39 research outputs found
Statistical Outliers and Dragon-Kings as Bose-Condensed Droplets
A theory of exceptional extreme events, characterized by their abnormal sizes
compared with the rest of the distribution, is presented. Such outliers, called
"dragon-kings", have been reported in the distribution of financial drawdowns,
city-size distributions (e.g., Paris in France and London in the UK), in
material failure, epileptic seizure intensities, and other systems. Within our
theory, the large outliers are interpreted as droplets of Bose-Einstein
condensate: the appearance of outliers is a natural consequence of the
occurrence of Bose-Einstein condensation controlled by the relative degree of
attraction, or utility, of the largest entities. For large populations, Zipf's
law is recovered (except for the dragon-king outliers). The theory thus
provides a parsimonious description of the possible coexistence of a power law
distribution of event sizes (Zipf's law) and dragon-king outliers.Comment: Latex file, 16 pages, 1 figur
Female chromosome X mosaicism is age-related and preferentially affects the inactivated X chromosome
To investigate large structural clonal mosaicism of chromosome X, we analysed the SNP
microarray intensity data of 38,303 women from cancer genome-wide association studies
(20,878 cases and 17,425 controls) and detected 124 mosaic X events42Mb in 97 (0.25%)
women. Here we show rates for X-chromosome mosaicism are four times higher than mean
autosomal rates; X mosaic events more often include the entire chromosome and participants
with X events more likely harbour autosomal mosaic events. X mosaicism frequency
increases with age (0.11% in 50-year olds; 0.45% in 75-year olds), as reported for Y and
autosomes. Methylation array analyses of 33 women with X mosaicism indicate events
preferentially involve the inactive X chromosome. Our results provide further evidence that
the sex chromosomes undergo mosaic events more frequently than autosomes, which could
have implications for understanding the underlying mechanisms of mosaic events and their
possible contribution to risk for chronic diseases
Cell death during Drosophila melanogaster early oogenesis is mediated through autophagy
Autophagy is a physiological and evolutionarily conserved process maintaining homeostatic functions, such as protein degradation and organelle turnover. Accumulating data provide evidence that autophagy also contributes to cell death under certain circumstances, but how this is achieved is not well known. Herein, we report that autophagy occurs during developmentally-induced cell death in the female germline, observed in the germarium and during middle developmental stages of oogenesis in Drosophila melanogaster. Degenerating germline cells exhibit caspase activation, chromatin condensation, DNA fragmentation and punctate staining of mCherry-DrAtg8a, a novel marker for monitoring autophagy in Drosophila. Genetic inhibition of autophagy, by removing atgl or atg7 function, results in significant reduction of DNA fragmentation, suggesting that autophagy acts genetically upstream of DNA fragmentation in this tissue. This study provides new insights into the mechanisms that regulate cell death in vivo during development. © 2009 Landes Bioscience