Optimal Control Problem with Necessary Optimality Conditions for the Viscous Dullin-Gottwald-Holm Equation

We study the quadratic cost optimal control problems for the viscous Dullin-Gottwald-Holm equation. The main novelty of this paper is to derive the necessary optimality conditions of optimal controls, corresponding to physically meaningful distributive observations. For this we prove the Gâteaux differentiability of nonlinear solution mapping on control variables. Moreover by making use of the second order Gâteaux differentiability of solution mapping on control variables, we prove the local uniqueness of optimal control. This is another novelty of the paper

Visual content analysis of visitors’ engagement with an instagrammable exhibition

This study aims to show how a museum exhibition designed to encourage visitors to take pictures can affect visitors’ behavior. We analyzed visitors’ engagement with the Yumi's Cell Special Exhibition (hereafter Yumi) held in South Korea, employing computer vision for the analysis of visitors’ Instagram pictures. Our research questions are: What types of pictures do visitors post on Instagram during or after their visit? And can Yumi’s instagrammable features make visitors interact more with the exhibition? We also formulated two corresponding hypotheses: Visitors are primarily interested in taking selfies in the instagrammable environment; and visitors struck more active poses when taking pictures in an instagrammable exhibition than in a traditional art exhibition. Through the image analysis of Instagram posts of the exhibition, we found many pictures of people, but the proportion of selfies was relatively limited. This suggests that visitors were more interested in interacting with the exhibition rather than taking selfies. This has also been confirmed by the pose analysis, which showed that the participatory feature of the exhibition encouraged visitors to take photos in active poses, interacting, mimicking, and performing. The framework presented and the findings offer insights about how to design exhibitions to increase visitors’ participation

The effect of motivational factor for using SNSs on tourist attitude

Purpose – This research examines the relationship between motivational factor in regards to writing comments and tourist attitude. Specifically, the study (a) explains the relationships between motivational factors and tourist recommendation intentions on SNSs, and (b) evaluates the factors influencing recommendation intentions on SNSs. Design – To develop a useful marketing strategy in the Social Networking Site (SNS) environment in Korea tourism, it is important to identify the relationship between the motivational factors regarding the reasons for writing comments and tourist attitude to suggest effective tourism marketing on SNSs due to the growing interest in Korea tourism among Chinese students and tourists. Methodology – The measurement items were adapted for an SNS setting from published studies related to the hospitality and tourism field. All of the measurement items were based on a 7-point Likert-type scale. Finding – The results offer valuable suggestions to SNS firms and marketers with important insights into the quality of SNS contents for developing marketing strategies. Originality – For further utilization as an effective bridging tool between SNS users, more detailed understanding of the developed approach for using SNSs is provided

Effect and Safety of Shihogyejitang for Drug Resistant Childhood Epilepsy

Objective. Herbal medicine has been widely used to treat drug resistant epilepsy. Shihogyejitang (SGT) has been commonly used to treat epilepsy. We investigated the effect and safety of SGT in children with drug resistant epilepsy. Design. We reviewed medical records of 54 patients with epilepsy, who failed to respond to at least two antiepileptic drugs and have been treated with SGT between April 2006 and June 2014 at the Department of Pediatric Neurology, I-Tomato Hospital, Korea. Effect was measured by the response rate, seizure-free rate, and retention rate at six months. We also checked adverse events, change in antiepileptic drugs use, and the variables related to the outcome. Results. Intent-to-treat analysis showed that, after six months, 44.4% showed a >50% seizure reduction, 24.1% including seizure-free, respectively, and 53.7% remained on SGT. Two adverse events were reported, mild skin rash and fever. Focal seizure type presented significantly more positive responses when compared with other seizure types at six months ( = 0.0284, Fisher's exact test). Conclusion. SGT is an effective treatment with excellent tolerability for drug resistant epilepsy patients. Our data provide evidence that SGT may be used as alternative treatment option when antiepileptic drug does not work in epilepsy children

Corporate Social Responsibility Reporting in the Casino Industry: A Content Analysis

The purpose of this study is to provide preliminary exploration of how corporate social responsibility issues are currently reported and communicated by US major casino companies. Empirical evidence is drawn from standalone CSR reports and websites of the 30 largest casino companies in the US, which is explored through content analysis methodology. This paper finds that there are substantial variations in the reporting and communication of CSR issues by casino companies. While casino companies mainly rely on websites to communicate CSR issues, 23% of the sample companies use standalone CSR reports. Whereas websites tend to provide relatively limited information about CSR activities, standalone CSR reports have a tendency to cover comprehensive CSR themes in a detailed manner. In addition, the content analysis based on website reveals that while most casino companies tend to be passive about responsible gaming, some are trying to behave more actively and responsibly about this issue

Choice modelling of a car traveler towards park-and-ride services in Putrajaya to create green development

Putrajaya is facing an increasing number of private car ownership and its usage. Inte-grated transportation infrastructure connecting the city with suburban areas and comparatively low-cost housing schemes are at the fringes of Putrajaya City. It creates a discrepancy between housing and employment attentiveness. Due to the attractiveness of jobs in the city centre, commuters’ travelling pattern is morning/evening peak hours, and it leads to traffic congestion on a few major artilleries leading to and from the city. In contrast, Putrajaya was designed to achieve a 70:30 modal split ratio. This policy was introduced to target 70% of the commuters towards a sustainable mode of transport as their mode choice. Currently, congestion in Putrajaya is due to the use of single-occupant vehicles (SOV). The SOV users cannot be convinced to use the park-and-ride services (P&RS) without understanding their travel behaviors. Therefore, the mode choice models (MCM) were developed through binary logit regression (BLR) approaches to determine the factors that influence the SOV travelers’ decisions to adopt the P&RS. As a result, several factors, which included the socio-demographic factors, travel time, travel expenses, environmental protection, avoiding stress, parking problems, vehicles sharing, and traveling directly, were found to be significant and will promote green development. Furthermore, the quality of the developed mode choice model was validated through the training and testing approach of logistic regression. Ultimately, this study can help stakeholders to encourage SOV users towards P&RS by overcoming these factors

Analysis of Changes in the Total Lymphocyte and Eosinophil Count during Immunotherapy for Metastatic Renal Cell Carcinoma: Correlation with Response and Survival

The aims of this study were to analyze lymphocyte and eosinophil counts in consecutive peripheral blood samples taken during immunotherapy for metastatic renal cell carcinoma (mRCC) and to correlate the findings with objective response and survival. A total of 40 patients with mRCC who received immunotherapy with interleukin-2, interferon-α, and 5-fluorouracil were analyzed. Objective responses were observed in 14 patients, including 2 (5%) who showed a complete response (CR) and 12 (30%) who showed a partial response (PR). Eleven patients (27%) achieved stable disease (SD), and 15 patients (38%) had progressive disease (PD). Changes from baseline in the total lymphocyte counts were significantly higher in the responding patients (CR+PR+SD) than in the non-responding patients (PD) (p=0.017), but no difference was seen in the total eosinophil counts (p=0.275). Univariate analysis identified the Eastern Cooperative Oncology Group (ECOG) performance status (p=0.017), the presence of a primary renal tumor (p<0.001) and the peripheral lymphocyte counts at week 4 (p=0.034) as prognostic factors, but a low ECOG performance status (p=0.003) and the presence of a primary renal tumor (p=0.001) were identified as independent poor prognostic factors by multivariate analysis. This study provides further evidence that changes in blood lymphocyte counts may serve as an objective indicator of objective responses

Lomerizine inhibits LPS-mediated neuroinflammation and tau hyperphosphorylation by modulating NLRP3, DYRK1A, and GSK3α/β

IntroductionLomerizine is a calcium channel blocker that crosses the blood–brain barrier and is used clinically in the treatment of migraines. However, whether lomerizine is beneficial in modulating neuroinflammatory responses has not been tested yet.MethodsTo assess the potential of lomerizine for repurposing as a treatment for neuroinflammation, we investigated the effects of lomerizine on LPS-induced proinflammatory responses in BV2 microglial cells, Alzheimer’s disease (AD) excitatory neurons differentiated from induced pluripotent stem cells (iPSCs), and in LPS-treated wild type mice.ResultsIn BV2 microglial cells, lomerizine pretreatment significantly reduced LPS-evoked proinflammatory cytokine and NLRP3 mRNA levels. Similarly, lomerizine pretreatment significantly suppressed the increases in Iba-1, GFAP, proinflammatory cytokine and NLRP3 expression induced by LPS in wild-type mice. In addition, lomerizine posttreatment significantly decreased LPS-stimulated proinflammatory cytokine and SOD2 mRNA levels in BV2 microglial cells and/or wild-type mice. In LPS-treated wild-type mice and AD excitatory neurons differentiated from iPSCs, lomerizine pretreatment ameliorated tau hyperphosphorylation. Finally, lomerizine abolished the LPS-mediated activation of GSK3α/β and upregulation of DYRK1A, which is responsible for tau hyperphosphorylation, in wild-type mice.DiscussionThese data suggest that lomerizine attenuates LPS-mediated neuroinflammatory responses and tau hyperphosphorylation and is a potential drug for neuroinflammation- or tauopathy-associated diseases

Characteristics of subclinical tuberculosis compared to active symptomatic tuberculosis using nationwide registry cohort in Korea: prospective cohort study

ObjectiveThe clinical manifestations of tuberculosis (TB) range from asymptomatic to disseminated depending on the microbiological and immunological status, making the diagnosis challenging. To improve our understanding of the disease progression mechanism, we aimed to identify the characteristics of subclinical TB and important predictors of symptom development.MethodsFrom July 2018 to June 2019, we systemically collected data from the National Surveillance System of South Korea on patients with pulmonary TB, and compared the characteristics of subclinical and active symptomatic TB patients.ResultsA total of 4,636 patients with pulmonary TB were included, and the prevalence of subclinical TB was 37.1% (1,720/4,636). In subclinical TB patients, the positivity rates of acid-fast bacilli (AFB) smear and culture were 16.2 and 50.2%, respectively. Subclinical TB patients were younger (55.6 ± 19.2 vs. 60.7 ± 19.5, P &lt; 0.001), had a higher body mass index (21.7 ± 3.1 vs. 21.0 ± 3.5, P &lt; 0.001), less under Medicaid support, and had lower rates of chronic lung disease, AFB smear and culture positivity, and bilateral disease. Regarding the characteristic differences of individual TB-related symptoms, age was positively associated with dyspnoea and general weakness but negatively associated with chest pain, haemoptysis, and weight loss. Male patients were more prone to weight loss. Chronic lung disease was related to symptoms including cough/phlegm, dyspnoea, and haemoptysis, while autoimmune diseases were associated with fever and weight loss.ConclusionsThe development of TB-related symptoms was associated with microbiological burden and clinical characteristics including underlying comorbidities, which should be evaluated carefully

Current Status of Targeted Therapy for Advanced Renal Cell Carcinoma

The treatment of metastatic renal cell carcinoma (mRCC) has recently evolved from being predominantly cytokine-based treatment to the use of targeted agents, which include sorafenib, sunitinib, bevacizumab (plus interferon alpha [IFN-α]), temsirolimus, everolimus, pazopanib, and most recently, axitinib. Improved understanding of the molecular pathways implicated in the pathogenesis of RCC has led to the development of specific targeted therapies for treating the disease. In Korea, it has been 5 years since targeted therapy became available for mRCC. Thus, we now have broader and better therapeutic options at hand, leading to a significantly improved prognosis for patients with mRCC. However, the treatment of mRCC remains a challenge and a major health problem. Many questions remain on the efficacy of combination treatments and on the best methods for achieving complete remission. Additional studies are needed to optimize the use of these agents by identifying those patients who would most benefit and by elucidating the best means of delivering these agents, either in combination or as sequential single agents. Furthermore, numerous ongoing research activities aim at improving the benefits of the new compounds in the metastatic situation or their application in the early phase of the disease. This review introduces what is currently known regarding the fundamental biology that underlies clear cell RCC, summarizes the clinical evidence supporting the benefits of targeted agents in mRCC treatment, discusses survival endpoints used in pivotal clinical trials, and outlines future research directions