Techtrends

Michio Kaku, author of Vis ions: How Science will Revolutionize the 21 \u27 Century, spoke at the most recent Texas Library Association conference in Dallas, Texas. A summary of his comments follow

Bell and Sacramento

In this white paper, Matthews explores corruption scandals prior to the Bell Scandal. He also presents two paradoxes to the Bell Scandal. One is that the Bell officials had the power to get into so much trouble in no small part because their power was so limited. Another paradox is that Bell was at once both a white- hot national scandal, singular in the attention it drew, and also just another small chapter in a long-running California scandal

In the News

Items in the news

Adding Value: The Key to the Future

Presentation slidesGiven the significant amount of change we are all experiencing in our lives and our increasing dependence on the Internet, people are no longer required to visit the library and other cultural organizations to gain access to this content. Thus, cultural organizations need to figure out how to add new value to their collections and services as the perceived value of the library and other cultural institutions is rapidly diminishing

Ami - The Chemist's Amanuensis

RIGHTS : This article is licensed under the BioMed Central licence at http://www.biomedcentral.com/about/license which is similar to the 'Creative Commons Attribution Licence'. In brief you may : copy, distribute, and display the work; make derivative works; or make commercial use of the work - under the following conditions: the original author must be given credit; for any reuse or distribution, it must be made clear to others what the license terms of this work are.Abstract The Ami project was a six month Rapid Innovation project sponsored by JISC to explore the Virtual Research Environment space. The project brainstormed with chemists and decided to investigate ways to facilitate monitoring and collection of experimental data. A frequently encountered use-case was identified of how the chemist reaches the end of an experiment, but finds an unexpected result. The ability to replay events can significantly help make sense of how things progressed. The project therefore concentrated on collecting a variety of dimensions of ancillary data - data that would not normally be collected due to practicality constraints. There were three main areas of investigation: 1) Development of a monitoring tool using infrared and ultrasonic sensors; 2) Time-lapse motion video capture (for example, videoing 5 seconds in every 60); and 3) Activity-driven video monitoring of the fume cupboard environs. The Ami client application was developed to control these separate logging functions. The application builds up a timeline of the events in the experiment and around the fume cupboard. The videos and data logs can then be reviewed after the experiment in order to help the chemist determine the exact timings and conditions used. The project experimented with ways in which a Microsoft Kinect could be used in a laboratory setting. Investigations suggest that it would not be an ideal device for controlling a mouse, but it shows promise for usages such as manipulating virtual molecules.Peer Reviewe

Systematic Discovery of New Recognition Peptides Mediating Protein Interaction Networks

Many aspects of cell signalling, trafficking, and targeting are governed by interactions between globular protein domains and short peptide segments. These domains often bind multiple peptides that share a common sequence pattern, or “linear motif” (e.g., SH3 binding to PxxP). Many domains are known, though comparatively few linear motifs have been discovered. Their short length (three to eight residues), and the fact that they often reside in disordered regions in proteins makes them difficult to detect through sequence comparison or experiment. Nevertheless, each new motif provides critical molecular details of how interaction networks are constructed, and can explain how one protein is able to bind to very different partners. Here we show that binding motifs can be detected using data from genome-scale interaction studies, and thus avoid the normally slow discovery process. Our approach based on motif over-representation in non-homologous sequences, rediscovers known motifs and predicts dozens of others. Direct binding experiments reveal that two predicted motifs are indeed protein-binding modules: a DxxDxxxD protein phosphatase 1 binding motif with a K (D) of 22 μM and a VxxxRxYS motif that binds Translin with a K (D) of 43 μM. We estimate that there are dozens or even hundreds of linear motifs yet to be discovered that will give molecular insight into protein networks and greatly illuminate cellular processes