Freely forming groups: trying to be rare

A simple weakly frequency dependent model for the dynamics of a population with a finite number of types is proposed, based upon an advantage of being rare. In the infinite population limit, this model gives rise to a non-smooth dynamical system that reaches its globally stable equilibrium in finite time. This dynamical system is sufficiently simple to permit an explicit solution, built piecewise from solutions of the logistic equation in continuous time. It displays an interesting tree-like structure of coalescing components

Proteomic Profiling of the Dystrophin-Deficient MDX Heart Reveals Drastically Altered Levels of Key Metabolic and Contractile Proteins

Although Duchenne muscular dystrophy is primarily classified as a neuromuscular disease, cardiac complications play an important role in the course of this X-linked inherited disorder. The pathobiochemical steps causing a progressive decline in the dystrophic heart are not well understood. We therefore carried out a fluorescence difference in-gel electrophoretic analysis of 9-month-old dystrophin-deficient versus age-matched normal heart, using the established MDX mouse model of muscular dystrophy-related cardiomyopathy. Out of 2,509 detectable protein spots, 79 2D-spots showed a drastic differential expression pattern, with the concentration of 3 proteins being increased, including nucleoside diphosphate kinase and lamin-A/C, and of 26 protein species being decreased, including ATP synthase, fatty acid binding-protein, isocitrate dehydrogenase, NADH dehydrogenase, porin, peroxiredoxin, adenylate kinase, tropomyosin, actin, and myosin light chains. Hence, the lack of cardiac dystrophin appears to trigger a generally perturbed protein expression pattern in the MDX heart, affecting especially energy metabolism and contractile proteins

Comparative transcription map of the wobbler critical region on mouse chromosome 11 and the homologous region on human chromosome 2p13-14

BACKGROUND: To support the positional cloning of the mouse mutation wobbler (wr) the corresponding regions on human Chr2p13-14 and mouse Chr11 were analyzed in detail and compared with respect to gene content, order, and orientation. RESULTS: The gene content of the investigated regions was highly conserved between the two species: 20 orthologous genes were identified on our BAC/YAC contig comprising 4.5 Mb between REL/Rel and RAB1A/Rab1a. Exceptions were pseudogenes ELP and PX19 whose mouse counterparts were not located within the analyzed region. Two independently isolated genomic clones indicate an inversion between man and mouse with the inverted segment being identical to the wobbler critical interval. We investigated the wobbler critical region by extensive STS/EST mapping and genomic sequencing. Additionally, the full-length cDNA sequences of four newly mapped genes as well as the previously mapped gene Otx1 were established and subjected to mutation analysis. Our data indicate that all genes in the wr critical region have been identified. CONCLUSION: Unexpectedly, neither mutation analysis of cDNAs nor levels of mRNAs indicated which of the candidate genes might be affected by the wr mutation. The possibility arises that there might be hitherto unknown effects of mutations, in addition to structural changes of the mRNA or regulatory abnormalities

"Selten gewinnt" - Rare wins. Changes in the frequencies of family names as a consequence of rational choice

Jockusch H, Fuhrmann A. "Selten gewinnt" - Rare wins. Changes in the frequencies of family names as a consequence of rational choice. Beiträge zur Namenforschung. 2010;45(2):127-142

Temperatursensitive Mutanten des Tabakmosaikvirus

Jockusch H. Temperatursensitive Mutanten des Tabakmosaikvirus. Tübingen; 1966

Migration of adult myogenic precursor cells as revealed by GFP/nLacZ labelling of mouse transplantation chimeras

Jockusch H, Voigt S. Migration of adult myogenic precursor cells as revealed by GFP/nLacZ labelling of mouse transplantation chimeras. JOURNAL OF CELL SCIENCE. 2003;116(8):1611-1616.We studied the migratory behaviour of adult muscle precursor cells in the mouse into and from skeletal muscle grafts using green fluorescent protein (GFP) and nuclear LacZ transgenes as complementary and double markers of the cell's origin. Owing to the small molecular mass and extreme solubility of GFP, this label provided a drastically increased sensitivity for detection compared with the markers that had been used previously. During the first six weeks after the operation, the graft/host border was well defined, with only occasional local intermingling and co-fusion of host and donor myogenic cells. Seven to eleven weeks after the operation we found that the host myogenic cells had migrated into the graft, and graft myogenic cells had migrated into the adjacent host muscle, with integration of donor nuclei into pre-existing myotubes or muscle fibres. There was no indication of an origin of, or target for, these myogenic cells besides neighbouring muscles. Our observations indicate migration of these cells through solid muscle tissue, over a distance of several millimetres. The migratory activity of adult myogenic precursor cells can be stimulated by traumatic events in either the target muscle or the muscle of origin

DOLICHOS BIFLORUS AGGLUTININ RECEPTORS IN MOUSE MUSCLE .2. BIOCHEMICAL-PROPERTIES IN RELATION TO MOLECULAR-FORMS OF ACETYLCHOLINESTERASE

KAUPMANN K, Jockusch H. DOLICHOS BIFLORUS AGGLUTININ RECEPTORS IN MOUSE MUSCLE .2. BIOCHEMICAL-PROPERTIES IN RELATION TO MOLECULAR-FORMS OF ACETYLCHOLINESTERASE. EUROPEAN JOURNAL OF CELL BIOLOGY. 1988;46(3):419-424

ANALYSIS OF NEURAL AND GONADAL PROTEINS IN A MOUSE MUTANT, WOBBLER

STUHLFAUTH I, Jockusch H. ANALYSIS OF NEURAL AND GONADAL PROTEINS IN A MOUSE MUTANT, WOBBLER. JOURNAL OF SUBMICROSCOPIC CYTOLOGY AND PATHOLOGY. 1984;16(1):197-197