Semi-automated procedure for windowing time series and computing Fourier amplitude spectra (FAS) for the NGA-West2 database

This document introduces and describes the data processing methods developed for computing Fourier amplitude spectra (FAS) in the NGA-West2 project. The products of this study can be used to estimate high-frequency attenuation, kappa (κ), to estimate site amplification through empirical spectral ratios, as well as to aid in the development of ground-motion models (GMMs) based on FAS. To accommodate different potential user objectives, we selected five time windows in the acceleration time series (noise, P-wave, S-wave, coda, and the entire record) for which we compute the FAS. The processing starts with the time-aligned, instrument-corrected, tapered, and filtered acceleration time series. The proposed window selection method is developed through trial and error, and tested against a range of ground motions with different magnitudes and hypocentral distances from different regions. This document summarizes the steps for window selection and FAS computation, and describes the output data format. This report will be accompanied by the final products of the PEER NGA-West2 Project, namely, the published report describing the database [Ancheta et al. 2013] and the flatfile, which can be downloaded in excel format at: http://peer.berkeley.edu/ngawest2/databases/

A methodology for the estimation of kappa (κ) for large datasets. Example application to rock sites in the NGA-East database

This report reviews four of the main approaches (two band-limited and two broadband) currently used for estimating the site κ0: the acceleration slope (AS) above the corner frequency, the displacement slope (DS) below the corner frequency, the broadband (BB) fit of the spectrum, and the response spectral shape (RESP) template. Using these four methods, estimates of κ0 for rock sites in Central Eastern North America (CENA) in the shallow crustal dataset from NGAEast are computed for distances less than 100 km. Using all of the data within 100 km, the mean κ0 values are 8 msec for the AS approach and 27 msec for the DS approach. These mean values include negative κ estimates for some sites. If the negative κ values are removed, then the mean values are 25 msec and 42 msec, respectively. Stacking all spectra together led to mean κ0 values of 7 and 29 msec, respectively. Overall, the DS approach yields 2–3 times higher values than the AS, which agrees with previous observations, but the uncertainty of the estimates in each case is large. The AS approach seems consistent for magnitudes down to M3 but not below. There is large within-station variability of κ that may be related to differences in distance, Q, complexity along the path, or particular source characteristics, such as higher or lower stress drop. The station-to-station differences may be due to site-related factors. Because most sites have been assigned Vs30 = 2000 m/sec, it is not possible to correlate variations in κ0 with rock stiffness. Based on the available profile, the individual spectra are corrected for crustal amplification and only affect results below 15 Hz. Since the AS and DS approaches are applied over different frequency ranges, we find that only the DS results are sensitive to the amplification correction. More detailed knowledge of individual near-surface profiles may have effects on AS results, too. Although κ is considered to be caused solely by damping in the shallow crust, measurement techniques often cannot separate the effects of damping and amplification, and yield the net effect of both phenomena. The two broadband approaches, BB and RESP, yield similar results. The mean κ0_BB is 5±0.5 msec across all NEHRP class A sites. The κ0_RESP for the two events examined is 5 and 6 msec. From literature, the average value of κ0 in CENA is 6 ± 2 msec. This typical value is similar to the broadband estimates of this study and to the mean κAS when all available recordings are used along with all flags. When only recordings with down-going FAS slope are selected from the dataset, the mean value of κAS increases by a factor of 2–3. To evaluate the scaling of high-frequency ground motion with κ, we analyze residuals from ground motion prediction equations (GMPEs) versus κ estimates. Using the κ values from the AS approach, the average trend of the ln(PSA) residuals for hard-rock data do not show the expected strong dependence on κ, but when using κ values from the DS approach, there is a stronger correlation of the residuals, i.e., a κ that is more consistent with the commonly used analytically based scaling. The κDS estimates may better reflect the damping in the shallow crust, while the κAS estimates may reflect a net effect of damping and amplification that has not been decoupled. The κDS estimates are higher than the κAS estimates, so the expected effect on the high-frequency ground motion is smaller than that expected for the κAS estimates. An empirical hard-rock site factor model is developed that represents the combined Vs-κ0 site factor relative to a 760 m/sec reference-site condition. At low frequencies ( 10 Hz), the residuals do not show the strong increase in the site factors as seen in the analytical model results. A second hard-rock dataset from British Columbia, Canada, is also used. This BC hard-rock residuals show an increase in the 15–50 Hz range that is consistent with the analytical κ0 scaling for a hard-rock κ0 of about 0.015 sec. The variability of the PSA residuals is also used to evaluate the κ0 scaling for hard-rock sites from analytical modeling. The scatter in existing κ0 values found in literature is disproportionately large compared to the observed variability in high-frequency ground motions. We compared the predicted ground-motion variability based on analytical modeling to the observed variability in our residuals. While the hard-rock sites are more variable at high frequencies due to the additional κ0 variability, this additional variability is much less than the variability predicted by the analytical modeling using the variability from κ0-Vs30 correlations. This is consistent with weaker κ0 scaling compared to that predicted by the analytical modelling seen in the mean residuals

Squeezing Kappa (κ) out of the transportable array: A strategy for using bandlimited data in regions of sparse seismicity

The κ parameter (Anderson and Hough, 1984), and namely its site-specific component (κ0), is important for predicting and simulating high-frequency ground motion. We develop a framework for estimating κ0 and addressing uncertainties under the challenging conditions often imposed in practice: 1. Low seismicity (limited, poor-quality, distant records); 2. Limited-bandwidth data from the Transportable Array (maximum usable frequency 16 Hz); 3. Low magnitudes (ML1.2-3.4) and large uncertainty in stress drop (corner frequency). We cannot resolve stress drop within the bandwidth, so we propose an approach that only requires upper and lower bounds on its regional values to estimate κ0. To address uncertainties, we combine three measurement approaches (acceleration spectrum slope, AS; displacement spectrum slope, DS; broadband spectral fit, BB). We also examine the effect of crustal amplification, and find that neglecting it can affect κ0 by up to 35%. DS estimates greatly exceed AS estimates. We propose a reason behind this bias, related to the residual effect of the corner frequency on κAS and κDS. For our region, we estimate a frequency-independent mean S-wave Q of 900±300 at 9-16 Hz, and an ensemble mean κ0 over all sites of 0.033±0.014 s. This value is similar to the native κ0 of the NGA-West2 ground motion prediction equations, indicating that these do not need to be adjusted for κ0 for use in Southern Arizona. We find that stress drop values in this region may be higher compared to estimates of previous studies, possibly due to trade-offs between stress drop and κ0. For this dataset, the within-approach uncertainty is much larger than the between-approach uncertainty, and it cannot be reduced if the data quality is not improved. The challenges discussed here will be relevant in studies of κ for other regions with band-limited data, e.g., any region where data come primarily from the TA

PEER Arizona strong-motion database and GMPEs evaluation

This report summarizes the products and results of a study on the collection, processing, and analysis of earthquake ground-motions recorded in Arizona at several recording stations within 200 km from the Palo Verde Nuclear Generating Station in central Arizona. The recorded ground motion in Arizona were compiled and processed according to the Pacific Earthquake Engineering Research Center’s (PEER) record-processing standards. Shear wave velocity profiles at ten recording stations were measured through the spectral analysis of surface wave dispersion technique. Additionally, “kappa” a measure of energy dissipation in the top 1 to 2 km of the crust, was estimated by three methodologies. The average κ0 (kappa at zero-kilometer distance) was estimated from all sites as 0.033 sec. Finally, response spectra of the recorded ground motions in Arizona were compared with those predicted by the NGA-West2 ground motion prediction equations at large distances in Arizona. The comparison showed that overall the recorded 5% damped response spectral ordinates were over predicted by the NGA-West2 models by a range of 0-0.35 natural log units for events occurring in Central California, and by a range of 0.2-0.7 natural log units for events occurring in Southern California and the Gulf of California

International multicenter expert survey on endoscopic treatment of upper gastrointestinal anastomotic leaks

Background and study aims: A variety of endoscopic techniques are currently available for treatment of upper gastrointestinal (UGI) anastomotic leaks; however, no definite consensus exists on the most appropriate therapeutic approach. Our aim was to explore current management of UGI anastomotic leaks. Methods: A survey questionnaire was distributed among international expert therapeutic endoscopists regarding management of UGI anastomotic leaks. Results: A total of 44 % of 163 surveys were returned; 69 % were from gastroenterologists and 56 % had > 10 years of experience. A third of respondents treat between 10 and 19 patients annually. Fifty-six percent use fully-covered self-expandable metal stents as their usual first option; 80% use techniques to minimize migration; 4 weeks was the most common reported stent dwell time. Sixty percent perform epithelial ablation prior to over-the-scope-clip placement or suturing. Regarding endoscopic vacuum therapy (EVT), 56 % perform balloon dilation and intracavitary EVT in patients with large cavities but small leak defects. Regarding endoscopic septotomy, 56 % consider a minimal interval of 4 weeks from surgery and 90 % consider the need to perform further sessions. Regarding endoscopic internal drainage (EID), placement of two stents and shorter stents is preferred. Persistent inflammation with clinical sepsis was the definition most commonly reported for endoscopic failure. EVT/stent placement and EVT/EID were the therapeutic options most often chosen in patients with previous oncologic surgery and previous bariatric surgery, respectively. Conclusions: There is a wide variation in the management of patients with UGI anastomotic leaks. Future prospective studies are needed to move from an expert- to evidence- and personalization-based care

Immune-Complex Mimics as a Molecular Platform for Adjuvant-Free Vaccine Delivery

Protein-based vaccine development faces the difficult challenge of finding robust yet non-toxic adjuvants suitable for humans. Here, using a molecular engineering approach, we have developed a molecular platform for generating self-adjuvanting immunogens that do not depend on exogenous adjuvants for induction of immune responses. These are based on the concept of Immune Complex Mimics (ICM), structures that are formed between an oligomeric antigen and a monoclonal antibody (mAb) to that antigen. In this way, the roles of antigens and antibodies within the structure of immune complexes are reversed, so that a single monoclonal antibody, rather than polyclonal sera or expensive mAb cocktails can be used. We tested this approach in the context of Mycobacterium tuberculosis (MTB) infection by linking the highly immunogenic and potentially protective Ag85B with the oligomeric Acr (alpha crystallin, HspX) antigen. When combined with an anti-Acr monoclonal antibody, the fusion protein formed ICM which bound to C1q component of the complement system and were readily taken up by antigen-presenting cells in vitro. ICM induced a strong Th1/Th2 mixed type antibody response, which was comparable to cholera toxin adjuvanted antigen, but only moderate levels of T cell proliferation and IFN-γ secretion. Unfortunately, the systemic administration of ICM did not confer statistically significant protection against intranasal MTB challenge, although a small BCG-boosting effect was observed. We conclude that ICM are capable of inducing strong humoral responses to incorporated antigens and may be a suitable vaccination approach for pathogens other than MTB, where antibody-based immunity may play a more protective role

Dapagliflozin and Kidney Outcomes in Hospitalized Patients with COVID-19 Infection:An Analysis of the DARE-19 Randomized Controlled Trial

Background and objectives: Patients who were hospitalized with coronavirus disease 2019 (COVID-19) infection are at high risk of AKI and KRT, especially in the presence of CKD. The Dapagliflozin in Respiratory Failure in Patients with COVID-19 (DARE-19) trial showed that in patients hospitalized with COVID-19, treatment with dapagliflozin versus placebo resulted in numerically fewer participants who experienced organ failure or death, although these differences were not statistically significant. We performed a secondary analysis of the DARE-19 trial to determine the efficacy and safety of dapagliflozin on kidney outcomes in the overall population and in prespecified subgroups of participants defined by baseline eGFR. Design, setting, participants, & measurements: The DARE-19 trial randomized 1250 patients who were hospitalized (231 [18%] had eGFR <60 ml/min per 1.73 m2) with COVID-19 and cardiometabolic risk factors to dapagliflozin or placebo. Dual primary outcomes (time to new or worsened organ dysfunction or death, and a hierarchical composite end point of recovery [change in clinical status by day 30]), and the key secondary kidney outcome (composite of AKI, KRT, or death), and safety were assessed in participants with baseline eGFR <60 and ≥60 ml/min per 1.73 m2. Results: The effect of dapagliflozin versus placebo on the primary prevention outcome (hazard ratio, 0.80; 95% confidence interval, 0.58 to 1.10), primary recovery outcome (win ratio, 1.09; 95% confidence interval, 0.97 to 1.22), and the composite kidney outcome (hazard ratio, 0.74; 95% confidence interval, 0.50 to 1.07) were consistent across eGFR subgroups (P for interaction: 0.98, 0.67, and 0.44, respectively). The effects of dapagliflozin on AKI were also similar in participants with eGFR <60 ml/min per 1.73 m2 (hazard ratio, 0.71; 95% confidence interval, 0.29 to 1.77) and ≥60 ml/min per 1.73 m2 (hazard ratio, 0.69; 95% confidence interval, 0.37 to 1.29). Dapagliflozin was well tolerated in participants with eGFR <60 and ≥60 ml/min per 1.73 m2. Conclusions: The effects of dapagliflozin on primary and secondary outcomes in hospitalized participants with COVID-19 were consistent in those with eGFR below/above 60 ml/min per 1.73 m2. Dapagliflozin was well tolerated and did not increase the risk of AKI in participants with eGFR below or above 60 ml/min per 1.73 m2

Diabetic Choroidopathy: Choroidal Vascular Density and Volume in Diabetic Retinopathy With Swept-Source Optical Coherence Tomography

Purpose To compare choroidal vascular density (CVD) and volume (CVV) in diabetic eyes and controls, using en face swept-source optical coherence tomography (SS-OCT). Design Prospective cross-sectional study. Methods Setting: Multicenter. Patient Population: Total of 143 diabetic eyes—27 with no diabetic retinopathy (DR), 47 with nonproliferative DR (NPDR), 51 with NPDR and diabetic macular edema (DME), and 18 with proliferative DR (PDR)—and 64 age-matched nondiabetic control eyes. Observation Procedures: Complete ophthalmologic examination and SS-OCT imaging. En face SS-OCT images of the choroidal vasculature were binarized. Main Outcome Measures: CVD, calculated as the percent area occupied by choroidal vessels in the central macular region (6-mm-diameter circle centered on the fovea), and throughout the posterior pole (12 × 9 mm). The central macular CVV was calculated by multiplying the average CVD by macular area and choroidal thickness (obtained with SS-OCT automated software). Multilevel mixed linear models were performed for analyses. Results Compared to controls (0.31 ± 0.07), central macular CVD was significantly decreased by 9% in eyes with NPDR + DME (0.28 ± 0.06; ß = −0.03, P = .02) and by 15% in PDR (0.26 ± 0.05; ß = −0.04, P = .01). The central macular CVV was significantly decreased by 19% in eyes with PDR (0.020 ± 0.005 mm3, ß = −0.01, P = .01) compared to controls (0.025 ± 0.01 mm3). Conclusions Choroidal vascular density and volume are significantly reduced in more advanced stages of diabetic retinopathy. New imaging modalities should allow further exploration of the contributions of choroidal vessel disease to diabetic eye disease pathogenesis, prognosis, and treatment response.info:eu-repo/semantics/publishedVersio

Are MRI-defined fat infiltrations in the multifidus muscles associated with low back pain?

BACKGROUND: Because training of the lumbar muscles is a commonly recommended intervention in low back pain (LBP), it is important to clarify whether lumbar muscle atrophy is related to LBP. Fat infiltration seems to be a late stage of muscular degeneration, and can be measured in a non-invasive manner using magnetic resonance imaging. The purpose of this study was to investigate if fat infiltration in the lumbar multifidus muscles (LMM) is associated with LBP in adults and adolescents. METHODS: In total, 412 adults (40-year-olds) and 442 adolescents (13-year-olds) from the general Danish population participated in this cross-sectional cohort study. People with LBP were identified through questionnaires. Using MRI, fat infiltration of the LMM was visually graded as none, slight or severe. Odds ratios were calculated for both age groups, taking into account sex, body composition and leisure time physical activity for both groups, and physical workload (in adults only) or daily bicycling (in adolescents only). RESULTS: Fat infiltration was noted in 81% of the adults but only 14% of the adolescents. In the adults, severe fat infiltration was strongly associated with ever having had LBP (OR 9.2; 95% CI 2.0–43.2), and with having LBP in the past year (OR 4.1; 1.5–11.2), but there was no such association in adolescents. None of the investigated moderating factors had an obvious effect on the OR in the adults. CONCLUSION: Fat infiltration in the LMM is strongly associated with LBP in adults only. However, it will be necessary to quantify these measurements objectively and to investigate the direction of this link longitudinally in order to determine if the abnormal muscle is the cause of LBP or vice versa

Urinary Mass Spectrometry Profiles in Age-Related Macular Degeneration

We and others have shown that patients with different severity stages of age-related macular degeneration (AMD) have distinct plasma metabolomic profiles compared to controls. Urine is a biofluid that can be obtained non-invasively and, in other fields, urine metabolomics has been proposed as a feasible alternative to plasma biomarkers. However, no studies have applied urinary mass spectrometry (MS) metabolomics to AMD. This study aimed to assess urinary metabolomic profiles of patients with different stages of AMD and a control group. We included two prospectively designed, multicenter, cross-sectional study cohorts: Boston, US (n = 185) and Coimbra, Portugal (n = 299). We collected fasting urine samples, which were used for metabolomic profiling (Ultrahigh Performance Liquid chromatography-Mass Spectrometry). Multivariable logistic and ordinal logistic regression models were used for analysis, accounting for gender, age, body mass index and use of AREDS supplementation. Results from both cohorts were then meta-analyzed. No significant differences in urine metabolites were seen when comparing patients with AMD and controls. When disease severity was considered as an outcome, six urinary metabolites differed significantly (p < 0.01). In particular, two of the metabolites identified have been previously shown by our group to also differ in the plasma of patients of AMD compared to controls and across severity stages. While there are fewer urinary metabolites associated with AMD than plasma metabolites, this study identified some differences across stages of disease that support previous work performed with plasma, thus highlighting the potential of these metabolites as future biomarkers for AMD