3D geological models and their hydrogeological applications : supporting urban development : a case study in Glasgow-Clyde, UK

Urban planners and developers in some parts of the United Kingdom can now access geodata in an easy-to-retrieve and understandable format. 3D attributed geological framework models and associated GIS outputs, developed by the British Geological Survey (BGS), provide a predictive tool for planning site investigations for some of the UK's largest regeneration projects in the Thames and Clyde River catchments. Using the 3D models, planners can get a 3D preview of properties of the subsurface using virtual cross-section and borehole tools in visualisation software, allowing critical decisions to be made before any expensive site investigation takes place, and potentially saving time and money. 3D models can integrate artificial and superficial deposits and bedrock geology, and can be used for recognition of major resources (such as water, thermal and sand and gravel), for example in buried valleys, groundwater modelling and assessing impacts of underground mining. A preliminary groundwater recharge and flow model for a pilot area in Glasgow has been developed using the 3D geological models as a framework. This paper focuses on the River Clyde and the Glasgow conurbation, and the BGS's Clyde Urban Super-Project (CUSP) in particular, which supports major regeneration projects in and around the City of Glasgow in the West of Scotland

The Ursinus Weekly, January 17, 1949

Lauterbach to address February student forum • Ron Landes selected assistant grid coach • Lorelei will retain turnabout custom, say student voters • Rosicrucian society honors thirty girls at Hobson Hall tea • Variety of careers chosen by eighteen semester graduates • Wednesday deadline made by publishers for Ruby material • President\u27s budget, Secretary of State top news of week • Men\u27s council ends work for semester in lengthy session • Which beauty will reign at May festivities? • Flood strikes Ursinus; run for your lives! • Campus cut-up waves bon voyage • Sportsmanship • Single tally downs bears at Delaware; final score, 49-48 • Belles rout Albright 44-27 in opening tilt of season • League lead fixed after Cadets\u27 loss to little Quakers • Bruin Quintet bows 70-48 to superb Garnet squad • Maxwell Club fete attended by Young • Wins prove scarce as cubs drop twohttps://digitalcommons.ursinus.edu/weekly/1606/thumbnail.jp

First large-scale study of antimicrobial susceptibility data, and genetic resistance determinants, in Fusobacterium necrophorum highlighting the importance of continuing focused susceptibility trend surveillance

Objectives: The objective of the study was to explore antimicrobial resistance gene determinant, and phenotypic antibiotic susceptibility, data for Fusobacterium necrophorum from a collection of UK strains. In addition, antimicrobial resistance genes detected in publicly available assembled whole genome sequences were investigated for comparison.Methods: Three hundred and eighty five F. necrophorum strains (1982-2019) were revived from cryovials (Prolab). Subsequent to sequencing (Illumina) and quality checking, 374 whole genomes were available for analysis. These genomes, in addition to publicly available assembled F. necrophorum genetic data, were interrogated using BioNumerics (bioMérieux; v 8.1), for the presence of known antimicrobial resistance genes (ARGs). Agar dilution susceptibility results for 313 F. necrophorum isolates (2016-2021) were also examined.Results: The phenotypic antibiotic test data for the 313 contemporary strains demonstrated potential resistance to penicillin, without increased dosing, in only three isolates. Otherwise, all strains were susceptible to ceftriaxone, clindamycin, co-amoxiclav, meropenem, metronidazole, penicillin and piperacillin/tazobactam, using EUCAST (v 11.0) interpretive guidance. The tet(O), tet(M), tet(40), aph(3’)-III, ant(6)-la and blaOXA-85 ARGs were present in publicly available assembled genomes. tet(M), tet(32), erm(A) and erm(B) were found within the UK strains, with correspondingly raised clindamycin and tetracycline minimum inhibitory concentrations.Conclusions: Current antibiotics recommended for the treatment of infections caused by F. necrophorum, including Lemierre’s disease, are likely to be effective in most cases. However, with evidence of potential ARG transmission from oral bacteria, and the detection of a transposon-mediated beta-lactamase resistance determinant in F. necrophorum, surveillance of both phenotypic and genotypic antimicrobial susceptibility trends must continue, and increase.<br/

A Rossby whistle: a resonant basin mode observed in the Caribbean Sea

We show that an important source of coastal sea level variability around the Caribbean Sea is a resonant basin mode. The mode consists of a baroclinic Rossby wave which propagates westward across the basin and is rapidly returned to the east along the southern boundary as coastal shelf waves. Almost two wavelengths of the Rossby wave fit across the basin, and it has a period of 120 days. The porous boundary of the Caribbean Sea results in this mode exciting a mass exchange with the wider ocean, leading to a dominant mode of bottom pressure variability which is almost uniform over the Grenada, Venezuela, and Colombia basins and has a sharp spectral peak at 120 day period. As the Rossby waves have been shown to be excited by instability of the Caribbean Current, this resonant mode is dynamically equivalent to the operation of a whistle

The effect of electro-hydrodynamic shockwaves on the quality of striploin and brisket beef muscles during long-term storage

Shockwaves generate instantaneous high pressures, which could affect meat shelf-life or quality. This study assessed microbiological counts, pH, drip, cook and moisture loss and texture of striploin (longissimus lumborum) and brisket (pectoralis profundus) treated with electrical shockwave (25 kV, 8 pulses) and subsequently stored (−0.5 °C) for 0, 4, 8, 12, 16 and 20 weeks. Shockwave did not affect total viable counts (p>0.05), with all samples considered microbiologically acceptable (0.05). Shockwave × storage time increased moisture losses in striploin (p<0.01) and brisket (p<0.01) at week 0 but this decreased over subsequent storage weeks. Shockwave technology did not affect meat shelf-life and has potential for beef tenderisation

The Ursinus Weekly, December 6, 1948

Who\u27s Who honors thirteen seniors • Seniors to present year\u27s first formal at local ballroom • Students picked to represent Ursinus in annual edition of campus leaders • Outstanding artists featured Thursday in annual Messiah • Sociology studies confirm results of CORE racial poll • Students of Ursinus place small value on peace of world • Four IRC members visit State College • Annex gets number one stooper rating • Performance of Uncle Harry outstanding • Ursinus students selected to appear in annual Who\u27s Who • Don Young tops bruins in all statistics; prize back selected Player of the year • Frosh grid squad mangles sophs 13-0 on two long runs • JVs extend streak; Penn defeated 3-0 • Last period tally gives Penn lassies victory over belles • U.C. football squad gains easy victory in battle on court • Grunt and groaners show much talent as practice begins • Court campaign to open Wednesday • Temple pathologist to discuss cancer • Omwake assists in preparation of University Business Administration manual • Dr. Armstrong completes book as part of church history serieshttps://digitalcommons.ursinus.edu/weekly/1603/thumbnail.jp

The Ursinus Weekly, December 13, 1948

Coeds in customary dazzle and dither at Christmas week • Galaxy of events highlights Christmas week at Ursinus • Men students view yuletide festivities with unawareness • Lovely dispositions of staff triumph to present faculty with season\u27s token • What gift would you give to the world? • Messiah\u27s largest audience enjoys superb interpretation • Bud Williams\u27 band applauded • January 3 date set for junior jubilee • Bruin soccer star honored by Mules • Pharmacy bows 66-36 in court opener • Strong team looms as coed hoopsters click in practice • Host of veteran grapplers certain of winning season • F&M rallies in last period to trip bear quintet 52-44 • John Logue boosts world federalism at meeting of IRC • Exams to be given for civil service • Scholarship to Yale awarded Dillinger • Club 49 opening slated for Jan. 7 in T-G gymnasium • Communion service to be held Thursday in Bomberger chapel • Authority on international law speaks to class in geopoliticshttps://digitalcommons.ursinus.edu/weekly/1604/thumbnail.jp

The Ursinus Weekly, October 18, 1948

Sophs apparently foiled as freshmen prexy, Lee Trimble, is safely hidden • WAA introduces \u2752 to Ursinus sports • Dale White elected editor of Lantern as Wentzel resigns • Football, fun, light fantastic promise successful old timers\u27 day celebration • Forum to feature election discussion • Grads get degrees on Founders\u27 Day • Five men appointed to act with faculty committees • Dressner, Buchanan picked as council representatives • German club plans dinner; to make Philadelphia trip • Thespians greet applicants at first meeting of year • Former student to return in concert with soprano • Frosh show ends customs for men • NSA head requests college democracy • A happy thought for hapless frosh • Freshman reviews first two weeks • Frosh live again after customs end • Soph ruler reveals innermost thoughts • Junior looks back on freshman year • Frosh views hist.1 with heavy heart • Modern miss visits ancient Latin lands • Subs work all year but get no credit • Dickinson romps to 24-0 victory over bear; Gerry Miller features with 85 yard runback • Bears seek victory on old timers\u27 day • Coeds triumph 5-2 in season\u27s opener • Mules trip bruins in soccer opener • Church colleges hit by Lafayette prexy • Footlighters start ambitious season • Staiger writes article for organic chemistry journal • Pre-meds plan activities; members need high gradeshttps://digitalcommons.ursinus.edu/weekly/1598/thumbnail.jp

Ethanol reversal of tolerance to the respiratory depressant effects of morphine

Opioids are the most common drugs associated with unintentional drug overdose. Death results from respiratory depression. Prolonged use of opioids results in the development of tolerance but the degree of tolerance is thought to vary between different effects of the drugs. Many opioid addicts regularly consume alcohol (ethanol), and post-mortem analyses of opioid overdose deaths have revealed an inverse correlation between blood morphine and ethanol levels. In the present study, we determined whether ethanol reduced tolerance to the respiratory depressant effects of opioids. Mice were treated with opioids (morphine, methadone, or buprenorphine) for up to 6 days. Respiration was measured in freely moving animals breathing 5% CO(2) in air in plethysmograph chambers. Antinociception (analgesia) was measured as the latency to remove the tail from a thermal stimulus. Opioid tolerance was assessed by measuring the response to a challenge dose of morphine (10 mg/kg i.p.). Tolerance developed to the respiratory depressant effect of morphine but at a slower rate than tolerance to its antinociceptive effect. A low dose of ethanol (0.3 mg/kg) alone did not depress respiration but in prolonged morphine-treated animals respiratory depression was observed when ethanol was co-administered with the morphine challenge. Ethanol did not alter the brain levels of morphine. In contrast, in methadone- or buprenorphine-treated animals no respiratory depression was observed when ethanol was co-administered along with the morphine challenge. As heroin is converted to morphine in man, selective reversal of morphine tolerance by ethanol may be a contributory factor in heroin overdose deaths

The Victorian Newsletter (Fall 1990)

The Victorian Newsletter is sponsored for the Victorian Group of Modern Language Association by the Western Kentucky University and is published twice annually.Antinomianism or Anarchy: A Note of Oscar Wilde's "Pen, Pencil and Poison" / William E. Buckler -- Sara Coleridge: The Gigadibs Complex / Nathan Cervo -- "On Tuesday Last, at St George's...": The Dandaical Wedding in Dickens / Patricia Marks -- Ruskin to the "Elusive" Mr. Horn: An Unpublished Letter from a Neglected Friendship / Warren Dwyer -- "Three Cups in One": A Reading of "The Woodspurge" / Andrew Leng -- Faith of Our Mothers: Elizabeth Gaskell's "Lizzie Leigh" / Joanne Thompson -- The Problem of the Man-Trap in Hardy's The Woodlanders / Jonathan C. Glance -- Sartor Redivivus, or Retailoring Carlyle for the Undergraduate Classroom / Linda K. Hughes -- Identification of Literary, Historical and other References in Trollope's The Mac dermots of Ballycloran (1847), The Three Clerks (1858), Rachel Ray (1863), The Vicar of Bullhampton (1870), Ralph the Heir (1871), and The American Senator (1877) / James Means -- Books Receive