Model-based acceleration control of turbofan engines with a Hammerstein-Wiener representation

Acceleration control of turbofan engines is conventionally designed through either schedule-based or acceleration-based approach. With the widespread acceptance of model-based design in aviation industry, it becomes necessary to investigate the issues associated with model-based design for acceleration control. In this paper, the challenges for implementing model-based acceleration control are explained; a novel Hammerstein-Wiener representation of engine models is introduced; based on the Hammerstein-Wiener model, a nonlinear generalized minimum variance type of optimal control law is derived; the feature of the proposed approach is that it does not require the inversion operation that usually upsets those nonlinear control techniques. The effectiveness of the proposed control design method is validated through a detailed numerical study

Two Iterative algorithms for the matrix sign function based on the adaptive filtering technology

In this paper, two new efficient algorithms for calculating the sign function of the large-scale sparse matrix are proposed by combining filtering algorithm with Newton method and Newton Schultz method respectively. Through the theoretical analysis of the error diffusion in the iterative process, we designed an adaptive filtering threshold, which can ensure that the filtering has little impact on the iterative process and the calculation result. Numerical experiments are consistent with our theoretical analysis, which shows that the computational efficiency of our method is much better than that of Newton method and Newton Schultz method, and the computational error is of the same order of magnitude as that of the two methods.Comment: 18 pages,12 figure

Exome Sequencing and the Management of Neurometabolic Disorders

BACKGROUND: Whole-exome sequencing has transformed gene discovery and diagnosis in rare diseases. Translation into disease-modifying treatments is challenging, particularly for intellectual developmental disorder. However, the exception is inborn errors of metabolism, since many of these disorders are responsive to therapy that targets pathophysiological features at the molecular or cellular level. METHODS: To uncover the genetic basis of potentially treatable inborn errors of metabolism, we combined deep clinical phenotyping (the comprehensive characterization of the discrete components of a patient's clinical and biochemical phenotype) with whole-exome sequencing analysis through a semiautomated bioinformatics pipeline in consecutively enrolled patients with intellectual developmental disorder and unexplained metabolic phenotypes. RESULTS: We performed whole-exome sequencing on samples obtained from 47 probands. Of these patients, 6 were excluded, including 1 who withdrew from the study. The remaining 41 probands had been born to predominantly nonconsanguineous parents of European descent. In 37 probands, we identified variants in 2 genes newly implicated in disease, 9 candidate genes, 22 known genes with newly identified phenotypes, and 9 genes with expected phenotypes; in most of the genes, the variants were classified as either pathogenic or probably pathogenic. Complex phenotypes of patients in five families were explained by coexisting monogenic conditions. We obtained a diagnosis in 28 of 41 probands (68%) who were evaluated. A test of a targeted intervention was performed in 18 patients (44%). CONCLUSIONS: Deep phenotyping and whole-exome sequencing in 41 probands with intellectual developmental disorder and unexplained metabolic abnormalities led to a diagnosis in 68%, the identification of 11 candidate genes newly implicated in neurometabolic disease, and a change in treatment beyond genetic counseling in 44%. (Funded by BC Children's Hospital Foundation and others.)

GRAPHENE BIOREACTOR FOR MICROBIAL FUEL CELL

Master'sMASTER OF ENGINEERING (CDE

Reasoning Method Based on Intervals with Symmetric Truncated Normal Density

Error parameters are inevitable in systems. In formal verification, previous reasoning methods seldom considered the probability information of errors. In this article, errors are described as symmetric truncated normal intervals consisting of the intervals and symmetric truncated normal probability density. Furthermore, we also rigorously prove lemmas and a theorem to partially simplify the calculation process of truncated normal intervals and independently verify the formulas of variance and expectation of symmetric truncated interval given by some scholars. The mathematical derivation process or verification codes are provided for most of the key formulas in this article. Hence, we propose a new reasoning method that combines the probability information of errors with the previous statistical reasoning methods. Finally, an engineering example of the reasoning verification of train acceleration is provided. After simulating the large-scale cases, it is shown that the simulation results are consistent with the theoretical reasoning results. This method needs more calculation, while it is more effective in detecting non-error’s fault factors than other error reasoning methods