Efecto de los antimaláricos sobre los diferentes dominios del índice de daño SLICC en pacientes de la cohorte GLADEL

Objetivos: estimar el efecto de los antimaláricos (AM) sobre los diferentes dominios del índice de daño SLICC (SDI). Métodos: se estudiaron pacientes con diagnóstico clínico reciente (≤2 años) de lupus eritematoso sistémico (LES) de la cohorte GLADEL

Antimalarial Treatment May Have a Time-Dependent Effect on Lupus Survival

Objective. To evaluate the beneficial effect of antimalarial treatment on lupus survival in a large, multiethnic, international longitudinal inception cohort.Methods. Socioeconomic and demographic characteristics, clinical manifestations, classification criteria, laboratory findings, and treatment variables were examined in patients with systemic lupus erythematosus (SLE) from the Grupo Latino Americano de Estudio del Lupus Eritematoso (GLADEL) cohort. the diagnosis of SLE, according to the American College of Rheumatology criteria, was assessed within 2 years of cohort entry. Cause of death was classified as active disease, infection, cardiovascular complications, thrombosis, malignancy, or other cause. Patients were subdivided by antimalarial use, grouped according to those who had received antimalarial drugs for at least 6 consecutive months (user) and those who had received antimalarial drugs for 2 years. Mortality rates among users by duration of antimalarial treatment (per 1,000 person-months of followup) were 3.85 (95% confidence interval [95% CI] 1.41-8.37), 2.7 (95% CI 1.41-4.76), and 0.54 (95% CI 0.37-0.77), respectively, while for nonusers, the mortality rate was 3.07 (95% CI 2.18-4.20) (P for trend < 0.001). After adjustment for potential confounders in a Cox regression model, antimalarial use was associated with a 38% reduction in the mortality rate (hazard ratio 0.62, 95% CI 0.39-0.99).Conclusion. Antimalarial drugs were shown to have a protective effect, possibly in a time-dependent manner, on SLE survival. These results suggest that the use of antimalarial treatment should be recommended for patients with lupus.Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Federico Wilhelm Agricola FoundationHosp Prov Rosario, Rheumatol Serv, RA-2000 Rosario, Santa Fe, ArgentinaUniv São Paulo, Fac Med, Hosp Clin, São Paulo, BrazilUniv Nacl Rosario, RA-2000 Rosario, Santa Fe, ArgentinaUniv Antioquia, Medellin, ColombiaHosp Univ San Vicente de Paul, Medellin, ColombiaHosp Interzonal Gen Agudos Dr Oscar Alende, Mar Del Plata, Buenos Aires, ArgentinaHosp Clin Porto Alegre, Porto Alegre, RS, BrazilUniv Fed Rio Grande do Sul, Porto Alegre, RS, BrazilHosp Univ Caracas, Caracas, VenezuelaHosp Salvador, Santiago, ChileUniv Chile, Santiago, ChileHosp Escuela Eva Peron, Rosario, Santa Fe, ArgentinaHosp Gen Occidente Secretaria Salud, Guadalajara, Jalisco, MexicoHosp Nacl Guillermo Almenara Irigoyen, Lima, PeruPontificia Univ Catolica Chile, Santiago, ChileHosp Especialidades Ctr Med Nacl Siglo XXI, Inst Mexicano Seguro Social, Mexico City, DF, MexicoHosp Privado, Ctr Med Cordoba, Cordoba, ArgentinaInst Nacl Cardiol Ignacio Chavez, Mexico City, DF, MexicoUniversidade Federal de São Paulo, São Paulo, BrazilHosp Nacl Clin, Cordoba, ArgentinaUniv Alabama, Birmingham, W Midlands, EnglandUniversidade Federal de São Paulo, São Paulo, BrazilCNPq: 305468/2006-5CNPq: 3031165/2008-1Web of Scienc

Supplemental Material - Time to diagnosis in systemic lupus erythematosus: Associated factors and its impact on damage accrual and mortality. Data from a multi-ethnic, multinational Latin American lupus cohort

Supplemental Material for Time to diagnosis in systemic lupus erythematosus: Associated factors and its impact on damage accrual and mortality. Data from a multi-ethnic, multinational Latin American lupus cohort by Romina Nieto, Rosana Quintana, Ernesto Zavala-Flores, Rosa Serrano, Karen Roberts, Luis J Catoggio, Mercedes A García, Guillermo A Berbotto, Verónica Saurit, Eloisa Bonfa, Eduardo F Borba, Lilian T Lavras Costallat, Nilzio A Da Silva, Emilia I Sato, Joao C Tavares Brenol, Loreto Massardo, Oscar J Neira, Gloria Vázquez, Marlene Guibert Toledano, Virginia Pascual-Ramos, María J Sauza del Pozo, Leonor A Barile-Fabris, Mary-Carmen Amigo, Ignacio García De La Torre, Eduardo M Acevedo-Vásquez, María I Segami, Rosa Chacón-Díaz, María H Esteva-Spinetti, Graciela S Alarcón, Bernardo A Pons-Estel, and Guillermo J Pons-Estel in Lupus.</p