7,068 research outputs found
ImageJ2: ImageJ for the next generation of scientific image data
ImageJ is an image analysis program extensively used in the biological
sciences and beyond. Due to its ease of use, recordable macro language, and
extensible plug-in architecture, ImageJ enjoys contributions from
non-programmers, amateur programmers, and professional developers alike.
Enabling such a diversity of contributors has resulted in a large community
that spans the biological and physical sciences. However, a rapidly growing
user base, diverging plugin suites, and technical limitations have revealed a
clear need for a concerted software engineering effort to support emerging
imaging paradigms, to ensure the software's ability to handle the requirements
of modern science. Due to these new and emerging challenges in scientific
imaging, ImageJ is at a critical development crossroads.
We present ImageJ2, a total redesign of ImageJ offering a host of new
functionality. It separates concerns, fully decoupling the data model from the
user interface. It emphasizes integration with external applications to
maximize interoperability. Its robust new plugin framework allows everything
from image formats, to scripting languages, to visualization to be extended by
the community. The redesigned data model supports arbitrarily large,
N-dimensional datasets, which are increasingly common in modern image
acquisition. Despite the scope of these changes, backwards compatibility is
maintained such that this new functionality can be seamlessly integrated with
the classic ImageJ interface, allowing users and developers to migrate to these
new methods at their own pace. ImageJ2 provides a framework engineered for
flexibility, intended to support these requirements as well as accommodate
future needs
Photonic Phase Gate via an Exchange of Fermionic Spin Waves in a Spin Chain
We propose a new protocol for implementing the two-qubit photonic phase gate.
In our approach, the pi phase is acquired by mapping two single photons into
atomic excitations with fermionic character and exchanging their positions. The
fermionic excitations are realized as spin waves in a spin chain, while photon
storage techniques provide the interface between the photons and the spin
waves. Possible imperfections and experimental systems suitable for
implementing the gate are discussed.Comment: 4 pages, 1 figure. V2: extended the discussion of the main idea,
removed supplementary information and inessential extensions, added
references. V3: slightly modified references and text - final version as
published in Phys. Rev. Let
A joint time-dependent density-functional theory for excited states of electronic systems in solution
We present a novel joint time-dependent density-functional theory for the
description of solute-solvent systems in time-dependent external potentials.
Starting with the exact quantum-mechanical action functional for both electrons
and nuclei, we systematically eliminate solvent degrees of freedom and thus
arrive at coarse-grained action functionals which retain the highly accurate
\emph{ab initio} description for the solute and are, in principle, exact. This
procedure allows us to examine approximations underlying popular embedding
theories for excited states. Finally, we introduce a novel approximate action
functional for the solute-water system and compute the solvato-chromic shift of
the lowest singlet excited state of formaldehyde in aqueous solution, which is
in good agreement with experimental findings.Comment: 11 page
Should everolimus be stopped after radiological progression in metastatic insulinoma? A "pro" point of view
The radical character of the acenes: A density matrix renormalization group study
We present a detailed investigation of the acene series using high-level
wavefunction theory. Our ab-initio Density Matrix Renormalization Group
algorithm has enabled us to carry out Complete Active Space calculations on the
acenes from napthalene to dodecacene correlating the full pi-valence space.
While we find that the ground-state is a singlet for all chain-lengths,
examination of several measures of radical character, including the natural
orbitals, effective number of unpaired electrons, and various correlation
functions, suggests that the longer acene ground-states are polyradical in
nature.Comment: 10 pages, 8 figures, supplementary material, to be published in J.
Chem. Phys. 127, 200
A critical assessment of the pairing symmetry in NaxCoO2.yH2O
We examine each of the symmetry-allowed pairing states of NaxCoO2.yH2O and
compare their properties to what is experimentally and theoretically
established about the compound. In this way, we can eliminate the vast majority
of states that are technically allowed and narrow the field to two, both of
f-wave type states. We discuss the expected features of these states and
suggest experiments that can distinguish between them. We also discuss
odd-frequency gap pairing and how it relates to available experimental
evidence
Willmore minimizers with prescribed isoperimetric ratio
Motivated by a simple model for elastic cell membranes, we minimize the
Willmore functional among two-dimensional spheres embedded in R^3 with
prescribed isoperimetric ratio
Existing fluid responsiveness studies using the mini-fluid challenge may be misleading:Methodological considerations and simulations
BACKGROUND: The mini-fluid challenge (MFC) is a clinical concept of predicting fluid responsiveness by rapidly infusing a small amount of intravenous fluids, typically 100 ml, and systematically assessing its haemodynamic effect. The MFC method is meant to predict if a patient will respond to a subsequent, larger fluid challenge, typically another 400 ml, with a significant increase in stroke volume. METHODS: We critically evaluated the general methodology of MFC studies, with statistical considerations, secondary analysis of an existing study, and simulations. RESULTS: Secondary analysis of an existing study showed that the MFC could predict the total fluid response (MFC + 400 ml) with an area under the receiver operator characteristics curve (AUROC) of 0.92, but that the prediction was worse than random for the response to the remaining 400 ml (AUROC = 0.33). In a null simulation with no response to both the MFC and the subsequent fluid challenge, the commonly used analysis could predict fluid responsiveness with an AUROC of 0.73. CONCLUSION: Many existing MFC studies are likely overestimating the classification accuracy of the MFC. This should be considered before adopting the MFC into clinical practice. A better study design includes a second, independent measurement of stroke volume after the MFC. This measurement serves as reference for the response to the subsequent fluid challenge
Fire and Smoke Remote Sensing and Modeling Uncertainties: Case Studies in Northern SubâSaharan Africa
Significant uncertainties are incurred in deriving various quantities related to biomass burning from satellite measurements at different scales, and, in general, the coarser the resolution of observation the larger the uncertainty. WRFâChem model simulations of smoke over the northern subâSaharan African (NSSA) region for JanuaryâFebruary 2010, using fire energetics and emissions research version 1.0 (FEERv1) aerosol emissions derived from MODIS measurements of fire radiative power (FRP) and aerosol optical depth (AOD), resulted in a severe model underestimation of AOD compared with satellite retrievals. Such uncertainties are attributable to three major factors: limitations in the spatial and temporal resolutions of the satellite observations used to quantify emissions, modeling parameters and assumptions, and the unique geographic characteristics of NSSA. It is recommended that field campaigns involving synergistic coordination of groundâbased, airborne, and satellite measurements with modeling be conducted in major and complex biomass burning regions such as the NSSA, and that significant improvements in the spatial and temporal resolutions of observation systems needed to reduce uncertainties in biomass burning characterization be seriously considered in future satellite missions
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