Rehabilitation Using Mobile Health for Older Adults With Ischemic Heart Disease in the Home Setting (RESILIENT): Protocol for a Randomized Controlled Trial

BACKGROUND: Participation in ambulatory cardiac rehabilitation remains low, especially among older adults. Although mobile health cardiac rehabilitation (mHealth-CR) provides a novel opportunity to deliver care, age-specific impairments may limit older adults\u27 uptake, and efficacy data are currently lacking. OBJECTIVE: This study aims to describe the design of the rehabilitation using mobile health for older adults with ischemic heart disease in the home setting (RESILIENT) trial. METHODS: RESILIENT is a multicenter randomized clinical trial that is enrolling patients aged \u3e /=65 years with ischemic heart disease in a 3:1 ratio to either an intervention (mHealth-CR) or control (usual care) arm, with a target sample size of 400 participants. mHealth-CR consists of a commercially available mobile health software platform coupled with weekly exercise therapist sessions to review progress and set new activity goals. The primary outcome is a change in functional mobility (6-minute walk distance), which is measured at baseline and 3 months. Secondary outcomes are health status, goal attainment, hospital readmission, and mortality. Among intervention participants, engagement with the mHealth-CR platform will be analyzed to understand the characteristics that determine different patterns of use (eg, persistent high engagement and declining engagement). RESULTS: As of December 2021, the RESILIENT trial had enrolled 116 participants. Enrollment is projected to continue until October 2023. The trial results are expected to be reported in 2024. CONCLUSIONS: The RESILIENT trial will generate important evidence about the efficacy of mHealth-CR among older adults in multiple domains and characteristics that determine the sustained use of mHealth-CR. These findings will help design future precision medicine approaches to mobile health implementation in older adults. This knowledge is especially important in light of the COVID-19 pandemic that has shifted much of health care to a remote, internet-based setting. TRIAL REGISTRATION: ClinicalTrials.gov NCT03978130; https://clinicaltrials.gov/ct2/show/NCT03978130. INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID): DERR1-10.2196/32163

Slow gait speed and cardiac rehabilitation participation in older adults after acute myocardial infarction

Background Lack of participation in cardiac rehabilitation ( CR ) and slow gait speed have both been associated with poor long‐term outcomes in older adults after acute myocardial infarction ( AMI ). Whether the effect of CR participation on outcomes after AMI differs by gait speed is unknown. Methods and Results We examined the association between gait speed and CR participation at 1 month after discharge after AMI , and death and disability at 1 year, in 329 patients aged ≥65 years enrolled in the TRIUMPH (Translational Research Investigating Underlying Disparities in Recovery From Acute Myocardial Infarction: Patients' Health Status) registry. Among these patients, 177 (53.7%) had slow gait speed (&lt;0.8 m/s) and 109 (33.1%) participated in CR . Patients with slow gait speed were less likely to participate in CR compared with patients with normal gait speed (27.1% versus 40.1%; P =0.012). In unadjusted analysis, CR participants with normal gait speed had the lowest rate of death or disability at 1 year (9.3%), compared with those with slow gait speed and no CR participation (43.2%). After adjustment for cardiovascular risk factors and cognitive impairment, both slow gait speed (odds ratio, 2.30; 95% confidence interval, 1.30–4.06) and non‐ CR participation (odds ratio, 2.34; 95 confidence interval, 1.22–4.48) were independently associated with death or disability at 1 year. The effect of CR on the primary outcome did not differ by gait speed ( P =0.70). Conclusions CR participation is associated with reduced risk for death or disability after AMI . The beneficial effect of CR participation does not differ by gait speed, suggesting that slow gait speed alone should not preclude referral to CR for older adults after AMI . </jats:sec

Characterization of microRNA expression in bovine adipose tissues: a potential regulatory mechanism of subcutaneous adipose tissue development

<p>Abstract</p> <p>Background</p> <p>MicroRNAs (miRNAs), a family of small non-coding RNA molecules, appear to regulate animal lipid metabolism and preadipocyte conversion to form lipid-assimilating adipocytes (<it>i.e. </it>adipogenesis). However, no miRNA to date has been reported to modulate adipogenesis and lipid deposition in beef cattle.</p> <p>Results</p> <p>The expression patterns of 89 miRNAs including four bovine specific miRNAs in subcutaneous adipose tissues from three groups of crossbred steers differing in backfat thickness were compared using qRT-PCR analysis. Eighty-six miRNAs were detectable in all samples, with 42 miRNAs differing among crossbreds (P < 0.05) and 15 miRNAs differentially expressed between tissues with high and low backfat thickness (P < 0.05). The expression levels of 18 miRNAs were correlated with backfat thickness (P < 0.05). The miRNA most differentially expressed and the most strongly associated with backfat thickness was miR-378, with a 1.99-fold increase in high backfat thickness tissues (r = 0.72).</p> <p>Conclusions</p> <p>MiRNA expression patterns differed significantly in response to host genetic components. Approximately 20% of the miRNAs in this study were identified as being correlated with backfat thickness. This result suggests that miRNAs may play a regulatory role in white adipose tissue development in beef animals.</p

Proteome differences associated with fat accumulation in bovine subcutaneous adipose tissues

<p>Abstract</p> <p>Background</p> <p>The fat components of red meat products have been of interest to researchers due to the health aspects of excess fat consumption by humans. We hypothesized that differences in protein expression have an impact on adipose tissue formation during beef cattle development and growth. Therefore, in this study we evaluated the differences in the discernable proteome of subcutaneous adipose tissues of 35 beef crossbred steers [Charolais × Red Angus (CHAR) (n = 13) and Hereford × Angus (HEAN) (n = 22)] with different back fat (BF) thicknesses. The goal was to identify specific protein markers that could be associated with adipose tissue formation in beef cows.</p> <p>Results</p> <p>Approximately 541-580 protein spots were detected and compared in each crossbred group, and 33 and 36 protein spots showed expression differences between tissues with high and low BF thicknesses from HEAN and CHAR crossbed, respectively. The annexin 1 protein was highly expressed in both crossbred steers that had a higher BF thickness (p < 0.05) and this was further validated by a western blot analysis. In 13 tissues of CHAR animals and 22 tissues of HEAN animals, the relative expression of annexin 1 was significantly different (p < 0.05) between tissues with high and low BF thicknesses.</p> <p>Conclusion</p> <p>The increased expression of annexin 1 protein has been found to be associated with higher BF thickness in both crossbred steers. This result lays the foundation for future studies to develop the protein marker for assessing animals with different BF thickness.</p

A Spitzer IRS Study of Debris Disks Around Planet-Host Stars

Since giant planets scatter planetesimals within a few tidal radii of their orbits, the locations of existing planetesimal belts indicate regions where giant planet formation failed in bygone protostellar disks. Infrared observations of circumstellar dust produced by colliding planetesimals are therefore powerful probes of the formation histories of known planets. Here we present new Spitzer IRS spectrophotometry of 111 Solar-type stars, including 105 planet hosts. Our observations reveal 11 debris disks, including two previously undetected debris disks orbiting HD 108874 and HD 130322. Combining our 32 micron spectrophotometry with previously published MIPS photometry, we find that the majority of debris disks around planet hosts have temperatures in the range 60 < T < 100 K. Assuming a dust temperature T = 70 K, which is representative of the nine debris disks detected by both IRS and MIPS, we find that debris rings surrounding Sunlike stars orbit between 15 and 240 AU, depending on the mean particle size. Our observations imply that the planets detected by radial-velocity searches formed within 240 AU of their parent stars. If any of the debris disks studied here have mostly large, blackbody emitting grains, their companion giant planets must have formed in a narrow region between the ice line and 15 AU.Comment: Accepted for publication in the Astronomical Journal. 14 pages, including five figures and two table

Vacuum ultraviolet photoionization cross section of the hydroxyl radical

The absolute photoionization spectrum of the hydroxyl (OH) radical from 12.513 to 14.213 eV was measured by multiplexed photoionization mass spectrometry with time-resolved radical kinetics. Tunable vacuum ultraviolet (VUV) synchrotron radiation was generated at the Advanced Light Source. OH radicals were generated from the reaction of O(^1D) + H_2O in a flow reactor in He at 8 Torr. The initial O(^1D) concentration, where the atom was formed by pulsed laser photolysis of ozone, was determined from the measured depletion of a known concentration of ozone. Concentrations of OH and O(^3P) were obtained by fitting observed time traces with a kinetics model constructed with literature rate coefficients. The absolute cross section of OH was determined to be σ(13.436 eV) = 3.2 ± 1.0 Mb and σ(14.193 eV) = 4.7 ± 1.6 Mb relative to the known cross section for O(^3P) at 14.193 eV. The absolute photoionization spectrum was obtained by recording a spectrum at a resolution of 8 meV (50 meV steps) and scaling to the single-energy cross sections. We computed the absolute VUV photoionization spectrum of OH and O(^3P) using equation-of-motion coupled-cluster Dyson orbitals and a Coulomb photoelectron wave function and found good agreement with the observed absolute photoionization spectra

Towards global sustainability: Education on environmentally clean energy technologies

The recent climate change agreement in Paris highlights the imperative to aggressively decarbonize the energy economy and develop new technologies, especially for the generation of electrical energy that are environmentally clean. This challenge can only be addressed by a multi-pronged approach to research and education of the next generation of scientists and engineers as well as informed public discourse. Consequently this requires the introduction of new and comprehensive education programs on sustainable energy technologies for universities and, possibly, high schools. Among others, the new programs should provide in-depth knowledge in the development of new materials for more efficient energy conversion systems and devices. The enhanced level of education is also needed for properly assessing the competing technologies in terms of their economic and social benefits. The increasing recognition of the significance of clean and efficient energy conversion indicates the need for a comprehensive education program to be developed. The purpose of the present work is to consider the structure of both an education program and the related textbook where the energy-related fundamental and applied subjects are presented in a concentrated and uniform manner. Such a textbook could be an education aid for students of energy-related courses as well as the teachers involved in the formulation of the education programs. The textbook, which should be dedicated mainly for students at the undergraduate levels at universities, and possibly high schools, should include in-depth interdisciplinary sections dedicated to energy experts and graduate students. This paper considers the present international efforts in reducing the impact of climate change and the need to develop new technologies for clean energy generation. It is argued that progress in this area requires recognition of hydrogen as the main energy carrier of the future. This work also delineates the goals of the Sustainable Energy Network, SEN, involved in the UN program of Future Earth