell.” These studies use statistical techniques based on finding the modal depth of the bathymetry. Such an analysis, however, does not completely isolate these features, or their associated oceanic plateaus and localized hot spot swells, from the ridge-generated regional bathymetry upon which they are superimposed. Accordingly, a technique is required that passes beneath topographic constructs rather than through them, as is the tendency of the mean, median, or mode. We have developed an algorithm, MiMIC, that reproducibly removes all these features and reveals the large-scale bathymetric trends in a manner based upon and consistent with manual interpretation. Application of the algorithm to bathymetry data in the southwest Pacific shows that the depth anomaly with respect to a cooling plate model changes steadily from being too deep at the East Pacific Rise (EPR) crest to being too shallow at the superswell. The largest shallow anomaly of 712 ± 66 m occurs at 98 Ma, not 1300 m at 65 Ma, as has been previously suggested. Most significantly, the superswell appears to be part of a large-scale, “plate-like,” subsidence that extends to the EPR crest, rather than an isolated shallowing that reverses the subsidence and causes uplift. We interpret the plate-like subsidence as due in part to cooling of the oceanic lithosphere and in part to a lateral temperature gradient in the underlying asthenosphere which is maintained by the flow of relatively hot material from beneath the superswell toward the relative cold material beneath the EPR. The best fit model implies a lateral temperature gradient of 0.014°C km−1 and is in general accord with the available effective elastic thickness, crustal thickness, heat flow, and seismic tomography data

The Rho kinases I and II regulate different aspects of myosin II activity

The homologous mammalian rho kinases (ROCK I and II) are assumed to be functionally redundant, based largely on kinase construct overexpression. As downstream effectors of Rho GTPases, their major substrates are myosin light chain and myosin phosphatase. Both kinases are implicated in microfilament bundle assembly and smooth muscle contractility. Here, analysis of fibroblast adhesion to fibronectin revealed that although ROCK II was more abundant, its activity was always lower than ROCK I. Specific reduction of ROCK I by siRNA resulted in loss of stress fibers and focal adhesions, despite persistent ROCK II and guanine triphosphate–bound RhoA. In contrast, the microfilament cytoskeleton was enhanced by ROCK II down-regulation. Phagocytic uptake of fibronectin-coated beads was strongly down-regulated in ROCK II–depleted cells but not those lacking ROCK I. These effects originated in part from distinct lipid-binding preferences of ROCK pleckstrin homology domains. ROCK II bound phosphatidylinositol 3,4,5P3 and was sensitive to its levels, properties not shared by ROCK I. Therefore, endogenous ROCKs are distinctly regulated and in turn are involved with different myosin compartments

Measured and self-estimated trait emotional intelligence in a UK sample of managers

AbstractTrait emotional intelligence (EI) was measured and self-estimated in a UK sample of 128 managers (52.3% female), recruited at a professional services firm. Participants’ measured scores were compared to standardization sample data and gender differences in measured and estimated scores, as well as in estimation bias and accuracy were examined. As hypothesized, managers’ global trait EI scores were significantly higher than those of the normative sample of the measure used, although the scores of female participants were largely responsible for this difference. Gender-specific hypotheses were confirmed for measured scores (differences only hypothesized at the factor level) and estimation accuracy (males estimating their trait EI more accurately), but not for estimated scores (female participants had higher estimates, but the opposite was hypothesized). Further, female managers showed signs of estimation bias

Climate variability and change in the spices and plantation cropping systems in Kerala state, India

Kerala state in India has rich bio-diversity and tropical rain forests and is spread in 13 agro-ecological zones under the humid tropics. Rainfall decline (annual as well as monsoon), increase in temperature and climate shift towards lesser humid zones within the humid climate are the notable characteristics of the state. Cropping system changes, as well as changes in the production of spices and plantation crops in Kerala, were analyzed from 1952-53 to 2018-19. Area and production changes of various crops in the Idukki district have also been studied and presented in this paper. The average temperature in Kerala has risen by 0.65 °C from 1956 to 2014. In Idukki high ranges, the maximum temperature is increasing, and the minimum temperature is declining, resulting in a widening of temperature ranges. Such a scenario may adversely affect the thermo-sensitive crops, which may need urgent attention as these crops are grown in the forest-agro-ecosystems across the Cardamom Hill Reserve (CHR) of the Idukki district. Deforestation, the shift in cropping systems, declining wetlands, and depletion of surface and groundwater resources had deepened the adverse effects of floods and droughts on spice and plantation crops. Therefore, there is an urgent need for proactive steps on a short and long-term basis against the climate change risks for the sustenance of crop production both in terms of quality and volume

mRNA transfection of mouse and human neural stem cell cultures

The use of synthetic mRNA as an alternative gene delivery vector to traditional DNA-based constructs provides an effective method for inducing transient gene expression in cell cultures without genetic modification. Delivery of mRNA has been proposed as a safer alternative to viral vectors in the induction of pluripotent cells for regenerative therapies. Although mRNA transfection of fibroblasts, dendritic and embryonic stem cells has been described, mRNA delivery to neurosphere cultures has not been previously reported. Here we sought to establish an efficient method for delivering mRNA to primary neurosphere cultures. Neurospheres derived from the subventricular zone of adult mice or from human embryonic stem cells were transfected with EGFP mRNA by lipofection and electroporation. Transfection efficiency and expression levels were monitored by flow cytometry. Cell survival following transfection was examined using live cell counting and the MTT assay. Both lipofection and electroporation provided high efficiency transfection of neurospheres. In comparison with lipofection, electroporation resulted in increased transfection efficiencies, but lower expression per cell and shorter durations of expression. Additional rounds of lipofection renewed EGFP expression in neurospheres, suggesting this method may be suitable for reprogramming applications. In summary, we have developed a protocol for achieving high efficiency transfection rates in mouse and human neurosphere cell culture that can be applied for future studies of gene function studies in neural stem cells, such as defining efficient differentiation protocols for glial and neuronal linages

Evaluation of milk yield losses associated with Salmonella antibodies in bulk-tank milk in bovine dairy herds

The effect of Salmonella on milk production is not well established in cattle. The objective of this study was to investigate whether introduction of Salmonella into dairy cattle herds was associated with reduced milk yield and the duration of any effect. Longitudinal data from 2005 through 2009 were used, with data from 12 months before until 18 months after the estimated date of infection. Twenty-eight case herds were selected based on an increase in the level of Salmonella specific antibodies in bulk-tank milk from < 10 corrected optic density percentage (ODC%) to ≥ 70 ODC% between two consecutive 3-monthly measurements in the Danish Salmonella surveillance program. All selected case herds were conventional Danish Holstein herds. Control herds (n = 40) were selected randomly from Danish Holstein herds with Salmonella antibody levels consistently < 10 ODC%. A date of herd infection was randomly allocated to the control herds. Hierarchical mixed effect models with the outcome test day energy corrected milk yield (ECM)/cow were used to investigate the daily milk yield before and after the estimated herd infection date for cows in parity 1, 2 and 3+. Control herds were used to evaluate whether the effects in the case herds could be reproduced in herds without Salmonella infection. Herd size, days in milk, somatic cell count, season, and year were included in the models. The key results were that first parity cow yield was reduced by a mean of 1.4 kg (95% CI: 0.5 to 2.3) ECM/cow per day from seven to 15 months after the estimated herd infection date, compared with first parity cows in the same herds in the 12 months before the estimated herd infection date. Yield for parity 3+ was reduced by a mean of 3.0 kg (95% CI: 1.3 to 4.8) ECM/cow per day from seven to 15 months after herd infection compared with parity 3+ cows in the 12 months before the estimated herd infection. There were minor differences in yield in second parity cows before and after herd infection, and no difference between cows in control herds before and after the simulated infection date. There was a significant drop in milk yield in affected herds and the reduction was detectable several months after the increase in bulk-tank milk Salmonella antibodies. It took more than a year for milk yield to return to pre- infection levels

A Mixed Phase of SUSY Gauge Theories from a-Maximization

We study N=1 supersymmetric SU(N) gauge theories with an antisymmetric tensor and F flavors using the recent proposal of a-maximization by Intriligator and Wecht. This theory had previously been studied using the method of "deconfinement", but such an analysis was not conclusive since anomalous dimensions in the non-perturbative regime could not be calculated. Using a-maximization we show that for a large range of F the theory is at an interacting superconformal fixed point. However, we also find evidence that for a range of F the theory in the IR splits into a free "magnetic" gauge sector and an interacting superconformal sector.Comment: 18 pages, 3 figure