Experiences of unplanned deliveries outside the hospital environment

Objective: This study aims to identify the experiences of mothers that gave an unplanned out-of-hospital birth. Design: An integrative review was performed in Medline and SciVerse Scopus databases. Publications in English and Portuguese, covering the period between 2000 and 2021, were included. The final selection consisted of four articles. Results: The experiences are ambiguous, showing vulnerability, stress, and guilt, but also feelings of good  fortune, relief, and pride after labor. Furthermore, the time spent traveling to a health institution is a determinant of births out of the hospital. Other factors influencing the occurrence are related to single mothers, insufficient education, and lack of prenatal care. Conclusion: It is acknowledged that the country’s socio-economic development level is a decisive factor, in which mothers from developed countries felt more secure with the experience  than mothers from developing countries. In addition, medical education based on humanized care has enhanced the promotion of a positive experience concerning unplanned childbirth in an out-of-hospital environment for women.Objetivo: identificar as experiências das mães em partos não planejados fora do ambiente hospitalar.Metodologia: Foi realizada revisão integrativa nas bases de dados Medline e SciVerse Scopus. Foram incluídas publicações em inglês e em português, no período entre 2000 e 2021. A amostra final foi composta de quatro artigos. Resultados: As experiências vividas se mostram ambíguas, com relatos de vulnerabilidade, estresse e culpa, mas, também, sensações de sorte, alívio e orgulho após o nascimento. Ainda, o tempo de deslocamentoaté uma instituição de saúde é determinante na realização de partos fora do ambiente hospitalar. Outros fatores que influenciam na ocorrência dizem respeito às mães solo, baixa escolaridade e falta de assistência pré-natal. Conclusões: O nível de desenvolvimento socioeconômico do país é um fator decisivo, no qual mães procedentes de países desenvolvidos sentiam-se mais seguras com a experiência do que as mães de países em desenvolvimento. Além disso, a educação médica baseada em um atendimento humanizado potencializou a promoção de uma vivência positiva em relação ao parto não planejado fora do ambiente hospitalar para as mulheres

Experiências de partos não planejados fora do ambiente hospitalar

Objetivo: identificar as experiências das mães em partos não planejados fora do ambiente hospitalar. Metodologia: Foi realizada revisão integrativa nas bases de dados Medline e SciVerse Scopus. Foram incluídas publicações em inglês e em português, no período entre 2000 e 2021. A amostra final foi composta de quatro artigos. Resultados: As experiências vividas se mostram ambíguas, com relatos de vulnerabilidade, estresse e culpa, mas, também, sensações de sorte, alívio e orgulho após o nascimento. Ainda, o tempo de deslocamento até uma instituição de saúde é determinante na realização de partos fora do ambiente hospitalar. Outros fatores que influenciam na ocorrência dizem respeito às mães solo, baixa escolaridade e falta de assistência pré-natal. Conclusões: O nível de desenvolvimento socioeconômico do país é um fator decisivo, no qual mães procedentes de países desenvolvidos sentiam-se mais seguras com a experiência do que as mães de países em desenvolvimento. Além disso, a educação médica baseada em um atendimento humanizado potencializou a promoção de uma vivência positiva em relação ao parto não planejado fora do ambiente hospitalar para as mulheres

PROCALCITONIN AS ANTIMICROBIAL MANAGEMENT TOOL IN COVID-19 PATIENTS

Objective: to investigate the relationship between procalcitonin in the differential diagnosis of bacterial coinfection in COVID-19 patients.Method: a cross-sectional retrospective study conducted between February and March 2021 in the Intensive Care Unit of a public hospital from southern Brazil by filling in a form. Descriptive statistical analyses were performed, as well as of association between variables.Results: of the 231 patients, 28.14% presented infection (63.20% in the lungs), 25% had bacteria isolated, 77.49% used antimicrobials and, in 14.72% of the cases, procalcitonin > 2 ng/mL. There was a significant association between antimicrobial use and infection (p=0.001), isolation of bacteria (p<0.001), topography of the infection (p<0.001) and procalcitonin values (p<0.001). Procalcitonin use showed an association with bacterial infection (p<0.001), isolation of bacteria (p<0.001), antimicrobial use (p=0.001) and death (p<0.001).Conclusion: procalcitonin can reduce empirical antimicrobial use and stimulate detection and identification of pathogens, taking into account the clinical and epidemiological data

PROCALCITONINA COMO FERRAMENTA DE GERENCIAMENTO DE ANTIMICROBIANOS EM PACIENTES COM COVID-19

Objetivo: investigar a relação da procalcitonina no diagnóstico diferencial de coinfecção bacteriana em pacientes com Covid-19.Método: estudo transversal retrospectivo, realizado em unidade de terapia intensiva em hospital público do sul do Brasil, entre fevereiro e março de 2021, mediante formulário. Realizaram-se análises estatísticas descritivas e de associação entre variáveis.Resultados: dos 231 pacientes, 28,14% apresentaram infecção, 63,20% de sítio pulmonar, em 25% ocorreu isolamento de bactérias, 77,49% utilizaram antimicrobianos e em 14,72% dos casos foi observada procalcitonina > dois ng/mL. Houve associação significativa entre uso de antimicrobiano e infeção (p=0,001), isolamento de bactérias (p<0,001), topografia da infeção (p<0,001), valores de procalcitonina (p<0,001). O uso da procalcitonina mostrou associação com infeção bacteriana (p<0,001), isolamento de bactéria (p<0,001), uso de antimicrobianos (p=0,001), e óbito (p<0,001).Conclusão: a procalcitonina pode reduzir o uso empírico de antimicrobianos e estimular a detecção e identificação de patógenos, levando em consideração os dados clínicos e epidemiológicos

PROCALCITONINA COMO HERRAMIENTA PARA EL MANEJO DE ANTIMICROBIANOS EN PACIENTES CON COVID-19

Objetivo: investigar la relación de la procalcitonina en el diagnóstico diferencial de coinfección bacteriana en pacientes con COVID-19.Método: estudio transversal y retrospectivo realizado entre febrero y marzo de 2021 en la unidad de cuidados intensivos de un hospital público del sur de Brasil, por medio de un formulario. Se realizaron análisis estadísticos descriptivos y de asociación entre variables.Resultados: de los 231 pacientes, el 28,14% presentó infección (el 63,20% en los pulmones), en el 25% se aislaron las bacterias, el 77,49% utilizó antimicrobianos y en el 14,72% de los casos se empleó procalcitonina > 2 ng/mL. Hubo una significativa asociación entre uso de antimicrobianos e infección (p=0,001), aislamiento de bacterias (p<0,001), topografía de la infección (p<0,001) y valores de procalcitonina (p<0,001). La utilización de procalcitonina demostró estar asociada con infección bacteriana (p<0,001), aislamiento de bacterias (p<0,001), uso de antimicrobianos (p=0,001) y fallecimiento (p<0,001).Conclusión: la procalcitonina puede reducir el uso empírico de antimicrobianos y estimular la detección e identificación de patógenos, considerando los datos clínicos y empíricos

Extensionist pioneering at the Universidade do Estado do Rio Grande do Norte: online course in first aids and basic life support

The university´s extension has as main aim to develop interventions that impact and embrace the society. The first aids and basic life support (BLS) in the UERN has as principal objective to include, by means of the dissemination of the practical and theoretical knowledge, the first aids procedures turned to the general public, by means of an accessible language and of dynamical methodologies. Conditions of urgency and emergency are presented, usually the most frequent in the pre-hospital´ treatment, where precocious intervention word as the way to save lives, by means of practical and theoretical classes. This work tried to show how these initiatives have been developed, implanting new modalities of access to technical information about first aids, as well as all the used strategies to train effectively academic and not academic people. This Project have been under execution since 2013 and, consequently due to the importance of the theme, every year, the number of trained participants have been increasing, corroborating to the quality of the information presented and to the backup of the university and the citizens. In this way, it is of extremely importance the continuity of the permanent character of the course, in order to promote the importance and constant actualization in the field so neglected and recurrent, also considering, the promotion of the health in the virtual world too, bringing the information to any place in the world with internet access

Canagliflozin and renal outcomes in type 2 diabetes and nephropathy

BACKGROUND Type 2 diabetes mellitus is the leading cause of kidney failure worldwide, but few effective long-term treatments are available. In cardiovascular trials of inhibitors of sodium–glucose cotransporter 2 (SGLT2), exploratory results have suggested that such drugs may improve renal outcomes in patients with type 2 diabetes. METHODS In this double-blind, randomized trial, we assigned patients with type 2 diabetes and albuminuric chronic kidney disease to receive canagliflozin, an oral SGLT2 inhibitor, at a dose of 100 mg daily or placebo. All the patients had an estimated glomerular filtration rate (GFR) of 30 to &lt;90 ml per minute per 1.73 m2 of body-surface area and albuminuria (ratio of albumin [mg] to creatinine [g], &gt;300 to 5000) and were treated with renin–angiotensin system blockade. The primary outcome was a composite of end-stage kidney disease (dialysis, transplantation, or a sustained estimated GFR of &lt;15 ml per minute per 1.73 m2), a doubling of the serum creatinine level, or death from renal or cardiovascular causes. Prespecified secondary outcomes were tested hierarchically. RESULTS The trial was stopped early after a planned interim analysis on the recommendation of the data and safety monitoring committee. At that time, 4401 patients had undergone randomization, with a median follow-up of 2.62 years. The relative risk of the primary outcome was 30% lower in the canagliflozin group than in the placebo group, with event rates of 43.2 and 61.2 per 1000 patient-years, respectively (hazard ratio, 0.70; 95% confidence interval [CI], 0.59 to 0.82; P=0.00001). The relative risk of the renal-specific composite of end-stage kidney disease, a doubling of the creatinine level, or death from renal causes was lower by 34% (hazard ratio, 0.66; 95% CI, 0.53 to 0.81; P&lt;0.001), and the relative risk of end-stage kidney disease was lower by 32% (hazard ratio, 0.68; 95% CI, 0.54 to 0.86; P=0.002). The canagliflozin group also had a lower risk of cardiovascular death, myocardial infarction, or stroke (hazard ratio, 0.80; 95% CI, 0.67 to 0.95; P=0.01) and hospitalization for heart failure (hazard ratio, 0.61; 95% CI, 0.47 to 0.80; P&lt;0.001). There were no significant differences in rates of amputation or fracture. CONCLUSIONS In patients with type 2 diabetes and kidney disease, the risk of kidney failure and cardiovascular events was lower in the canagliflozin group than in the placebo group at a median follow-up of 2.62 years

Predictive Score for Carbapenem-Resistant Gram-Negative Bacilli Sepsis: Single-Center Prospective Cohort Study

A clinical–epidemiological score to predict CR-GNB sepsis to guide empirical antimicrobial therapy (EAT), using local data, persists as an unmet need. On the basis of a case–case–control design in a prospective cohort study, the predictive factors for CR-GNB sepsis were previously determined as prior infection, use of mechanical ventilation and carbapenem, and length of hospital stay. In this study, each factor was scored according to the logistic regression coefficients, and the ROC curve analysis determined its accuracy in predicting CR-GNB sepsis in the entire cohort. Among the total of 629 admissions followed by 7797 patient-days, 329 single or recurrent episodes of SIRS/sepsis were enrolled, from August 2015 to March 2017. At least one species of CR-GNB was identified as the etiology in 108 (33%) episodes, and 221 were classified as the control group. The cutoff point of ≥3 (maximum of 4) had the best sensitivity/specificity, while ≤1 showed excellent sensitivity to exclude CR-GNB sepsis. The area under the curve was 0.80 (95% CI: 0.76–0.85) and the number needed to treat was 2.0. The score may improve CR-GNB coverage and spare polymyxins with 22% (95% CI: 17–28%) adequacy rate change. The score has a good ability to predict CR-GNB sepsis and to guide EAT in the future