Creep fatigue life prediction for engine hot section materials (isotropic): Fourth year progress review

As gas turbine technology continues to advance, the need for advanced life prediction methods for hot section components is becoming more and more evident. The complex local strain and temperature histories at critical locations must be accurately interpreted to account for the effects of various damage mechanisms (such as fatigue, creep, and oxidation) and their possible interactions. As part of the overall NASA HOST effort, this program is designed to investigate these fundamental damage processes, identify modeling strategies, and develop practical models which can be used to guide the early design and development of new engines and to increase the durability of existing engines

Creep fatigue life prediction for engine hot section materials (isotropic): Third year progress review

This program is designed to investigate fundamental damage processes, identify modeling strategies, and develop practical models which can be used to guide the early design and development of new engines and to increase the durability of existing engines. A review is given of the base program, completed in 1984, which included the comparison and evaluation of several popular high-temperature life prediction approaches as applied to continuously cycled isothermal specimen tests. The option program, of which one year is completed, is designed to develop models which can account for complex cycles and loadings, such as thermomechanical cycling, cumulative damage, multiaxial stress/strain rates, and environmental effects

Cyclura ricordii

Number of Pages: 3Integrative BiologyGeological Science

Cyclura cornuta

Number of Pages: 6Integrative BiologyGeological Science

Mifepristone reduces insulin resistance in patient volunteers with adrenal incidentalomas that secrete low levels of cortisol : a pilot study

Background: Incidental adrenal masses are commonly detected during imaging for other pathologies. 10% of the elderly population has an ‘adrenal incidentaloma’, up to 20% of these show low-grade autonomous cortisol secretion and 60% of patients with autonomous cortisol secretion have insulin resistance. Cortisol excess is known to cause insulin resistance, an independent cardiovascular risk marker, however in patients with adrenal incidentalomas it is unknown whether their insulin resistance is secondary to the excess cortisol and therefore potentially reversible. In a proof of concept study we examined the short-term effects of glucocorticoid receptor (GR) antagonism in patients with an adrenal incidentaloma to determine whether their insulin resistance was reversible. Methodology/Principal Findings: In a prospective open-label pilot study, six individuals with adrenal incidentalomas and autonomous cortisol secretion were treated with mifepristone (a GR antagonist) 200 mg twice daily and studied for 4 weeks on a Clinical Research Facility. Insulin resistance at four weeks was assessed by insulin resistance indices, lnHOMA-IR and lnMatsuda, and AUC insulin during a 2-hour glucose tolerance test. Biochemical evidence of GR blockade was shown in all individuals and across the group there was a significant reduction in insulin resistance: lnHOMA-IR (1.0vs0.6; p = 0.03), lnHOMA-%beta (4.8vs4.3; p = 0.03) and lnMatsuda (1.2vs1.6; p = 0.03). Five out of six individuals showed a reduction in insulin AUC .7237 pmol/l.min, and in two patients this showed a clinically significant cardiovascular benefit (as defined by the Helsinki heart study). Conclusions: Short-term GR antagonism is sufficient to reduce insulin resistance in some individuals with adrenal incidentalomas and mild cortisol excess. Further assessment is required to assess if the responses may be used to stratify therapy as adrenal incidentalomas may be a common remediable cause of increased cardiovascular risk

Shadow of noncommutativity

We analyse the structure of the $\kappa=0$ limit of a family of algebras $A_\kappa$ describing noncommutative versions of space-time, with $\kappa$ a parameter of noncommutativity. Assuming the Poincar\'e covariance of the $\kappa=0$ limit, we show that, besides the algebra of functions on Minkowski space, $A_0$ must contain a nontrivial extra factor $A^I_0$ which is Lorentz covariant and which does not commute with the functions whenever it is not commutative. We give a general description of the possibilities and analyse some representative examples.Comment: 19 pages, Latex2e, available at http://qcd.th.u-psud.f

Markerless View Independent Gait Analysis with Self-camera Calibration

We present a new method for viewpoint independent markerless gait analysis. The system uses a single camera, does not require camera calibration and works with a wide range of directions of walking. These properties make the proposed method particularly suitable for identification by gait, where the advantages of completely unobtrusiveness, remoteness and covertness of the biometric system preclude the availability of camera information and use of marker based technology. Tests on more than 200 video sequences with subjects walking freely along different walking directions have been performed. The obtained results show that markerless gait analysis can be achieved without any knowledge of internal or external camera parameters and that the obtained data that can be used for gait biometrics purposes. The performance of the proposed method is particularly encouraging for its appliance in surveillance scenarios