10 research outputs found
Observation of gravitational waves from the coalescence of a 2.5â4.5 Mâ compact object and a neutron star
- Author
- Abac Adrian
- Abbott R.
- Abouelfettouh I.
- Acernese F.
- Ackley Kendall
- Adhicary S.
- Adhikari Naresh
- Adhikari Rana X.
- Adkins V. K.
- Afif Ismail M.
- Agarwal Deepali
- Agathos Michalis
- Aghaei Abchouyeh Maryam
- Aguiar Odylio D.
- Aguilar I.
- Aiello Lorenzo
- Ain Anirban
- Ajith Parameswaran
- Akcay Sarp
- Akseli Hannuksela Otto
- Akutsu Tomotada
- Al-Jodah Ammar
- Al-Shammari S.
- Albanesi Simone
- Alex iandolo Guido
- Alfaidi Reem Atallah E
- Allocca Annalisa
- Alléné C.
- Altin Paul
- Alvarez-Lopez Sofia
- Amato Alex
- Amez-Droz L.
- Amorosi A.
- Amra C.
- Ananyeva A.
- Anderson Stuart
- Anderson Warren G.
- Andia Manuel
- Ando M.
- Andrade T.
- Andrea Prodi Giovanni
- Andres Nicolas
- Andric Tomislav
- Andrés Vallejo Peña Sergio
- Andrés-Carcasona Marc
- Anglin J.
- Anne Bizouard Marie
- Ansoldi Stefano
- Antelis Javier M.
- Antier Sarah
- Antoni Ramis Vidal Felip
- Antonietta Palaia Maria
- Antonio Font Roda Jose
- Aoumi M.
- Appavuravther E. Z.
- Appert S.
- Apple S. K.
- Arai Koji
- Araya Akito
- Araya Melody
- Areeda Joseph
- Argianas L.
- Arif Shaikh Md
- Aritomi N.
- Armato Federico
- Arnaud Nicolas
- Arogeti Megan
- Aronson Scott
- Arun K. G.
- Ashton Gregory
- Aso Yoichi
- Assiduo M.
- Aston S. M.
- Astone Pia
- Attadio Francesca
- Aubin Florian
- AVALLONE Guerino
- Azrad D.
- Babak Stanislav
- Badaracco Francesca
- Badger C.
- Bae Sangwook
- Bagnasco Stefano
- Bagui E.
- Baier Jeremy
- Baiotti Luca
- Bajpai Rishabh
- Baka T.
- Ball M.
- Ballardin G.
- Ballmer S. W.
- Banagiri Sharan
- Banerjee Biswajit
- Bankar Deepak
- Baral Pratyusava
- Barayoga J. C.
- Barish B. C.
- Barker D.
- Barneo Pablo
- Barone Fabrizio
- Barr Bryan
- Barsotti Lisa
- Barsuglia Matteo
- Barta DĂĄniel
- Bartoletti A. M.
- Barton Mark Andrew
- Bartos I.
- Basak Soummyadip
- Basalaev Artem
- Bassiri Riccardo
- Basti Andrea
- Bates D. E.
- Bawaj Mateusz
- Baxi P.
- Bayley Joseph
- Baylor Amanda
- Baynard II. P. A.
- Bazzan M.
- Bedakihale V. M.
- Beirnaert Freija
- Bejger MichaĆ
- Belardinelli Daniele
- Bell Angus
- Benedetto V.
- Benoit William
- Bentley Joe
- Bera Sayantani
- Berbel Marina
- Bergamin Fabio
- Berger Beverly
- Bernuzzi Sebastiano
- Beroiz Martin
- Berry Christopher P. L.
- Bersanetti Diego
- Bertolini A.
- Betzwieser Joseph
- Beveridge Damon
- Bevins Nathaniel
- Bhandare R.
- Bhardwaj Uddipta
- Bhatt R.
- Bhattacharjee Dripta
- Bhaumik Shubhagata
- Bhowmick S.
- Bianchi A.
- Bilenko I. A.
- Billingsley GariLynn
- Binetti Alberto
- Bini Sophie
- Birnholtz Ofek
- Bisht A.
- Bitossi Massimiliano
- Blackburn Kent
- Blagg L. A.
- Blair C. D.
- Blair D. G.
- Bobba F.
- Bode Nina
- Boileau Guillaume
- Boldrini Mattia
- Bolingbroke Georgia
- Bolliand A.
- Bondarescu Ruxandra
- Bondu François
- Bonilla Carrasquel Edgard
- Bonino A.
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- Borchers A.
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- Bossilkov V.
- Boudart Vincent
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- BRANCHESI Marica
- Brandt J.
- Braun I.
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- Briant Tristan
- Brillet A.
- Brinkmann M.
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- Buonanno Alessandra
- Burtnyk K.
- Buscicchio Riccardo
- Buskulic D.
- Bustillo J. CalderĂłn
- Buy Christelle
- Byer R. L.
- Cabourn Davies Gareth
- Cabras Giuseppe
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- Cadonati Laura
- Cagnoli Gianpietro
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- Callister T. A.
- Calloni E.
- Camp J. B.
- Canepa M.
- Caneva Santoro Giada
- Cannon Kipp C.
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- Carlassara M.
- Carlin Julian
- Carolina Silva Oliveira Ana
- Carpinelli Massimo
- Carrillo G.
- Carter Jonathan
- Carullo Gregorio
- Casentini Claudio
- Castro-Lucas S. Y.
- Caudill S.
- Cavaglia Marco
- Cavalieri Roberto
- Cella Giancarlo
- CerdĂĄ-DurĂĄn Pablo
- Cesarini Elisabetta
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- Chakraborty Pratik
- Chalathadka Subrahmanya Shreevathsa
- Chan M.
- Chandra K.
- Chang R. -J.
- Chao Shiuh
- Char Prasanta
- Charlton E. L.
- Charlton Philip
- Chassande-Mottin Eric
- Chatterjee Chayan
- Chatterjee Debarati
- Chatterjee Deep
- Chattopadhyay Debatri
- Chaturvedi M.
- Chaty Sylvain
- Chatziioannou Katerina
- Chen A.
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- Chen Dan
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- Chen Junxin
- Chen K. H.
- Chen Y.
- Chen Yanbei
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- Christensen Nelson
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- Chun Lung Chan Juno
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- CieĆlar Marek
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- Clasey Essick Reed
- Claudio Diaz Mario
- Clearwater P.
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- Coccia E.
- Codazzo Elena
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- Colace Stefano
- Colleoni Marta
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- Concetta Tringali Maria
- Connolly G.
- Conti Livia
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- Cordero-CarriĂłn Isabel
- Corezzi S.
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- Corsi Alessandra
- Cortese Stefano
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- Cottingham R.
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- Countryman Stefan
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- Crook S.
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- Cudell Jean-René
- Cullen Torrey
- Cumming Alan
- Cuoco E.
- Cusinato Marco
- CĂĄceres-Barbosa V.
- CĂ©sar Martins Julio
- D'Angelo Beatrice
- D'Antonio Sabrina
- d'Emilio V.
- D'Onofrio Luca
- D'Urso D.
- Dabadie P.
- Dal Canton Tito
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- DALL'OSSO Simone
- Danilishin Stefan
- Danzmann K.
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- De Rosa Rosario
- de rossi camilla
- De Simone R.
- de Souza Melo S. Assis
- Deenadayalan M.
- Degallaix Jerome
- Del Pozzo Walter
- Dell'Aquila Daniele
- Deléglise Samuel
- Demos N.
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- Depasse Antoine
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- Dhani A.
- Di Cesare Martina
- Di Fiore L.
- Di Fronzo Chiara
- Di Giovanni Matteo
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- Di Michele Alessandro
- Di Palma Irene
- Di Renzo Francesco
- Diab R.
- Diaz J. Casanueva
- Dideron G.
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- Effler Anamaria
- Eichholz Johannes
- Einsle H.
- Eisenmann M.
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- Emma Mattia
- Endo K.
- enea romano antonio
- Engl A. J.
- Enloe E.
- Erasmo Peña Arellano Fabiån
- Errico Luciano
- error error
- error error
- Estellés Estrella Héctor
- Estevez Dimitri
- Etzel T.
- Evans Matthew J.
- Evstafyeva T.
- Ewing B. E.
- Fabrizi Federica
- Faedi F.
- Fafone Viviana
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- Favata Marc
- Fays Maxime
- Fazio M.
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- Fenyvesi Edit
- Ferguson Deborah
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- Ferrante Isidoro
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- Fidecaro Francesco
- Figura PrzemysĆaw
- Fiori Alessio
- Fiori Irene
- Fishbach Maya
- Fisher R. P.
- Fittipaldi R.
- FIUMARA VINCENZO.
- Flaminio R.
- Fleischer Svenja
- Fleming L. S.
- Floden E.
- Foley E. M.
- Fong H.
- Fornal Bartosz
- Forsyth P. W. F.
- Franceschetti K.
- Franchini N.
- Francisco Nuño Siles José
- Frasca S.
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- Frei Zsolt
- Freise Andreas
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- Frey Raymond
- Frischhertz W.
- Fritschel P.
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- Fuentes-Garcia Melina
- Fujii S.
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- Fulda P.
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- ĂrpĂĄd Gergely LĂĄszlĂł
- ć ćæŹœ
- éœäžž éèĄ
- Publication venue
- Publication date
- 23/04/2024
- Field of study
Preceptor recruitment, training, and retentionâa nation-wide survey of colleges of pharmacy
- Author
- Publication venue
- 'Northern Arizona University College of Education'
- Publication date
- 01/01/2013
- Field of study
Recent changes surrounding the profession of pharmacy resulted in a growing number of new pharmacy programs as well as expansion of existing class sizes. This extreme growth, coupled with changes to accreditation standards which require volunteer licensed pharmacists to supervise student interns for a minimum of thirty percent of the Doctor of Pharmacy curriculum, have created a great burden amongst higher education administrators to meet these requirements, specifically in terms of recruiting, training, and retaining a qualified and committed pool of preceptors. The purpose of this study was to identify what strategies the American Association of Colleges of Pharmacy Experiential Education Section members utilize to recruit, train, retain, and acknowledge volunteer pharmacist preceptors. The following research questions were answered in this study: 1) What are the strategies utilized by American Association of Colleges of Pharmacy (AACP) schools to: a) recruit, b) train, c) retain, and d) acknowledge volunteer pharmacist preceptors? 2) What are some of the practices associated with ways AACP Experiential Education Section members handle the supply and demand issues associated with training future pharmacists? 3) What are the characteristics of respondents in terms of institutional demographics (geographic location, three- versus four-year programs, private versus public, class size, teaching or research focus, etc.)? An extensive review and report of the literature (AACP, 2004; AAMC, 2008; ACPE, 2007; ACPE 2011; Bandura, 1977; Brown, 2010; Cotter, 2010; Dewey, 1938; Dziedzic, 2010; Freire, 1970; James, 1907; Kolb, 1984; Knowles, 2005; Lewin, 1951; Lillibridge, 2007; NABP, 2012; Rogers, 1961; Zlatic, 2001) preceded design of the survey instrument utilized in the study. Experiential education theoretical frameworks highlighted adult learning theories which showed how hands-on, learning in real world settings promoted meaningful learning experiences. The history of pharmacy education, changes in the profession, and updated accreditation guidelines, including standards which required increased intern hours to be completed under the supervision of a licensed pharmacist preceptor emphasized the necessity for a strong group of volunteer preceptors to successfully fulfill the needs of the Pharm.D. curriculum. Additional literature (ACCP, 2012; Bird, Duong, Hagemann, Burton, Britton, & St. Cyr, 2012; Bock, Duong, & Williams, 2008; Brown, Barner, & Shepherd, 2004; DiFrancesco, 2011; Flaherty, 2011; Hill & Kirkwood, 2005; McDonough & Bennett, 2006; Mersfelder & Bonthillier, 2012; O'Neil & Berdine, 2007; Popovich, Katz, & Peverly, 2010; Rodis, Legg & Casper, 2009; Yorra, 2012) highlighted how such practice opportunities benefited students, preceptors, and positively impacted patient care. Coupled with the positives of such experiences were the realities of the challenges to recruitment, training, and retention faced by higher education administrators. Barriers (Assemi et al., 2011; Cerulli & Briceland, 2004; Crill, 2009; Duncan-Hewitt, 2005; Gulseth et al., 2006; Karimi et al., 2011; Lee et al., 2006; Lillibridge, 2007; Marrs & Rackham, 2010; Marriott et al., 2006; McBane & Karr, 2012; McKauge & Coombes, 2005; Medina, 2008; Reid et al., 2007; Scarvell & Stone, 2010; Snyder et al., 2010; Sonthisombat, 2008; Talley, 2006; Verstraten et al., 2006; Warren & Denham, 2010; Wuller, 2008; Zarembski et al., 2004) to effective precepting listed in the literature included lack of training, insufficient resources and personnel, lack of confidence, workload and time stressors, handling difficult students, and balancing resident, clinician, and student roles. Practices in related fields of international pharmacy, nursing, and medicine provided studies of best practices in regards to preceptor recruitment, training, acknowledgement, and retention. This study utilized a survey design methodology with thirteen quantitative survey items as well as eight open-ended commentaries allowing for qualitative analysis to address the research questions. Active members of the American Association of Colleges of Pharmacy Experiential Education Section were voluntarily surveyed and 233 participants answered using online survey collection in the summer of 2013. Data was analyzed and reported in descriptive statistics. Results identified current strategies utilized by Doctor of Pharmacy programs who are members of the American Association of Colleges of Pharmacy Experiential Education Special Interest Group to recruit, train, retain, and acknowledge volunteer pharmacist preceptors. Additionally, the study provided information related to the practices associated with supply and demand issues associated with training future pharmacists. Findings of this study are useful for those involved in academia in the health professions, specifically higher education administrators looking to fulfill accreditation guidelines for experiential education in a Doctor of Pharmacy curriculum. Conclusions and recommendations revealed opportunity for growth and development in the areas of experiential education especially as related to preceptor recruitment, training, retention, and acknowledgement, as well as for future research
Abuse and diversion of buprenorphine sublingual tablets and film
- Author
- AAPCC
- Amass
- Andrew Rosenblum
- Auriacombe
- Becki Bucher-Bartelson
- Cicero
- Cicero
- Comer
- Daniulaityte
- Dart
- Dasgupta
- Eric J. Lavonas
- Erin M. Martinez
- FDA
- Fiellin
- Fudala
- Hakansson
- Hilary L. Surratt
- Inciardi
- Jody L. Green
- Johanson
- Johnson
- Lenn E. Murrelle
- Maremmani
- Marie-Claire Le Lait
- Mattick
- Mendelson
- Monte
- Richard C. Dart
- S. Geoffrey Severtson
- Schuman-Olivier
- Schwarz
- Severtson
- Smith
- Steven P. Kurtz
- Strang
- Sullivan
- Theodore J. Cicero
- Uosukainen
- Walsh
- Walsh
- Winter
- Winter
- Yokell
- Publication venue
- 'Elsevier BV'
- Publication date
- Field of study
Customer Satisfaction in Transnational BuyerâSupplier Relationships
- Author
- Adams Ronald J.
- Adler Nancy
- Adler Nancy
- Agbonifoh Barnabas A.
- Alguire Mary S.
- Anderson Erin
- Anderson Eugene W.
- Anderson Rolph E.
- Bagozzi Richard P.
- Bagozzi Richard P.
- Bandyopadhyay Soumava
- Baumgartner Hans
- Biong Harald
- Birou Laura M.
- Bush Victoria D.
- Caddick Roy
- Cannon Joseph P.
- Douglas Susan P.
- Dwyer F. Robert
- Dwyer F. Robert
- Festinger Leon
- Ford David
- Forker Laura B.
- Garvin David A.
- Gaski John F.
- Gilliland David I.
- Gyrna Frank M.
- Hallén Lars
- Han San-Lin
- Haytko Diana L.
- Hofstede Geert
- Homburg Christian
- Horng Ching
- Hovland Carl D.
- HĂ„kansson Hakan
- HĂ„kansson Hakan
- Johanson Jan
- Johanson Jan
- Jöreskog Karl G.
- Jöreskog Karl G.
- Mohr Jakki
- Oliver Richard L.
- Oliver Richard L.
- Oliver Richard L.
- Oliver Richard L.
- Parasuraman A.
- Qualls William J.
- Schul Patrick L.
- Schuler R.
- Steenkamp Jan-Benedict E.M.
- Wilson David
- Wilson David
- Publication venue
- 'American Marketing Association (AMA)'
- Publication date
- Field of study
Information Networks as a Safeguard from Opportunism in Industrial Supplier-Buyer Relationships
- Author
- Achim / Loose
- Andreas Bïżœhme
- Anna / Grandori
- Bart / Nooteboom
- Bart Nooteboom
- Bengt Johannison
- Bettina Mïżœnnel
- Brian Uzzi
- Christel / Lane
- David
- Dawn / Iacobucci
- Denise M Rousseau
- Dietmar Rïżœïżœl
- Erin / Anderson
- Everett M Rogers
- Gary L Frazier
- Gary L Frazier
- Geert / Duysters
- Gregory T Gundlach
- Hans / Berger
- Hans B Thorelli
- Heribert Gierl
- Hermann Diller
- Holger Siebert
- J Jarillo
- J Peter
- Jakki J Mohr
- Jakki J Mohr
- Jan / Johanson
- Jan / Johanson
- Jan B Heide
- Jan B Heide
- Jan B Heide
- Jay B Barney
- Joachim Bïżœschken
- Joseph L Soeters
- Jule B Gassenheimer
- Jïżœrg Freiling
- Jïżœrg Sydow
- Keith G Provan
- Keith G Provan
- Kenneth H Wathne
- Klaus / Bellmann
- Margit / Meyer
- Margit Meyer
- Mark / Fichman
- Mark Ebers
- Mark Granovetter
- Maurizio / Sobrero
- Michael E Porter
- Niels G Noorderhaven
- Oliver E Williamson
- Ravi P Achrol
- Richard M Emerson
- Robert / Dahlstrom
- Robin / Croft
- Seung Park
- Shankar Ganesan
- Silke Bambauer
- Walter W Powell
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2003
- Field of study
The Internationalization of Indian Pharmaceutical Firms: A Comparison of Entry Mode Theories
- Author
- Angelo Fusari
- Anoop Madhok
- Avinandan Mukherjee
- B Kogut
- C Dahlman
- C K Prahalad
- Erin Anderson
- Erin Anderson
- Franklin R Root
- Franklin R Root
- G Benito
- G Hofstede
- Hans Jansson
- Harris M Cooper
- Howard V Perlmutter
- Ikechi Ekeledo
- J Johanson
- J L Arbuckle
- Jay B Barney
- John H Dunning
- John H Dunning
- John H Dunning
- K Bollen
- K G Joreskog
- Kate Gillespie
- Kathleen J Conner
- Kenneth J Arrow
- Mike W Peng
- Mona Makhija
- O Williamson
- O Williamson
- P A Francis
- P W Beamish
- Rajendra K Srivastava
- Raphael Amit
- Raymond Vernon
- Richard Reed
- S Schneider
- Sanjeev Agarwal
- Scott Shane
- Shelby D Hunt
- Sundar G Bharadwaj
- Varinder M Sharma
- Y Aharoni
- Yao-Su Hu
- Yoram Wind
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2013
- Field of study
COMT val158met genotype alters the effects of methamphetamine dependence on dopamine and dopamine-related executive function: preliminary findings
- Author
- Adarsh Kumar
- Ashok
- Barnett
- Beck
- Bennett
- Berman
- Bousman
- Cai
- Caitlin Wei-Ming Watson
- Chen
- Cherner
- Cherner
- Cherner
- Compton
- Cools
- Davidson
- Dean
- Egan
- Erin E. Sundermann
- Felger
- Felger
- Halpin
- Heaton
- Heaton
- Heinzerling
- Hodgkinson
- Itoh
- Janssens
- Jennifer E. Iudicello
- Johanson
- Kish
- Korshunov
- Kumar
- Kumar
- Lee
- Leventhal
- Li
- Mariana Cherner
- Mattay
- McDonnell-Dowling
- Meyer-Lindenberg
- Moszczynska
- Norman
- Palmatier
- Pifl
- Rawson
- Rippeth
- Robertson
- Ronald J. Ellis
- Rowan Saloner
- Salo
- Salo
- Saloner
- Scott
- Scott L. Letendre
- Sekine
- Sekine
- Silverstein
- Slifstein
- Spitzer
- Starr
- Sundermann
- Tunbridge
- Venniro
- Verrico
- Volkow
- Volkow
- Volkow
- Volkow
- Wang
- Wishart
- Zahrt
- Publication venue
- 'Elsevier BV'
- Publication date
- Field of study
Network Ties and the Political Strategies of Firms
- Author
- Allen Hicken
- Allen Hicken
- Amy J Hillman
- Arnold Zellner
- Avner Greif
- Benjamin A T Graham
- Benjamin A. T. Graham
- Cesi Cruz
- Cesi Cruz
- Daniel Corstange
- De Figueiredo
- Edith De Leeuw
- Edmund J Malesky
- Elvira Sojli
- Erin Troland
- Estelle Chaussard
- Gabriella Montinola
- Gilberto M Llanto
- Gillian K Hadfield
- I Dinïżœ
- J Teehankee
- Jennifer Dykema
- Jennifer Victor
- Johanson
- John Mcmillan
- Jordi Blanes-I Vidal
- Joseph Capuno
- Joseph Capuno
- Kevin B Grier
- Leslie Johns
- Mancur Olson
- Mara Faccio
- Marianne Bertrand
- Mi Shin
- Nathan M Jensen
- Nicholas Bloom
- Patricio N Abinales
- Paul Hutchcroft
- Pinelopi Goldberg
- Raymond Fisman
- Robert E Hoskisson
- Ronald U Mendoza
- Sara Watson
- Simon Luechinger
- Stephen Weymouth
- Wendy L Hansen
- William T Gormley
- Yann Bramoulle
- Yating Chuang
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2017
- Field of study
A provider-cost/patron-effort schema for classifying products
- Author
- Ben M. Enis
- Ben M. Enis
- Bert Rosenbloom
- Charles I. Stubbart
- Charles Parlin
- Eleanor Rosch
- Eleanor Rosch
- Erin Anderson
- Erin Anderson
- Franklin S. Houston
- Gene R. Laczniak
- George S. Day
- Gordon H. G. McDougall
- Gordon Miracle
- Jagdish N. Sheth
- Jan Johanson
- Joel E. Urbany
- Joel R. Evans
- John E. G. Bateson
- John E. G. Bateson
- John M. Rathmell
- John T. Lanzetta
- Joseph P. Guiltinan
- Judith Lynne Zaichkowsky
- Leo V. Aspinwall
- Leonard L. Berry
- Louis Bucklin
- Lynn G. Shostack
- Mario Bunge
- Martin L. Bell
- Melvin T. Copeland
- Michael R. Hyman
- Michael Roloff
- Morris B. Holbrook
- Parthasarathy Krishnamurthy
- Patrick E. Murphy
- Peter D. Bennett
- Peter P. Ekeh
- Philip Kotler
- Philip Kotler
- Raymond A. Bauer
- Richard M. Holton
- Richard P. Bagozzi
- Richard P. Bagozzi
- Robert C. Judd
- Robert H. Hayes
- Robert Skipper
- Shelby D. Hunt
- Shelby D. Hunt
- Stanley Kaish
- Subhash C. Jain
- Theodore Levitt
- U.S. Department of Commerce Bureau of the Census
- Valarie A. Zeithaml
- Varinder M. Sharma
- Wroe Alderson
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Ezetimibe added to statin therapy after acute coronary syndromes
- Author
- Aagnes I
- Aambakk MB
- Aase O
- Aaser E
- Abdel-Latief A
- Abell T
- Aboufakher R
- Abramson B
- Abrantes J
- Achilli A
- Adams A
- Adams K
- Adamus J
- Addington J
- Adgey A
- Adjei A
- Agarwal J
- Aggarwal A
- Aggarwal K
- Aggarwal R
- Agocha A
- Agraou B
- Aguirre O
- Ahmed A
- Ahmed O
- Ahsan A
- Airaksinen J
- Airoldi F
- Aji J
- Akkad H
- Akubzanova E
- Al-Ani R
- Al-Jumaily J
- Alameda J
- Albirini A
- Albuquerque A
- Albuquerque D
- Alcasena S
- Alexander J
- Alfonso F
- Ali MI
- Alings MA
- Allall O
- Allen J
- Allen RP
- Allred S
- Almeira AS
- Alonso L
- Alsagheer S
- Alshaher M
- Altschuller A
- Alvarez J
- Alvarez J
- Alvarez Y
- Alves A
- Amidon T
- Amos M
- Anaszewicz M
- Andersen M
- Andersen O
- Andersson E
- Andersson G
- Andrade G
- Andrade M
- Andrea B
- Andreou C
- Antonangelo A
- Antorrena I
- Appel K
- Arana C
- Aranda M
- Araujo J
- Arce R
- Ardito RV
- Ardito W
- Arend C
- Arias V
- Armada E
- Armstrong P
- Arnold A
- Arnold M
- Arntsen BI
- Arora P
- Aros F
- Arriagada G
- Arriagada G
- Artaecheverria J
- Arvesen K
- Arvigo L
- Ash Y
- Aske R
- Ata N
- Atar D
- Atar S
- Atassi K
- Atieh M
- Atkinson C
- Atzenhofer-Baumgartner K
- Auer J
- Aug L
- Ausen K
- Aycock G
- Aylward P
- Aylward P
- Ayres T
- Azize G
- Azrin M
- Azzolini P
- Babu R
- Bach R
- Badings EA
- Baeza N
- Baig M
- Baiz A
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- Balaguera J
- Balcells E
- Baldari D
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- Bali H
- Ballantyne C
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- Banerjee S
- Bang-Hansen T
- Banikova A
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- Bansal M
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- Ă ngman K
- Ădes I
- Ăstberg S
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2015
- Field of study
BACKGROUND: Statin therapy reduces low-density lipoprotein (LDL) cholesterol levels and the risk of cardiovascular events, but whether the addition of ezetimibe, a nonstatin drug that reduces intestinal cholesterol absorption, can reduce the rate of cardiovascular events further is not known. METHODS: We conducted a double-blind, randomized trial involving 18,144 patients who had been hospitalized for an acute coronary syndrome within the preceding 10 days and had LDL cholesterol levels of 50 to 100 mg per deciliter (1.3 to 2.6 mmol per liter) if they were receiving lipid-lowering therapy or 50 to 125 mg per deciliter (1.3 to 3.2 mmol per liter) if they were not receiving lipid-lowering therapy. The combination of simvastatin (40 mg) and ezetimibe (10 mg) (simvastatin-ezetimibe) was compared with simvastatin (40 mg) and placebo (simvastatin monotherapy). The primary end point was a composite of cardiovascular death, nonfatal myocardial infarction, unstable angina requiring rehospitalization, coronary revascularization ( 6530 days after randomization), or nonfatal stroke. The median follow-up was 6 years. RESULTS: The median time-weighted average LDL cholesterol level during the study was 53.7 mg per deciliter (1.4 mmol per liter) in the simvastatin-ezetimibe group, as compared with 69.5 mg per deciliter (1.8 mmol per liter) in the simvastatin-monotherapy group (P<0.001). The Kaplan-Meier event rate for the primary end point at 7 years was 32.7% in the simvastatin-ezetimibe group, as compared with 34.7% in the simvastatin-monotherapy group (absolute risk difference, 2.0 percentage points; hazard ratio, 0.936; 95% confidence interval, 0.89 to 0.99; P = 0.016). Rates of pre-specified muscle, gallbladder, and hepatic adverse effects and cancer were similar in the two groups. CONCLUSIONS: When added to statin therapy, ezetimibe resulted in incremental lowering of LDL cholesterol levels and improved cardiovascular outcomes. Moreover, lowering LDL cholesterol to levels below previous targets provided additional benefit