Garlic Consumption and All-Cause Mortality among Chinese Oldest-Old Individuals: A Population-Based Cohort Study.

In vitro and in vivo experimental studies have shown garlic has protective effects on the aging process; however, there is no evidence that garlic consumption is associated with all-cause mortality among oldest-old individuals (≥80 years). From 1998 to 2011, 27,437 oldest-old participants (mean age: 92.9 years) were recruited from 23 provinces in China. The frequencies of garlic consumption at baseline and at age 60 were collected. Cox proportional hazards models adjusted for potential covariates were constructed to estimate hazard ratios (HRs) relating garlic consumption to all-cause mortality. Among 92,505 person-years of follow-up from baseline to September 1, 2014, 22,321 participants died. Participants who often (≥5 times/week) or occasionally (1-4 times/week) consumed garlic survived longer than those who rarely (less than once/week) consumed it (p < 0.001). Participants who consumed garlic occasionally or often had a lower risk for mortality than those who rarely consumed garlic at baseline; the adjusted HRs for mortality were 0.92(0.89-0.94) and 0.89(0.85-0.92), respectively. The inverse associations between garlic consumption and all-cause mortality were robust in sensitivity analyses and subgroup analyses. In this study, habitual consumption of garlic was associated with a lower all-cause mortality risk; this advocates further investigation into garlic consumption for promoting longevity

Human activities accelerated the degradation of saline seepweed red beaches by amplifying top‐down and bottom‐up forces

Salt marshes dominated by saline seepweed (Suaeda heteroptera) provide important ecosystem services such as sequestering carbon (blue carbon), maintaining healthy fisheries, and protecting shorelines. These salt marshes also constitute stunning red beach landscapes, and the resulting tourism significantly contributes to the local economy. However, land use change and degradation have led to a substantial loss of the red beach area. It remains unclear how human activities influence the top‐down and bottom‐up forces that regulate the distribution and succession of these salt marshes and lead to the degradation of the red beaches. We examined how bottom‐up forces influenced the germination, emergence, and colonization of saline seepweed with field measurements and a laboratory experiment. We also examined whether top‐down forces affected the red beach distribution by conducting a field survey for crab burrows and density, laboratory feeding trials, and waterbird investigations. The higher sediment accretion rate induced by human activities limited the establishment of new red beaches. The construction of tourism facilities and the frequent presence of tourists reduced the density of waterbirds, which in turn increased the density of crabs, intensifying the top‐down forces such as predators and herbivores that drive the degradation of the coastal red beaches. Our results show that sediment accretion and plant–herbivory changes induced by human activities were likely the two primary ecological processes leading to the degradation of the red beaches. Human activities significantly shaped the abundance and distribution of the red beaches by altering both top‐down and bottom‐up ecological processes. Our findings can help us better understand the dynamics of salt marshes and have implications for the management and restoration of coastal wetlands

Climate change impact on China food security in 2050

Climate change is now affecting global agriculture and food production worldwide. Nonetheless the direct link between climate change and food security at the national scale is poorly understood. Here we simulated the effect of climate change on food security in China using the CERES crop models and the IPCC SRES A2 and B2 scenarios including CO2 fertilization effect. Models took into account population size, urbanization rate, cropland area, cropping intensity and technology development. Our results predict that food crop yield will increase +3-11 % under A2 scenario and +4 % under B2 scenario during 2030-2050, despite disparities among individual crops. As a consequence China will be able to achieve a production of 572 and 615 MT in 2030, then 635 and 646 MT in 2050 under A2 and B2 scenarios, respectively. In 2030 the food security index (FSI) will drop from +24 % in 2009 to -4.5 % and +10.2 % under A2 and B2 scenarios, respectively. In 2050, however, the FSI is predicted to increase to +7.1 % and +20.0 % under A2 and B2 scenarios, respectively, but this increase will be achieved only with the projected decrease of Chinese population. We conclude that 1) the proposed food security index is a simple yet powerful tool for food security analysis; (2) yield growth rate is a much better indicator of food security than yield per se; and (3) climate change only has a moderate positive effect on food security as compared to other factors such as cropland area, population growth, socio-economic pathway and technology development. Relevant policy options and research topics are suggested accordingly

Learning to Fuse Monocular and Multi-view Cues for Multi-frame Depth Estimation in Dynamic Scenes

Multi-frame depth estimation generally achieves high accuracy relying on the multi-view geometric consistency. When applied in dynamic scenes, e.g., autonomous driving, this consistency is usually violated in the dynamic areas, leading to corrupted estimations. Many multi-frame methods handle dynamic areas by identifying them with explicit masks and compensating the multi-view cues with monocular cues represented as local monocular depth or features. The improvements are limited due to the uncontrolled quality of the masks and the underutilized benefits of the fusion of the two types of cues. In this paper, we propose a novel method to learn to fuse the multi-view and monocular cues encoded as volumes without needing the heuristically crafted masks. As unveiled in our analyses, the multi-view cues capture more accurate geometric information in static areas, and the monocular cues capture more useful contexts in dynamic areas. To let the geometric perception learned from multi-view cues in static areas propagate to the monocular representation in dynamic areas and let monocular cues enhance the representation of multi-view cost volume, we propose a cross-cue fusion (CCF) module, which includes the cross-cue attention (CCA) to encode the spatially non-local relative intra-relations from each source to enhance the representation of the other. Experiments on real-world datasets prove the significant effectiveness and generalization ability of the proposed method.Comment: Accepted by CVPR 2023. Code and models are available at: https://github.com/ruili3/dynamic-multiframe-dept

Comparison of the Electrochemical Performance and Thermal Stability for Three Kinds of Charged Cathodes

The electrochemical performance and thermal stability of Li(Ni0.5Co0.2Mn0.3)O2, LiMn2O4, and LiFePO4 are investigated by the multi-channel battery cycler, electrochemical workstation, thermogravimetric analysis (TGA) and C80 instrument in this work. For electrochemical performance, Li(Ni0.5Co0.2Mn0.3)O2 shows the highest specific capacity but the worst cycle stability. For the thermal stability, the experimental results of thermogravimetry and C80 indicate that the charged Li(Ni0.5Co0.2Mn0.3)O2 has the worst thermal stability compared with charged LiFePO4 and LiMn2O4. It is also testified by calculating the chemical kinetic parameters of cathode materials based on the Arrhenius law. The pure Li(Ni0.5Co0.2Mn0.3)O2 starts to self-decompose at around 250°C with total heat generation of −88 J/g. As for a full battery, the total heat generation is −810 J/g with exothermic peak temperature of 242°C. The present results show that thermal runaway is more likely to occur for Li(Ni0.5Co0.2Mn0.3)O2 with the full battery

Cripto-1 Promotes the Epithelial-Mesenchymal Transition in Esophageal Squamous Cell Carcinoma Cells

Esophageal carcinoma is a major public health problem worldwide and one of the most aggressively malignant neoplasms. Although considerable diagnostic and therapeutic progress has been made in recent years, the prognosis of EC patients still remains dismal due to high rates of recurrence/metastasis and invasion. Previous studies have demonstrated that Epithelial mesenchymal transition (EMT) is proposed as a critical mechanism for the acquisition of malignant phenotypes by epithelial cells. Several lines of evidence have shown that Cripto-1 plays an important oncogenic role during tumorigenesis by promoting EMT. The aim of our study was to evaluate the significance of Cripto-1 which plays a role in EMT and its metastasis in esophageal carcinoma. Data of this study suggest that Cripto-1 overexpression is connected with the tumorigenesis and progression of esophageal carcinoma; shRNA might be feasible for the inhibition of the invasion and metastasis of esophageal carcinoma

Long-term use of antibiotics and risk of type 2 diabetes in women:a prospective cohort study

BACKGROUND: Accumulating evidence suggested that long-term antibiotic use may alter the gut microbiome, which has, in turn, been linked to type 2 diabetes. We undertook this study to investigate whether antibiotic use was associated with increased risk of type 2 diabetes. METHODS: This prospective cohort study included women free of diabetes, cardiovascular disease and cancer in the Nurses’ Health Study (NHS 2008–2014) and NHS II (2009–2017). We evaluated the overall duration of antibiotics use in the past 4 years and subsequent diabetes risk with Cox proportional-hazards regression adjusting for demography, family history of diabetes and lifestyle factors. RESULTS: Pooled analyses of NHS and NHS II (2837 cases, 703 934 person-years) revealed that a longer duration of antibiotic use in the past 4 years was associated with higher risk of diabetes [Trend-coefficient = 0.09, 95% confidence interval (CI) 0.04 to 0.13]. Participants who received antibiotics treatment for a medium duration of 15 days to 2 months [hazard ratio (HR) 1.23, 95% CI 1.10 to 1.39] or long duration of >2 months (HR 1.20, 95% CI 1.02 to 1.38) had higher risk of type 2 diabetes as compared with non-users. Subgroup analyses suggested that the associations were unlikely to be modified by age, family history of diabetes, obesity, smoking, alcohol drinking, physical activity and overall diet quality. CONCLUSIONS: A longer duration of antibiotic use in recent years was associated with increased risk of type 2 diabetes in women. Physicians should exercise caution when prescribing antibiotics, particularly for long-term use

Polypharmacology of Berberine Based on Multi-Target Binding Motifs

Background: Polypharmacology is emerging as the next paradigm in drug discovery. However, considerable challenges still exist for polypharmacology modeling. In this study, we developed a rational design to identify highly potential targets (HPTs) for polypharmacological drugs, such as berberine.Methods and Results: All the proven co-crystal structures locate berberine in the active cavities of a redundancy of aromatic, aliphatic, and acidic residues. The side chains from residues provide hydrophobic and electronic interactions to aid in neutralization for the positive charge of berberine. Accordingly, we generated multi-target binding motifs (MBM) for berberine, and established a new mathematical model to identify HPTs based on MBM. Remarkably, the berberine MBM was embodied in 13 HPTs, including beta-secretase 1 (BACE1) and amyloid-β1-42 (Aβ1-42). Further study indicated that berberine acted as a high-affinity BACE1 inhibitor and prevented Aβ1-42 aggregation to delay the pathological process of Alzheimer’s disease.Conclusion: Here, we proposed a MBM-based drug-target space model to analyze the underlying mechanism of multi-target drugs against polypharmacological profiles, and demonstrated the role of berberine in Alzheimer’s disease. This approach can be useful in derivation of rules, which will illuminate our understanding of drug action in diseases

The gut microbiome dysbiosis and regulation by fecal microbiota transplantation: umbrella review

BackgroundGut microbiome dysbiosis has been implicated in various gastrointestinal and extra-gastrointestinal diseases, but evidence on the efficacy and safety of fecal microbiota transplantation (FMT) for therapeutic indications remains unclear.MethodsThe gutMDisorder database was used to summarize the associations between gut microbiome dysbiosis and diseases. We performed an umbrella review of published meta-analyses to determine the evidence synthesis on the efficacy and safety of FMT in treating various diseases. Our study was registered in PROSPERO (CRD42022301226).ResultsGut microbiome dysbiosis was associated with 117 gastrointestinal and extra-gastrointestinal. Colorectal cancer was associated with 92 dysbiosis. Dysbiosis involving Firmicutes (phylum) was associated with 34 diseases. We identified 62 published meta-analyses of FMT. FMT was found to be effective for 13 diseases, with a 95.56% cure rate (95% CI: 93.88–97.05%) for recurrent Chloridoids difficile infection (rCDI). Evidence was high quality for rCDI and moderate to high quality for ulcerative colitis and Crohn’s disease but low to very low quality for other diseases.ConclusionGut microbiome dysbiosis may be implicated in numerous diseases. Substantial evidence suggests FMT improves clinical outcomes for certain indications, but evidence quality varies greatly depending on the specific indication, route of administration, frequency of instillation, fecal preparation, and donor type. This variability should inform clinical, policy, and implementation decisions regarding FMT