Do you have to win it to fix it? a longitudinal studyof lottery winners and their health care demand

We exploit lottery wins to investigate the effects of exogenous changes to individuals' income on health care demand in the United Kingdom. This strategy allows us to estimate lottery income elasticities for a range of health care services that are publicly and privately provided. The results indicate that lottery winners with larger wins are more likely to choose private health services than public health services from the National Health Service. For high-income individuals without private medical insurance, the larger their winnings, the more likely they are to obtain private overnight hospital care. For privately insured individuals, the larger their winnings, the more likely they are to obtain private care for dental services and for eye, blood pressure, and cervical examinations. We find that medium to large winners ( $500) are more likely to have private health insurance. Larger winners are also more likely to drop coverage earlier, possibly after their winnings have been exhausted. The elasticities with respect to lottery wins are comparable in magnitude to the elasticities of household income from fixed effect models

Do you have to win it to fix it? A longitudinal studyof lottery winners and their health care demand

We exploit lottery wins to investigate the effects of exogenous changes to individuals' income on the utilization of health care services, and the choice between private and public health care in the United Kingdom. Our empirical strategy focuses on lottery winners in an individual fixed effects framework and hence the variation of winnings arises from within-individual differences in small versus large winnings. The results indicate that lottery winners with larger wins are more likely to choose private health services than public health services from the National Health Service. The positive effect of wins on the choice of private care is driven largely by winners with medium to large winnings (win category > $500 (or US$750); mean = $1922:5 (US$2,893.5), median = $1058:2 (US$1592.7)). There is some evidence that the effect of winnings vary by whether individuals have private health insurance. We also find weak evidence that large winners are more likely to take up private medical insurance. Large winners are also more likely to drop private insurance coverage between approximately 9 and 10 months earlier than smaller winners, possibly after their winnings have been exhausted. Our estimates for the lottery income elasticities for public health care (relative to no care) are very small and are not statistically distinguishable from zero; those of private health care range from 0 { 0.26 for most of the health services considered, and 0.82 for cervical smear

A new approach to observational cosmology using the scattering transform

Parameter estimation with non-Gaussian stochastic fields is a common challenge in astrophysics and cosmology. In this paper we advocate performing this task using the scattering transform, a statistical tool rooted in the mathematical properties of convolutional neural nets. This estimator can characterize a complex field without explicitly computing higher-order statistics, thus avoiding the high variance and dimensionality problems. It generates a compact set of coefficients which can be used as robust summary statistics for non-Gaussian information. It is especially suited for fields presenting localized structures and hierarchical clustering, such as the cosmological density field. To demonstrate its power, we apply this estimator to the cosmological parameter inference problem in the context of weak lensing. Using simulated convergence maps with realistic noise, the scattering transform outperforms the power spectrum and peak counts, and is on par with the state-of-the-art CNN. It retains the advantages of traditional statistical descriptors (it does not require any training nor tuning), has provable stability properties, allows to check for systematics, and importantly, the scattering coefficients are interpretable. It is a powerful and attractive estimator for observational cosmology and, in general, the study of physically-motivated fields.Comment: 15 pages, 7 figures; comments welcom

Focal Adhesion Kinase-mediated Phosphorylation of Beclin1 Protein Suppresses Cardiomyocyte Autophagy and Initiates Hypertrophic Growth

Autophagy is an evolutionarily conserved intracellular degradation/recycling system that is essential for cellular homeostasis but is dysregulated in a number of diseases, including myocardial hypertrophy. Although it is clear that limiting or accelerating autophagic flux can result in pathological cardiac remodeling, the physiological signaling pathways that fine-tune cardiac autophagy are poorly understood. Herein, we demonstrated that stimulation of cardiomyocytes with phenylephrine (PE), a well known hypertrophic agonist, suppresses autophagy and that activation of focal adhesion kinase (FAK) is necessary for PE-stimulated autophagy suppression and subsequent initiation of hypertrophic growth. Mechanistically, we showed that FAK phosphorylates Beclin1, a core autophagy protein, on Tyr-233 and that this post-translational modification limits Beclin1 association with Atg14L and reduces Beclin1-dependent autophagosome formation. Remarkably, although ectopic expression of wild-type Beclin1 promoted cardiomyocyte atrophy, expression of a Y233E phosphomimetic variant of Beclin1 failed to affect cardiomyocyte size. Moreover, genetic depletion of Beclin1 attenuated PE-mediated/FAK-dependent initiation of myocyte hypertrophy in vivo. Collectively, these findings identify FAK as a novel negative regulator of Beclin1-mediated autophagy and indicate that this pathway can facilitate the promotion of compensatory hypertrophic growth. This novel mechanism to limit Beclin1 activity has important implications for treating a variety of pathologies associated with altered autophagic flux

Demographic change and increasing late singlehood in East Asia, 2010-2050

Background: Marriage is a central institution for social reproduction in East Asia. Until the 1970s and 1980s, marriage across much of East Asia was early and universal. In recent decades, though, this pattern has begun shifting to one of later and less marriage. Objective: We explore the long-term implications for universal marriage patterns of future demographic change in marriage markets in the context of prevailing marriage norms by projecting trends in late singlehood (ages 45 to 49) in four East Asian societies (China, South Korea, Taiwan, and Japan). Methods: We estimate forces of attraction to characterize marriage matching norms by age and education across these different societies by drawing on large-scale population data. Next, we develop counterfactual scenarios in which we apply contemporary norms to future population structures in these societies, as well as scenarios based on more gender-symmetrical matching norms to examine how populations who have never been married by ages 45 to 49 would evolve. Results: Our projections indicate that in the coming decades there will be a substantial increase in late singlehood across all these societies relative to their 2010 levels. These increases in singlehood are driven by forthcoming demographic changes in the marriage market that intensify the effects of prevailing matching norms. These increases are notable in Taiwan and South Korea, where recent data indicate generalized weak propensities to marry in current norms. While a shift toward greater gender symmetry in matching norms would reverse gender gaps between men and women in nonmarriage, it would have little impact on the overall projected proportions of singles by ages 45 to 49. Conclusions: If prevailing norms in each of these contexts continue, the universality of marriage will be substantially eroded in the coming decades, even if norms become more gender symmetrical. The extent to which nonmarital cohabitation and childbearing emerge in the future will determine how marriage will influence fertility trends, population growth, aging, and social reproduction. Contribution: For the first time, we project the implications for universal marriage of recent shifts in marriage norms and demographic change in East Asian countries

Regulation of MYC Expression and Differential JQ1 Sensitivity in Cancer Cells

High level MYC expression is associated with almost all human cancers. JQ1, a chemical compound that inhibits MYC expression is therapeutically effective in preclinical animal models in midline carcinoma, and Burkitt’s lymphoma (BL). Here we show that JQ1 does not inhibit MYC expression to a similar extent in all tumor cells. The BL cells showed a ∼90% decrease in MYC transcription upon treatment with JQ1, however, no corresponding reduction was seen in several non-BL cells. Molecularly, these differences appear due to requirements of Brd4, the most active version of the Positive Transcription Elongation Factor B (P-TEFb) within the Super Elongation Complex (SEC), and transcription factors such as Gdown1, and MED26 and also other unknown cell specific factors. Our study demonstrates that the regulation of high levels of MYC expression in different cancer cells is driven by unique regulatory mechanisms and that such exclusive regulatory signatures in each cancer cells could be employed for targeted therapeutics

Hydroclimate variability during the last 2700 years based on stalagmite multi-proxy records in the central-western Mediterranean

This study presents the first high-resolution speleothem-based hydrological reconstruction for much of the last 2.7 kyr in the central-western Mediterranean. The paleohydrological information comes from a combination of five U-Th dated stalagmites from two Mallorca island caves. Interpretations are based on high-resolution records of d18O, d13C and trace element analyses combined with information from mineralogical X-ray diffraction, fabrics and morphological features, and cave monitoring data. None of the studied stalagmites cover the whole 2.7 kyr period but they provide sufficient overlap to replicate most of the discussed climatic intervals with the exception of the Medieval Climate Anomaly (MCA), which is represented by a hiatus. Taking into account the results of five years farmed calcite collected in glass plates and cave environmental parameters, we argue that main patterns in the stalagmite geochemical records are mostly controlled by changing rates of prior calcite precipitation (PCP) that respond to hydrological changes in the region. We apply a principal component analysis to the stalagmite geochemical data set and a composite d18O record to obtain a robust regional hydrological record. This record supports wet conditions for the early Roman Period (RP), the first half of the Early Middle Ages (EMA) and the Little Ice Age (LIA), and drier conditions for the late RP, the late EMA and the entire MCA. These results are discussed in the context of other climatic and oceanographic records from the region including paleo North Atlantic Oscillation (NAO) records. This ocean-atmosphere approach suggests complex non-stationary climate patterns for the last 2.7 kyr, including the occurrence of both wetwarm and wet-cold intervals and underlying the complex interaction of factors controlling climate evolution in the region. Overall, positive (negative) NAO phases appear coincident with drier (wetter) conditions for all the examined period at decadal time-scale